The Amyloid-β Peptide in Amyloid Formation Processes: Interactions with Blood Proteins and Naturally Occurring Metal Ions

Association of Selenoprotein P with Alzheimer's Pathology in Human Cortex

(2017) Frederick P. Bellinger et al.   JOURNAL OF ALZHEIMERS DISEASE

NMR Studies of Zinc, Copper, and Iron Binding to Histidine, the Principal Metal Ion Complexing Site of Amyloid-β Peptide

(2017) Nanditha G. Nair et al.   JOURNAL OF ALZHEIMERS DISEASE

Imbalanced cholesterol metabolism in Alzheimer's disease

(2016) Zhao Xue-shan et al.   CLINICA CHIMICA ACTA

How Zn can impede Cu detoxification by chelating agents in Alzheimer's disease: a proof-of-concept study

(2016) Amandine Conte-Daban et al.   DALTON TRANSACTIONS

Antibody-Based Drugs and Approaches Against Amyloid-β Species for Alzheimer’s Disease Immunotherapy

(2016) Jing Liu et al.   DRUGS & AGING

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Specific Binding of Cu(II) Ions to Amyloid-Beta Peptides Bound to Aggregation-Inhibiting Molecules or SDS Micelles Creates Complexes that Generate Radical Oxygen Species

(2016) Ann Tiiman et al.   JOURNAL OF ALZHEIMERS DISEASE

Ionic Strength Modulation of the Free Energy Landscape of Aβ40 Peptide Fibril Formation

(2016) Axel Abelein et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of Mn(II) ion binding to the amyloid-β peptide in Alzheimer⿿s disease

(2016) Cecilia Wallin et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

(2016) Marielle Aulikki Wälti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HSA targets multiple Aβ42 species and inhibits the seeding-mediated aggregation and cytotoxicity of Aβ42 aggregates

(2016) Conggang Wang et al.   RSC Advances

Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid depositsin vivo

(2016) Raya Al-Shawi et al.   Open Biology

Analysis of Amyloid Precursor Protein Function in Drosophila melanogaster

(2016) Marlène Cassar et al.   Frontiers in Molecular Neuroscience

Regulation of Copper and Iron Homeostasis by Metal Chelators: A Possible Chemotherapy for Alzheimer’s Disease

(2015) Anne Robert et al.   ACCOUNTS OF CHEMICAL RESEARCH

Alzheimer’s Disease: A Heme–Aβ Perspective

(2015) Chandradeep Ghosh et al.   ACCOUNTS OF CHEMICAL RESEARCH

Heterogeneity and Turnover of Intermediates during Amyloid-β (Aβ) Peptide Aggregation Studied by Fluorescence Correlation Spectroscopy

(2015) Ann Tiiman et al.   BIOCHEMISTRY

Studies on Drug – Human Serum Albumin Binding: The Current State of the Matter

(2015) Zvetanka Zhivkova   CURRENT PHARMACEUTICAL DESIGN

Antibody drugs for Alzheimer’s show glimmers of promise

(2015) Sara Reardon   NATURE

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Zinc as chaperone-mimicking agent for retardation of amyloid β peptide fibril formation

(2015) Axel Abelein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's amyloid theory gets modest boost

(2015) E. Underwood   SCIENCE

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Reelin protects against amyloid β toxicity in vivo

(2015) Courtney Lane-Donovan et al.   Science Signaling

A comparison of hair and serum trace elements in patients with Alzheimer disease and healthy participants

(2015) Emine Rabia KOÇ et al.   Turkish Journal Of Medical Sciences

Reelin protects against amyloid β toxicity in vivo

(2015) Courtney Lane-Donovan et al.   Science Signaling

Molecular basis for mid-region amyloid-β capture by leading Alzheimer's disease immunotherapies

(2015) Gabriela A. N. Crespi et al.   Scientific Reports

The Ongoing Search for Small Molecules to Study Metal-Associated Amyloid-β Species in Alzheimer’s Disease

(2014) Masha G. Savelieff et al.   ACCOUNTS OF CHEMICAL RESEARCH

Alzheimer Peptides Aggregate into Transient Nanoglobules That Nucleate Fibrils

(2014) Jinghui Luo et al.   BIOCHEMISTRY

Endogenous Polyamines Reduce the Toxicity of Soluble Aβ Peptide Aggregates Associated with Alzheimer’s Disease

(2014) Jinghui Luo et al.   BIOMACROMOLECULES

Biological metals and metal-targeting compounds in major neurodegenerative diseases

(2014) Kevin J. Barnham et al.   CHEMICAL SOCIETY REVIEWS

Non-chaperone Proteins Can Inhibit Aggregation and Cytotoxicity of Alzheimer Amyloid β Peptide

(2014) Jinghui Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The hairpin conformation of the amyloid β peptide is an important structural motif along the aggregation pathway

(2014) Axel Abelein et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biometals and Their Therapeutic Implications in Alzheimer’s Disease

(2014) Scott Ayton et al.   Neurotherapeutics

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

(2014) Georg Meisl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exposure to As-, Cd-, and Pb-Mixture Induces Aβ, Amyloidogenic APP Processing and Cognitive Impairments via Oxidative Stress-Dependent Neuroinflammation in Young Rats

(2014) Anushruti Ashok et al.   TOXICOLOGICAL SCIENCES

Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer’s disease

(2014) Lluís Pujadas et al.   Nature Communications

The role of pro-inflammatory S100A9 in Alzheimer’s disease amyloid-neuroinflammatory cascade

(2013) Chao Wang et al.   ACTA NEUROPATHOLOGICA

Mapping the Interactions between the Alzheimer’s Aβ-Peptide and Human Serum Albumin beyond Domain Resolution

(2013) Moustafa Algamal et al.   BIOPHYSICAL JOURNAL

Biophysical Studies of the Amyloid β-Peptide: Interactions with Metal Ions and Small Molecules

(2013) Sebastian Wärmländer et al.   CHEMBIOCHEM

Aβ Interacts with Both the Iron Center and the Porphyrin Ring of Heme: Mechanism of Heme’s Action on Aβ Aggregation and Disaggregation

(2013) Can Yuan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Inhibiting and Reversing Amyloid-β Peptide (1-40) Fibril Formation with Gramicidin S and Engineered Analogues

(2013) Jinghui Luo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Formation of Dynamic Soluble Surfactant-induced Amyloid β Peptide Aggregation Intermediates

(2013) Axel Abelein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Common Binding Mode for Imaging Agents to Amyloid Fibrils from Molecular Dynamics Simulations

(2013) Katrine Kirkeby Skeby et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vitro and Mechanistic Studies of an Antiamyloidogenic Self-Assembled Cyclic d,l-α-Peptide Architecture

(2013) Michal Richman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function

(2013) Su Ling Leong et al.   Metallomics

Blood Amyloid Beta Levels in Healthy, Mild Cognitive Impairment and Alzheimer’s Disease Individuals: Replication of Diastolic Blood Pressure Correlations and Analysis of Critical Covariates

(2013) Agustín Ruiz et al.   PLoS One

Atomic structure and hierarchical assembly of a cross-  amyloid fibril

(2013) A. W. P. Fitzpatrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance

(2013) Itender Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteolytic Degradation of Amyloid  -Protein

(2013) T. Saido et al.   Cold Spring Harbor Perspectives in Medicine

The blood-brain barrier in health and disease

(2012) Richard Daneman   ANNALS OF NEUROLOGY

pH-dependence of the specific binding of Cu(II) and Zn(II) ions to the amyloid-β peptide

(2012) Leila Ghalebani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ca2+enhances Aβ polymerization rate and fibrillar stability in a dynamic manner

(2012) Kristoffer Brännström et al.   BIOCHEMICAL JOURNAL

The Elevated Copper Binding Strength of Amyloid-β Aggregates Allows the Sequestration of Copper from Albumin: A Pathway to Accumulation of Copper in Senile Plaques

(2012) Dianlu Jiang et al.   BIOCHEMISTRY

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Transient small molecule interactions kinetically modulate amyloid β peptide self-assembly

(2012) Axel Abelein et al.   FEBS LETTERS

Metallostasis in Alzheimer's disease

(2012) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

Human Serum Albumin Can Regulate Amyloid-β Peptide Fiber Growth in the Brain Interstitium

(2012) Helen F. Stanyon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineered non-fluorescent Affibody molecules facilitate studies of the amyloid-beta (Aβ) peptide in monomeric form: Low pH was found to reduce Aβ/Cu(II) binding affinity

(2012) Joel Lindgren et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain

(2012) Sven O. Dahms et al.   JOURNAL OF MOLECULAR BIOLOGY

Oligomeric Intermediates in Amyloid Formation: Structure Determination and Mechanisms of Toxicity

(2012) Marcus Fändrich   JOURNAL OF MOLECULAR BIOLOGY

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Metal dyshomeostasis and oxidative stress in Alzheimer’s disease

(2012) Mark A. Greenough et al.   NEUROCHEMISTRY INTERNATIONAL

Metal ions, Alzheimer's disease and chelation therapy

(2011) Ana Budimir   ACTA PHARMACEUTICA

Solid-State NMR Studies of Amyloid Fibril Structure

(2011) Robert Tycko   Annual Review of Physical Chemistry

Stoichiometry and Affinity of the Human Serum Albumin-Alzheimer's Aβ Peptide Interactions

(2011) Julijana Milojevic et al.   BIOPHYSICAL JOURNAL

Alzheimer's disease & metals: therapeutic opportunities

(2011) Vijaya B Kenche et al.   BRITISH JOURNAL OF PHARMACOLOGY

Exploring the Reactions of β-Amyloid (Aβ) Peptide 1–28 with AlIIIand FeIIIIons

(2011) Daniela Valensin et al.   INORGANIC CHEMISTRY

Iron(II) Binding to Amyloid-β, the Alzheimer’s Peptide

(2011) Fatima Bousejra-ElGarah et al.   INORGANIC CHEMISTRY

Distinct Effects of Zn2+, Cu2+, Fe3+, and Al3+on Amyloid-β Stability, Oligomerization, and Aggregation

(2011) Wei-Ting Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

(2011) Samuel I. A. Cohen et al.   JOURNAL OF CHEMICAL PHYSICS

Measurement of Aβ1-42 in cerebrospinal fluid is influenced by matrix effects

(2011) J. Randall Slemmon et al.   JOURNAL OF NEUROCHEMISTRY

Heme–Cu Bound Aβ Peptides: Spectroscopic Characterization, Reactivity, and Relevance to Alzheimer’s Disease

(2011) Debajyoti Pramanik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Two Functions, One Molecule: A Metal-Binding and a Targeting Moiety to Combat Alzheimer's Disease

(2010) Christelle Hureau  et al.   CHEMBIOCHEM

Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation

(2010) Beinan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetics of Amyloid β Monomer-to-Oligomer Exchange by NMR Relaxation

(2010) Nicolas L. Fawzi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Active Site Environment of Heme-Bound Amyloid β Peptide Associated with Alzheimer’s Disease

(2010) Debajyoti Pramanik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biological metals and Alzheimer's disease: Implications for therapeutics and diagnostics

(2010) James A. Duce et al.   PROGRESS IN NEUROBIOLOGY

N-terminal engineering of amyloid-β-binding Affibody molecules yields improved chemical synthesis and higher binding affinity

(2010) Joel Lindgren et al.   PROTEIN SCIENCE

In Silico Analysis of the Apolipoprotein E and the Amyloid β Peptide Interaction: Misfolding Induced by Frustration of the Salt Bridge Network

(2010) Jinghui Luo et al.   PLoS Computational Biology

Decreased cerebrospinal fluid Aβ42correlates with brain atrophy in cognitively normal elderly

(2009) Anne M. Fagan et al.   ANNALS OF NEUROLOGY

Human and rodent amyloid-β peptides differentially bind heme: Relevance to the human susceptibility to Alzheimer’s disease

(2009) Hani Atamna et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Human Serum Albumin Inhibits Aβ Fibrillization through a “Monomer-Competitor” Mechanism

(2009) Julijana Milojevic et al.   BIOPHYSICAL JOURNAL

Cerebrospinal Fluid Total Tau Is Associated with Shorter Survival in Dementia with Lewy Bodies

(2009) Fredrik Boström et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Amyloid-targeted therapeutics in Alzheimer's disease: Use of human albumin in plasma exchange as a novel approach for abeta mobilization

(2009) M. Boada et al.   DRUG NEWS & PERSPECTIVES

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Clioquinol and other hydroxyquinoline derivatives inhibit Aβ(1–42) oligomer assembly

(2009) Harry LeVine et al.   NEUROSCIENCE LETTERS

Reelin signaling antagonizes  -amyloid at the synapse

(2009) M. S. Durakoglugil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptides and proteins in plasma and cerebrospinal fluid as biomarkers for the prediction, diagnosis, and monitoring of therapeutic efficacy of Alzheimer's disease

(2008) Christopher D. Aluise et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide

(2008) Peter Faller et al.   DALTON TRANSACTIONS

A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

(2008) Jae K. Ryu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Stabilization of a β-hairpin in monomeric Alzheimer's amyloid-β peptide inhibits amyloid formation

(2008) Wolfgang Hoyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma lipoprotein  -amyloid in subjects with Alzheimer's disease or mild cognitive impairment

(2008) J C L Mamo et al.   ANNALS OF CLINICAL BIOCHEMISTRY