How Zn can impede Cu detoxification by chelating agents in Alzheimer's disease: a proof-of-concept study

Therapeutic strategies for Alzheimer's disease in clinical trials

(2016) Justyna Godyń et al.   Pharmacological Reports

Regulation of Copper and Iron Homeostasis by Metal Chelators: A Possible Chemotherapy for Alzheimer’s Disease

(2015) Anne Robert et al.   ACCOUNTS OF CHEMICAL RESEARCH

Tools of the Trade: Investigations into Design Strategies of Small Molecules to Target Components in Alzheimer's Disease

(2015) Jeffrey S. Derrick et al.   CHEMBIOCHEM

Copper(i) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand

(2015) E. Atrián-Blasco et al.   Metallomics

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

(2015) Sagar H. Barage et al.   NEUROPEPTIDES

A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease

(2015) Michael W. Beck et al.   Chemical Science

Metal Ions and Intrinsically Disordered Proteins and Peptides: From Cu/Zn Amyloid-β to General Principles

(2014) Peter Faller et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Ongoing Search for Small Molecules to Study Metal-Associated Amyloid-β Species in Alzheimer’s Disease

(2014) Masha G. Savelieff et al.   ACCOUNTS OF CHEMICAL RESEARCH

Biological metals and metal-targeting compounds in major neurodegenerative diseases

(2014) Kevin J. Barnham et al.   CHEMICAL SOCIETY REVIEWS

Characterization of New Specific Copper Chelators as Potential Drugs for the Treatment of Alzheimer’s Disease

(2014) Michel Nguyen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Use of a new water-soluble Zn sensor to determine Zn affinity for the amyloid-β peptide and relevant mutants

(2014) Sabrina Noël et al.   Metallomics

Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease

(2013) Masha G. Savelieff et al.   ACS Chemical Biology

Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity

(2013) Bruno Alies et al.   CHEMICAL COMMUNICATIONS

A small molecule that displays marked reactivity toward copper– versus zinc–amyloid-β implicated in Alzheimer's disease

(2013) Masha G. Savelieff et al.   CHEMICAL COMMUNICATIONS

The benzazole scaffold: a SWAT to combat Alzheimer's disease

(2013) Sabrina Noël et al.   CHEMICAL SOCIETY REVIEWS

Role of Metal Ions in the Self-assembly of the Alzheimer’s Amyloid-β Peptide

(2013) Peter Faller et al.   INORGANIC CHEMISTRY

Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease

(2013) Sanghyun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The missing link in the amyloid cascade of Alzheimer’s disease – Metal ions

(2013) Ann Tiiman et al.   NEUROCHEMISTRY INTERNATIONAL

Copper and Oxidative Stress in the Pathogenesis of Alzheimer’s Disease

(2012) Gözde Eskici et al.   BIOCHEMISTRY

Bioinorganic Chemistry of Alzheimer’s Disease

(2012) Kasper P. Kepp   CHEMICAL REVIEWS

Affinity of copper and zinc ions to proteins and peptides related to neurodegenerative conditions (Aβ, APP, α-synuclein, PrP)

(2012) Izabela Zawisza et al.   COORDINATION CHEMISTRY REVIEWS

Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-β peptides involved in Alzheimer disease. Part 1: An overview

(2012) Christelle Hureau   COORDINATION CHEMISTRY REVIEWS

The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases

(2012) Cristina Rodríguez-Rodríguez et al.   COORDINATION CHEMISTRY REVIEWS

Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-β peptides involved in Alzheimer disease. Part 2: Dependence of Cu(II) binding sites with Aβ sequences

(2012) Christelle Hureau et al.   COORDINATION CHEMISTRY REVIEWS

Methods and techniques to study the bioinorganic chemistry of metal–peptide complexes linked to neurodegenerative diseases

(2012) Peter Faller et al.   COORDINATION CHEMISTRY REVIEWS

Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases)

(2012) Henryk Kozlowski et al.   COORDINATION CHEMISTRY REVIEWS

A new water-soluble Cu(II) chelator that retrieves Cu from Cu(amyloid-β) species, stops associated ROS production and prevents Cu(II)‐induced Aβ aggregation

(2012) Sabrina Noël et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42 Peptide

(2012) Anuj K. Sharma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper Chelator Induced Efficient Episodic Memory Recovery in a Non-Transgenic Alzheimer’s Mouse Model

(2012) Johnatan Ceccom et al.   PLoS One

Metal ions, Alzheimer's disease and chelation therapy

(2011) Ana Budimir   ACTA PHARMACEUTICA

Structural characterization of Cu2+, Ni2+ and Zn2+ binding sites of model peptides associated with neurodegenerative diseases

(2011) Caterina Migliorini et al.   COORDINATION CHEMISTRY REVIEWS

Coordination of zinc ions to the key proteins of neurodegenerative diseases: Aβ, APP, α-synuclein and PrP

(2011) Vello Tõugu et al.   COORDINATION CHEMISTRY REVIEWS

Zn2+’s Ability to Alter the Distribution of Cu2+among the Available Binding Sites of Aβ(1–16)-Polyethylenglycol-ylated Peptide: Implications in Alzheimer’s Disease

(2011) Chiara A. Damante et al.   INORGANIC CHEMISTRY

Selective, quantitative measurement of releasable synaptic zinc in human autopsy hippocampal brain tissue from Alzheimer's disease patients

(2011) Nicole L. Bjorklund et al.   JOURNAL OF NEUROSCIENCE METHODS

Role of metal dyshomeostasis in Alzheimer's disease

(2011) David J. Bonda et al.   Metallomics

Design of small molecules that target metal-A  species and regulate metal-induced A  aggregation and neurotoxicity

(2010) J.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rôles biologiques des éléments traces dans le cerveau – exemples du Zn et du Fe

(2010) S. Bohic et al.   REVUE NEUROLOGIQUE

In vitro studies of 3-hydroxy-4-pyridinones and their glycosylated derivatives as potential agents for Alzheimer's disease

(2009) David E. Green et al.   DALTON TRANSACTIONS

Two pyridine derivatives as potential Cu(ii) and Zn(ii) chelators in therapy for Alzheimer's disease

(2009) Andrea Lakatos et al.   DALTON TRANSACTIONS

Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-β (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators

(2009) Vello Tõugu et al.   JOURNAL OF NEUROCHEMISTRY

Identifying the Minimal Copper- and Zinc-binding Site Sequence in Amyloid-β Peptides

(2008) Velia Minicozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

Preparation and Study of New Poly-8-Hydroxyquinoline Chelators for an anti-Alzheimer Strategy

(2007) Céline Deraeve et al.   CHEMISTRY-A EUROPEAN JOURNAL