Review
Cell Biology
Ravi K. Adapala, Venkatesh Katari, Lakshminarayan Reddy Teegala, Sathwika Thodeti, Sailaja Paruchuri, Charles K. Thodeti
Summary: The review discusses the mechanism of fibrosis and proposes TRPV4 as a potential therapeutic target for the condition, highlighting the need for specific drugs in the treatment of fibrosis.
Review
Biochemistry & Molecular Biology
Anna Valeria Samarelli, Roberto Tonelli, Alessandro Marchioni, Giulia Bruzzi, Filippo Gozzi, Dario Andrisani, Ivana Castaniere, Linda Manicardi, Antonio Moretti, Luca Tabbi, Stefania Cerri, Bianca Beghe, Massimo Dominici, Enrico Clini
Summary: This review discusses the pathogenic mechanisms leading to the onset and progression of different IIPs, starting from the most studied IPF, in order to identify common and standalone molecular and cellular key players. A deeper molecular and cellular characterization of various interstitial lung diseases with unknown causes would contribute to providing more accurate diagnoses for patients, leading to more effective treatment decisions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pathology
Margaret A. T. Freeberg, Apostolos Perelas, Jane K. Rebman, Richard P. Phipps, Thomas H. Thatcher, Patricia J. Sime
Summary: Idiopathic pulmonary fibrosis is a progressive disease characterized by accumulation of extracellular matrix in lung tissue, leading to altered mechanical properties. Recent studies suggest that these changes create a feed-forward loop, contributing to fibroblast differentiation and activation. Mechanotransduction pathways, including mechanosensors like integrins and downstream transcription factors, play a role in fibrosis progression.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Cell Biology
Mugdha Sawant, Boris Hinz, Katrin Schonborn, Isabel Zeinert, Beate Eckes, Thomas Krieg, Ronen Schuster
Summary: Our skin is constantly exposed to mechanical challenges, with fibroblasts and myofibroblasts playing crucial roles in maintaining and repairing normal skin. However, failure of myofibroblasts to stop their activities can lead to issues such as scarring and fibrosis.
WOUND REPAIR AND REGENERATION
(2021)
Article
Multidisciplinary Sciences
Mingchen Xu, Chenghe Zhao, Haiming Song, Chunmei Wang, He Li, Xudong Qiu, He Jing, Wenyue Zhuang
Summary: The ingredient Sch C in schisandra has been found to have significant therapeutic effects on pulmonary fibrosis by reducing extracellular matrix accumulation and inhibiting the production of lysyl oxidase. This study provides valuable insights into the pathogenesis of pulmonary fibrosis and potential therapeutic approaches.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Edsfeldt, Pratibha Singh, Frank Matthes, Christoffer Tengryd, Michele Cavalera, Eva Bengtsson, Pontus Duner, Petr Volkov, Glykeria Karadimou, Anton Gistera, Marju Orho-Melander, Jan Nilsson, Jiangming Sun, Isabel Goncalves
Summary: This study investigated the association of TGF-beta 1, 2, and 3 isoforms with plaque stability in atherosclerosis. The results showed that TGF-beta 2 is the most abundant isoform in human plaques and may maintain plaque stability by reducing inflammation and matrix degradation.
CARDIOVASCULAR RESEARCH
(2023)
Article
Oncology
Hector Franco-Valls, Elsa Tusquets-Uxo, Laura Sala, Maria Val, Raul Pena, Alessandra Iaconcig, Alvaro Villarino, Martin Jimenez-Arriola, Pere Masso, Juan L. Trincado, Eduardo Eyras, Andres F. Muro, Jorge Otero, Antonio Garcia de Herreros, Josep Baulida
Summary: This study found that SNAIL1 is associated with the expression of fibronectin in breast cancer. SNAIL1 can regulate the alternative splicing of fibronectin, affecting the behavior of tumor cells and fibroblasts. Blocking fibronectin deposition may help reduce the formation of a pro-metastatic environment.
BREAST CANCER RESEARCH
(2023)
Article
Chemistry, Physical
Whee-Soo Kim, Sungjin Min, Su Kyeom Kim, Sunghwi Kang, Soohwan An, Ernesto Criado-Hidalgo, Hunter Davis, Avinoam Bar-Zion, Dina Malounda, Yu Heun Kim, Jae-Hyun Lee, Soo Han Bae, Jin Gu Lee, Minsuk Kwak, Seung-Woo Cho, Mikhail G. Shapiro, Jinwoo Cheon
Summary: Magneto-gas vesicles (MGVs) are protein nanostructures that combine gas vesicles and magnetic nanoparticles, enabling non-invasive, long-term, and quantitative monitoring of mechanical properties in living tissues. They significantly improve signal strength and detection sensitivity, offering potential for non-invasive imaging of tissue elasticity and applications in disease diagnosis and treatment.
Article
Cell Biology
Irene Lopez-Antona, Constanza Contreras-Jurado, Laura Luque-Martin, Antonio Carpintero-Leyva, Paula Gonzalez-Mendez, Ignacio Palmero
Summary: Cellular senescence has a significant impact on the regulation of the myofibroblastic phenotype in primary fibroblasts. The loss of myofibroblastic markers and functional features upon senescence implementation can be transmitted in a paracrine manner, most likely through soluble secreted factors. The Notch/TGF-beta axis is found to be the main pathway mediating the changes in the myofibroblast phenotype.
Review
Medicine, Research & Experimental
Xun Ye, Jinhu Li, Zibo Liu, Xue Sun, Daneng Wei, Linjiang Song, Chunjie Wu
Summary: Fibrosis is a disease characterized by excessive accumulation of extracellular matrix, which can lead to organ failure and death. Activated myofibroblasts have been identified as the main cellular elements responsible for the replacement of normal tissues with nonfunctional fibrotic tissue. The transforming growth factor-beta pathway plays a significant role in fibrosis. Although there is no specific drug for fibrosis treatment, various peptides have shown promise in anti-fibrosis therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Alexander Hillsley, Javier E. Santos, Adrianne M. Rosales
Summary: Cardiac fibrosis is a pathological process characterized by excessive tissue deposition, matrix remodeling, and tissue stiffening. In this study, a computer vision model is proposed to automate stress fiber identification in cardiac fibroblasts, enhancing reproducibility. The model successfully predicts trends in stress fiber formation and has broad applications in fibrotic model research.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Rui Qin, Qian Zhao, Bo Han, Hong-Ping Zhu, Cheng Peng, Gu Zhan, Wei Huang
Summary: Indole alkaloids have diverse biological activities and are important candidate drugs for the treatment of organ fibrosis. Natural indole alkaloids and indole derivatives can alleviate fibrosis through the suppression of inflammatory response and oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Yao Wang, Xiaoyue Xu, Jacqueline E. Marshall, Muxue Gong, Yang Zhao, Kamal Dua, Philip M. Hansbro, Jincheng Xu, Gang Liu
Summary: HAPLN1 is downregulated in CRC patients, and it controls collagen deposition through the TGF-beta signaling pathway to regulate tumor growth. Therefore, increasing HAPLN1 levels may be a novel therapeutic option for CRC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Joshua M. Peterson, Jayson W. Jay, Ye Wang, Alejandro A. Joglar, Anesh Prasai, Alen Palackic, Steven E. Wolf, Amina El Ayadi
Summary: Galunisertib, an inhibitor of ALK5, has anti-fibrotic effects on dermal fibroblasts and enhances in vitro wound closure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Shih-Yi Lee, Yueh-Hsiung Kuo, Chen-Xuan Du, Cheng-Wei Huang, Hui-Chun Ku
Summary: Differentiation of cardiac fibroblasts into myofibroblasts is a critical event in the progression of cardiac fibrosis. The study investigated the effect of caffeic acid ethanolamide (CAEA) on cardiac remodeling induced by Angiotensin (Ang) II. CAEA inhibited fibroblast differentiation, protected against cardiac fibrosis and dysfunction, and regulated the TGF-beta/SMAD/NOX4 signaling pathway. The study supports CAEA administration as a viable method to prevent Ang II-induced cardiac remodeling.
BIOMEDICINE & PHARMACOTHERAPY
(2023)