Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation

Affinity Capture of p97 with Small-Molecule Ligand Bait Reveals a 3.6 Å Double-Hexamer Cryoelectron Microscopy Structure

(2021) Md Rejaul Hoq et al.   ACS Nano

Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes

(2021) Purbasha Nandi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The conserved theme of ribosome hibernation: from bacteria to chloroplasts of plants

(2019) Raphael Trösch et al.   BIOLOGICAL CHEMISTRY

Structure of the Cdc48 segregase in the act of unfolding an authentic substrate

(2019) Ian Cooney et al.   SCIENCE

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

(2019) Edward C. Twomey et al.   SCIENCE

VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling

(2018) Johannes van den Boom et al.   MOLECULAR CELL

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Structural Basis of p97 Inhibition by the Site-Selective Anti-Cancer Compound CB-5083

(2018) Wai Kwan Tang et al.   MOLECULAR PHARMACOLOGY

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Monoubiquitination of Syntaxin 5 Regulates Golgi Membrane Dynamics during the Cell Cycle

(2016) Shijiao Huang et al.   DEVELOPMENTAL CELL

Nucleotide-dependent conformational changes of the AAA+ ATPase p97 revisited

(2016) Jan M. Schuller et al.   FEBS LETTERS

Structure and function of the AAA+ ATPase p97/Cdc48p

(2016) Di Xia et al.   GENE

Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response

(2016) Tao Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine

(2016) Dominik Barthelme et al.   JOURNAL OF MOLECULAR BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

2.3 A resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

(2016) S. Banerjee et al.   SCIENCE

Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97

(2016) Petra Hänzelmann et al.   STRUCTURE

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

(2015) Daniel J. Anderson et al.   CANCER CELL

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

(2014) Raymond J Deshaies   BMC BIOLOGY

Specific Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate Interaction between D1 and D2 ATPase Domains

(2014) Tsui-Fen Chou et al.   JOURNAL OF MOLECULAR BIOLOGY

Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants

(2013) Wai Kwan Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

(2013) Paola Magnaghi et al.   Nature Chemical Biology

A Newly Uncovered Group of Distantly Related Lysine Methyltransferases Preferentially Interact with Molecular Chaperones to Regulate Their Activity

(2013) Philippe Cloutier et al.   PLoS Genetics

The Role of the N-Domain in the ATPase Activity of the Mammalian AAA ATPase p97/VCP

(2012) Hajime Niwa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

The Ubiquitin Regulatory X (UBX) Domain-containing Protein TUG Regulates the p97 ATPase and Resides at the Endoplasmic Reticulum-Golgi Intermediate Compartment

(2011) Charisse M. Orme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

ATP-bound form of the D1 AAA domain inhibits an essential function of Cdc48p/p97This paper is one of a selection of papers published in this special issue entitled 8th International Conference on AAA Proteins and has undergone the Journal's usual peer review process.

(2010) Masatoshi Esaki et al.   Biochemistry and Cell Biology

A novel ATP-dependent conformation in p97 N–D1 fragment revealed by crystal structures of disease-related mutants

(2010) Wai Kwan Tang et al.   EMBO JOURNAL

p97/valosin-containing protein (VCP) is highly modulated by phosphorylation and acetylation

(2009) Chiho Mori-Konya et al.   GENES TO CELLS

Analysis of Nucleotide Binding to P97 Reveals the Properties of a Tandem AAA Hexameric ATPase

(2008) Louise C. Briggs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved Structures of Full-Length p97, an AAA ATPase: Implications for Mechanisms of Nucleotide-Dependent Conformational Change

(2008) Jason M. Davies et al.   STRUCTURE