Endocannabinoid system and pain: an introduction

Acute Stress Contributes to Individual Differences in Pain and Pain-Related Brain Activity in Healthy and Chronic Pain Patients

(2013) E. Vachon-Presseau et al.   JOURNAL OF NEUROSCIENCE

Chronic treatment with krill powder reduces plasma triglyceride and anandamide levels in mildly obese men

(2013) Kjetil Berge et al.   Lipids in Health and Disease

Anandamide deficiency and heightened neuropathic pain in aged mice

(2013) Philipp Bishay et al.   NEUROPHARMACOLOGY

Multiple Functions of Endocannabinoid Signaling in the Brain

(2012) István Katona et al.   Annual Review of Neuroscience

Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system

(2012) Bright N Okine et al.   BRITISH JOURNAL OF PHARMACOLOGY

Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat

(2012) SG Woodhams et al.   BRITISH JOURNAL OF PHARMACOLOGY

Highly Selective Inhibitors of Monoacylglycerol Lipase Bearing a Reactive Group that Is Bioisosteric with Endocannabinoid Substrates

(2012) Jae Won Chang et al.   CHEMISTRY & BIOLOGY

Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamide

(2012) Christopher J. Fowler et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Activation of Type 5 Metabotropic Glutamate Receptors and Diacylglycerol Lipase-  Initiates 2-Arachidonoylglycerol Formation and Endocannabinoid-Mediated Analgesia

(2012) L. C. Gregg et al.   JOURNAL OF NEUROSCIENCE

The Economic Costs of Pain in the United States

(2012) Darrell J. Gaskin et al.   JOURNAL OF PAIN

Anandamide and 2-arachidonoylglycerol: Pharmacological Properties, Functional Features, and Emerging Specificities of the Two Major Endocannabinoids

(2012) Antonio Luchicchi et al.   MOLECULAR NEUROBIOLOGY

Brain CB1 receptor expression following lipopolysaccharide-induced inflammation

(2012) H. Hu et al.   NEUROSCIENCE

An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee

(2012) John P. Huggins et al.   PAIN

Amygdala activity contributes to the dissociative effect of cannabis on pain perception

(2012) Michael C. Lee et al.   PAIN

The role of CB1 in immune modulation by cannabinoids

(2012) Barbara L.F. Kaplan   PHARMACOLOGY & THERAPEUTICS

Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system

(2012) K. Starowicz et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The endocannabinoid system in normal and pathological brain ageing

(2012) A. Bilkei-Gorzo   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Dynamic changes to the endocannabinoid system in models of chronic pain

(2012) D. Rani Sagar et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Why do cannabinoid receptors have more than one endogenous ligand?

(2012) V. Di Marzo et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Discovery of Prostamide F2α and Its Role in Inflammatory Pain and Dorsal Horn Nociceptive Neuron Hyperexcitability

(2012) Luisa Gatta et al.   PLoS One

Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes

(2012) Matthew A. Windsor et al.   ACS Medicinal Chemistry Letters

Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation

(2011) Mireille Alhouayek et al.   FASEB JOURNAL

Inhibition of Monoacylglycerol Lipase Attenuates Nonsteroidal Anti-Inflammatory Drug-Induced Gastric Hemorrhages in Mice

(2011) S. G. Kinsey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Spinal anandamide produces analgesia in neuropathic rats: Possible CB1- and TRPV1-mediated mechanisms

(2011) K. Starowicz et al.   NEUROPHARMACOLOGY

Spinal cannabinoid CB2 receptors as a target for neuropathic pain: an investigation using chronic constriction injury

(2011) P.W. Brownjohn et al.   NEUROSCIENCE

Is lipid signaling through cannabinoid 2 receptors part of a protective system?

(2011) P. Pacher et al.   PROGRESS IN LIPID RESEARCH

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain

(2010) Devi Rani Sagar et al.   ARTHRITIS AND RHEUMATISM

Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice

(2010) Michelle R. Hoot et al.   BRAIN RESEARCH

Central and peripheral sites of action for CB2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats

(2010) Gin C Hsieh et al.   BRITISH JOURNAL OF PHARMACOLOGY

CB2: a cannabinoid receptor with an identity crisis

(2010) Brady K Atwood et al.   BRITISH JOURNAL OF PHARMACOLOGY

Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain

(2010) Josée Guindon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas

(2010) Nephi Stella   GLIA

The cannabinoid WIN55,212-2 protects against oxidized LDL-induced inflammatory response in murine macrophages

(2010) Ming-xiu Hao et al.   JOURNAL OF LIPID RESEARCH

Neuronal circuitry for pain processing in the dorsal horn

(2010) Andrew J. Todd   NATURE REVIEWS NEUROSCIENCE

Exposure to a high-fat diet decreases sensitivity to Δ9-tetrahydrocannabinol-induced motor effects in female rats

(2010) Jenny L. Wiley et al.   NEUROPHARMACOLOGY

Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain

(2010) N. Schuelert et al.   OSTEOARTHRITIS AND CARTILAGE

Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms

(2010) Jessica M. Spradley et al.   PHARMACOLOGICAL RESEARCH

The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice

(2010) Barbara Costa et al.   PHARMACOLOGICAL RESEARCH

Anandamide Suppresses Proliferation and Cytokine Release from Primary Human T-Lymphocytes Mainly via CB2 Receptors

(2010) Maria Teresa Cencioni et al.   PLoS One

Evidence for a Role of Endocannabinoids, Astrocytes and p38 Phosphorylation in the Resolution of Postoperative Pain

(2010) Matthew S. Alkaitis et al.   PLoS One

N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA)

(2010) Natsuo Ueda et al.   PROGRESS IN LIPID RESEARCH

Spinal Microglial and Perivascular Cell Cannabinoid Receptor Type 2 Activation Reduces Behavioral Hypersensitivity without Tolerance after Peripheral Nerve Injury

(2009) Alfonso Romero-Sandoval et al.   ANESTHESIOLOGY

CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages

(2009) K. H. Han et al.   CARDIOVASCULAR RESEARCH

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Endogenous Anandamide and Cannabinoid Receptor-2 Contribute to Electroacupuncture Analgesia in Rats

(2009) Lin Chen et al.   JOURNAL OF PAIN

Dynamic Regulation of the Endocannabinoid System: Implications for Analgesia

(2009) Devi Rani Sagar et al.   Molecular Pain

A Cytochrome P450-Derived Epoxygenated Metabolite of Anandamide Is a Potent Cannabinoid Receptor 2-Selective Agonist

(2009) N. T. Snider et al.   MOLECULAR PHARMACOLOGY

Sonic Hedgehog gets another role

(2009) Catherine E Krull   NATURE NEUROSCIENCE

Endocannabinoid-Mediated Control of Synaptic Transmission

(2009) Masanobu Kano et al.   PHYSIOLOGICAL REVIEWS

A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells

(2008) Fernando Correa et al.   BIOCHEMICAL PHARMACOLOGY

Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine

(2008) Andreas Artmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inhibition of fatty acid amide hydrolase produces PPAR-α-mediated analgesia in a rat model of inflammatory pain

(2008) D R Sagar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anandamide Biosynthesis Catalyzed by the Phosphodiesterase GDE1 and Detection of Glycerophospho-N-acyl Ethanolamine Precursors in Mouse Brain

(2008) Gabriel M. Simon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crucial Role of CB2 Cannabinoid Receptor in the Regulation of Central Immune Responses during Neuropathic Pain

(2008) I. Racz et al.   JOURNAL OF NEUROSCIENCE

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats

(2008) Vito de Novellis et al.   NEUROPHARMACOLOGY

Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain

(2008) Maulik D. Jhaveri et al.   NEUROPHARMACOLOGY

Endocannabinoid signaling in microglial cells

(2008) Nephi Stella   NEUROPHARMACOLOGY

The Kyoto protocol of IASP Basic Pain Terminology☆

(2008) John D. Loeser et al.   PAIN

Cortical expression of brain derived neurotrophic factor and type-1 cannabinoid receptor after striatal excitotoxic lesions

(2007) Z. De March et al.   NEUROSCIENCE