Increased expression of SLC25A1/CIC causes an autistic-like phenotype with altered neuron morphology

Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway

(2021) Inca A. Dieterich et al.   Scientific Reports

Emerging behavioral and neuroimaging biomarkers for early and accurate characterization of autism spectrum disorders: a systematic review

(2021) Chandrakanta S. Hiremath et al.   Translational Psychiatry

ATG9A regulates proteostasis through reticulophagy receptors FAM134B and SEC62 and folding chaperones CALR and HSPB1

(2021) Brendan K. Sheehan et al.   iScience

Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism

(2021) Michael J. Rigby et al.   Communications Biology

The endoplasmic reticulum acetyltransferases ATase1/NAT8B and ATase2/NAT8 are differentially regulated to adjust engagement of the secretory pathway

(2020) Michael J. Rigby et al.   JOURNAL OF NEUROCHEMISTRY

Revealing Dynamic Protein Acetylation across Subcellular Compartments

(2020) Josue Baeza et al.   JOURNAL OF PROTEOME RESEARCH

Diseases Caused by Mutations in Mitochondrial Carrier Genes SLC25: A Review

(2020) Ferdinando Palmieri et al.   Biomolecules

Abnormalities of synaptic mitochondria in autism spectrum disorder and related neurodevelopmental disorders

(2020) Liliana Rojas-Charry et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Increased lipid accumulation in Mucor Circinelloides by overexpression of mitochondrial citrate transporter genes

(2019) Junhuan Yang et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat

(2019) Brian R. Barnett et al.   Translational Psychiatry

Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk

(2019) Inca A. Dieterich et al.   Nature Communications

Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype

(2018) Yajing Peng et al.   AGING CELL

ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism

(2018) Carlotta Granchi   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bidirectional Microglia–Neuron Communication in Health and Disease

(2018) Zsuzsanna Szepesi et al.   Frontiers in Cellular Neuroscience

Nε-lysine acetylation in the endoplasmic reticulum – a novel cellular mechanism that regulates proteostasis and autophagy

(2018) Mark A. Farrugia et al.   JOURNAL OF CELL SCIENCE

Robust and fast nonlinear optimization of diffusion MRI microstructure models

(2017) R.L. Harms et al.   NEUROIMAGE

Candidate Biomarkers in Children with Autism Spectrum Disorder: A Review of MRI Studies

(2017) Dongyun Li et al.   Neuroscience Bulletin

Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder

(2017) Aditi Deshpande et al.   Cell Reports

Nϵ-lysine acetylation in the lumen of the endoplasmic reticulum: A way to regulate autophagy and maintain protein homeostasis in the secretory pathway

(2016) Yajing Peng et al.   Autophagy

Improved proteostasis in the secretory pathway rescues Alzheimer’s disease in the mouse

(2016) Yajing Peng et al.   BRAIN

Targeting endoplasmic reticulum acetylation to restore proteostasis in Alzheimer’s disease

(2016) Claudia Duran-Aniotz et al.   BRAIN

Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation

(2016) Rikki Hullinger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Autism and the synapse

(2015) Darius Ebrahimi-Fakhari et al.   CURRENT OPINION IN NEUROLOGY

JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse

(2015) Jamee M. Berg et al.   NEURON

High-Resolution Enabled 12-Plex DiLeu Isobaric Tags for Quantitative Proteomics

(2014) Dustin C. Frost et al.   ANALYTICAL CHEMISTRY

The Endoplasmic Reticulum-based Acetyltransferases, ATase1 and ATase2, Associate with the Oligosaccharyltransferase to Acetylate Correctly Folded Polypeptides

(2014) Yun Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-Translational Regulation of CD133 by ATase1/ATase2-Mediated Lysine Acetylation

(2014) Anthony B. Mak et al.   JOURNAL OF MOLECULAR BIOLOGY

Deficient Import of Acetyl-CoA into the ER Lumen Causes Neurodegeneration and Propensity to Infections, Inflammation, and Cancer

(2014) Y. Peng et al.   JOURNAL OF NEUROSCIENCE

50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

(2014) Eric Verdin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transgenic mouse models for ADHD

(2013) Damiana Leo et al.   CELL AND TISSUE RESEARCH

Bidirectional Microglia-Neuron Communication in the Healthy Brain

(2013) Ukpong B. Eyo et al.   NEURAL PLASTICITY

Mutations in SLC33A1 Cause a Lethal Autosomal-Recessive Disorder with Congenital Cataracts, Hearing Loss, and Low Serum Copper and Ceruloplasmin

(2012) Peter Huppke et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Lysine acetylation in the lumen of the ER: A novel and essential function under the control of the UPR

(2012) Mariana Pehar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Proteomic Assessment Shows That Many Endoplasmic Reticulum (ER)-resident Proteins Are Targeted by Nϵ-Lysine Acetylation in the Lumen of the Organelle and Predicts Broad Biological Impact

(2012) Mariana Pehar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SLC33A1/AT-1 Protein Regulates the Induction of Autophagy Downstream of IRE1/XBP1 Pathway

(2012) Mariana Pehar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Inhibition of the Acetyltransferases ATase1 and ATase2 Reduces β-Secretase (BACE1) Levels and Aβ Generation

(2012) Yun Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microscopic diffusion tensor atlas of the mouse brain

(2011) Yi Jiang et al.   NEUROIMAGE

Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism

(2011) Stephan J. Sanders et al.   NEURON

Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death

(2010) Mariana Pehar et al.   AGING CELL

AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability

(2010) M. C. Jonas et al.   JOURNAL OF CELL SCIENCE

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

Orientationally invariant indices of axon diameter and density from diffusion MRI

(2010) Daniel C. Alexander et al.   NEUROIMAGE

Social deficits, stereotypy and early emergence of repetitive behavior in the C58/J inbred mouse strain

(2009) Bryce C. Ryan et al.   BEHAVIOURAL BRAIN RESEARCH

A Missense Mutation in SLC33A1, which Encodes the Acetyl-CoA Transporter, Causes Autosomal-Dominant Spastic Paraplegia (SPG42)

(2008) Pengfei Lin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Two Endoplasmic Reticulum (ER)/ER Golgi Intermediate Compartment-based Lysine Acetyltransferases Post-translationally Regulate BACE1 Levels

(2008) Mi Hee Ko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY