Anticancer Activities of Mushrooms: A Neglected Source for Drug Discovery

Antrodia salmonea induces apoptosis and enhances cytoprotective autophagy in colon cancer cells

(2021) Hsin-Ling Yang et al.   Aging-US

Artificial Intelligence and Cancer Drug Development

(2021) Fan Yang et al.   Recent Patents on Anti-Cancer Drug Discovery

Medicinal mushrooms: Clinical perspective and challenges

(2021) Sujogya Kumar Panda et al.   DRUG DISCOVERY TODAY

Clinical Cancer Advances 2020: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology

(2020) Merry Jennifer Markham et al.   JOURNAL OF CLINICAL ONCOLOGY

Discovering Anti-Cancer Drugs via Computational Methods

(2020) Wenqiang Cui et al.   Frontiers in Pharmacology

Structure-Functional Activity Relationship of β-Glucans From the Perspective of Immunomodulation: A Mini-Review

(2020) Biao Han et al.   Frontiers in Immunology

Evaluation of anticancer activities of Poria cocos ethanol extract in breast cancer: In vivo and in vitro, identification and mechanism

(2020) Yu Jiang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Identification of Biologically Active Ganoderma lucidum Compounds and Synthesis of Improved Derivatives That Confer Anti-cancer Activities in vitro

(2019) Michelle M. Martínez-Montemayor et al.   Frontiers in Pharmacology

One new sterpurane sesquiterpene from cultures of the basidiomycete Pholiota nameko

(2019) Wan-Rong Niu et al.   NATURAL PRODUCT RESEARCH

Cancer drug development: The missing links

(2019) Ajaikumar B Kunnumakkara et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Cordycepin Inhibits Drug-resistance Non-small Cell Lung Cancer Progression by Activating AMPK Signaling Pathway

(2019) Chunli Wei et al.   PHARMACOLOGICAL RESEARCH

Antcin-A Modulates Epithelial-to-Mesenchymal Transition and Inhibits Migratory and Invasive Potentials of Human Breast Cancer Cells via p53-Mediated miR-200c Activation

(2019) K. J. Senthil Kumar et al.   PLANTA MEDICA

Recent Advances and Perspectives in Cancer Drug Design

(2018) LUMA G. MAGALHAES et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Antrodia cinnamomea extract inhibits the proliferation of tamoxifen-resistant breast cancer cells through apoptosis and skp2/microRNAs pathway

(2018) Yu-Shih Lin et al.   BMC Complementary and Alternative Medicine

Two new sesquiterpenes from cultures of the higher fungus Pholiota nameko

(2018) Xiao-Yan Yang et al.   NATURAL PRODUCT RESEARCH

Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells

(2018) Eliana Noelia Alonso et al.   Oncotarget

Ganoderic acid A exerts antitumor activity against MDA‑MB‑231 human breast cancer cells by inhibiting the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway

(2018) Yuguang Yang et al.   Oncology Letters

Antrodia salmonea suppresses invasion and metastasis in triple-negative breast cancer cells by reversing EMT through the NF-κB and Wnt/β-catenin signaling pathway

(2018) You-Cheng Hseu et al.   FOOD AND CHEMICAL TOXICOLOGY

Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review

(2017) Solomon P. Wasser   INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS

Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway

(2017) Yizhi Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Coriolus versicolor (Yunzhi) Use as Therapy in Advanced Hepatocellular Carcinoma Patients with Poor Liver Function or Who Are Unfit for Standard Therapy

(2017) Wen Yee Chay et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Antrodia salmonea induces G2 cell-cycle arrest in human triple-negative breast cancer (MDA-MB-231) cells and suppresses tumor growth in athymic nude mice

(2017) Chia-Ting Chang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cancer Screening and Early Detection in the 21 st Century

(2017) Jennifer T. Loud et al.   Seminars in Oncology Nursing

A preliminary randomised controlled study of short-term Antrodia cinnamomea treatment combined with chemotherapy for patients with advanced cancer

(2016) Ming-Yen Tsai et al.   BMC Complementary and Alternative Medicine

Protein tyrosine phosphatase 1B inhibitory properties of seco-cucurbitane triterpenes obtained from fruiting bodies of Russula lepida

(2016) Wilmar Maarisit et al.   Journal of Natural Medicines

Cordycepin Induces Apoptosis and Inhibits Proliferation of Human Lung Cancer Cell Line H1975 via Inhibiting the Phosphorylation of EGFR

(2016) Zheng Wang et al.   MOLECULES

Structures and biological activities of triterpenes and sesquiterpenes obtained from Russula lepida

(2016) Jong-Soo Lee et al.   PHYTOCHEMISTRY

Fucose-containing fraction of Ling-Zhi enhances lipid rafts-dependent ubiquitination of TGFβ receptor degradation and attenuates breast cancer tumorigenesis

(2016) Shu-Ming Tsao et al.   Scientific Reports

Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice

(2016) Agustina Roldan-Deamicis et al.   Cancer Medicine

A phase I trial of mushroom powder in patients with biochemically recurrent prostate cancer: Roles of cytokines and myeloid-derived suppressor cells forAgaricus bisporus-induced prostate-specific antigen responses

(2015) Przemyslaw Twardowski et al.   CANCER

Pachymic acid induces apoptosis via activating ROS-dependent JNK and ER stress pathways in lung cancer cells

(2015) Jun Ma et al.   Cancer Cell International

Seven new drimane-type sesquiterpenoids from cultures of fungus Laetiporus sulphureus

(2015) Jiang-Bo He et al.   FITOTERAPIA

Shotgun proteomic analysis of tiger milk mushroom (Lignosus rhinocerotis) and the isolation of a cytotoxic fungal serine protease from its sclerotium

(2015) Hui-Yeng Y. Yap et al.   JOURNAL OF ETHNOPHARMACOLOGY

Soluble β-glucan from Grifola frondosa induces tumor regression in synergy with TLR9 agonist via dendritic cell-mediated immunity

(2015) Yuki Masuda et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Metabolites identification and multi-component pharmacokinetics of ergostane and lanostane triterpenoids in the anticancer mushroom Antrodia cinnamomea

(2015) Xue Qiao et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Purification and characterization of a ∼43 kDa antioxidant protein with antitumor activity fromPholiota nameko

(2015) Lei Qian et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Pachymic Acid Induces Apoptosis of EJ Bladder Cancer Cells by DR5 Up-Regulation, ROS Generation, Modulation of Bcl-2 and IAP Family Members

(2015) Jin-Woo Jeong et al.   PHYTOTHERAPY RESEARCH

Purification and identification of a polysaccharide from medicinal mushroom Amauroderma rude with immunomodulatory activity and inhibitory effect on tumor growth

(2015) Honghui Pan et al.   Oncotarget

Ergosterol purified from medicinal mushroom Amauroderma rude inhibits cancer growth in vitro and in vivo by up-regulating multiple tumor suppressors

(2015) Xiangmin Li et al.   Oncotarget

Chemical, Bioactive, and Antioxidant Potential of Twenty Wild Culinary Mushroom Species

(2015) S. K. Sharma et al.   Biomed Research International

Immunomodulatory Effects of theAgaricus blazeiMurrill-Based Mushroom Extract AndoSan in Patients with Multiple Myeloma Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation: A Randomized, Double Blinded Clinical Study

(2015) Jon-Magnus Tangen et al.   Biomed Research International

Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study

(2014) Kathleen M. Wesa et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

An appraisal of eighteen commonly consumed edible plants as functional food based on their antioxidant and starch hydrolase inhibitory activities

(2014) Yian Hoon Lee et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Reduction of Adverse Effects by a Mushroom Product, Active Hexose Correlated Compound (AHCC) in Patients With Advanced Cancer During Chemotherapy—The Significance of the Levels of HHV-6 DNA in Saliva as a Surrogate Biomarker During Chemotherapy

(2014) Toshinori Ito et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

In vivo and in vitro anti-tumor and anti-metastasis effects of Coriolus versicolor aqueous extract on mouse mammary 4T1 carcinoma

(2014) Ke-Wang Luo et al.   PHYTOMEDICINE

Panepoxydone Targets NF-kB and FOXM1 to Inhibit Proliferation, Induce Apoptosis and Reverse Epithelial to Mesenchymal Transition in Breast Cancer

(2014) Ritu Arora et al.   PLoS One

Medicinal mushroom science: Current perspectives, advances, evidences, and challenges

(2014) SolomonP Wasser   Biomedical Journal

Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus

(2013) Lishuai Ma et al.   FOOD CHEMISTRY

Effect of Agaricus sylvaticus supplementation on nutritional status and adverse events of chemotherapy of breast cancer: A randomized, placebo-controlled, double-blind clinical trial

(2013) Roberto Cañete et al.   INDIAN JOURNAL OF PHARMACOLOGY

Antitumor Activity of a Polysaccharide−Protein Complex Isolated from a Wood-Rotting Polypore Macro Fungus Phellinus rimosus (Berk) Pilat

(2013) C R Meera et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Genes Related to Suppression of Malignant Phenotype Induced by Maitake D-Fraction in Breast Cancer Cells

(2013) Eliana Noelia Alonso et al.   JOURNAL OF MEDICINAL FOOD

Anticancer Activity of Amauroderma rude

(2013) Chunwei Jiao et al.   PLoS One

Ganoderiol A-Enriched Extract Suppresses Migration and Adhesion of MDA-MB-231 Cells by Inhibiting FAK-SRC-Paxillin Cascade Pathway

(2013) Guo-Sheng Wu et al.   PLoS One

Inhibition of Cell Growth and Induction of Apoptosis byAntrodia camphoratain HER-2/neu-Overexpressing Breast Cancer Cells through the Induction of ROS, Depletion of HER-2/neu, and Disruption of the PI3K/Akt Signaling Pathway

(2012) Chuan-Chen Lee et al.   Evidence-based Complementary and Alternative Medicine

Ganoderic acids suppress growth and angiogenesis by modulating the NF-?B signaling pathway in breast cancer cells

(2012) Funian Li et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Schizophyllan inhibits the development of mammary and hepatic carcinomas induced by 7,12 dimethylbenz(α)anthracene and decreases cell proliferation: comparison with tamoxifen

(2012) Ahmed Mansour et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Cytotoxic constituents from the fungusDaldinia concentrica(Xylariaceae)

(2012) Dang Ngoc Quang et al.   NATURAL PRODUCT RESEARCH

BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer

(2012) JIAHUA JIANG et al.   ONCOLOGY REPORTS

Ethanol extracts of fruiting bodies of Antrodia cinnamomea exhibit anti-migration action in human adenocarcinoma CL1-0 cells through the MAPK and PI3K/AKT signaling pathways

(2012) Ying-Yi Chen et al.   PHYTOMEDICINE

Efficacy and Safety of Orally Administered Lentinula edodes Mycelia Extract for Patients Undergoing Cancer Chemotherapy: A Pilot Study

(2011) Yoshiyuki Yamaguchi et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Spore Powder ofGanoderma lucidumImproves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial

(2011) Hong Zhao et al.   Evidence-based Complementary and Alternative Medicine

Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells

(2011) Guo-Sheng Wu et al.   FITOTERAPIA

Soluble  -glucan from Grifola frondosa induces proliferation and Dectin-1/Syk signaling in resident macrophages via the GM-CSF autocrine pathway

(2011) Y. Masuda et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting

(2011) F. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current findings, future trends, and unsolved problems in studies of medicinal mushrooms

(2010) Solomon P. Wasser   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Identification of Antrocin from Antrodia camphorata as a Selective and Novel Class of Small Molecule Inhibitor of Akt/mTOR Signaling in Metastatic Breast Cancer MDA-MB-231 Cells

(2010) Yerra Koteswara Rao et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway

(2010) Hsin-Ling Yang et al.   FOOD AND CHEMICAL TOXICOLOGY

Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells

(2010) Sliva   INTERNATIONAL JOURNAL OF ONCOLOGY

Dietary Administration of Mushroom Mycelium Extracts in Patients with Early Stage Prostate Cancers Managed Expectantly: A Phase II Study

(2010) Y. Sumiyoshi et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Purification and characterization of a laccase from the edible wild mushroom Tricholoma mongolicum

(2010) Hexiang Wang   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells

(2010) Mi Ja Chung et al.   Nutrition Research and Practice

Natural products for cancer chemotherapy

(2010) Arnold L. Demain et al.   Microbial Biotechnology

Purification of a Water Extract of Chinese Sweet Tea Plant (Rubus suavissimusS. Lee) by Alcohol Precipitation

(2009) Gar Yee Koh et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects

(2009) Gary Deng et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The effects of β-glucan on human immune and cancer cells

(2009) Godfrey Chan et al.   Journal of Hematology & Oncology

Structural Basis for the Tumor Cell Apoptosis-Inducing Activity of an Antitumor Lectin from the Edible Mushroom Agrocybe aegerita

(2009) Na Yang et al.   JOURNAL OF MOLECULAR BIOLOGY

Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC

(2008) Po Yang et al.   ADVANCES IN THERAPY

Contribution of dectin-1 and granulocyte macrophage–colony stimulating factor (GM-CSF) to immunomodulating actions of β-glucan

(2008) Toshie Harada et al.   INTERNATIONAL IMMUNOPHARMACOLOGY