Brain activity of anandamide: a rewarding bliss?

Fatty acid amide hydrolase inhibitors produce rapid anti-anxiety responses through amygdala long-term depression in male rodents

(2017) Tingting Duan et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

The cannabinoid system and pain

(2017) Stephen G. Woodhams et al.   NEUROPHARMACOLOGY

The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice

(2017) Jenny L. Wilkerson et al.   NEUROPHARMACOLOGY

The endocannabinoid system as a target for addiction treatment: Trials and tribulations

(2017) Matthew E. Sloan et al.   NEUROPHARMACOLOGY

Blockade of alcohol escalation and “relapse” drinking by pharmacological FAAH inhibition in male and female C57BL/6J mice

(2017) Yan Zhou et al.   PSYCHOPHARMACOLOGY

Metabolism of the Endocannabinoid Anandamide: Open Questions after 25 Years

(2017) Mauro Maccarrone   Frontiers in Molecular Neuroscience

Involvement of Endocannabinoids in Alcohol “Binge” Drinking: Studies of Mice with Human Fatty Acid Amide Hydrolase Genetic Variation and After CB1 Receptor Antagonists

(2016) Yan Zhou et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

The effects of Δ9-tetrahydrocannabinol on the dopamine system

(2016) Michael A. P. Bloomfield et al.   NATURE

Preclinical studies on the reinforcing effects of cannabinoids. A tribute to the scientific research of Dr. Steve Goldberg

(2016) Gianluigi Tanda   PSYCHOPHARMACOLOGY

Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys

(2016) Charles W. Schindler et al.   PSYCHOPHARMACOLOGY

Endocannabinoid signalling in reward and addiction

(2015) Loren H. Parsons et al.   NATURE REVIEWS NEUROSCIENCE

Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse

(2015) Zuzana Justinova et al.   NEUROPSYCHOPHARMACOLOGY

Inhibition of monoacylglycerol lipase (MAGL) enhances cue-induced reinstatement of nicotine-seeking behavior in mice

(2015) Jose M. Trigo et al.   PSYCHOPHARMACOLOGY

Enhancement of endocannabinoid signaling protects against cocaine-induced neurotoxicity

(2015) Luciano R. Vilela et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats

(2014) Andrew J. Kwilasz et al.   BEHAVIOURAL PHARMACOLOGY

Endocannabinoid-mediated retrograde modulation of synaptic transmission

(2014) Takako Ohno-Shosaku et al.   CURRENT OPINION IN NEUROBIOLOGY

Early phytocannabinoid chemistry to endocannabinoids and beyond

(2014) Raphael Mechoulam et al.   NATURE REVIEWS NEUROSCIENCE

Species Differences in Cannabinoid Receptor 2 and Receptor Responses to Cocaine Self-Administration in Mice and Rats

(2014) Hai-Ying Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Glutamate neurons within the midbrain dopamine regions

(2014) M. Morales et al.   NEUROSCIENCE

Cannabinoid CB2receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice

(2014) Hai-Ying Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Endocannabinoid System as a Potential Therapeutic Target for Pain Modulation

(2014) Ahmet Ulugol   Balkan Medical Journal

Endocannabinoid 2-Arachidonoylglycerol Self-Administration by Sprague-Dawley Rats and Stimulation of in vivo Dopamine Transmission in the Nucleus Accumbens Shell

(2014) Maria Antonietta De Luca et al.   Frontiers in Psychiatry

Cannabinoid Regulation of Brain Reward Processing with an Emphasis on the Role of CB1 Receptors: A Step Back into the Future

(2014) George Panagis et al.   Frontiers in Psychiatry

Cocaine-induced endocannabinoid release modulates behavioral and neurochemical sensitization in mice

(2013) Maddalena Mereu et al.   ADDICTION BIOLOGY

Biphasic effects of Δ9-tetrahydrocannabinol on brain stimulation reward and motor activity

(2013) Vicky Katsidoni et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Dual Inhibition of Endocannabinoid Catabolic Enzymes Produces Enhanced Antiwithdrawal Effects in Morphine-Dependent Mice

(2013) Divya Ramesh et al.   NEUROPSYCHOPHARMACOLOGY

What's conditioned in conditioned place preference?

(2013) Joseph P. Huston et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Endocannabinoids Anandamide and Virodhamine Modulate the Activity of the Candidate Cannabinoid Receptor GPR55

(2012) Haleli Sharir et al.   Journal of Neuroimmune Pharmacology

Endocannabinoids at the synapse a decade after thedies mirabilis(29 March 2001): what we still do not know

(2012) Bradley E. Alger   JOURNAL OF PHYSIOLOGY-LONDON

Anandamide and 2-arachidonoylglycerol: Pharmacological Properties, Functional Features, and Emerging Specificities of the Two Major Endocannabinoids

(2012) Antonio Luchicchi et al.   MOLECULAR NEUROBIOLOGY

Endocannabinoid system and mood disorders: Priming a target for new therapies

(2012) Vincenzo Micale et al.   PHARMACOLOGY & THERAPEUTICS

Why do cannabinoid receptors have more than one endogenous ligand?

(2012) V. Di Marzo et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors

(2011) J. R. Savinainen et al.   Acta Physiologica

Endocannabinoid system dysfunction in mood and related disorders

(2011) C. H. Ashton et al.   ACTA PSYCHIATRICA SCANDINAVICA

Cannabinoid receptor stimulation increases motivation for nicotine and nicotine seeking

(2011) Islam Gamaleddin et al.   ADDICTION BIOLOGY

The selective anandamide transport inhibitor VDM11 attenuates reinstatement of nicotine seeking behaviour, but does not affect nicotine intake

(2011) Islam Gamaleddin et al.   BRITISH JOURNAL OF PHARMACOLOGY

The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats

(2011) Maria Scherma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Brain cannabinoid CB2 receptors modulate cocaine's actions in mice

(2011) Zheng-Xiong Xi et al.   NATURE NEUROSCIENCE

Role of GLT-1 transporter activation in prevention of cannabinoid tolerance by the beta-lactam antibiotic, ceftriaxone, in mice

(2011) Ozgur Gunduz et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Endocannabinoid Regulation of Acute and Protracted Nicotine Withdrawal: Effect of FAAH Inhibition

(2011) Andrea Cippitelli et al.   PLoS One

Effects of fatty acid amide hydrolase inhibition on neuronal responses to nicotine, cocaine and morphine in the nucleus accumbens shell and ventral tegmental area: involvement of PPAR-α nuclear receptors

(2010) Antonio Luchicchi et al.   ADDICTION BIOLOGY

Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol

(2010) Natsuo Ueda et al.   BIOFACTORS

CB1 Cannabinoid Receptors and their Associated Proteins

(2010) Allyn Howlett et al.   CURRENT MEDICINAL CHEMISTRY

Cocaine sensitization models an anhedonia-like condition in rats

(2010) Simona Scheggi et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

(2010) William R Marrs et al.   NATURE NEUROSCIENCE

The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase α Mediates Retrograde Suppression of Synaptic Transmission

(2010) Asami Tanimura et al.   NEURON

AMPA Receptor Synaptic Plasticity Induced by Psychostimulants: The Past, Present, and Therapeutic Future

(2010) M. Scott Bowers et al.   NEURON

Kicking the habit: The neural basis of ingrained behaviors in cocaine addiction

(2010) R. Christopher Pierce et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Pharmacological characterization of GPR55, a putative cannabinoid receptor

(2010) Haleli Sharir et al.   PHARMACOLOGY & THERAPEUTICS

Cannabinoids and the gut: New developments and emerging concepts

(2010) Angelo A. Izzo et al.   PHARMACOLOGY & THERAPEUTICS

Reducing endocannabinoid metabolism with the fatty acid amide hydrolase inhibitor, URB597, fails to modify reinstatement of morphine-induced conditioned floor preference and naloxone-precipitated morphine withdrawal-induced conditioned floor avoidance

(2010) Amanda L. McCallum et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of D2-induced formation of anandamide

(2010) Marcello Solinas et al.   PSYCHOPHARMACOLOGY

An introduction to the endocannabinoid system: from the early to the latest concepts

(2009) Luciano De Petrocellis et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

A ventral tegmental CRF–glutamate–dopamine interaction in addiction

(2009) Roy A. Wise et al.   BRAIN RESEARCH

Species differences in cannabinoid receptor 2 (CNR2gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands

(2009) Q.-R. Liu et al.   GENES BRAIN AND BEHAVIOR

Cannabinoid activation of peroxisome proliferator-activated receptors: Potential for modulation of inflammatory disease

(2009) S.E. O'Sullivan et al.   IMMUNOBIOLOGY

Anandamide Increases the Differentiation of Rat Adipocytes and Causes PPARγ and CB1 Receptor Upregulation

(2009) Sevasti Karaliota et al.   Obesity

Endocannabinoid-Mediated Control of Synaptic Transmission

(2009) Masanobu Kano et al.   PHYSIOLOGICAL REVIEWS

Rimonabant (SR141716) has no effect on alcohol self-administration or endocrine measures in nontreatment-seeking heavy alcohol drinkers

(2009) David Ted George et al.   PSYCHOPHARMACOLOGY

Inhibition of fatty acid amide hydrolase reduces reinstatement of nicotine seeking but not break point for nicotine self-administration—comparison with CB1 receptor blockade

(2009) Benoit Forget et al.   PSYCHOPHARMACOLOGY

The future of endocannabinoid-oriented clinical research after CB1 antagonists

(2009) Bernard Le Foll et al.   PSYCHOPHARMACOLOGY

Roles for nigrostriatal—not just mesocorticolimbic—dopamine in reward and addiction

(2009) Roy A. Wise   TRENDS IN NEUROSCIENCES

Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond

(2008) Roger G. Pertwee   ADDICTION BIOLOGY

Fatty Acid Amide Hydrolase Inhibition Heightens Anandamide Signaling Without Producing Reinforcing Effects in Primates

(2008) Zuzana Justinova et al.   BIOLOGICAL PSYCHIATRY

‘Entourage’ effects ofN-palmitoylethanolamide andN-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors

(2008) W-SV Ho et al.   BRITISH JOURNAL OF PHARMACOLOGY

Enzymatic Pathways That Regulate Endocannabinoid Signaling in the Nervous System

(2008) Kay Ahn et al.   CHEMICAL REVIEWS

Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test

(2008) Sabrina F. Lisboa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cannabinoid Receptor 1 Blocker Rimonabant (SR 141716) for Treatment of Alcohol Dependence

(2008) Michael Soyka et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Cannabinoid Receptors: Where They are and What They do

(2008) K. Mackie   JOURNAL OF NEUROENDOCRINOLOGY

Endogenous Fatty Acid Ethanolamides Suppress Nicotine-Induced Activation of Mesolimbic Dopamine Neurons through Nuclear Receptors

(2008) M. Melis et al.   JOURNAL OF NEUROSCIENCE

The Endogenous Cannabinoid System Modulates Nicotine Reward and Dependence

(2008) L. L. Merritt et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inhibition of Anandamide Hydrolysis by Cyclohexyl Carbamic Acid 3'-Carbamoyl-3-yl Ester (URB597) Reverses Abuse-Related Behavioral and Neurochemical Effects of Nicotine in Rats

(2008) M. Scherma et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Blockade of THC-Seeking Behavior and Relapse in Monkeys by the Cannabinoid CB1-Receptor Antagonist Rimonabant

(2008) Zuzana Justinova et al.   NEUROPSYCHOPHARMACOLOGY

Brain Neuronal CB2 Cannabinoid Receptors in Drug Abuse and Depression: From Mice to Human Subjects

(2008) Emmanuel S. Onaivi et al.   PLoS One

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

(2008) J. E. Lauckner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat

(2008) Andrea Cippitelli et al.   PSYCHOPHARMACOLOGY

An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters

(2008) Anna M. Moise et al.   PSYCHOPHARMACOLOGY

FAAH and anandamide: is 2-AG really the odd one out?

(2008) Vincenzo Di Marzo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The role of the CB1 cannabinoid receptor and its endogenous ligands, anandamide and 2-arachidonoylglycerol, in amphetamine-induced behavioural sensitization

(2007) G THIEMANN et al.   BEHAVIOURAL BRAIN RESEARCH

Species-specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers

(2007) B Bingham et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain

(2007) M D Jhaveri et al.   BRITISH JOURNAL OF PHARMACOLOGY

The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects

(2007) D G Johns et al.   BRITISH JOURNAL OF PHARMACOLOGY

The orphan receptor GPR55 is a novel cannabinoid receptor

(2007) E Ryberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition

(2007) Maria Scherma et al.   NEUROPHARMACOLOGY

Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors

(2007) Fabricio A. Moreira et al.   NEUROPHARMACOLOGY

AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain

(2006) Barbara Costa et al.   BRITISH JOURNAL OF PHARMACOLOGY