Psilocybin, a Naturally Occurring Indoleamine Compound, Could Be Useful to Prevent Suicidal Behaviors

A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain

(2021) Nakul Ravi Raval et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The acute effects of classic psychedelics on memory in humans

(2021) C. J. Healy   PSYCHOPHARMACOLOGY

Clinical and biological predictors of psychedelic response in the treatment of psychiatric and addictive disorders: a systematic review

(2021) Bruno Romeo et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Characteristics and treatment outcome of suicidal depression: Two large naturalistic cohorts of depressed outpatients

(2021) Bénédicte Nobile et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo

(2021) Ling-Xiao Shao et al.   NEURON

Synthesis, antioxidant and cytoprotective activity evaluation of C-3 substituted indole derivatives

(2021) Beata Jasiewicz et al.   Scientific Reports

Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics

(2021) Cato M. H. de Vos et al.   Frontiers in Psychiatry

Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications

(2021) Mustafa N. Mithaiwala et al.   Cells

Anti-Inflammatory Effects of Four Psilocybin-Containing Magic Mushroom Water Extracts in vitro on 15-Lipoxygenase Activity and on Lipopolysaccharide-Induced Cyclooxygenase-2 and Inflammatory Cytokines in Human U937 Macrophage Cells

(2021) Sanah Malomile Nkadimeng et al.   Journal of Inflammation Research

Suicide attempts are associated with activated immune-inflammatory, nitro-oxidative, and neurotoxic pathways: A systematic review and meta-analysis

(2021) Asara Vasupanrajit et al.   JOURNAL OF AFFECTIVE DISORDERS

Peripheral BDNF levels in psychiatric patients with and without a history of suicide attempt: A systematic review and meta-analysis

(2021) Laura Fusar-Poli et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression

(2020) Meghan Hibicke et al.   ACS Chemical Neuroscience

Psychedelics and Psychedelic-Assisted Psychotherapy

(2020) Collin M. Reiff et al.   AMERICAN JOURNAL OF PSYCHIATRY

A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding

(2020) Martin Korsbak Madsen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Differences in brain surface area and cortical volume between suicide attempters and non-attempters with major depressive disorder

(2020) Seung-Gul Kang et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Rethinking Therapeutic Strategies for Anorexia Nervosa: Insights From Psychedelic Medicine and Animal Models

(2020) Claire J. Foldi et al.   Frontiers in Neuroscience

Learning to Let Go: A Cognitive-Behavioral Model of How Psychedelic Therapy Promotes Acceptance

(2020) Max Wolff et al.   Frontiers in Psychiatry

Psychedelic Psychiatry’s Brave New World

(2020) David Nutt et al.   CELL

The role of dopamine in dynamic effort-reward integration

(2020) Jochen Michely et al.   NEUROPSYCHOPHARMACOLOGY

Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications

(2020) Fiammetta Cosci et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Depression, Mindfulness, and Psilocybin: Possible Complementary Effects of Mindfulness Meditation and Psilocybin in the Treatment of Depression. A Review

(2020) Kristin Heuschkel et al.   Frontiers in Psychiatry

Brain-derived neurotrophic factor and mental disorders

(2020) Chin-Chuen Lin et al.   Biomedical Journal

Characterization of depressed bipolar patients with current suicidal ideation

(2020) Bénédicte Nobile et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Posttraumatic Stress Disorder After a Psychedelic Experience, a Case Report

(2020) Dafna Sara Rubin-Kahana et al.   Journal of Addiction Medicine

Comparative efficacy of racemic ketamine and esketamine for depression: a systematic review and meta-analysis

(2020) Anees Bahji et al.   JOURNAL OF AFFECTIVE DISORDERS

Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders

(2020) Franz X. Vollenweider et al.   NATURE REVIEWS NEUROSCIENCE

Epigenetic marks and their relationship with BDNF in the brain of suicide victims

(2020) Paulina Misztak et al.   PLoS One

Prefrontal activation in suicide attempters during decision making with emotional feedback

(2020) Adrián Alacreu-Crespo et al.   Translational Psychiatry

Phytochemical, Cytotoxicity, Antioxidant and Anti-Inflammatory Effects of Psilocybe Natalensis Magic Mushroom

(2020) Sanah M. Nkadimeng et al.   Plants-Basel

Soyons plus ambitieux pour traiter le suicide

(2020) Philippe Courtet et al.   M S-MEDECINE SCIENCES

Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms

(2020) Antonio Inserra et al.   PHARMACOLOGICAL REVIEWS

Effects and safety of Psilocybe cubensis and Panaeolus cyanescens magic mushroom extracts on endothelin-1-induced hypertrophy and cell injury in cardiomyocytes

(2020) Sanah M. Nkadimeng et al.   Scientific Reports

Commentary: Psychedelic Psychiatry's Brave New World

(2020) Bénédicte Nobile et al.   Frontiers in Psychiatry

Reward Responsiveness in Suicide Attempters: An Electroencephalography/Event-Related Potential Study

(2020) Aliona Tsypes et al.   Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder

(2020) Alan K. Davis et al.   JAMA Psychiatry

Dopamine modulates the reward experiences elicited by music

(2019) Laura Ferreri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels

(2019) Martin K. Madsen et al.   NEUROPSYCHOPHARMACOLOGY

Serotonin 2A receptors are a stress response system

(2019) Kevin Sean Murnane   BEHAVIOURAL PHARMACOLOGY

Emotional breakthrough and psychedelics: Validation of the Emotional Breakthrough Inventory

(2019) Leor Roseman et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Critical appraisal of major depression with suicidal ideation

(2019) Maurizio Pompili   Annals of General Psychiatry

The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial

(2019) Richard J. Zeifman et al.   Frontiers in Pharmacology

Biological bases of suicidal behaviours: A narrative review

(2019) Aiste Lengvenyte et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment

(2019) Malin V Uthaug et al.   PSYCHOPHARMACOLOGY

Suicide Has Many Faces, So Does Ketamine: a Narrative Review on Ketamine’s Antisuicidal Actions

(2019) Aiste Lengvenyte et al.   Current Psychiatry Reports

DARK Classics in Chemical Neuroscience: Psilocybin

(2018) Haden A. Geiger et al.   ACS Chemical Neuroscience

Transient Osmotic Perturbation Causes Long-Term Alteration to the Gut Microbiota

(2018) Carolina Tropini et al.   CELL

High dose psilocybin is associated with positive subjective effects in healthy volunteers

(2018) Christopher R Nicholas et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Role of Kynurenine Pathway and its Metabolites in Mood Disorders: A Systematic Review and Meta-Analysis of Clinical Studies

(2018) Danilo Arnone et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Acceptance and Commitment Therapy for the Management of Suicidal Patients: A Randomized Controlled Trial

(2018) Déborah Ducasse et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Psychedelics Promote Structural and Functional Neural Plasticity

(2018) Calvin Ly et al.   Cell Reports

Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression

(2018) Leor Roseman et al.   Frontiers in Pharmacology

Value-Based Choice, Contingency Learning, and Suicidal Behavior in Mid- and Late-Life Depression

(2018) Alexandre Y. Dombrovski et al.   BIOLOGICAL PSYCHIATRY

Consistency of trajectories of suicidal ideation and depression symptoms: Evidence from a randomized controlled trial

(2018) Philip J. Batterham et al.   DEPRESSION AND ANXIETY

Classic Psychedelics: An integrative review of epidemiology, mystical experience, brain network function, and therapeutics

(2018) Matthew W. Johnson et al.   PHARMACOLOGY & THERAPEUTICS

Association between baseline pro-inflammatory cytokines and brain activation during social exclusion in patients with vulnerability to suicide and depressive disorder

(2018) I Conejero et al.   PSYCHONEUROENDOCRINOLOGY

Serotonin receptors and suicide, major depression, alcohol use disorder and reported early life adversity

(2018) Mark D. Underwood et al.   Translational Psychiatry

Comparing factor structures of depressed patients with and without suicidal ideation, a measurement invariance analysis

(2018) Wouter van Ballegooijen et al.   JOURNAL OF AFFECTIVE DISORDERS

Mushrooms: A rich source of the antioxidants ergothioneine and glutathione

(2017) Michael D. Kalaras et al.   FOOD CHEMISTRY

Serotonin and brain function: a tale of two receptors

(2017) RL Carhart-Harris et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The interpersonal theory of suicide: A systematic review and meta-analysis of a decade of cross-national research.

(2017) Carol Chu et al.   PSYCHOLOGICAL BULLETIN

Cortisol reactivity and suicidal behavior: Investigating the role of hypothalamic-pituitary-adrenal axis responses to stress in suicide attempters and ideators

(2017) Daryl B. O’Connor et al.   PSYCHONEUROENDOCRINOLOGY

Blunted HPA axis activity prior to suicide attempt and increased inflammation in attempters

(2017) Nadine M. Melhem et al.   PSYCHONEUROENDOCRINOLOGY

Psilocybin with psychological support improves emotional face recognition in treatment-resistant depression

(2017) J. B. Stroud et al.   PSYCHOPHARMACOLOGY

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up

(2017) R. L. Carhart-Harris et al.   PSYCHOPHARMACOLOGY

Biomarkers of Suicide Attempt Behavior: Towards a Biological Model of Risk

(2017) Katherin Sudol et al.   Current Psychiatry Reports

Gene expression associated with suicide attempts in US veterans

(2017) J D Flory et al.   Translational Psychiatry

Clinical and Sociodemographic Characteristics Associated with Suicidal Ideation in Depressed Outpatients

(2017) Madhukar H Trivedi et al.   CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE

The effect of Sertraline, Paroxetine, Fluoxetine and Escitalopram on testicular tissue and oxidative stress parameters in rats

(2017) Fikret Erdemir et al.   International Braz J Urol

The experience of social exclusion in women with a history of suicidal acts: a neuroimaging study

(2017) Emilie Olié et al.   Scientific Reports

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder

(2016) Sagar V. Parikh et al.   CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE

SUICIDAL DEPRESSED PATIENTS RESPOND LESS WELL TO ANTIDEPRESSANTS IN THE SHORT TERM

(2016) Jorge Lopez-Castroman et al.   DEPRESSION AND ANXIETY

Ego-Dissolution and Psychedelics: Validation of the Ego-Dissolution Inventory (EDI)

(2016) Matthew M. Nour et al.   Frontiers in Human Neuroscience

The influence of thoughts of death and suicidal ideation on the course of depression in older depressed patients

(2016) Ista C.H.M. Bogers et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Acute Effects of Lysergic Acid Diethylamide on Circulating Steroid Levels in Healthy Subjects

(2016) P. Strajhar et al.   JOURNAL OF NEUROENDOCRINOLOGY

Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial

(2016) Roland R Griffiths et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Effects of serotonin 2A/1A receptor stimulation on social exclusion processing

(2016) Katrin H. Preller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Endogenous Hallucinogen and Trace Amine N,N-Dimethyltryptamine (DMT) Displays Potent Protective Effects against Hypoxia via Sigma-1 Receptor Activation in Human Primary iPSC-Derived Cortical Neurons and Microglia-Like Immune Cells

(2016) Attila Szabo et al.   Frontiers in Neuroscience

Effect of Psilocin on Extracellular Dopamine and Serotonin Levels in the Mesoaccumbens and Mesocortical Pathway in Awake Rats

(2015) Yuichi Sakashita et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Psychedelic medicine: a re-emerging therapeutic paradigm

(2015) Kenneth W. Tupper et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Oxidative Stress and Antioxidant Parameters in Patients With Major Depressive Disorder Compared to Healthy Controls Before and After Antidepressant Treatment

(2015) Sara Jiménez-Fernández et al.   JOURNAL OF CLINICAL PSYCHIATRY

Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population

(2015) Peter S Hendricks et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Neuroinflammation in suicide: Toward a comprehensive model

(2015) Philippe Courtet et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database

(2015) C. Coupland et al.   BMJ-British Medical Journal

Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database

(2015) C. Coupland et al.   BMJ-British Medical Journal

Toward a Biosignature for Suicide

(2014) Maria A. Oquendo et al.   AMERICAN JOURNAL OF PSYCHIATRY

Poor response to antidepressants predicts new suicidal ideas and behavior in depressed outpatients

(2014) Philippe Courtet et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Repeated lysergic acid diethylamide in an animal model of depression: Normalisation of learning behaviour and hippocampal serotonin 5-HT2 signalling

(2014) Tobias Buchborn et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: Effect of antidepressant treatment

(2014) Carolina Muguruza et al.   NEUROPHARMACOLOGY

Correction: Psychedelics and the Human Receptorome

(2014) Thomas S. Ray   PLoS One

Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells

(2014) Attila Szabo et al.   PLoS One

Suicidal behaviour and memory: A systematic review and meta-analysis

(2014) Stephane Richard-Devantoy et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Positron Emission Tomography Quantification of Serotonin Transporter in Suicide Attempters with Major Depressive Disorder

(2013) Jeffrey M. Miller et al.   BIOLOGICAL PSYCHIATRY

Psilocybin – Summary of knowledge and new perspectives

(2013) Filip Tylš et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Oxidative stress and lowered total antioxidant status are associated with a history of suicide attempts

(2013) Heber Odebrecht Vargas et al.   JOURNAL OF AFFECTIVE DISORDERS

Discovery and validation of blood biomarkers for suicidality

(2013) H Le-Niculescu et al.   MOLECULAR PSYCHIATRY

Regulation of Serotonin-Induced Trafficking and Migration of Eosinophils

(2013) Bit Na Kang et al.   PLoS One

Pain and suicidality: Insights from reward and addiction neuroscience

(2013) Igor Elman et al.   PROGRESS IN NEUROBIOLOGY

Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin

(2012) R. L. Carhart-Harris et al.   BRITISH JOURNAL OF PSYCHIATRY

Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder

(2012) Guilherme A. Behr et al.   Oxidative Medicine and Cellular Longevity

Differential pattern of response in mood symptoms and suicide risk measures in severely ill depressed patients assigned to citalopram with placebo or citalopram combined with lithium: Role of lithium levels

(2011) Arif Khan et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens

(2011) Adam L. Halberstadt et al.   NEUROPHARMACOLOGY

Psilocybin-Induced Deficits in Automatic and Controlled Inhibition are Attenuated by Ketanserin in Healthy Human Volunteers

(2011) Boris B Quednow et al.   NEUROPSYCHOPHARMACOLOGY

Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects

(2011) Roland R. Griffiths et al.   PSYCHOPHARMACOLOGY

Antioxidant activity of unexplored indole derivatives: Synthesis and screening

(2010) Mónica S. Estevão et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The administration of psilocybin to healthy, hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerability

(2010) Robin L Carhart-Harris et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The neurobiology of psychedelic drugs: implications for the treatment of mood disorders

(2010) Franz X. Vollenweider et al.   NATURE REVIEWS NEUROSCIENCE

Association between the use of serotonin receptor 2A-blocking antidepressants and joint disorders

(2009) Anders Kling et al.   ARTHRITIS AND RHEUMATISM

Interleukin-6 Is Elevated in the Cerebrospinal Fluid of Suicide Attempters and Related to Symptom Severity

(2009) Daniel Lindqvist et al.   BIOLOGICAL PSYCHIATRY

Anterior cingulate pyramidal neurons display altered dendritic branching in depressed suicides

(2009) Christa Hercher et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Prodrug Approaches for CNS Delivery

(2008) Jarkko Rautio et al.   AAPS Journal

Serotonin 5-Hydroxytryptamine2A Receptor Activation Suppresses Tumor Necrosis Factor- -Induced Inflammation with Extraordinary Potency

(2008) B. Yu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A

(2008) R.C. Shelton et al.   NEUROSCIENCE

Association study of two polymorphisms of the serotonin‐2A receptor gene and suicide attempts

(2007) Concepcion Vaquero‐Lorenzo et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Genetic variations in the serotonin 5-HT2A receptor gene (HTR2A) are associated with rheumatoid arthritis

(2007) A Kling et al.   ANNALS OF THE RHEUMATIC DISEASES