Article
Pharmacology & Pharmacy
Bin Pan, Lin Zheng, Jiawei Fang, Ye Lin, Hehuan Lai, Jiawei Gao, Wenzheng Pan, Yejin Zhang, Kainan Ni, Chao Lou, Dengwei He
Summary: Azilsartan inhibits osteoclastogenesis by reducing ROS production and may serve as a novel treatment strategy for osteoporosis caused by osteoclast overactivation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Xiaohui Su, Wanyi Guo, Bei Yuan, Dong Wang, Liling Liu, Xuan Wu, Yanqiong Zhang, Xiangying Kong, Na Lin
Summary: Artesunate (ARS) acts as an effective antioxidant by inhibiting ROS production and activating the Nrf2/p62 signaling pathway, which can suppress osteoclastogenesis and ameliorate arthritic bone erosion.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Min Chu, Zhenyu Sun, Zhanghao Fan, Degang Yu, Yuanqing Mao, Yaping Guo
Summary: La-LDH nanohybrid scaffolds exhibit dual functions of promoting osteogenesis and inhibiting osteoclastogenesis, showing potential value for bone regeneration in osteoporotic patients.
Article
Pharmacology & Pharmacy
Qiyun Wu, Panzhu Bai, Hongsheng Guo, Maggie S. S. Guo, Yingjie Xia, Yiteng Xia, Xiong Gao, Xiaoyang Wang, Jiahui Wu, Tina T. X. Dong, Karl W. K. Tsim
Summary: Capsaicin, a major ingredient in chili pepper, has been shown to have broad pharmaceutical applications, including reversing UV-induced skin damage by reducing ROS generation in dermal fibroblasts. This suggests that capsaicin may be a promising agent for anti-skin aging in dermatology.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Bo Li, Fuji Liu, Jing Ye, Xinmei Cai, Runliu Qian, Kaiwang Zhang, Yufeng Zheng, Shuilin Wu, Yong Han
Summary: In this study, anti-oxidized polydopamine (PDA) was deposited on hydroxyapatite nanorods to form a core-shell structural nanorod-like array (PDA@HA), which showed both ROS scavenging ability and near-infrared light derived photo-thermal effects. PDA@HA suppressed inflammation and the periodic photo-thermal treatment further accelerated the transition of macrophages from a pro-inflammatory phenotype to an anti-inflammatory phenotype, promoting osteogenesis through immunomodulatory mechanisms.
Article
Engineering, Chemical
Junli Tian, Lianxue Wei, Jiaqi Hu, Jinfeng Lu
Summary: This study established a coupling system by integrating sulfate radical-based advanced oxidation processes (AOPs) with photocatalysis to enhance the activation of peroxymonosulfate (PMS) under visible light. The researchers developed a novel catalyst, 5%Bi3O4Br/CuBi2O4, for the rapid and efficient degradation of tetracycline (TC). The degradation rate constant in the 5%Bi3O4Br/CuBi2O4 + PMS + Vis system was significantly higher than that of photocatalysis and (SO4-)-S-center dot-AOPs alone. The study provides insights into the degradation pathways of TC and demonstrates the potential of this environmentally-friendly system for the efficient degradation of antibiotics.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Ning Sheng, Fei Xing, Jie Wang, Qing-Yi Zhang, Rong Nie, Jesse Li-Ling, Xin Duan, Hui-Qi Xie
Summary: Bone regeneration is challenging in diabetic conditions due to various pathological factors, including immune abnormalities, inflammation, oxidative stress, and vascular damage. Strategies for bone repair in diabetes involve immune regulation, inflammation inhibition, angiogenesis promotion, and stem cell mobilization, but face challenges and have future prospects.
MATERIALS TODAY BIO
(2023)
Review
Pharmacology & Pharmacy
Caiyan Zhao, Hongzhang Deng, Xiaoyuan Chen
Summary: This review provides an overview of the latest progress in ROS-nanotechnology mediated immunomodulation. Inorganic biomaterials can modulate immune responses by generating or eliminating ROS, with potential applications in combating inflammation, autoimmune diseases, and cancers.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Jacob Miszuk, Hongli Sun
Summary: As the world's population ages, addressing the health issues of the elderly population becomes crucial. This article discusses the challenges faced in age-related bone defect repair and the cutting-edge strategies in biomimetic therapies to tackle these challenges.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Jiaying Li, Fengxuan Han, Jinjin Ma, Huan Wang, Jun Pan, Guangbao Yang, He Zhao, Jiayue Zhao, Jinbo Liu, Zhuang Liu, Bin Li
Summary: This study visualizes the spatial and temporal profile of ROS in the bone injury microenvironment using photoacoustic imaging technique for the first time. It demonstrates that the levels of H2O2 increase significantly upon bone injury, peak at a certain stage of bone healing, and gradually decrease towards baseline level. Regulating ROS with hollow manganese dioxide nanoparticles (hMNPs) can promote cell growth and repair in bone injury environments.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Engineering, Multidisciplinary
Wenjun Ma, Wenhan Wang, Feng Liu, Ying Kong, Bowei Xia, Hongru Yang, Hang Zhao, Liang Wang, Keyi Li, Yiwei Li, Yuanhua Sang, Hong Liu, Xingbang Wang, Jichuan Qiu
Summary: Stem cell-based bone repair requires the osteogenic differentiation of stem cells and the immune activities of immune cells. This study introduces calcium nervonate nanoparticles as a dual-functional therapeutic platform for bone regeneration, capable of simultaneously modulating the osteoinductive and inflammatory microenvironments. The nanoparticles release calcium ions and nervonic acid, promoting osteogenic differentiation and reducing inflammation, respectively. In vitro and in vivo experiments demonstrate the superior performance of calcium nervonate nanoparticles in promoting bone regeneration compared to calcium ions or nervonic acid alone.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Biology
Tsutomu Shimura, Rina Totani, Hyougo Ogasawara, Keiki Inomata, Megumi Sasatani, Kenji Kamiya, Akira Ushiyama
Summary: This study investigates the impact of oxygen concentration on the response of mitochondria to X-ray radiation and fibroblast activation in tumor microenvironment formation. The results suggest that high oxygen levels enhance the effects of radiation on mitochondria and fibroblast activation. Lower oxygen concentration can mitigate radiation damage and fibroblast activation.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ali A. A. Akhiani, Anna Martner
Summary: Activation of NADPH oxidases (NOX) and the resulting formation of reactive oxygen species (ROS) play important roles in antimicrobial defense and oncogenesis. Enhanced NOX activity has been linked to the activation of oncogenic cascades such as the phosphoinositide 3-kinase (PI3K) signaling pathway, which is upregulated in various malignancies. This review examines the role of PI3K in regulating NOX-induced ROS formation in cancer.
Article
Nutrition & Dietetics
Ning Wang, Yongqiang Hao, Lingjie Fu
Summary: In osteoporosis, TMAO promotes osteoclast differentiation and bone loss by activating the ROS-dependent NF-kappa B signaling pathway.
Article
Endocrinology & Metabolism
Xiaoli Zhao, Shuai Lin, Huiying Li, Shuyi Si, Zhen Wang
Summary: The study shows that MPO plays a protective role in bone turnover by limiting osteoclastogenesis and bone resorption through modulating intracellular H2O2 level.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Surgery
Ottis Scrivner, Emma Fletcher, Carson Hoffmann, Feifei Li, Trevor Wilkinson, Dimitrios Miserlis, Robert S. Smith, William T. Bohannon, Roy Sutliff, William D. Jordan, Panagiotis Koutakis, Luke P. Brewster
Summary: This study found that serum myoglobin levels are a biomarker for peripheral arterial disease (PAD) and are inversely related to nitric oxide bioavailability. Myoglobin can increase vascular tone, decrease vascular relaxation, and cause endothelial dysfunction. These results suggest that myoglobin may contribute to the vulnerability of PAD patients to cardiovascular events and death.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2023)
Article
Engineering, Biomedical
Zhao Liu, Huan Wang, Zhangqin Yuan, Qiang Wei, Fengxuan Han, Song Chen, Hao Xu, Jiaying Li, Jiayuan Wang, Zexi Li, Qixin Chen, Jerry Fuh, Lin Ding, Hui Wang, Bin Li
Summary: In this study, high-resolution polycaprolactone (PCL) scaffolds were successfully fabricated using a new electrohydrodynamic 3D printing technique, allowing for accurate simulation of the native annulus fibrosus (AF) structure. In vivo experiments showed that the tissue-engineered intervertebral discs (TE-IVDs) constructed with the 3D printed AF scaffold maintained disc height, reduced loss of nucleus pulposus (NP) water content, and partially restored the biomechanical function of the intervertebral disc.
Article
Chemistry, Multidisciplinary
Feng Han, Zhengdong Tu, Zhuang Zhu, Dachuan Liu, Qingchen Meng, Qifan Yu, Ying Wang, Jianquan Chen, Tao Liu, Fengxuan Han, Bin Li
Summary: Excessive ROS level, inflammation, and weak tissue regeneration ability hinder annulus fibrosus (AF) repair, but a composite hydrogel incorporating antioxidant, anti-inflammatory, and AF cell recruitment properties has been developed. This hydrogel eliminates ROS, induces anti-inflammatory response, and promotes extracellular matrix secretion. It can effectively repair AF in rats and has potential applications in AF repair and intervertebral disc herniation prevention.
Article
Gastroenterology & Hepatology
Yongjun Zhu, Weixin Wu, Liangliang Qiao, Jingfen Ji, Lunxi Duan, Longlong Gong, Dandan Ren, Feifei Li, Lihui Wei, Ke Pan
Summary: This study investigates the tumor fusion burden (TFB) in non-Epstein-Barr-virus-positive gastric cancer (GC) patients and finds that the TFB-low group exhibits significant differences in gene mutation frequency, gene copy number, loss of heterozygosity score, and tumor mutation burden compared to the TFB-high group. Additionally, the TFB-low group has higher abundance of immune cells and significantly upregulated immune gene signatures. The TFB-low group has higher 2-year disease-specific survival and higher rates of durable clinical benefit and response with Pembrolizumab treatment. Low TFB may serve as a predictor of GC prognosis and is associated with higher immunogenicity.
BMC GASTROENTEROLOGY
(2023)
Article
Engineering, Environmental
Hang Ren, Ranyun Xu, Tongtong Chi, Feifei Li, Yuhan Zheng, Jinping Tian, Lyujun Chen
Summary: The study investigated the performance of 2,5-dichloronitrobenzene in UV/sulfite advanced reduction processes (ARPs) in terms of reaction rate, inhibition mechanisms, and degradation pathways. The results showed that the reaction rate of 2,5-dichloronitrobenzene increased with increasing sulfite dosage and pH value. Hydrated electron was found to play a dominant role in the UV/sulfite ARPs. A new sulfite activating pathway and the inhibitions of Cl- and NO3- were discovered. The reduction pathways of 2,5-dichloronitrobenzene and its final product were also predicted.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Francesca Bartoli-Leonard, Jonas Zimmer, Abhijeet R. R. Sonawane, Katelyn Perez, Mandy E. E. Turner, Shiori Kuraoka, Tan Pham, Feifei Li, Masanori Aikawa, Sasha Singh, Luke Brewster, Elena Aikawa
Summary: The study reveals the significant role of NLRP3 inflammasome activation in peripheral arterial disease (PAD), contributing to macrophage accumulation and calcification in the arteries of PAD patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Genetics & Heredity
Xiaoli Li, Ziyang An, Wenqing Zhang, Feifei Li
Summary: The multi-level spatial chromatin organization in the nucleus is closely related to chromatin activity. Recent research shows that phase separation is a key aspect to drive high-order chromatin structure and remodeling, and also plays an important role in overall chromatin structure. In this review, the role of phase separation in spatial chromatin organization, its direct and indirect effects on 3D chromatin organization, and its impact on transcription regulation are summarized.
Article
Chemistry, Multidisciplinary
Yongchao Gao, Hanchen Zhang, Lin Tang, Feifei Li, Li Yang, Haihua Xiao, Johannes Karges, Weihua Huang, Wei Zhang, Chaoyong Liu
Summary: This study describes a novel polymer that releases a drug to kill cancer cells and activate immune cells, thus enhancing antitumor immunity. Additionally, the study found that the polymer can decrease glutamine levels, resulting in upregulation of programmed death ligand 1 (PD-L1) and further improving the efficacy when combined with anti-PD-L1 therapy.
Article
Environmental Sciences
Feifei Li, Yingyu Bao, Lyujun Chen, Zhiguo Su, Yushi Tang, Donghui Wen
Summary: Antibiotics as emerging pollutants have detrimental effects on organisms in the environment. A comprehensive PBTR framework that incorporates resistance risk with persistence, bioaccumulation, and toxicity was established to assess antibiotic-specific risk. The study evaluated 74 antibiotics in Chinese seawater and provided a feasible screening strategy and monitoring recommendations for priority antibiotics.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Engineering, Environmental
Feifei Li, Shanshan Tang, Jitao Lv, Anen He, Yarui Wang, Shuting Liu, Huiming Cao, Lixia Zhao, Yawei Wang, Guibin Jiang
Summary: In this study, the formation of chemically diverse brown carbon (BrC) products through the oxidation of phenolic compounds by iron (Fe) catalysts was systematically investigated. The results provide insights into the reaction mechanism and product composition of BrC, which is important for understanding global warming and air pollution.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Infectious Diseases
Feifei Li, Hairong Li, Linsheng Yang, Li Wang, Lijuan Gu, Gemei Zhong, Lan Zhang
Summary: This study used Japanese encephalitis incidence data in Guangxi Province, China from 2004 to 2010 to examine the driving forces and interactive effects of environmental and social factors on the disease. The findings revealed a fluctuating downward trend in Japanese encephalitis incidence during the study period, with the disease being seasonal and concentrated in northwestern Guangxi. Factors such as high temperatures, slope, vegetation, GDP of tertiary industries, GDP of primary industries, and number of pigs slaughtered contributed significantly to the occurrence of Japanese encephalitis. This study highlights the importance of understanding the combined effects of social and environmental factors in controlling and preventing the transmission of Japanese encephalitis.
INFECTION GENETICS AND EVOLUTION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jiajing Zheng, Yueying Zhang, Qiuyue Wu, Hua Xiao, Feifei Li
Summary: This study investigated the changes in the 3D spatial morphology of TMJ and condyle position in adult patients with Class II division 2 malocclusion using a 3D spatial measurement method. It compared the effects of fixed appliance and clear aligner treatments on TMJ. The results showed significant changes in condylar shape and position post-treatment, indicating adaptive reconstruction of the condyle during orthodontic treatment.
Article
Engineering, Biomedical
Shenghao Wang, Wenbo He, Huan Wang, Dachuan Liu, Miao Wang, Huilin Yang, Guoqing Pan, Bin Li
Summary: In this study, a dynamic hydrogel that mimics the antimicrobial and reparative properties of hematoma was designed for treating infected bone fractures. The hydrogel rapidly eradicated bacteria, improved bone regeneration, and restored the local inflammatory microenvironment. These findings suggest that the use of hematoma-like dynamic hydrogel could revolutionize surgical strategies against susceptible bone fractures.
BIOACTIVE MATERIALS
(2023)
Article
Anatomy & Morphology
Na-Shun Mengke, Fei-fei Li, Qian Zhang, Chang Su, Pu Chun, Xi-da Ma, Tao Qin, Yan-yan Chi, Sheng-bo Yu, Hong-jin Sui
Summary: The study clarified the path of the temporal branch of facial nerve (TB) as it crosses the zygomatic arch (ZA) through anatomical dissection and observation on plastinated slices. The TB was found to cross the ZA in three types: type I (21.8%), type II (50.0%), and type III (28.1%) twigs. The average distances between the anterior and posterior trunks of TB and the anterior part of the auricle at the superior and inferior edges of the ZA were measured. The study also highlighted the recommended avoidance of this area during clinical operations to prevent TB injury.
INTERNATIONAL JOURNAL OF MORPHOLOGY
(2023)
Article
Materials Science, Biomaterials
Wenmin Guo, Huanhuan Xu, Dachuan Liu, Li Dong, Ting Liang, Bin Li, Bin Meng, Song Chen
Summary: The stress distribution of six lattice-inspired structures was investigated using finite element simulations, and scaffolds with pre-designed structures were prepared using selective laser sintering (SLS) technology. Scaffolds with face-centered cubic (FCC) structures exhibited the highest compressive strength. Composite scaffolds composed of polylactic acid/anhydrous calcium hydrogen phosphate (PLA/DCPA) showed good mechanical properties and bioactivity, promoting cell proliferation significantly and showing excellent osteogenic performance. FCC structures are promising for bone tissue engineering.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)