Impaired intestinal stem cell activity in ETEC infection: enterotoxins, cyclic nucleotides, and Wnt signaling

Zinc L-Aspartate enhances intestinal stem cell activity to protect the integrity of the intestinal mucosa against deoxynivalenol through activation of the Wnt/β-catenin signaling pathway

(2020) Jia-yi Zhou et al.   ENVIRONMENTAL POLLUTION

Next-generation physiology approaches to study microbiome function at single cell level

(2020) Roland Hatzenpichler et al.   NATURE REVIEWS MICROBIOLOGY

Lactobacillus reuteri maintains intestinal epithelial regeneration and repairs damaged intestinal mucosa

(2020) Haiqin Wu et al.   Gut Microbes

Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection

(2020) Jennifer Foulke-Abel et al.   Gut Microbes

PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity

(2020) Gary A. Piazza et al.   DRUG DISCOVERY TODAY

The Association Between Phosphodiesterase-5 Inhibitors and Colorectal Cancer in a National Cohort of Patients

(2020) S. Scott Sutton et al.   Clinical and Translational Gastroenterology

Intestinal Regeneration: Regulation by the Microenvironment

(2020) Joris H. Hageman et al.   DEVELOPMENTAL CELL

Integrated Metabolic Modeling, Culturing, and Transcriptomics Explain Enhanced Virulence of Vibrio cholerae during Coinfection with Enterotoxigenic Escherichia coli

(2020) Alyaa M. Abdel-Haleem et al.   mSystems

Defective CFTR promotes intestinal proliferation via inhibition of the hedgehog pathway during cystic fibrosis

(2019) Kaisheng Liu et al.   CANCER LETTERS

Cell type and receptor identity regulate cholera toxin subunit B (CTB) internalization

(2019) Anirudh Sethi et al.   Interface Focus

NHERF3 is Necessary for E. coli Heat Stable Enterotoxin (ST)-induced Inhibition of NHE3 - Differences in Signaling in Mouse Small Intestine and Caco-2 Cells

(2019) Tiane Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Active PKG II inhibited the growth and migration of ovarian cancer cells through blocking Raf/ MEK and PI3K/Akt signaling pathways

(2019) Yan Wu et al.   BIOSCIENCE REPORTS

Enterococcus faecium NCIMB 10415 administration improves the intestinal health and immunity in neonatal piglets infected by enterotoxigenic Escherichia coli K88

(2019) Xie Peng et al.   Journal of Animal Science and Biotechnology

Human gut bacteria contain acquired interbacterial defence systems

(2019) Benjamin D. Ross et al.   NATURE

Plumbagin Prevents Secretory Diarrhea by Inhibiting CaCC and CFTR Channel Activities

(2019) Bo Yu et al.   Frontiers in Pharmacology

Lactobacillus rhamnosus GG and Saccharomyces cerevisiae boulardii exert synergistic antipathogenic activity in vitro against enterotoxigenic Escherichia coli

(2019) F. Moens et al.   Beneficial Microbes

PGE2 increases inflammatory damage in Escherichia coli-infected bovine endometrial tissue in vitro via the EP4-PKA signaling pathway

(2018) Tingting Li et al.   BIOLOGY OF REPRODUCTION

Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization

(2018) Curtis A. Thorne et al.   DEVELOPMENTAL CELL

Cystic Fibrosis Colorectal Cancer Screening Consensus Recommendations

(2018) Denis Hadjiliadis et al.   GASTROENTEROLOGY

Critical Role of Zinc in a New Murine Model of Enterotoxigenic Escherichia coli Diarrhea

(2018) D. T. Bolick et al.   INFECTION AND IMMUNITY

Interplay of a secreted protein with type IVb pilus for efficient enterotoxigenicEscherichia colicolonization

(2018) Hiroya Oki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding TGEV-ETEC Coinfection through the Lens of Proteomics: A Tale of Porcine Diarrhea

(2018) Guillermo Arango Duque et al.   Proteomics Clinical Applications

Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models

(2018) Illona-Marie Boulete et al.   WORLD JOURNAL OF GASTROENTEROLOGY

GM1 ganglioside-independent intoxication by Cholera toxin

(2018) Jakob Cervin et al.   PLoS Pathogens

Fucosylated Molecules Competitively Interfere with Cholera Toxin Binding to Host Cells

(2018) Amberlyn M. Wands et al.   ACS Infectious Diseases

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Christopher Troeger et al.   LANCET INFECTIOUS DISEASES

Probiotic Lactobacillus plantarum Promotes Intestinal Barrier Function by Strengthening the Epithelium and Modulating Gut Microbiota

(2018) Jing Wang et al.   Frontiers in Microbiology

Intestinal microbiota mediates Enterotoxigenic Escherichia coli-induced diarrhea in piglets

(2018) Peng Bin et al.   BMC Veterinary Research

Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development

(2018) Yong-Soo Lee et al.   Cell Host & Microbe

Murine immunization with CS21 pili or LngA major subunit of enterotoxigenic Escherichia coli (ETEC) elicits systemic and mucosal immune responses and inhibits ETEC gut colonization

(2017) Chengxian Zhang et al.   VETERINARY MICROBIOLOGY

Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions

(2017) Alaullah Sheikh et al.   PLoS Neglected Tropical Diseases

Tracking Bioluminescent ETEC during In vivo BALB/c Mouse Colonization

(2017) Gerardo E. Rodea et al.   Frontiers in Cellular and Infection Microbiology

Heat-Labile Enterotoxin-Induced PERK-CHOP Pathway Activation Causes Intestinal Epithelial Cell Apoptosis

(2017) Xi Lu et al.   Frontiers in Cellular and Infection Microbiology

Escherichia coli Heat-Labile Enterotoxin B Limits T Cells Activation by Promoting Immature Dendritic Cells and Enhancing Regulatory T Cell Function

(2017) Alexandre Bignon et al.   Frontiers in Immunology

Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa

(2016) Øystein Brenna et al.   CELL AND TISSUE RESEARCH

CFTR- β -catenin interaction regulates mouse embryonic stem cell differentiation and embryonic development

(2016) Zhenqing Liu et al.   CELL DEATH AND DIFFERENTIATION

A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress

(2016) M A Aguileta et al.   CELL DEATH AND DIFFERENTIATION

Mouse intestinal niche cells express a distinct α1,2-fucosylated glycan recognized by a lectin fromBurkholderia cenocepacia

(2016) Daisuke Sugahara et al.   GLYCOBIOLOGY

Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage

(2016) Pauline T. Ikpa et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

(2016) Henner F. Farin et al.   NATURE

Guanylyl cyclase C signaling axis and colon cancer prevention

(2016) Amanda M Pattison et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts

(2015) Jurian Schuijers et al.   Cell Stem Cell

Cell clustering and delay/arrest in T-cell division implicate a novel mechanism of immune modulation by E. coli heat-labile enterotoxin B-subunits

(2015) Seham El-Kassas et al.   CELLULAR IMMUNOLOGY

Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10

(2015) Nan Li et al.   Oncotarget

Fucosylation and protein glycosylation create functional receptors for cholera toxin

(2015) Amberlyn M Wands et al.   eLife

The Paracrine Hormone for the GUCY2C Tumor Suppressor, Guanylin, Is Universally Lost in Colorectal Cancer

(2014) C. Wilson et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

The MAL-ED Study: A Multinational and Multidisciplinary Approach to Understand the Relationship Between Enteric Pathogens, Malnutrition, Gut Physiology, Physical Growth, Cognitive Development, and Immune Responses in Infants and Children Up to 2 Years of Age in Resource-Poor Environments

(2014) et al.   CLINICAL INFECTIOUS DISEASES

The potential of targeting Wnt/β-catenin in colon cancer

(2014) Ana Sebio et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Simultaneous Exposure to Escherichia coli Heat-Labile and Heat-Stable Enterotoxins Increases Fluid Secretion and Alters Cyclic Nucleotide and Cytokine Production by Intestinal Epithelial Cells

(2014) Lisa T. Read et al.   INFECTION AND IMMUNITY

Downregulation of CFTR promotes epithelial-to-mesenchymal transition and is associated with poor prognosis of breast cancer

(2013) Jie Ting Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Origin and evolution of the cystic fibrosis transmembrane regulator protein R domain

(2013) Aswathy Sebastian et al.   GENE

Intestinal Cell Proliferation and Senescence Are Regulated by Receptor Guanylyl Cyclase C and p21

(2013) Nirmalya Basu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

(2013) Xiaolei Yin et al.   NATURE METHODS

Glycosphingolipid composition of epithelial cells isolated along the villus axis of small intestine of a single human individual

(2012) M. E. Breimer et al.   GLYCOBIOLOGY

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

(2011) Guri Tzivion et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

(2011) Thérèse Keravis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Clever cancer strategies with FoxO transcription factors

(2011) Kenneth Maiese et al.   CELL CYCLE

 -catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis

(2011) W. van Veelen et al.   GUT

Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in ApcMin/+ mice

(2011) Kristoffer W Brudvik et al.   Molecular Cancer

Mucin dynamics and enteric pathogens

(2011) Michael A. McGuckin et al.   NATURE REVIEWS MICROBIOLOGY

Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine

(2010) Robert L. Jakab et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Colon Tumor Cell Growth-Inhibitory Activity of Sulindac Sulfide and Other Nonsteroidal Anti-Inflammatory Drugs Is Associated with Phosphodiesterase 5 Inhibition

(2010) H. N. Tinsley et al.   Cancer Prevention Research

Cystic fibrosis transmembrane conductance regulator gene mutation and lung cancer risk

(2010) Yafei Li et al.   LUNG CANCER

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

PKG inhibits TCF signaling in colon cancer cells by blocking β-catenin expression and activating FOXO4

(2010) I-K Kwon et al.   ONCOGENE

Heat-Labile Enterotoxin: Beyond G M1 Binding

(2010) Benjamin Mudrak et al.   Toxins

Cyclic AMP-mediated endocytosis of intestinal epithelial NHE3 requires binding to synaptotagmin 1

(2009) Mark W. Musch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Involvement of the intrinsic and extrinsic cell-death pathways in the induction of apoptosis of mature lymphocytes by the Escherichia coli heat-labile enterotoxin

(2009) Esther Tamayo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Hormone Receptor GUCY2C Suppresses Intestinal Tumor Formation by Inhibiting AKT Signaling

(2009) Jieru Egeria Lin et al.   GASTROENTEROLOGY

Effects of Various Selective Phosphodiesterase Inhibitors on Relaxation and Cyclic Nucleotide Contents in Porcine Iris Sphincter

(2009) Takuya YOGO et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Activation of Protein Kinase G Increases the Expression of p21CIP1, p27KIP1, and Histidine Triad Protein 1 through Sp1

(2008) B. Cen et al.   CANCER RESEARCH

The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression

(2008) Elizabeth Vincan et al.   CLINICAL & EXPERIMENTAL METASTASIS

A Diffusion Tensor Imaging Tractography Algorithm Based on Navier–Stokes Fluid Mechanics

(2008) N.S. Hageman et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Cyclic AMP Receptor Protein-Dependent Repression of Heat-Labile Enterotoxin

(2008) M. D. Bodero et al.   INFECTION AND IMMUNITY