Identification of Biologically Active Ganoderma lucidum Compounds and Synthesis of Improved Derivatives That Confer Anti-cancer Activities in vitro

Novel vitexin-inspired scaffold against leukemia

(2018) Taotao Ling et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anticancer Action and Mechanism of Ergosterol Peroxide from Paecilomyces cicadae Fermentation Broth

(2018) Linfu He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis and biological evaluation of novel steroidal 5α,8α-endoperoxide derivatives with aliphatic side-chain as potential anticancer agents

(2017) Ming Bu et al.   STEROIDS

Elimination of quiescent slow-cycling cells via reducing quiescence depth by natural compounds purified from Ganoderma lucidum

(2017) Jian Dai et al.   Oncotarget

Ergosterol peroxide activates Foxo3-mediated cell death signaling by inhibiting AKT and c-Myc in human hepatocellular carcinoma cells

(2016) Xiangmin Li et al.   Oncotarget

Ganoderma lucidum Combined with the EGFR Tyrosine Kinase Inhibitor, Erlotinib Synergize to Reduce Inflammatory Breast Cancer Progression

(2016) Ivette J. Suárez-Arroyo et al.   Journal of Cancer

Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer

(2015) Ju-Hee Kang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ergosterol purified from medicinal mushroom Amauroderma rude inhibits cancer growth in vitro and in vivo by up-regulating multiple tumor suppressors

(2015) Xiangmin Li et al.   Oncotarget

PTEN-Deficient Tumors Depend on AKT2 for Maintenance and Survival

(2014) Y. R. Chin et al.   Cancer Discovery

Inflammatory breast cancer (IBC): clues for targeted therapies

(2013) Sandra V. Fernandez et al.   BREAST CANCER RESEARCH AND TREATMENT

Anti-Tumor Effects of Ganoderma lucidum (Reishi) in Inflammatory Breast Cancer in In Vivo and In Vitro Models

(2013) Ivette J. Suarez-Arroyo et al.   PLoS One

Regulation of Inflammatory Breast Cancer Cell Invasion through Akt1/PKB  Phosphorylation of RhoC GTPase

(2012) H. L. Lehman et al.   MOLECULAR CANCER RESEARCH

Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum

(2011) Soniamol Joseph et al.   ACTA PHARMACEUTICA

ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK

(2011) Anita Thyagarajan-Sahu et al.   BMC Complementary and Alternative Medicine

Mechanism of the Mesenchymal-Epithelial Transition and Its Relationship with Metastatic Tumor Formation

(2011) D. Yao et al.   MOLECULAR CANCER RESEARCH

Ganoderma lucidum total triterpenes prevent radiation-induced DNA damage and apoptosis in splenic lymphocytes in vitro

(2011) T.P. Smina et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Ganoderma lucidum (Reishi) Inhibits Cancer Cell Growth and Expression of Key Molecules in Inflammatory Breast Cancer

(2011) Michelle M. Martínez-Montemayor et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin

(2011) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beyond ergosterol: Linking pH to antifungal mechanisms

(2011) Yongqiang Zhang et al.   Virulence

Pro-apoptotic activity of ergosterol peroxide and (22E)-ergosta-7,22-dien-5α-hydroxy-3,6-dione in human prostate cancer cells

(2010) A. Russo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Automated High-Throughput System to Fractionate Plant Natural Products for Drug Discovery

(2010) Ying Tu et al.   JOURNAL OF NATURAL PRODUCTS

Triterpenes FromGanoderma LucidumInduce Autophagy in Colon Cancer Through the Inhibition of p38 Mitogen-Activated Kinase (p38 MAPK)

(2010) Anita Thyagarajan et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols

(2009) Linette Castillo-Pichardo et al.   CLINICAL & EXPERIMENTAL METASTASIS

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Reverses Mesenchymal to Epithelial Phenotype and Inhibits Metastasis in Inflammatory Breast Cancer

(2009) D. Zhang et al.   CLINICAL CANCER RESEARCH

Development of a new method for improved identification and relative quantification of unknown metabolites in complex samples: Determination of a triterpenoid metabolic fingerprint for thein situcharacterization of Ganoderma bioactive compounds

(2009) Jiri Adamec et al.   JOURNAL OF SEPARATION SCIENCE

Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer

(2009) Deborah Silvera et al.   NATURE CELL BIOLOGY

Expression of HER-2 in MCF-7 breast cancer cells modulates anti-apoptotic proteins Survivin and Bcl-2 via the extracellular signal-related kinase (ERK) and phosphoinositide-3 kinase (PI3K) signalling pathways

(2008) Aisha Siddiqa et al.   BMC CANCER

Structure of Dehydroergosterol Monohydrate and Interaction with Sterol Carrier Protein-2

(2008) Avery L. McIntosh et al.   LIPIDS