Metabolic derangement in polycystic kidney disease mouse models is ameliorated by mitochondrial-targeted antioxidants

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

(2020) Nobu Oshima et al.   Cell Reports

A novel approach to measure mitochondrial respiration in frozen biological samples

(2020) Rebeca Acin‐Perez et al.   EMBO JOURNAL

Increased mitochondrial fragmentation in polycystic kidney disease acts as a modifier of disease progression

(2020) Laura Cassina et al.   FASEB JOURNAL

Oxidative Stress and Mitochondrial Abnormalities Contribute to Decreased Endothelial Nitric Oxide Synthase Expression and Renal Disease Progression in Early Experimental Polycystic Kidney Disease

(2020) Alp S. Kahveci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease

(2020) Yi Lu et al.   Science Translational Medicine

Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy

(2018) Amel Karaa et al.   NEUROLOGY

A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed

(2018) Cheng-Chao Lin et al.   Scientific Reports

Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease

(2017) Yu Ishimoto et al.   MOLECULAR AND CELLULAR BIOLOGY

The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function

(2017) Valeria Padovano et al.   MOLECULAR BIOLOGY OF THE CELL

Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons

(2017) Matthew Redmann et al.   Redox Biology

A Redox-Dependent Mechanism for Regulation of AMPK Activation by Thioredoxin1 during Energy Starvation

(2014) Dan Shao et al.   Cell Metabolism

Tolvaptan plus Pasireotide Shows Enhanced Efficacy in a PKD1 Model

(2014) K. Hopp et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease

(2013) Xia Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Strategies Targeting cAMP Signaling in the Treatment of Polycystic Kidney Disease

(2013) V. E. Torres et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy

(2013) Isaline Rowe et al.   NATURE MEDICINE

Prevalence of Cardiovascular Events in Patients with Autosomal Dominant Polycystic Kidney Disease

(2012) Imed Helal et al.   AMERICAN JOURNAL OF NEPHROLOGY

Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity

(2012) Katharina Hopp et al.   JOURNAL OF CLINICAL INVESTIGATION

Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress

(2011) Lonnie Schneider et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria-Targeted Peptide Accelerates ATP Recovery and Reduces Ischemic Kidney Injury

(2011) H. H. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammation, Oxidative Stress, and Insulin Resistance in Polycystic Kidney Disease

(2010) V. Menon et al.   Clinical Journal of the American Society of Nephrology

Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

(2009) Dao-Fu Dai et al.   CIRCULATION

Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease

(2009) Sandro Rossetti et al.   KIDNEY INTERNATIONAL

Autosomal dominant polycystic kidney disease: the last 3 years

(2009) Vicente E. Torres et al.   KIDNEY INTERNATIONAL

Ectopic Catalase Expression in Mitochondria by Adeno-Associated Virus Enhances Exercise Performance in Mice

(2009) Dejia Li et al.   PLoS One