Dynamic regulation of myofibroblast phenotype in cellular senescence

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

Classical and Nonclassical Intercellular Communication in Senescence and Ageing

(2020) Juan Antonio Fafián-Labora et al.   TRENDS IN CELL BIOLOGY

Senescence and the SASP: many therapeutic avenues

(2020) Jodie Birch et al.   GENES & DEVELOPMENT

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

(2020) Raffaella Di Micco et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SIX1 represses senescence and promotes SOX2-mediated cellular plasticity during tumorigenesis

(2019) Cristina De Lope et al.   Scientific Reports

Short-term gain, long-term pain: the senescence life cycle and cancer

(2019) Adelyne Sue Li Chan et al.   GENES & DEVELOPMENT

The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer

(2019) Francesco Dituri et al.   Cells

Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome

(2018) Paul Hiebert et al.   DEVELOPMENTAL CELL

Resolution of organ fibrosis

(2018) Joon-Il Jun et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Senescent Cells in Fibrosis: Pathology, Paradox, and Practical Considerations

(2018) Marissa J. Schafer et al.   Current Rheumatology Reports

Signaling Mechanisms of Myofibroblastic Activation: Outside-in and Inside-Out

(2018) Joshua Zent et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

DNA damage signaling mediates the functional antagonism between replicative senescence and terminal muscle differentiation

(2017) Lucia Latella et al.   GENES & DEVELOPMENT

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis

(2017) Eleni Mavrogonatou et al.   MATRIX BIOLOGY

Spatial and Temporal Control of Senescence

(2017) Yoko Ito et al.   TRENDS IN CELL BIOLOGY

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway

(2017) Valentina Rapisarda et al.   Cell Reports

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis

(2016) Massimiliano Mellone et al.   Aging-US

Essential Role for Premature Senescence of Myofibroblasts in Myocardial Fibrosis

(2016) Kathleen Meyer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

NOTCH1 mediates a switch between two distinct secretomes during senescence

(2016) Matthew Hoare et al.   NATURE CELL BIOLOGY

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes

(2015) I Adrados et al.   ONCOGENE

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of NF-κB by TNF family cytokines

(2014) Matthew S. Hayden et al.   SEMINARS IN IMMUNOLOGY

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers

(2012) C Freudlsperger et al.   ONCOGENE

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence

(2011) Atsushi Kaneda et al.   PLoS Genetics

Regulation of the MicroRNA Processor DGCR8 by the Tumor Suppressor ING1

(2010) D. Gomez-Cabello et al.   CANCER RESEARCH

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Senescence impairs successful reprogramming to pluripotent stem cells

(2009) A. Banito et al.   GENES & DEVELOPMENT

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY