Bempedoic acid and its role in contemporary management of hyperlipidemia in atherosclerosis

Role of Bempedoic Acid in Clinical Practice

(2021) Christie M. Ballantyne et al.   CARDIOVASCULAR DRUGS AND THERAPY

Target Populations and Treatment Cost for Bempedoic Acid and PCSK9 Inhibitors: A Simulation Study in a Contemporary CAD Cohort

(2021) Christopher Blaum et al.   CLINICAL THERAPEUTICS

Absence of effect of steady state bempedoic acid on cardiac repolarization: Results of a thorough QT/QTc study in healthy volunteers

(2021) Benny M. Amore et al.   CTS-Clinical and Translational Science

Evaluating pharmacokinetics of bempedoic acid in the treatment of hypercholesterolemia

(2021) Arrigo F.G. Cicero et al.   Expert Opinion on Drug Metabolism & Toxicology

Greater than expected reduction in low-density lipoprotein-cholesterol (LDL-C) with bempedoic acid in a patient with heterozygous familial hypercholesterolemia (HeFH)

(2021) Ali M. Agha et al.   Journal of Clinical Lipidology

Pharmacodynamic effect of bempedoic acid and statin combinations: predictions from a dose–response model

(2021) Satyawan B Jadhav et al.   European Heart Journal-Cardiovascular Pharmacotherapy

Real-world utilization of bempedoic acid in an academic preventive cardiology practice

(2021) Bruce A. Warden et al.   Journal of Clinical Lipidology

The multifaceted therapeutic value of targeting ATP-citrate lyase in atherosclerosis

(2021) Sanne G.S. Verberk et al.   TRENDS IN MOLECULAR MEDICINE

Clinical approach to the inflammatory etiology of cardiovascular diseases

(2020) Massimiliano Ruscica et al.   PHARMACOLOGICAL RESEARCH

Efficacy and safety of bempedoic acid in patients with hypercholesterolemia: A systematic review and meta-analysis of randomized controlled trials

(2020) Lei Dai et al.   European Journal of Preventive Cardiology

Association of Bempedoic Acid Administration With Atherogenic Lipid Levels in Phase 3 Randomized Clinical Trials of Patients With Hypercholesterolemia

(2020) Maciej Banach et al.   JAMA Cardiology

Rationale and design of the CLEAR-outcomes trial: Evaluating the effect of Bempedoic acid on cardiovascular events in patients with statin intolerance

(2020) Stephen J Nicholls et al.   AMERICAN HEART JOURNAL

Effect of bempedoic acid on new onset or worsening diabetes: A meta-analysis

(2020) Walter Masson et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Bempedoic acid safety analysis: Pooled data from four phase 3 clinical trials

(2020) Harold E. Bays et al.   Journal of Clinical Lipidology

Bempedoic Acid and Glycemic Control: A Pooled Analysis of 4 Phase 3 Clinical Trials

(2020) Lawrence Leiter et al.   Journal of Clinical Lipidology

Bempedoic Acid and Ezetimibe for the Treatment of Hypercholesterolemia: A Systematic Review and Meta-Analysis of Randomized Phase II/III trials

(2020) Akshaya Srikanth Bhagavathula et al.   CLINICAL DRUG INVESTIGATION

Statin Toxicity

(2019) Natalie C. Ward et al.   CIRCULATION RESEARCH

Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol

(2019) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mendelian Randomization Study of ACLY and Cardiovascular Disease

(2019) Brian A. Ference et al.   NEW ENGLAND JOURNAL OF MEDICINE

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

(2019) Emelia J. Benjamin et al.   CIRCULATION

Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia and Statin Intolerance

(2019) Ulrich Laufs et al.   Journal of the American Heart Association

PCSK9 inhibition and inflammation: A narrative review

(2019) Massimiliano Ruscica et al.   ATHEROSCLEROSIS

Bempedoic acid plus ezetimibe fixed-dose combination in patients with hypercholesterolemia and high CVD risk treated with maximally tolerated statin therapy

(2019) Christie M Ballantyne et al.   European Journal of Preventive Cardiology

2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk

(2019) François Mach et al.   EUROPEAN HEART JOURNAL

Effect of Bempedoic Acid vs Placebo Added to Maximally Tolerated Statins on Low-Density Lipoprotein Cholesterol in Patients at High Risk for Cardiovascular Disease

(2019) Anne C. Goldberg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Efficacy and safety of bempedoic acid added to ezetimibe in statin-intolerant patients with hypercholesterolemia: A randomized, placebo-controlled study

(2018) Christie M. Ballantyne et al.   ATHEROSCLEROSIS

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: Executive Summary

(2018) Scott M. Grundy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Use of Risk Assessment Tools to Guide Decision-Making in the Primary Prevention of Atherosclerotic Cardiovascular Disease

(2018) Donald M. Lloyd-Jones et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome

(2018) Gregory G. Schwartz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of ETC-1002 on Serum Low-Density Lipoprotein Cholesterol in Hypercholesterolemic Patients Receiving Statin Therapy

(2016) Christie M. Ballantyne et al.   AMERICAN JOURNAL OF CARDIOLOGY

Bempedoic Acid (ETC-1002): an Investigational Inhibitor of ATP Citrate Lyase

(2016) Ozlem Bilen et al.   Current Atherosclerosis Reports

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

(2016) Stephen L. Pinkosky et al.   Nature Communications

Achievement of Dual Low-Density Lipoprotein Cholesterol and High-Sensitivity C-Reactive Protein Targets More Frequent With the Addition of Ezetimibe to Simvastatin and Associated With Better Outcomes in IMPROVE-ITCLINICAL PERSPECTIVES

(2015) Erin A. Bohula et al.   CIRCULATION

Use of ETC-1002 to treat hypercholesterolemia in patients with statin intolerance

(2015) Paul D. Thompson et al.   Journal of Clinical Lipidology

National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 1—Full Report

(2015) Terry A. Jacobson et al.   Journal of Clinical Lipidology

Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events

(2015) Marc S. Sabatine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

(2015) Christopher P. Cannon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of ETC-1002, a Novel Investigational Low-Density Lipoprotein-Cholesterol–Lowering Therapy for the Treatment of Patients With Hypercholesterolemia and Type 2 Diabetes Mellitus

(2014) Maria J. Gutierrez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ETC-1002: A future option for lipid disorders?

(2014) Dragana Nikolic et al.   ATHEROSCLEROSIS

De novo lipogenesis in health and disease

(2014) Fatima Ameer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK

(2013) Sergey Filippov et al.   JOURNAL OF LIPID RESEARCH

Understanding Statin Use in America and Gaps in Patient Education (USAGE): An internet-based survey of 10,138 current and former statin users

(2012) Jerome D. Cohen et al.   Journal of Clinical Lipidology

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism

(2012) Stephen L. Pinkosky et al.   JOURNAL OF LIPID RESEARCH

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

(2011) Sandra Galic et al.   JOURNAL OF CLINICAL INVESTIGATION

C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis

(2009)   LANCET