Pre-Clinical Evidence for the Anti-Obesity Potential of Quercetin and Curcumin Loaded Chitosan/PEG Blended PLGA Nanoparticles

Anti-Atherogenic Effects of Orlistat on Obesity-Induced Vascular Oxidative Stress Rat Model

(2021) Zaidatul Akmal Othman et al.   Antioxidants

Quercetin attenuates adipose hypertrophy, in part through activation of adipogenesis in rats fed a high-fat diet

(2020) Diahann J. Perdicaro et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Phenolic Compounds and the Anti-Atherogenic Effect of Bee Bread in High-Fat Diet-Induced Obese Rats

(2020) Zaidatul Akmal Othman et al.   Antioxidants

Embelin modulates metabolic endotoxemia and associated obesity in high fat diet fed C57BL/6 mice

(2020) P Bansal et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Recent Advances in Nanoencapsulation of Phytochemicals to Combat Obesity and Its Comorbidities

(2020) Zeynep Goktas et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Etoricoxib treatment prevented body weight gain and ameliorated oxidative stress in the liver of high-fat diet–fed rats

(2020) Fariha Kabir et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Comparative Effects of Curcumin versus Nano-Curcumin on Insulin Resistance, Serum Levels of Apelin and Lipid Profile in Type 2 Diabetic Rats

(2020) Ali Shamsi-Goushki et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Effects of Cangfu Daotan Decoction on obese polycystic ovary syndrome and its mechanism

(2020) Weimin Yi et al.   STEROIDS

Smilax china L. polyphenols alleviates obesity and inflammation by modulating gut microbiota in high fat/high sucrose diet-fed C57BL/6J mice

(2020) Xin Li et al.   Journal of Functional Foods

Adipogenesis and metabolic health

(2019) Alexandra L. Ghaben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nose-to-brain delivery of lamotrigine-loaded PLGA nanoparticles

(2019) Kuldeep Nigam et al.   Drug Delivery and Translational Research

Nanotechnology‐Mediated Drug Delivery for the Treatment of Obesity and Its Related Comorbidities

(2019) Yung‐Hao Tsou et al.   Advanced Healthcare Materials

Green tea polyphenols attenuate hepatic steatosis, and reduce insulin resistance and inflammation in high-fat diet-induced rats

(2019) Hong‑Miao Xia et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Low-Dose Curcumin Nanoparticles Normalise Blood Pressure in Male Wistar Rats with Diet-Induced Metabolic Syndrome

(2019) Ryan du Preez et al.   Nutrients

Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE−/− mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-κB inflammation

(2019) Dan Feng et al.   Nutrition & Metabolism

High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation

(2019) Shoumen Lasker et al.   Scientific Reports

Evaluation of curcumin loaded chitosan/PEG blended PLGA nanoparticles for effective treatment of pancreatic cancer

(2018) Geetanjali Arya et al.   BIOMEDICINE & PHARMACOTHERAPY

Quercetin and low level laser therapy promote wound healing process in diabetic rats via structural reorganization and modulatory effects on inflammation and oxidative stress

(2018) Osama M. Ahmed et al.   BIOMEDICINE & PHARMACOTHERAPY

Preparation, characterization and in vivo evaluation of pH sensitive, safe quercetin-succinylated chitosan-alginate core-shell-corona nanoparticle for diabetes treatment

(2018) Piyasi Mukhopadhyay et al.   CARBOHYDRATE POLYMERS

Impact of wall material physicochemical characteristics on the stability of encapsulated phytochemicals: A review

(2018) Philip Labuschagne   FOOD RESEARCH INTERNATIONAL

Kefir Peptides Prevent Hyperlipidemia and Obesity in High-Fat-Diet-Induced Obese Rats via Lipid Metabolism Modulation

(2018) Yu-Tang Tung et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data

(2018) Maria Mantzorou et al.   PHYTOTHERAPY RESEARCH

IL-10/STAT3 is reduced in childhood obesity with hypertriglyceridemia and is related to triglyceride level in diet-induced obese rats

(2018) Yuesheng Liu et al.   BMC Endocrine Disorders

Beneficial effects of curcumin and capsaicin on cyclophosphamide-induced premature ovarian failure in a rat model

(2018) Rauf Melekoglu et al.   Journal of Ovarian Research

Quercetin increases the antioxidant capacity of the ovary in menopausal rats and in ovarian granulosa cell culture in vitro

(2018) Jiao Wang et al.   Journal of Ovarian Research

The effects of quercetin supplementation on metabolic and hormonal parameters as well as plasma concentration and gene expression of resistin in overweight or obese women with polycystic ovary syndrome

(2018) Masoud Khorshidi et al.   PHYTOTHERAPY RESEARCH

Amelioration by quercetin of insulin resistance and uterine GLUT4 and ERα gene expression in rats with polycystic ovary syndrome (PCOS)

(2018) Asma Neisy et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Curcumin-loaded chitosan–bovine serum albumin nanoparticles potentially enhanced Aβ 42 phagocytosis and modulated macrophage polarization in Alzheimer’s disease

(2018) Rui Yang et al.   Nanoscale Research Letters

Modulating impacts of quercetin/sitagliptin combination on streptozotocin-induced diabetes mellitus in rats

(2018) Hebatollah E. Eitah et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Loss of RIP3 initiates annihilation of high-fat diet initialized nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4 and oxidative stress

(2018) Ge Chenxu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quercetin exerts preventive, ameliorative and prophylactic effects on cadmium chloride - induced oxidative stress in the uterus and ovaries of female Wistar rats

(2017) Victor Udo Nna et al.   FOOD AND CHEMICAL TOXICOLOGY

Chitosan nanoparticles enhances the anti-quorum sensing activity of kaempferol

(2017) Sedef Ilk et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium

(2017) Fei Tong et al.   International Journal of Nanomedicine

Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kB signaling and Nrf2 pathway in high fat diet fed mice

(2017) Min-Xuan Xu et al.   International Journal of Nanomedicine

Antiobesity Efficacy of Quercetin-Rich Supplement on Diet-Induced Obese Rats: Effects on Body Composition, Serum Lipid Profile, and Gene Expression

(2017) Yuwen Ting et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The effect of increasing body mass index on cardio-metabolic risk and biomarkers of oxidative stress and inflammation in nascent metabolic syndrome

(2017) Roma Pahwa et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Reactive Oxygen Species Mediated Prostaglandin E2 Contributes to Acute Response of Epithelial Injury

(2017) Yi-Ping Hu et al.   Oxidative Medicine and Cellular Longevity

Metabolic disturbances due to a high-fat diet in a non-insulin-resistant animal model

(2017) L Ramalho et al.   Nutrition & Diabetes

Bariatric Surgery: A Potential Treatment for Type 2 Diabetes in Youth: Table 1

(2016) Amy S. Shah et al.   DIABETES CARE

Correlation of TLR4 and KLF7 in Inflammation Induced by Obesity

(2016) Cuizhe Wang et al.   INFLAMMATION

Beneficial effects of quercetin–iron complexes on serum and tissue lipids and redox status in obese rats

(2016) Asmahan Imessaoudene et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Curcumin as potential therapeutic natural product: a nanobiotechnological perspective

(2016) Soumitra Shome et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Herbal Formula HT048 Attenuates Diet-Induced Obesity by Improving Hepatic Lipid Metabolism and Insulin Resistance in Obese Rats

(2016) Yoon Lee et al.   MOLECULES

Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-κB and P2X7R Signaling in PMA-Induced Macrophages

(2016) Fanqi Kong et al.   Frontiers in Pharmacology

Hepatic TLR4 signaling in obese NAFLD

(2015) Torfay Sharifnia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Curcumin Modulates Macrophage Polarization Through the Inhibition of the Toll-Like Receptor 4 Expression and its Signaling Pathways

(2015) Yaoyao Zhou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The crucial roles of apolipoproteins E and C-III in apoB lipoprotein metabolism in normolipidemia and hypertriglyceridemia

(2015) Frank M. Sacks   CURRENT OPINION IN LIPIDOLOGY

The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue

(2015) Ana Elena Peredo-Escárcega et al.   Evidence-based Complementary and Alternative Medicine

Pyrrolidine Dithiocarbamate Inhibits Nuclear Factor κB and Toll-Like Receptor 4 Expression in Rats with Acute Necrotizing Pancreatitis

(2015) Min Xu et al.   Gut and Liver

The metabolome profiling and pathway analysis in metabolic healthy and abnormal obesity

(2015) H-H Chen et al.   INTERNATIONAL JOURNAL OF OBESITY

Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats

(2015) U. Etxeberria et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cystine accumulation attenuates insulin release from the pancreatic β-cell due to elevated oxidative stress and decreased ATP levels

(2015) Bernadette McEvoy et al.   JOURNAL OF PHYSIOLOGY-LONDON

Localization of resistin and its possible roles in the ovary of a vespertilionid bat, Scotophilus heathi

(2015) Ajit Singh et al.   STEROIDS

Polymeric nanoparticles: the future of nanomedicine

(2015) Brittany L. Banik et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Current trends and future prospects of lipstatin: a lipase inhibitor and pro-drug for obesity

(2015) Punit Kumar et al.   RSC Advances

The anti-obesity effects ofLactobacillus caseistrain Shirota versus Orlistat on high fat diet-induced obese rats

(2015) Golgis Karimi et al.   Food & Nutrition Research

Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1

(2014) Jing Dong et al.   JOURNAL OF LIPID RESEARCH

Curcumin Attenuates CFA Induced Thermal Hyperalgesia by Modulation of Antioxidant Enzymes and Down Regulation of TNF-α, IL-1β and IL-6

(2014) Ajeet Kumar Singh et al.   NEUROCHEMICAL RESEARCH

Measurement of Visceral Fat: Should We Include Retroperitoneal Fat?

(2014) Chi-Sheng Hung et al.   PLoS One

Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-κB pathways

(2013) Zhe Meng et al.   ACTA PHARMACOLOGICA SINICA

Quercetin negatively regulates TLR4 signaling induced by lipopolysaccharide through Tollip expression

(2013) Eui-Baek Byun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Betaine Protects Against High-Fat-Diet-Induced Liver Injury by Inhibition of High-Mobility Group Box 1 and Toll-Like Receptor 4 Expression in Rats

(2013) Wei Zhang et al.   DIGESTIVE DISEASES AND SCIENCES

Novel insights of dietary polyphenols and obesity

(2013) Shu Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Curcumin as a Potent and Selective Inhibitor of 11β-Hydroxysteroid Dehydrogenase 1: Improving Lipid Profiles in High-Fat-Diet-Treated Rats

(2013) Guo-Xin Hu et al.   PLoS One

Quercetin Protects against Diabetes-Induced Exaggerated Vasoconstriction in Rats: Effect on Low Grade Inflammation

(2013) Mona F. Mahmoud et al.   PLoS One

Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations

(2012) Fábio R.F. Seiva et al.   FOOD AND CHEMICAL TOXICOLOGY

Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils

(2012) Hua-Zhong Ying et al.   FOOD AND CHEMICAL TOXICOLOGY

Antioxidant Effects of Quercetin and Catechin Encapsulated into PLGA Nanoparticles

(2012) Hector Pool et al.   Journal of Nanomaterials

Transcriptomic and Metabonomic Profiling Reveal Synergistic Effects of Quercetin and Resveratrol Supplementation in High Fat Diet Fed Mice

(2012) Mingmei Zhou et al.   JOURNAL OF PROTEOME RESEARCH

α-Lipoic acid reduced weight gain and improved the lipid profile in rats fed with high fat diet

(2012) Eun Young Seo et al.   Nutrition Research and Practice

Curcumin attenuates lipolysis stimulated by tumor necrosis factor-α or isoproterenol in 3T3-L1 adipocytes

(2012) Xiao-yun Xie et al.   PHYTOMEDICINE

Curcumin Loaded-PLGA Nanoparticles Conjugated with Tet-1 Peptide for Potential Use in Alzheimer's Disease

(2012) Anila Mathew et al.   PLoS One

Curcumin Prevents High Fat Diet Induced Insulin Resistance and Obesity via Attenuating Lipogenesis in Liver and Inflammatory Pathway in Adipocytes

(2012) Weijuan Shao et al.   PLoS One

Effects of NF-κB Blocker Curcumin on Oogenesis and Immunocompetent Organ Cells in Immune Ovarian Injury in Mice

(2011) I. N. Alekseyeva et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Cardiac remodeling in a rat model of diet-induced obesity

(2011) André Soares Leopoldo et al.   CANADIAN JOURNAL OF CARDIOLOGY

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

(2011) Jacques Amar et al.   EMBO Molecular Medicine

TLR4 but not TLR2 regulates inflammation and tissue damage in acute pancreatitis induced by retrograde infusion of taurocholate

(2011) Darbaz Awla et al.   INFLAMMATION RESEARCH

PLGA Nanoparticles Improve the Oral Bioavailability of Curcumin in Rats: Characterizations and Mechanisms

(2011) Xiaoxia Xie et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Suppression of Free Fatty Acid-Induced Insulin Resistance by Phytopolyphenols in C2C12 Mouse Skeletal Muscle Cells

(2011) Yea-Tzy Deng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of acetyl salycilic acid and ibuprofen in chronic liver damage induced by CCl4

(2011) Enrique Chávez et al.   JOURNAL OF APPLIED TOXICOLOGY

Green Tea Extract Suppresses NFκB Activation and Inflammatory Responses in Diet-Induced Obese Rats with Nonalcoholic Steatohepatitis

(2011) Hea Jin Park et al.   JOURNAL OF NUTRITION

Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders

(2011) Giovanni Scapagnini et al.   MOLECULAR NEUROBIOLOGY

Long-term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism

(2011) Su-Kyung Shin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Antiapoptotic and proliferative activity of curcumin on ovarian follicles in mice exposed to whole body ionizing radiation

(2011) Cevat Aktas et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Biochemical Study of Oxidative Stress Markers in the Liver, Kidney and Heart of High Fat Diet Induced Obesity in Rats

(2011) Saad A Noeman et al.   Diabetology & Metabolic Syndrome

Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/β-catenin signaling

(2010) Jiyun Ahn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Corrigendum to “The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways” [Biochem. Biophys. Res. Commun. 373 (2008) 545–549]

(2010) Jiyun Ahn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Beneficial effect of oral administration of Lactobacillus casei strain Shirota on insulin resistance in diet-induced obesity mice

(2010) E. Naito et al.   JOURNAL OF APPLIED MICROBIOLOGY

Obesity induced by high-fat diet promotes insulin resistance in the ovary

(2010) Eliana H Akamine et al.   JOURNAL OF ENDOCRINOLOGY

Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice

(2010) Masuko Kobori et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Curcumin improves insulin resistance in skeletal muscle of rats

(2010) L.-X. Na et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Curcumin and obesity: evidence and mechanisms

(2010) Lini Alappat et al.   NUTRITION REVIEWS

Direct medical cost of overweight and obesity in the USA: a quantitative systematic review

(2010) A. G. Tsai et al.   Obesity Reviews

Dietary Polyphenols and Obesity

(2010) Mohsen Meydani et al.   Nutrients

Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice

(2009) Asma Ejaz et al.   JOURNAL OF NUTRITION

Mediating Tumor Targeting Efficiency of Nanoparticles Through Design

(2009) Steven D. Perrault et al.   NANO LETTERS

Red beet (Beta vulgaris L.) leaf supplementation improves antioxidant status in C57BL/6J mice fed high fat high cholesterol diet

(2009) Jeung Hee Lee et al.   Nutrition Research and Practice

Modulation of Ovarian Structure and Abdominal Obesity in Curcumin- and Flutamide-treated Aging FSH-R Haploinsufficient Mice

(2009) Rashmi Tiwari-Pandey et al.   Reproductive Sciences

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Evidence for Insulin Suppression of Baseline Luteinizing Hormone in Women with Polycystic Ovarian Syndrome and Normal Women

(2008) Mark A. Lawson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Oral administration of dahi containing probiotic Lactobacillus acidophilus and Lactobacillus casei delayed the progression of streptozotocin-induced diabetes in rats

(2008) Hariom Yadav et al.   JOURNAL OF DAIRY RESEARCH

Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin

(2008) Jeong-Yeh Yang et al.   LIFE SCIENCES

Insulin Modulation of Luteinizing Hormone Secretion in Normal Female Volunteers and Lean Polycystic Ovary Syndrome Patients

(2008) Mallory Moret et al.   NEUROENDOCRINOLOGY

Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes

(2008) Amanda M Gonzales et al.   Nutrition & Metabolism

Quercetin Ameliorates Metabolic Syndrome and Improves the Inflammatory Status in Obese Zucker Rats

(2008) Leonor Rivera et al.   Obesity

A comparative study on hypoglycemic and hypocholesterolemic effects of high and low molecular weight chitosan in streptozotocin-induced diabetic rats

(2007) Hsien-Tsung Yao et al.   FOOD AND CHEMICAL TOXICOLOGY

Preparation, physicochemical characterization, and antioxidant effects of quercetin nanoparticles

(2007) Tzu-Hui Wu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS