Review
Immunology
Sunghark Kwon
Summary: JAKs are important enzymes in the JAK-STAT signaling pathway, and dysfunctional JAKs can lead to severe immune system-related diseases. Various JAK inhibitors have been developed to block abnormal JAK-STAT signaling, but drug selectivity and resistance to these inhibitors remain challenges. This review discusses the role and structure of JAKs, as well as strategies for disrupting JAK dimerization to develop novel inhibitors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
So Jin Park, Hye Jin Jung
Summary: Bufotalin, a natural compound, exhibits antiproliferative and antimetastatic activities in triple-negative breast cancer (TNBC) cells by modulating the apoptotic pathway and the STAT3/EMT axis.
Article
Biochemistry & Molecular Biology
Woong Sub Byun, Eun Seo Bae, Jinsheng Cui, Hyen Joo Park, Dong-Chan Oh, Sang Kook Lee
Summary: Pulvomycin effectively inhibits cell proliferation, induces cell cycle arrest and apoptosis by suppressing STAT3 activation, significantly inhibits invasion and migration of TNBC cells, and in combination with docetaxel effectively inhibits tumor growth in xenograft mouse model through STAT3 regulation.
Review
Dermatology
Stephanie Chapman, Michael Kwa, Linda Stein Gold, Henry W. Lim
Summary: The JAK-STAT pathway is important in inflammatory dermatoses, and JAK inhibitors have shown efficacy in treating various dermatologic conditions.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Dermatology
Stephanie Chapman, Linda Stein Gold, Henry W. Lim
Summary: The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is important in the development of inflammatory skin conditions, and JAK inhibitors have shown efficacy in treating various dermatologic diseases. This review focuses on JAK inhibitors being investigated for the treatment of alopecia areata, vitiligo, sarcoidosis, necrobiosis lipoidica, granuloma annulare, and systemic lupus erythematosus, with a discussion on safety and the implications of JAK inhibitors during the COVID-19 pandemic.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yuhan Su, Tianyu Tao, Xiuxing Liu, Wenru Su
Summary: This review summarizes the diverse roles of the JAK-STAT signaling pathway in ocular homeostasis and non-infectious uveitis (NIU) pathology, and discusses the safety and efficacy of JAK inhibitors for treating NIU and potential approaches for treatment optimization.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Dermatology
Qi Yin, Albert Wolkerstorfer, Oren Lapid, Frank B. Niessen, Paul P. M. Van Zuijlen, Susan Gibbs
Summary: Keloid tissues contain inflammatory cells and upregulated pro-inflammatory cytokines. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway mediate cellular responses to these cytokines. Preclinical studies indicate a role for the JAK-STAT pathway in keloid pathogenesis and a potential role for JAK-STAT inhibitors in keloid treatment. Further investigation on relevant biomarkers in a human keloid skin model and in clinical studies is needed.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Plant Sciences
Xing Zhang, Jie Su, Jiacheng Lin, Lujiong Liu, Jiamin Wu, Wenli Yuan, Yibao Zhang, Qi Chen, Zi jian Su, Guihua Xu, Meng Sun, Yile Zhang, Xuan Chen, Wei Zhang
Summary: The Chinese herbal prescription Fu-Zheng-Tong-Luo (FZTL) formula is used to treat idiopathic pulmonary fibrosis (IPF). This study found that FZTL can alleviate IPF injury and inhibit lung fibroblast activation by regulating the JAK2/STAT3 signaling pathway, making it a potential complementary therapy for IPF.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Immunology
Lin Shang, Jiali Cao, Siqi Zhao, Jingya Zhang, Yanling He
Summary: This article reviews the pro-inflammatory mechanisms of the JAK-STAT signaling pathway, the regulatory roles of TYK2 in the pathogenesis of psoriasis, and provides updates on ongoing and recently completed clinical trials of TYK2 inhibitors.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Neurosciences
Jie Han, Zhen Hua, Wen-jie Yang, Shu Wang, Fang Yan, Jun-nan Wang, Tao Sun
Summary: In this study, the analgesic effect of Resveratrol (Res) and its underlying mechanism were investigated in a rat model of spinal cord injury (SCI). The results showed that intrathecal administration with Res effectively alleviated mechanical allodynia in rats with SCI. It was also found that Res suppressed the production of pro-inflammatory factors and inhibited the expressions of the JAK2/STAT3 signaling pathway. These findings suggest that Res has the potential to be an effective treatment for neuropathic pain following SCI.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Ge Jin, Lintao Wang, Jun Ma
Summary: Cardiac hypertrophy is a compensatory response to chronic pressure overload, and excessive angiotensin II plays a significant role in inducing cardiac hypertrophy. Previous studies have shown that STAT5, a member of the STATs family, is closely linked to non-tumor diseases, but its specific role in hypertrophy progression remains unclear. In this study, STAT5-IN-1, a STAT5 inhibitor, was administered to mice and H9c2s cells were used as cell models to investigate the effects of STAT5-IN-1 on cardiac hypertrophy induced by angiotensin II. The findings demonstrated that STAT5 inhibitor substantially decreased cardiac hypertrophy by reducing inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Zhendong Liu, Zhehao Fan, Rui Wang, Xiaolei Li, Hui Chen, Jingcheng Wang
Summary: This study investigated the effect of IFN-alpha-2b on preventing postoperative arthrofibrosis in rats and its antiproliferation effect on fibroblasts in vitro, as well as its molecular mechanism. The results showed that IFN-alpha-2b significantly reduced arthrofibrosis by inhibiting fibroblast proliferation and migration, possibly through the regulation of STAT1/p21 signaling pathway.
MEDIATORS OF INFLAMMATION
(2023)
Review
Immunology
I-Hsin Huang, Wen-Hung Chung, Po-Chien Wu, Chun-Bing Chen
Summary: Atopic dermatitis is a chronic, inflammatory, pruritic skin disease that significantly affects patients' quality of life. The JAK-STAT pathway plays a crucial role in the pathogenesis of AD, and targeting this pathway may alleviate inflammation and itchiness. Topical and oral JAK inhibitors offer promising therapeutic options for AD treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Chunyu Wu, Chenping Sun, Xianghui Han, Yiyi Ye, Yuenong Qin, Sheng Liu
Summary: Sanyin formula (SYF) is a complementary treatment for triple-negative breast cancer (TNBC). This study identified the potential active components of SYF and clarified its molecular mechanism in TNBC. The results showed that 3,4-dihydroxyphenyllactic acid, kaempferol, p-coumaric acid, and vanillic acid may be the active components of SYF. Molecular docking confirmed their stable binding to proteins such as AKR1C3, MMPs, and STAT3. SYF extract effectively suppressed TNBC cell proliferation, migration, invasion, and metastasis by inhibiting JAK/STAT3 signaling and regulating downstream genes.MMP-2/MMP-9. This study provides a better understanding of the mechanism by which SYF inhibits TNBC metastasis, laying a foundation for its further clinical development targeting the JAK/STAT3 pathway.
Article
Endocrinology & Metabolism
An-Ci Siao, Li-Jane Shih, Yen-Yue Lin, Yi-Wei Tsuei, Yow-Chii Kuo, Hui-Chen Ku, Chih-Ping Chuu, Po-Jen Hsiao, Yung-Hsi Kao
Summary: ET-3 stimulates white preadipocyte growth through the ETAR, AMPK, JNK/c-JUN, and STAT3 pathways, showing a preadipocyte type-dependent effect. These findings provide insights into how endothelin mediates fat cell activity and associated diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Lina Quan, Xue Chen, Aichun Liu, Yan Zhang, Xiuchen Guo, Shujie Yan, Yue Liu
Article
Biochemistry & Molecular Biology
Xiuwen Lan, Jun Xing, Hongyu Gao, Sen Li, Lina Quan, Yang Jiang, Shaohua Ding, Yingwei Xue
BIOLOGICAL TRACE ELEMENT RESEARCH
(2017)
Article
Oncology
Wen Xu, Xiaoxia Li, Lina Quan, Jiying Yao, Guannan Mu, Jingjie Guo, Yitong Wang
LEUKEMIA & LYMPHOMA
(2018)
Article
Biotechnology & Applied Microbiology
Xiuwen Lan, Sen Li, Hongyu Gao, Abiyasi Nanding, Lina Quan, Chunyan Yang, Shaohua Ding, Yingwei Xue
ONCOTARGETS AND THERAPY
(2017)
Article
Oncology
Juan Liu, Lina Quan, Chunhui Zhang, Aichun Liu, Dongxia Tong, Jinghua Wang
Article
Hematology
Lina Quan, Xiuwen Lan, Yuanyuan Meng, Xiuchen Guo, Yiwei Guo, Lina Zhao, Xue Chen, Aichun Liu
EXPERIMENTAL HEMATOLOGY
(2018)
Article
Genetics & Heredity
Yuanyuan Meng, Lina Quan, Aichun Liu
Article
Pathology
Chui-Ming Jia, Yu-Yang Tian, Li-Na Quan, Li Jiang, Ai-Chun Liu
PATHOLOGY RESEARCH AND PRACTICE
(2018)
Article
Oncology
Shujie Yan, Chuiming Jia, Lina Quan, Lina Zhao, Yuyang Tian, Aichun Liu
MOLECULAR MEDICINE REPORTS
(2019)
Article
Biochemical Research Methods
Yao Chen, Lina Quan, Chuiming Jia, Yiwei Guo, Xinya Wang, Yu Zhang, Yan Jin, Aichun Liu
Summary: This study utilized a quantitative proteomics approach to investigate the mechanisms of bortezomib-resistant recurrent multiple myeloma (RRMM), identifying differentially expressed proteins that may be involved in regulating various biological processes in RRMM. The top candidate for a promising therapeutic target was identified as SERPINB9.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Medicine, Research & Experimental
Lina Quan, Chuiming Jia, Yiwei Guo, Yao Chen, Xinya Wang, Qiuting Xu, Yu Zhang
Summary: This study investigates the methylation pattern of multiple myeloma and its effect on the expression of HNRNPA2B1 and downstream targets. The findings suggest that HNRNPA2B1 increases cell proliferation and deregulates cell apoptosis in multiple myeloma through TLR4 signaling.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)