GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity

eIF2B conformation and assembly state regulates the integrated stress response

(2021) Michael Schoof et al.   eLife

Structure of Gcn1 bound to stalled and colliding 80S ribosomes

(2021) Agnieszka A. Pochopien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sugar phosphate activation of the stress sensor eIF2B

(2021) Qi Hao et al.   Nature Communications

ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B

(2020) Alisa F. Zyryanova et al.   MOLECULAR CELL

eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response

(2019) Lillian R. Kenner et al.   SCIENCE

Structural basis for eIF2B inhibition in integrated stress response

(2019) Kazuhiro Kashiwagi et al.   SCIENCE

Structural basis for the inhibition of translation through eIF2α phosphorylation

(2019) Yuliya Gordiyenko et al.   Nature Communications

The structural basis of translational control by eIF2 phosphorylation

(2019) Tomas Adomavicius et al.   Nature Communications

eIF2B Mechanisms of Action and Regulation: A Thermodynamic View

(2018) Andrew M. Bogorad et al.   BIOCHEMISTRY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress

(2018) Ronald C. Wek   Cold Spring Harbor Perspectives in Biology

Protein Synthesis Initiation in Eukaryotic Cells

(2018) William C. Merrick et al.   Cold Spring Harbor Perspectives in Biology

Regulation of translation initiation factor eIF2B at the hub of the integrated stress response

(2018) Graham D. Pavitt   Wiley Interdisciplinary Reviews-RNA

Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes

(2017) Martin D Jennings et al.   eLife

Crystal structure of eukaryotic translation initiation factor 2B

(2016) Kazuhiro Kashiwagi et al.   NATURE

Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex

(2015) Jose L. Llácer et al.   MOLECULAR CELL

The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

eIF2B is a decameric guanine nucleotide exchange factor with a γ2ε2 tetrameric core

(2014) Yuliya Gordiyenko et al.   Nature Communications

A Yeast Purification System for Human Translation Initiation Factors eIF2 and eIF2Bε and Their Use in the Diagnosis of CACH/VWM Disease

(2013) Rogerio A. de Almeida et al.   PLoS One

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

Identification of Intersubunit Domain Interactions within Eukaryotic Initiation Factor (eIF) 2B, the Nucleotide Exchange Factor for Translation Initiation

(2012) Peter J. Reid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Guanine Nucleotide Pool Imbalance Impairs Multiple Steps of Protein Synthesis and Disrupts GCN4 Translational Control in Saccharomyces cerevisiae

(2010) D. Iglesias-Gato et al.   GENETICS

Structural Insights into the Catalytic Mechanism of Bacterial Guanosine-diphospho-d-mannose Pyrophosphorylase and Its Regulation by Divalent Ions

(2010) Marie-Cécile Pelissier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of ATP homeostasis during the respiro-fermentative transition in yeast

(2010) Thomas Walther et al.   Molecular Systems Biology