Review
Oncology
Xiaodong Guo, Can Can, Wancheng Liu, Yihong Wei, Xinyu Yang, Jinting Liu, Hexiao Jia, Wenbo Jia, Hanyang Wu, Daoxin Ma
Summary: Mitochondrial transfer serves as a new intercellular communication and plays a crucial role in hematological malignancies, leading to chemotherapy resistance. This review discusses the mechanisms and effects of mitochondrial transfer in different pathophysiological contexts, providing insights into its potential as a therapeutic target in improving treatment outcomes for hematological malignancies.
BIOMARKER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Qintao Fan, Yasuhiro Maejima, Lai Wei, Shun Nakagama, Yuka Shiheido-Watanabe, Tetsuo Sasano
Summary: Mitochondria play beneficial and detrimental roles in cells, depending on their functions. The maintenance of cellular physiological state requires a series of mitochondrial quality control pathways. Recent studies have shown that mitochondria can be ejected from cells for degradation or transferred to other cells for metabolic support or signaling regulation. This review summarizes the current understanding of the regulation of mitochondrial transmigration across plasma membranes and discusses its functional significance, particularly in the pathogenesis of cardiovascular diseases. The unrevealed mechanisms underlying mitochondrial ejection and challenges in therapeutic applications are also addressed.
Review
Biochemistry & Molecular Biology
Jonas Heyn, Marina Augusto Heuschkel, Claudia Goettsch
Summary: Mitochondria play crucial roles in regulating metabolism, cell death, and energy production. The maintenance of mitochondrial health is essential for cellular homeostasis. Recent studies have identified a novel cellular response called mitochondrial-derived vesicles (MDVs), which are released from mitochondria and can be degraded within lysosomes or peroxisomes. MDVs are implicated in cardiovascular disease (CVD) and may contribute to mitochondrial dysfunction. Furthermore, extracellular vesicles (EVs) have been found to contain mitochondrial content. This article provides an overview of MDV formation and trafficking, discusses the connection between MDVs and EV biogenesis, and explores their roles in CVD, as well as the potential cardioprotective effects of vesicle-mediated mitochondrial transfer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Marina O. Gomzikova, Victoria James, Albert A. Rizvanov
Summary: Mitochondria donation plays a crucial role in treating mitochondrial diseases and deficiencies, leading to increased ATP production, restoration of function, and rescue of recipient cells. Mitochondrial dysfunction affects cells with high energy demands, and is associated with diseases such as type 2 diabetes, Parkinson's, and Alzheimer's.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Yiming Qin, Xin Jiang, Qi Yang, Jiaqi Zhao, Qiong Zhou, Yanhong Zhou
Summary: Mitochondria are crucial organelles in cells, playing key roles in energy metabolism and apoptosis. Transcellular transfer of mitochondria, facilitated by structures like tunneling nanotubes, extracellular vesicles, and Cx43 gap junctions, is driven by a transport complex. Adapters like mitochondrial Rho small GTPase MIRO and motor proteins like myosin XIX aid in the transcellular transport of mitochondria. This review discusses the roles of these structures in mitochondrial transcellular transfer and their potential for clinical therapies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu Xu, Yanhua Yu, Bowen Yang, Jingjiao Hui, Cai Zhang, Hua Fang, Xiaoyun Bian, Min Tao, Yipeng Lu, Zhenglu Shang
Summary: Mitochondria, in addition to powering cells, also serve as intercellular signaling. They play a crucial role in the pathogenesis of cardiovascular disease and are emerging as a key regulator in its development. Mitochondrial transplantation challenges traditional methods and shows promise as a novel treatment paradigm for patients with acute cardiovascular accidents.
DNA AND CELL BIOLOGY
(2021)
Review
Cell Biology
Lan-Feng Dong, Jakub Rohlena, Renata Zobalova, Zuzana Nahacka, Anne-Marie Rodriguez, Michael V. V. Berridge, Jiri Neuzil
Summary: Jiri Neuzil and colleagues review the processes and mechanisms of horizontal mitochondrial transfer (HMT) and its metabolic consequences in cells. It has been found that mitochondria can move between mammalian cells, leading to various functional consequences. This phenomenon of mitochondrial trafficking is more prevalent than previously thought and has implications in bioenergetic crosstalk, disease treatment, cancer therapy resistance, and homeostasis.
JOURNAL OF CELL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Daniela Valenti, Rosa Anna Vacca, Loredana Moro, Anna Atlante
Summary: Mitochondria are intricate organelles playing diverse roles beyond energy production, including regulation of cell metabolism, proliferation, death, and immune response. Dysfunction in mitochondria is implicated in various diseases, while intercellular mitochondrial transfer has emerged as a promising field of research with therapeutic potential in different pathophysiological contexts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Yitian Du, Zhenzhen Yang, Qi Sun, Meng Lin, Rudong Wang, Yiwei Peng, Xinyi Chen, Xianrong Qi
Summary: This study demonstrated the use of engineered microglia as transport vectors to deliver paclitaxel for the treatment of glioma. Engineered microglia can cross the BBB, migrate towards gliomas, and transfer cargo to glioma cells. Extracellular vesicles and tunneling nanotubes were found to play unique roles in cargo transportation between microglia and glioma cells.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Loredana Leggio, Francesca L'Episcopo, Andrea Magri, Maria Jose Ulloa-Navas, Greta Paterno, Silvia Vivarelli, Carlos A. P. Bastos, Cataldo Tirolo, Nunzio Testa, Salvatore Caniglia, Pierpaolo Risiglione, Fabrizio Pappalardo, Alessandro Serra, Patricia Garcia-Tarraga, Nuno Faria, Jonathan J. Powell, Luca Peruzzotti-Jametti, Stefano Pluchino, Jose Manuel Garcia-Verdugo, Angela Messina, Bianca Marchetti, Nunzio Iraci
Summary: Extracellular vesicles released by astrocytes in the brain of Parkinson's disease patients play a significant role in cell-to-cell communication and have neuroprotective effects on dopaminergic neurons. Nigrostriatal astrocytes release the highest number of EVs, especially in response to CCL3, which promotes dopaminergic neuroprotection. These EVs specifically protect differentiated cells from oxidative stress-induced caspase-3 activation and restore impaired mitochondrial function caused by the neurotoxin MPP+. EVs from VMB-astrocytes fully restore ATP production in differentiated SH-SY5Y cells.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Caitlin E. Miller, Fangfang Xu, Yanming Zhao, Wei Luo, Weixiong Zhong, Kristy Meyer, Rani Jayswal, Heidi L. Weiss, William H. St Clair, Daret K. St Clair, Luksana Chaiswing
Summary: This study reveals a novel adaptive response to radiation treatment that promotes cancer recurrence. It shows that hydrogen peroxide (H2O2) can reprogram mitochondrial homeostasis in prostate cancer cells, allowing them to survive and regrow after radiation treatment. The study also demonstrates that radiation induces the release of extracellular vesicles (EVs) carrying mitochondrial antioxidant proteins, and H2O2 enhances the production of these EVs. Furthermore, functional mitochondria enhance cancer cell survival after radiation treatment.
Article
Biochemistry & Molecular Biology
Fei Wang, Xiaoping Chen, Haipeng Cheng, Lu Song, Jianghong Liu, Steve Caplan, Li Zhu, Jane Y. Wu
Summary: MICAL2PV is a novel TNT regulator that suppresses formation and modulates mitochondrial distribution, with its MO domain playing a key role in activity. Down-regulation of MICAL2PV enhances cell survival to chemotherapeutic drugs.
Review
Immunology
George B. Stefano, Pascal Buttiker, Simon Weissenberger, Tobias Esch, Martin Anders, Jiri Raboch, Richard M. Kream, Radek Ptacek
Summary: Mitochondria, traditionally seen as subcellular organelles fully dependent on the cell they are a part of, are now found to be more functionally independent than other organelles. They can function outside cells, engage in complex social interactions, and communicate with other cellular components, bacteria, and viruses. This new perspective may shed light on their biological function and lead to new strategies for treating diseases associated with mitochondrial dysfunction.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Cell Biology
Romain Perbet, Valentin Zufferey, Elodie Leroux, Enea Parietti, Jeanne Espourteille, Lucas Culebras, Sylvain Perriot, Renaud Du Pasquier, Severine Begard, Vincent Deramecourt, Nicole Deglon, Nicolas Toni, Luc Buee, Morvane Colin, Kevin Richetin
Summary: Tau protein accumulation in astrocytes is involved in neurodegenerative disorders. The origins of 3R and 4R isoforms of tau in astrocytes remain unclear. This study demonstrates that neurons with accumulated 3R or 4R tau have the ability to transfer tau to astrocytes through extracellular vesicles (EVs). Tau-containing EVs disrupt the mitochondrial system of astrocytes and the damage is more severe with 3R tau-containing EVs. EVs from the brain fluid of tauopathy patients also affect mitochondrial function in astrocytes derived from human induced pluripotent stem cells (iPSCs).
Article
Endocrinology & Metabolism
Rugivan Sabaratnam, Didde Riisager Hansen, Per Svenningsen
Summary: White adipose tissue (WAT) is an important organ that regulates energy metabolism. In obese individuals, dysfunctional adipocytes with reduced endocrine and mitochondrial function, increased inflammation and fibrosis, and altered extracellular structure can lead to systemic lipotoxicity and insulin resistance. Mitochondrial dysfunction in adipocytes is linked to unhealthy obesity, and interventions that improve mitochondrial function may reduce the risk of obesity-related diseases. This review discusses the importance of mitochondrial function and metabolism in human adipocyte biology and potential therapeutic approaches for improving adipocyte mitochondrial metabolism.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Yingzhou Shi, Xiaohe Zheng, Mingzhi Zheng, Linlin Wang, Yingying Chen, Yueliang Shen
Summary: This study analyzed the expression profiles of lncRNAs and mRNAs in septic mice hearts, identifying specific lncRNAs and mRNAs potentially responsible for cardiac mitochondrial dysfunction during sepsis. The dysregulation of numerous lncRNAs and mRNAs related to inflammation, mitochondrial metabolism, oxidative stress, and apoptosis in septic hearts was observed. Coexpression network analysis revealed potential interactions between lncRNAs and mitochondria-related mRNAs, providing insights into the molecular mechanisms underlying cardiac dysfunction in sepsis.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Review
Neurosciences
Lvwan Xu, Xin Ye, Jinjie Zhong, Ying-ying Chen, Lin-lin Wang
Summary: Recent studies have shown that circRNAs play important roles in CNS post-traumatic injury, associated with proliferation, inflammation, and apoptosis. The potential clinical value of circRNAs as a therapeutic target for CNS injury is discussed, bringing new possibilities for treatment.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Cell Biology
Lvwan Xu, Xin Ye, Qingyi Wang, Bihan Xu, Jinjie Zhong, Ying-ying Chen, Lin-lin Wang
Summary: T cells play a significant role in the repair process and immune response in the central nervous system post-traumatic injury, with both beneficial and harmful effects. The advancement of new techniques has made research focusing on T cells a valuable direction for future therapy of traumatic CNS injury.
CELL PROLIFERATION
(2021)
Article
Neurosciences
Ying Yao, Jingyu Wang, Teng He, Heyangzi Li, Jue Hu, Mingzhi Zheng, Yueming Ding, Ying-ying Chen, Yueliang Shen, Lin-lin Wang, Yongjian Zhu
BRAIN RESEARCH BULLETIN
(2020)
