Emerging insights in sarcoidosis: moving forward through reverse translational research

Novel three-dimensional biochip pulmonary sarcoidosis model

(2021) Tess M. Calcagno et al.   PLoS One

Elevated IL-15 concentrations in the sarcoidosis lung is independent of granuloma burden and disease phenotypes

(2021) Maksym Minasyan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis

(2021) Milica Vukmirovic et al.   EUROPEAN RESPIRATORY JOURNAL

Roles of Macrophage Polarization and Macrophage-Derived miRNAs in Pulmonary Fibrosis

(2021) Amit Kishore et al.   Frontiers in Immunology

Microcystin-LR ameliorates pulmonary fibrosis via modulating CD206+ M2-like macrophage polarization

(2020) Jie Wang et al.   Cell Death & Disease

Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline

(2020) Elliott D. Crouser et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Anti-inflammatory effects of α-MSH through p-CREB expression in sarcoidosis like granuloma model

(2020) Chongxu Zhang et al.   Scientific Reports

Successful Response to Treatment with Sirolimus in Pulmonary Sarcoidosis

(2020) Nishant Gupta et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Novel protein pathways in development and progression of pulmonary sarcoidosis

(2020) Maneesh Bhargava et al.   Scientific Reports

Biomarkers in the Diagnosis and Prognosis of Sarcoidosis: Current Use and Future Prospects

(2020) Raisa Kraaijvanger et al.   Frontiers in Immunology

Current Sarcoidosis Models and the Importance of Focusing on the Granuloma

(2020) Landon W. Locke et al.   Frontiers in Immunology

Models Contribution to the Understanding of Sarcoidosis Pathogenesis: “Are There Good Models of Sarcoidosis?”

(2020) Valérie Besnard et al.   Journal of Clinical Medicine

Phagosome-regulated mTOR Signalling during Sarcoidosis Granuloma Biogenesis

(2020) Elliott D. Crouser et al.   EUROPEAN RESPIRATORY JOURNAL

Translational Research in the Time of COVID-19—Dissolving Boundaries

(2020) Jonathan D. Edgeworth et al.   PLoS Pathogens

Schisandra Inhibit Bleomycin-Induced Idiopathic Pulmonary Fibrosis in Rats via Suppressing M2 Macrophage Polarization

(2020) Zhaojuan Guo et al.   Biomed Research International

Single Cell Transcriptomics Implicate Novel Monocyte and T Cell Immune Dysregulation in Sarcoidosis

(2020) Lori Garman et al.   Frontiers in Immunology

A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies

(2019) Yuanbin Song et al.   Nature Communications

Biologic Therapy in the Treatment of Cutaneous Sarcoidosis: A Literature Review

(2019) Christina Dai et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Plasma Mitochondrial DNA is Associated with Extrapulmonary Sarcoidosis

(2019) Changwan Ryu et al.   EUROPEAN RESPIRATORY JOURNAL

Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare

(2019) William Damsky et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Sarcoidosis

(2019) Johan Grunewald et al.   Nature Reviews Disease Primers

New advances in the management of pulmonary sarcoidosis

(2019) Daniel A Culver et al.   BMJ-British Medical Journal

IL-8 mediates idiopathic pulmonary fibrosis mesenchymal progenitor cell fibrogenicity

(2018) Libang Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

It's Time to Reverse our Thinking: The Reverse Translation Research Paradigm

(2018) Valentina Shakhnovich   CTS-Clinical and Translational Science

It's time to evolve from Scadding: phenotyping sarcoidosis

(2018) Daniel A. Culver et al.   EUROPEAN RESPIRATORY JOURNAL

Evidence for M2 macrophages in granulomas from pulmonary sarcoidosis: A new aspect of macrophage heterogeneity

(2018) Masoud Shamaei et al.   HUMAN IMMUNOLOGY

IL-13-regulated Macrophage Polarization during Granuloma Formation in an In Vitro Human Sarcoidosis Model

(2018) Landon W. Locke et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tofacitinib Treatment and Molecular Analysis of Cutaneous Sarcoidosis

(2018) William Damsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Humanized mice: A brief overview on their diverse applications in biomedical research

(2017) Shigeyoshi Fujiwara   JOURNAL OF CELLULAR PHYSIOLOGY

Animal models of sarcoidosis

(2016) Yijie Hu et al.   CELL AND TISSUE RESEARCH

Pulmonary fibrosis in a mouse model of sarcoid granulomatosis induced by booster challenge with Propionibacterium acnes

(2016) Dingyuan Jiang et al.   Oncotarget

TNF-α: a treatment target or cause of sarcoidosis?

(2015) K.T. Amber et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes

(2014) R. Su et al.   EUROPEAN RESPIRATORY JOURNAL

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Chitinase 3-Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis

(2014) Y. Zhou et al.   Science Translational Medicine

Pulmonary Antifibrotic Mechanisms Aspirin-Triggered Lipoxin A4Synthetic Analog

(2013) Rafael F. Guilherme et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Circulating cytokines in sarcoidosis: Phenotype-specific alterations for fibrotic and non-fibrotic pulmonary disease

(2013) Karen C. Patterson et al.   CYTOKINE

Granuloma Formation in Pulmonary Sarcoidosis

(2013) Caroline E. Broos et al.   Frontiers in Immunology

IL-2 receptor γ-chain molecule is critical for intestinal T-cell reconstitution in humanized mice

(2012) P W Denton et al.   Mucosal Immunology

The clinical and immunologic features of pulmonary fibrosis in sarcoidosis

(2012) Karen C. Patterson et al.   Translational Research

Sarcoidosis-related Mortality in the United States from 1988 to 2007

(2011) Jeffrey J. Swigris et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Stage IV sarcoidosis: comparison of survival with the general population and causes of death

(2011) A. Nardi et al.   EUROPEAN RESPIRATORY JOURNAL

Successful treatment of systemic de novo sarcoidosis with cyclosporine discontinuation and provision of rapamune after liver transplantation

(2011) Tommaso Maria Manzia et al.   TRANSPLANT INTERNATIONAL

Defining Translational Research: Implications for Training

(2010) Doris McGartland Rubio et al.   ACADEMIC MEDICINE

Gene Set Analysis of Lung Samples Provides Insight into Pathogenesis of Progressive, Fibrotic Pulmonary Sarcoidosis

(2010) Helen E. Lockstone et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Alternatively activated alveolar macrophages in pulmonary fibrosis—mediator production and intracellular signal transduction

(2010) Dmitri V. Pechkovsky et al.   CLINICAL IMMUNOLOGY

FoxP3+ Regulatory T Cells Suppress Early Stages of Granuloma Formation but Have Little Impact on Sarcoidosis Lesions

(2009) Cécile Taflin et al.   AMERICAN JOURNAL OF PATHOLOGY

Serum Amyloid A Regulates Granulomatous Inflammation in Sarcoidosis through Toll-like Receptor-2

(2009) Edward S. Chen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Novel Mechanism for CCR4 in the Regulation of Macrophage Activation in Bleomycin-Induced Pulmonary Fibrosis

(2008) Glenda Trujillo et al.   AMERICAN JOURNAL OF PATHOLOGY