Article
Clinical Neurology
Gordana Nedic Erjavec, Lucija Tudor, Matea Nikolac Perkovic, Josip Podobnik, Katarina Dodig Curkovic, Mario Curkovic, Dubravka Svob Strac, Melita Cusek, Marco Bortolato, Nela Pivac
Summary: This study found an association between genetic polymorphisms of the 5-HT2A receptor and conduct disorder (CD). Certain genetic variations were strongly linked to irritability, physical aggression, and antisocial behavior. Additionally, CD subjects had significantly higher platelet 5-HT concentrations, which correlated with smoking status.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Behavioral Sciences
Jasmin Obermanns, Hanna Meiser, Saskia Hoberg, Cynthia Segura Vesterager, Frank Schulz, Georg Juckel, Barbara Emons
Summary: This study found higher concentrations of AEA and decreased concentrations of 2-AG in patients with depression compared to healthy participants. Lower concentrations of 2-AG were correlated with higher levels of anxiety symptoms. Male patients had increased concentrations of 2-AG, while female patients had increased anxiety symptoms. Genotypic variations of 5-HT1A rs6295 and 5-HT2A rs6311 were associated with altered serotonergic activity and serotonin content in patients.
BRAIN AND BEHAVIOR
(2023)
Article
Pharmacology & Pharmacy
Sean M. Collins, Christopher J. O'Connell, Evan L. Reeder, Sophia V. Norman, Kainat Lungani, Poornima Gopalan, Gary A. Gudelsky, Matthew J. Robson
Summary: Various forms of TBI are a leading cause of disability in the US, with the generation of neuropsychiatric complications such as depression and anxiety. This study found that mild TBI can lead to selective alterations in cortical 5-HT2A receptor signaling, which may be targeted for the development of pharmacotherapies to alleviate TBI-induced neuropsychiatric disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Maxemiliano V. Vargas, Lee E. Dunlap, Chunyang Dong, Samuel J. Carter, Robert J. Tombari, Shekib A. Jami, Lindsay P. Cameron, Seona D. Patel, Joseph J. Hennessey, Hannah N. Saeger, John D. McCorvy, John A. Gray, Lin Tian, David E. Olson
Summary: Decreased dendritic spine density in the cortex is a common feature of neuropsychiatric diseases, and psychedelics have been found to promote cortical neuron growth. This study shows that intracellular 5-HT2A receptors mediate the plasticity-promoting effects of psychedelics, providing insight into the mechanisms behind their therapeutic effects. The findings suggest that targeting intracellular 5-HT2A receptors could be a potential therapeutic approach.
Article
Chemistry, Multidisciplinary
Johannes Morstein, Giovanna Romano, Belinda E. Hetzler, Ambrose Plante, Caleb Haake, Joshua Levitz, Dirk Trauner
Summary: This study develops tools for optical control of serotonin receptors, providing a new method for studying receptor function. By constructing a repeatable and reversible optical control system, this study lays the foundation for extending photopharmacology to the serotonin receptor family.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Jean E. M. Ramirez, Ahmed B. Alarabi, Fadi T. Khasawneh, Fatima Z. Alshbool
Summary: Serotonin amplifies platelet functional responses by binding to 5HT(2A)R. However, developing antagonists for 5HT(2A)R as therapeutic agents in cardiovascular diseases has been challenging. In this study, a custom-made 5HT(2A)RAb was found to block platelet function and protect against thrombogenesis without impairing normal hemostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Lise Guilhemsang, Amaia Gutierrez-Ceballos, Mario Antonazzo, Nicolas P. Mallet, Luisa Ugedo, Teresa Morera-Herreras
Summary: This study investigated the modulatory effects of 5-HT2A receptor stimulation on the basal ganglia circuitry, specifically targeting the mPF information processing through trans-striatal pathways. The results showed that the 5-HT2A agonist TCB-2 increased the firing rate and inhibitory response of medial SNr neurons, while the 5-HT2A receptor antagonist MDL11939 blocked these effects. Overall, these findings suggest a preferential modulatory action of 5-HT2A receptors on the dynamic regulation of basal ganglia circuitry.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Kinga Gawlinska, Dawid Gawlinski, Malgorzata Filip, Edmund Przegalinski
Summary: Recent studies have shown a relationship between maternal diet composition and the risk of mental illnesses in offspring by affecting serotonin receptors in the brain. Different maternal diets, such as high-fat, high-carbohydrate, and mixed diets, induce specific changes in 5-HT2C and 5-HT2A receptor levels in different brain regions of the offspring. Specifically, high-fat maternal diet reduces 5-HT2C receptor expression in male rats at PND 28 but increases it at PND 63 in certain brain regions.
PHARMACOLOGICAL REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Orr Shahar, Alexander Botvinnik, Noam Esh-Zuntz, Michal Brownstien, Rachel Wolf, Amit Lotan, Gilly Wolf, Bernard Lerer, Tzuri Lifschytz
Summary: There is growing interest in the therapeutic potential of psilocybin. This study examined the role of different serotonergic receptors and TAAR1 in modulating the head twitch response induced by 5-HTP and psilocybin in mice. The findings suggest that compounds that modulate psychedelic-induced head twitch response may have important therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jianan Zhao, Lingxia Xu, Cen Chang, Ping Jiang, Kai Wei, Yiming Shi, Linshuai Xu, Yixin Zheng, Yu Shan, Yanqin Bian, Li Li, Shicheng Guo, Steven J. Schrodi, Rongsheng Wang, Dongyi He
Summary: This study found a significant hypermethylation of the promoter region of HTR2A, indicating its potential clinical diagnostic role in rheumatoid arthritis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Agata Zieba, Piotr Stepnicki, Dariusz Matosiuk, Agnieszka A. Kaczor
Summary: This article summarizes the applicability of 5-HT2A receptor signaling modulators in the treatment of depression and provides insights into the structural and physiological features of this receptor. It also presents an overview of recent virtual screening campaigns and additional data on synthesized ligands acting through this protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Anat Levit Kaplan, Danielle N. Confair, Kuglae Kim, Ximena Barros-Alvarez, Ramona M. Rodriguiz, Ying Yang, Oh Sang Kweon, Tao Che, John D. McCorvy, David N. Kamber, James P. Phelan, Luan Carvalho Martins, Vladimir M. Pogorelov, Jeffrey F. DiBerto, Samuel T. Slocum, Xi-Ping Huang, Jain Manish Kumar, Michael J. Robertson, Ouliana Panova, Alpay B. Seven, Autumn Q. Wetsel, William C. Wetsel, John J. Irwin, Georgios Skiniotis, Brian K. Shoichet, Bryan L. Roth, Jonathan A. Ellman
Summary: Researchers successfully screened and synthesized molecules that can activate the 5-HT2A receptor using structure-based docking and optimization methods. These molecules exhibited potent antidepressant activity in mouse models without psychedelic effects.
Article
Biochemistry & Molecular Biology
Jeong-Hee Kim, Hang-Keun Kim, Young-Don Son, Jong-Hoon Kim
Summary: This study explored the relationship between 5-HT2A receptor availability and aggression traits in healthy individuals, and found significant positive correlations between 5-HT2A receptor availability and overall aggression score as well as scores on different aggression subscales in multiple brain regions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Lina Wirestam, Klara Martinsson, Alf Kastbom
Summary: Serum serotonin levels are elevated in patients with increased risk of rheumatoid arthritis (RA) and those with early RA. However, increased serotonin is not predictive of arthritis development or disease course.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Gavin P. Schmitz, Manish K. Jain, Samuel T. Slocum, Bryan L. Roth
Summary: In this study, the researchers examined the effects of sequence variations in the 5-HT2AR gene on the signaling of four commonly used psychedelic drugs. They found that these genetic variations have statistically significant, but modest, effects on the efficacy and potency of the drugs. Importantly, these effects are specific to each drug.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Josefin E. Lofvenborg, Emma Ahlqvist, Lars Alfredsson, Tomas Andersson, Mozhgan Dorkhan, Leif Groop, Tiinamaija Tuomi, Alicja Wolk, Sofia Carlsson
EUROPEAN JOURNAL OF NUTRITION
(2020)
Article
Genetics & Heredity
Hunna J. Watson, Zeynep Yilmaz, Laura M. Thorntont, Christopher Hubel, Jonathan R. Coleman, Helena A. Gaspar, Julien Bryois, Anke Hinney, Virpi M. Leppa, Manuel Mattheisen, Sarah E. Medland, Stephan Ripke, Shuyang Yao, Paola Giusti-Rodriguez, Ken B. Hanscombe, Kirstin L. Purves, Roger A. H. Adan, Lars Alfredsson, Tetsuya Ando, Ole A. Andreassen, Jessica H. Baker, Wade H. Berrettini, Ilka Boehm, Claudette Boni, Vesna Boraska Perica, Katharina Buehren, Roland Burghardt, Matteo Cassina, Sven Cichon, Maurizio Clementi, Roger D. Cone, Philippe Courtet, Scott Crow, James J. Crowley, Unna N. Danner, Oliver S. P. Davis, Martina de Zwaan, George Dedoussis, Daniela Degortes, Janiece E. DeSocio, Danielle M. Dick, Dimitris Dikeos, Christian Dina, Monika Dmitrzak-Weglarz, Elisa Docampo, Laramie E. Duncan, Karin Egberts, Stefan Ehrlich, Georgia Escaramis, Tonu Eskos, Xavier Estivill, Anne Farmer, Angela Favaro, Fernando Fernandez-Aranda, Manfred M. Fichter, Krista Fischer, Manuel Foecker, Lenka Foretova, Andreas J. Forstner, Monica Forzan, Christopher S. Franklin, Steven Gallinger, Ina Giegling, Johanna Giuranna, Fragiskos Gonidakis, Philip Gorwood, Monica Gratacos Mayora, Sebastien Guillaume, Yiran Guo, Hakon Hakonarson, Konstantinos Hatzikotoulas, Joanna Hauser, Johannes Hebebrand, Sietske G. Helder, Stefan Herms, Beate Herpertz-Dahlmann, Wolfgang Herzog, Laura M. Huckins, James Hudson, Hartmut Imgart, Hidetoshi Inoko, Vladimir Janout, Susana Jimenez-Murcia, Antonio Julia, Gursharan Kalsi, Deborah Kaminska, Jaakko Kaprio, Leila Karhunen, Andreas Karwautz, Martien J. H. Kas, James L. Kennedy, Anna Keski-Rahkonen, Kirsty Kiezebrink, Youl-Ri Kim, Lars Klareskog, Kelly L. Klump, Gun Peggy S. Knudsen, Maria C. La Via, Stephanie Le Hellard, Robert D. Levitan, Dong Li, Lisa Lilenfeld, Bochao Danae Lin, Jolanta Lissowska, Jurjen Luykx, Pierre J. Magistretti, Mario Maj, Katrin Mannik, Sara Marsal, Christian R. Marshall, Morten Mattingsdal, Sara McDevitt, Peter McGuffin, Andres Metspalu, Ingrid Meulenbelt, Nadia Micali, Karen Mitchell, Alessio Maria Monteleone, Palmiero Monteleone, Melissa A. Munn-Chernoff, Benedetta Nacmias, Marie Navratilova, Ioanna Ntalla, Julie K. O'Toole, Roel A. Ophoff, Leonid Padyukov, Aarno Palotie, Jacques Pantel, Hana Papezova, Dalila Pinto, Raquel Rabionet, Anu Raevuori, Nicolas Ramoz, Ted Reichborn-Kjennerud, Valdo Ricca, Samuli Ripatti, Franziska Ritschel, Marion Roberts, Alessandro Rotondo, Dan Rujescu, Filip Rybakowski, Paolo Santonastaso, Andre Scherag, Stephen W. Scherer, Ulrike Schmidt, Nicholas J. Schork, Alexandra Schosser, Jochen Seitz, Lenka Slachtova, P. Eline Slagboom, Margarita C. T. Slof-Op 't Landt, Agnieszka Slopien, Sandro Sorbi, Beata Swiatkowska, Jin P. Szatkiewicz, Ioanna Tachmazidou, Elena Tenconi, Alfonso Tortorella, Federica Tozzi, Janet Treasure, Artemis Tsitsika, Marta Tyszkiewicz-Nwafor, Konstantinos Tziouvas, Annemarie A. van Elbur, Eric F. van Furth, Gudrun Wagner, Esther Walton, Elisabeth Widen, Eleftheria Zeggini, Stephanie Zerwas, Stephan Zipfel, Andrew W. Bergen, Joseph M. Boden, Harry Brandt, Steven Crawford, Katherine A. Halmi, L. John Horwood, Craig Johnson, Allan S. Kaplan, Walter H. Kaye, James E. Mitchell, Catherine M. Olsen, John F. Pearson, Nancy L. Pedersen, Michael Strober, Thomas Werge, David C. Whiteman, D. Blake Woodside, Garret D. Stuber, Scott Gordon, Jakob Grove, Anjali K. Henders, Anders Jureus, Katherine M. Kirk, Janne T. Larsen, Richard Parker, Liselotte Petersen, Jennifer Jordan, Martin Kennedy, Grant W. Montgomery, Tracey D. Wade, Andreas Birgegard, Paul Lichtenstein, Claes Norring, Mikael Landen, Nicholas G. Martin, Preben Bo Mortensen, Patrick F. Sullivan, Gerome Breen, Cynthia M. Bulik
Article
Genetics & Heredity
Chikashi Terao, Boel Brynedal, Zuomei Chen, Xia Jiang, Helga Westerlind, Monika Hansson, Per-Johan Jakobsson, Karin Lundberg, Karl Skriner, Guy Serre, Johan Ronnelid, Linda Mathsson-Alm, Mikael Brink, Solbritt Rantapaa Dahlqvist, Leonid Padyukov, Peter K. Gregersen, Anne Barton, Lars Alfredsson, Lars Klareskog, Soumya Raychaudhuri
AMERICAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Anesthesiology
Joern Loetsch, Lars Alfredsson, Jon Lampa
Review
Medicine, General & Internal
L. Klareskog, J. Ronnelid, S. Saevarsdottir, L. Padyukov, L. Alfredsson
JOURNAL OF INTERNAL MEDICINE
(2020)
Article
Clinical Neurology
Anna Karin Hedstrom, Nicole Brenner, Julia Butt, Jan Hillert, Tim Waterboer, Tomas Olsson, Lars Alfredsson
Summary: This study found that overweight/obesity in young adulthood interacts significantly with high EBNA-1 antibody levels, increasing the risk for multiple sclerosis. Furthermore, three-way interactions were present between HLA-DRB1*15:01, overweight/obesity at age 20 years, and each aspect of EBV infection.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Morten Mattingsdal, S. Sunna Ebenesersdottir, Kristjan H. S. Moore, Ole A. Andreassen, Thomas F. Hansen, Thomas Werge, Ingrid Kockum, Tomas Olsson, Lars Alfredsson, Agnar Helgason, Kari Stefansson, Eivind Hovig
Summary: This study describes the genetic structure of the Norwegian population, revealing distinctive patterns of genetic variation in the far northeast and south regions, with enriched Uralic Sami ancestry in the North. Migration rates are influenced by topography, and higher relatedness is found between the mid- and northern border areas towards Sweden. Despite Norway's maritime history, the region closest to mainland Europe seems to have been isolated, hindered by the open sea as a barrier to gene flow.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2021)
Review
Immunology
Leonid Padyukov
Summary: Rheumatoid arthritis is an inflammatory autoimmune disease with significant genetic associations and variations. Current research focuses on immune receptor binding, T cell activation, and cell signaling mechanisms. More than 150 candidate loci have been identified, with further discoveries expected in the future.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Article
Medicine, General & Internal
Goran Walldius, Ulf de Faire, Lars Alfredsson, Karin Leander, Peter Westerholm, Hakan Malmstrom, Torbjorn Ivert, Niklas Hammar
Summary: Elevated levels of apoB and apoB/apoA-1 ratio are associated with increased risk of MACEs, while decreased levels of apoA-1 potentiate the impact of apoB. MACEs occur earlier with higher apoB/apoA-1 ratio, suggesting the need for early recognition and primary prevention.
Article
Endocrinology & Metabolism
Jessica Edstorp, Yuxia Wei, Emma Ahlqvist, Lars Alfredsson, Valdemar Grill, Leif Groop, Bahareh Rasouli, Elin P. Sorgjerd, Per M. Thorsby, Tiinamaija Tuomi, Bjorn O. Asvold, Sofia Carlsson
Summary: The study reveals that smoking and snus use are associated with a higher risk of LADA and type 2 diabetes, and smoking acts synergistically with HLA high-risk genotypes in the development of LADA.
Article
Multidisciplinary Sciences
Olivia G. Thomas, Mattias Bronge, Katarina Tengvall, Birce Akpinar, Ola B. Nilsson, Erik Holmgren, Tara Hessa, Guro Gafvelin, Mohsen Khademi, Lars Alfredsson, Roland Martin, Andre Ortlieb Guerreiro-Cacais, Hans Groenlund, Tomas Olsson, Ingrid Kockum
Summary: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, with Epstein-Barr virus (EBV) infection as a likely prerequisite. This study found that antibody reactivity to CRYAB amino acids 7 to 16 was associated with MS, and the combination of high EBNA1 responses with CRYAB positivity greatly increased disease risk. Additionally, evidence of antibody cross-reactivity between EBNA1 and CRYAB, as well as T cell cross-reactivity, was found, further demonstrating the role of EBV immune responses in MS development.
Article
Biochemistry & Molecular Biology
Alexandre Xavier, Vicki E. Maltby, Ewoud Ewing, Maria Pia Campagna, Sean M. Burnard, Jesper N. Tegner, Mark Slee, Helmut Butzkueven, Ingrid Kockum, Lara Kular, Vilija G. Jokubaitis, Trevor Kilpatrick, Lars Alfredsson, Maja Jagodic, Anne-Louise Ponsonby, Bruce V. Taylor, Rodney J. Scott, Rodney A. Lea, Jeannette Lechner-Scott
Summary: This study reveals that DNA methylation differences in multiple sclerosis (MS) occur independently of known genetic risk loci. It shows that these differences more effectively differentiate the disease compared to known genetic risk loci. The study also indicates that the methylation differences in MS predominantly occur in B cells and monocytes, involving cell-specific biological pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Anna Ilar, Per Gustavsson, Pernilla Wiebert, Lars Alfredsson
Article
Rheumatology
Anna Ilar, Lars Klareskog, Saedis Saevarsdottir, Pernilla Wiebert, Johan Askling, Per Gustaysson, Lars Alfredsson
Meeting Abstract
Rheumatology
E. Pertsinidou, P. Zeng, B. Brynedal, V. A. Manivel, L. Klareskog, M. Mullazehi, S. Saevarsdottir, C. Bengtsson, L. Alfredsson, J. Ronnelid
ANNALS OF THE RHEUMATIC DISEASES
(2019)