Friends or Foes? Rapid Determination of Dissimilar Colistin and Ciprofloxacin Antagonism of Pseudomonas aeruginosa Phages

A Case of Phage Therapy against Pandrug-Resistant Achromobacter xylosoxidans in a 12-Year-Old Lung-Transplanted Cystic Fibrosis Patient

(2021) David Lebeaux et al.   Viruses-Basel

Heterogeneous Klebsiella pneumoniae Co-infections Complicate Personalized Bacteriophage Therapy

(2021) Jinhong Qin et al.   Frontiers in Cellular and Infection Microbiology

Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive Pulmonary Disease

(2021) Xin Tan et al.   Frontiers in Cellular and Infection Microbiology

Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients

(2021) Nannan Wu et al.   Emerging Microbes & Infections

Successful Treatment of a Recalcitrant Staphylococcus epidermidis Prosthetic Knee Infection with Intraoperative Bacteriophage Therapy

(2021) James B. Doub et al.   Pharmaceuticals

Case Report: Arthroscopic “Debridement Antibiotics and Implant Retention” With Local Injection of Personalized Phage Therapy to Salvage a Relapsing Pseudomonas Aeruginosa Prosthetic Knee Infection

(2021) Tristan Ferry et al.   Frontiers in Medicine

Potent antibody-mediated neutralization limits bacteriophage treatment of a pulmonary Mycobacterium abscessus infection

(2021) Rebekah M. Dedrick et al.   NATURE MEDICINE

Successful Treatment of Staphylococcus aureus Prosthetic Joint Infection with Bacteriophage Therapy

(2021) Claudia Ramirez-Sanchez et al.   Viruses-Basel

Diversity and Function of Phage Encoded Depolymerases

(2020) Leandra E. Knecht et al.   Frontiers in Microbiology

Safety of bacteriophage therapy in severe Staphylococcus aureus infection

(2020) Aleksandra Petrovic Fabijan et al.   Nature Microbiology

Phage Therapy for Limb-threatening Prosthetic Knee Klebsiella pneumoniae Infection: Case Report and In Vitro Characterization of Anti-biofilm Activity

(2020) Edison J Cano et al.   CLINICAL INFECTIOUS DISEASES

Combining bacteriophages with cefiderocol and meropenem/vaborbactam to treat a pan‐drug resistant Achromobacter species infection in a pediatric cystic fibrosis patient

(2020) Andrew B. Gainey et al.   PEDIATRIC PULMONOLOGY

Treatment of recurrent urinary tract infections in a 60‐year‐old kidney transplant recipient. The use of phage therapy

(2020) Olga Maria Rostkowska et al.   Transplant Infectious Disease

The Potential Innovative Use of Bacteriophages Within the DAC® Hydrogel to Treat Patients With Knee Megaprosthesis Infection Requiring “Debridement Antibiotics and Implant Retention” and Soft Tissue Coverage as Salvage Therapy

(2020) Tristan Ferry et al.   Frontiers in Medicine

Salvage Bacteriophage Therapy for a Chronic MRSA Prosthetic Joint Infection

(2020) James B. Doub et al.   Antibiotics-Basel

Bacteriophage Therapy for Critical Infections Related to Cardiothoracic Surgery

(2020) Evgenii Rubalskii et al.   Antibiotics-Basel

Bacteriophages: it's a medicine, Jim, but not as we know it

(2020) Jean-Paul Pirnay et al.   LANCET INFECTIOUS DISEASES

Combined Bacteriophage and Antibiotic Treatment Prevents Pseudomonas aeruginosa Infection of Wild Type and cftr- Epithelial Cells

(2020) Alexandre Luscher et al.   Frontiers in Microbiology

Lessons Learned From the First 10 Consecutive Cases of Intravenous Bacteriophage Therapy to Treat Multidrug-Resistant Bacterial Infections at a Single Center in the United States

(2020) Saima Aslam et al.   Open Forum Infectious Diseases

Inhibition and eradication of Salmonella Typhimurium biofilm using P22 bacteriophage, EDTA and nisin

(2019) Fatma Neslihan Yüksel et al.   BIOFOULING

Phage Therapy in the Postantibiotic Era

(2019) Fernando L. Gordillo Altamirano et al.   CLINICAL MICROBIOLOGY REVIEWS

Novel bacteriophage therapy for treatment of left ventricular assist device infection

(2019) Saima Aslam et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Adjunct phage treatment enhances the effectiveness of low antibiotic concentration against Staphylococcus aureus biofilms in vitro

(2019) James Dickey et al.   PLoS One

Fighting Pathogenic Bacteria on Two Fronts: Phages and Antibiotics as Combined Strategy

(2019) Thaysa Leite Tagliaferri et al.   Frontiers in Cellular and Infection Microbiology

Processing Phage Therapy Requests in a Brussels Military Hospital: Lessons Identified

(2019) Sarah Djebara et al.   Viruses-Basel

International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti‐infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP)

(2019) Brian T. Tsuji et al.   PHARMACOTHERAPY

Successful treatment of antibiotic resistant poly-microbial bone infection with bacteriophages and antibiotics combination

(2019) Ran Nir-Paz et al.   CLINICAL INFECTIOUS DISEASES

Successful adjunctive use of bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa infection in a cystic fibrosis patient

(2019) Nancy Law et al.   INFECTION

Phage therapy’s latest makeover

(2019) Charles Schmidt   NATURE BIOTECHNOLOGY

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

(2019) Rebekah M. Dedrick et al.   NATURE MEDICINE

Current State of Compassionate Phage Therapy

(2019) McCallin et al.   Viruses-Basel

Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents—How P. aeruginosa Can Escape Antibiotics

(2019) Oana Ciofu et al.   Frontiers in Microbiology

Early clinical experience of bacteriophage therapy in 3 lung transplant recipients

(2019) Saima Aslam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Adjunctive bacteriophage therapy for prosthetic valve endocarditis due to Staphylococcus aureus

(2019) Timothy Gilbey et al.   MEDICAL JOURNAL OF AUSTRALIA

Bacteriophage Therapy of Ventilator-associated Pneumonia and Empyema caused by Pseudomonas aeruginosa

(2019) Susan Maddocks et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhalable combination powder formulations of phage and ciprofloxacin for P. aeruginosa respiratory infections

(2019) Yu Lin et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Bacteriophage Application for Difficult-to-treat Musculoskeletal Infections: Development of a Standardized Multidisciplinary Treatment Protocol

(2019) Onsea et al.   Viruses-Basel

A Dutch Case Report of Successful Treatment of Chronic Relapsing Urinary Tract Infection with Bacteriophages in a Renal Transplant Patient

(2019) Saskia Kuipers et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Stronger together? Perspectives on phage-antibiotic synergy in clinical applications of phage therapy

(2019) Anca M Segall et al.   CURRENT OPINION IN MICROBIOLOGY

Bacteriophage Therapeutics: A Primer for Clinicians on Phage‐Antibiotic Combinations

(2019) Taylor Morrisette et al.   PHARMACOTHERAPY

Antibiotic Use in Agriculture and Its Consequential Resistance in Environmental Sources: Potential Public Health Implications

(2018) Christy Manyi-Loh et al.   MOLECULES

Phage Therapy: What Have We Learned?

(2018) Andrzej Górski et al.   Viruses-Basel

Development and Validation of a Microtiter Plate-Based Assay for Determination of Bacteriophage Host Range and Virulence

(2018) Yicheng Xie et al.   Viruses-Basel

Does Treatment Order Matter? Investigating the Ability of Bacteriophage to Augment Antibiotic Activity against Staphylococcus aureus Biofilms

(2018) Dilini Kumaran et al.   Frontiers in Microbiology

Phage Therapy for a Multidrug-Resistant Acinetobacter baumannii Craniectomy Site Infection

(2018) Stephanie LaVergne et al.   Open Forum Infectious Diseases

Bacteriophage Sb-1 enhances antibiotic activity against biofilm, degrades exopolysaccharide matrix and targets persisters of Staphylococcus aureus

(2018) Tamta Tkhilaishvili et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Synergy of nebulized phage PEV20 and ciprofloxacin combination against Pseudomonas aeruginosa

(2018) Yu Lin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Innovations for the treatment of a complex bone and joint infection due to XDR Pseudomonas aeruginosa including local application of a selected cocktail of bacteriophages

(2018) Tristan Ferry et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

OUP accepted manuscript

(2018)   JOURNAL OF THE HISTORY OF MEDICINE AND ALLIED SCIENCES

Enhanced antibacterial effect of the novel T4-like bacteriophage KARL-1 in combination with antibiotics against multi-drug resistant Acinetobacter baumannii

(2018) Mathias Jansen et al.   Scientific Reports

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial

(2018) Patrick Jault et al.   LANCET INFECTIOUS DISEASES

A Wake-Up Call: We Need Phage Therapy Now

(2018) Karin Moelling et al.   Viruses-Basel

Salvage ‘DAIR’ (debridement, antibiotics and implant retention) with local injection of a selected cocktail of bacteriophages: is it an option for an elderly patient with relapsing S. aureus prosthetic-joint infection?

(2018) Tristan Ferry et al.   Open Forum Infectious Diseases

Persistent bacterial infections and persister cells

(2017) Robert A. Fisher et al.   NATURE REVIEWS MICROBIOLOGY

Effects of single and combined use of bacteriophages and antibiotics to inactivate Escherichia coli

(2017) Nádia Valério et al.   VIRUS RESEARCH

Refractory Pseudomonas Bacteremia in a 2-Year-Old Sterilized by Bacteriophage Therapy

(2017) C. Duplessis et al.   Journal of the Pediatric Infectious Diseases Society

Synergy and Order Effects of Antibiotics and Phages in Killing Pseudomonas aeruginosa Biofilms

(2017) Waqas Nasir Chaudhry et al.   PLoS One

The O-specific polysaccharide lyase from the phage LKA1 tailspike reduces Pseudomonas virulence

(2017) Tomasz Olszak et al.   Scientific Reports

Dosing guidance for intravenous colistin in critically-ill patients

(2016) Roger L Nation et al.   CLINICAL INFECTIOUS DISEASES

Synergistic interaction between phage therapy and antibiotics clears Pseudomonas aeruginosa infection in endocarditis and reduces virulence

(2016) Frank Oechslin et al.   JOURNAL OF INFECTIOUS DISEASES

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

How topoisomerase IV can efficiently unknot and decatenate negatively supercoiled DNA molecules without causing their torsional relaxation

(2016) Eric J. Rawdon et al.   NUCLEIC ACIDS RESEARCH

Evolutionary Rationale for Phages as Complements of Antibiotics

(2016) Clara Torres-Barceló et al.   TRENDS IN MICROBIOLOGY

Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050?

(2016) Marlieke E. A. de Kraker et al.   PLOS MEDICINE

Influence of Environmental Factors on Phage–Bacteria Interaction and on the Efficacy and Infectivity of Phage P100

(2016) Susanne Fister et al.   Frontiers in Microbiology

A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections

(2016) Katarzyna Danis-Wlodarczyk et al.   Scientific Reports

Biofilm-specific antibiotic tolerance and resistance

(2015) I. Olsen   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus

(2015) Roger L Nation et al.   LANCET INFECTIOUS DISEASES

Colistin: How should It Be Dosed for the Critically Ill?

(2015) Cornelia Landersdorfer et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Antagonism between Bacteriostatic and Bactericidal Antibiotics Is Prevalent

(2014) Paolo S. Ocampo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial susceptibility testing in biofilm-growing bacteria

(2014) M.D. Macia et al.   CLINICAL MICROBIOLOGY AND INFECTION

Phage therapy gets revitalized

(2014) Sara Reardon   NATURE

A Window of Opportunity to Control the Bacterial Pathogen Pseudomonas aeruginosa Combining Antibiotics and Phages

(2014) Clara Torres-Barceló et al.   PLoS One

Effect of Bacteriophage Infection in Combination with Tobramycin on the Emergence of Resistance in Escherichia coli and Pseudomonas aeruginosa Biofilms

(2014) Lindsey Coulter et al.   Viruses-Basel

Ciprofloxacin Is Actively Transported across Bronchial Lung Epithelial Cells Using a Calu-3 Air Interface Cell Model

(2013) Hui Xin Ong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Trough colistin plasma level is an independent risk factor for nephrotoxicity: a prospective observational cohort study

(2013) Luisa Sorlí et al.   BMC INFECTIOUS DISEASES

Colistin: an update on the antibiotic of the 21st century

(2012) Silpak Biswas et al.   Expert Review of Anti-Infective Therapy

Heterogeneity of selection and the evolution of resistance

(2012)   TRENDS IN ECOLOGY & EVOLUTION

Population Pharmacokinetics of Colistin Methanesulfonate and Formed Colistin in Critically Ill Patients from a Multicenter Study Provide Dosing Suggestions for Various Categories of Patients

(2011) S. M. Garonzik et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Combination therapies for combating antimicrobial resistance

(2011) Michael A Fischbach   CURRENT OPINION IN MICROBIOLOGY

Bacteriophage therapy: potential uses in the control of antibiotic-resistant pathogens

(2011) Ben Burrowes et al.   Expert Review of Anti-Infective Therapy

Activity of tigecycline alone and in combination with colistin and meropenem against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae strains by time–kill assay

(2011) Spyros Pournaras et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

General Principles of Antimicrobial Therapy

(2011) Surbhi Leekha et al.   MAYO CLINIC PROCEEDINGS

The T7-Related Pseudomonas putida Phage φ15 Displays Virion-Associated Biofilm Degradation Properties

(2011) Anneleen Cornelissen et al.   PLoS One

Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae

(2010) Karen Bush   CURRENT OPINION IN MICROBIOLOGY

Phage Therapy in Clinical Practice: Treatment of Human Infections

(2010) Elizabeth Kutter et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Molecular and physiological analysis of three Pseudomonas aeruginosa phages belonging to the “N4-like viruses”

(2010) Pieter-Jan Ceyssens et al.   VIROLOGY

Initiation of Inappropriate Antimicrobial Therapy Results in a Fivefold Reduction of Survival in Human Septic Shock

(2009) Anand Kumar et al.   CHEST

Antimicrobial Susceptibility Testing: A Review of General Principles and Contemporary Practices

(2009) James H. Jorgensen et al.   CLINICAL INFECTIOUS DISEASES

Restricting ciprofloxacin-induced resistant variant formation in biofilm of Klebsiella pneumoniae B5055 by complementary bacteriophage treatment

(2009) V. Verma et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Decreased Susceptibility to Polymyxin B during Treatment for Carbapenem-Resistant Klebsiella pneumoniae Infection

(2009) J. Lee et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Representational Difference Analysis (RDA) of bacteriophage genomes

(2009) Elke Lammens et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy

(2009) T. K. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Use of Phages for the Removal of Infectious Biofilms

(2008) J. Azeredo et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Spread of colistin resistant non-mucoid Pseudomonas aeruginosa among chronically infected Danish cystic fibrosis patients

(2008) Helle Krogh Johansen et al.   Journal of Cystic Fibrosis

Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances

(2008) Irith Wiegand et al.   Nature Protocols