Structure of Gcn1 bound to stalled and colliding 80S ribosomes

RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1

(2020) Yoshitaka Matsuo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate

(2020) Colin Chih-Chien Wu et al.   CELL

Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control

(2020) Sezen Meydan et al.   MOLECULAR CELL

The ASC-1 Complex Disassembles Collided Ribosomes

(2020) Szymon Juszkiewicz et al.   MOLECULAR CELL

Ribosome collisions trigger cis-acting feedback inhibition of translation initiation

(2020) Szymon Juszkiewicz et al.   eLife

EDF1 coordinates cellular responses to ribosome collisions

(2020) Niladri K Sinha et al.   eLife

Ribosome quality control antagonizes the activation of the integrated stress response on colliding ribosomes

(2020) Liewei L. Yan et al.   MOLECULAR CELL

Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control pathways

(2019) Ken Ikeuchi et al.   EMBO JOURNAL

Activation of GCN2 by the ribosomal P-stalk

(2019) Alison J. Inglis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and functions of ribosome-associated protein quality control

(2019) Claudio A. P. Joazeiro   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ribosome Collisions Result in +1 Frameshifting in the Absence of No-Go Decay

(2019) Carrie L. Simms et al.   Cell Reports

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

(2019) Heather P Harding et al.   eLife

Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts

(2019) Petr Tesina et al.   EMBO JOURNAL

Quality controls induced by aberrant translation

(2019) Toshifumi Inada   NUCLEIC ACIDS RESEARCH

Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells

(2018) Alicia M. Darnell et al.   MOLECULAR CELL

ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps

(2018) Tristan Ian Croll   Acta Crystallographica Section D-Structural Biology

ZNF598 Is a Quality Control Sensor of Collided Ribosomes

(2018) Szymon Juszkiewicz et al.   MOLECULAR CELL

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Multi-protein bridging factor 1(Mbf1), Rps3 and Asc1 prevent stalled ribosomes from frameshifting

(2018) Jiyu Wang et al.   eLife

eIF5A Functions Globally in Translation Elongation and Termination

(2017) Anthony P. Schuller et al.   MOLECULAR CELL

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Activation of Gcn2 in response to different stresses

(2017) Silje Anda et al.   PLoS One

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The SWISS-MODEL Repository—new features and functionality

(2016) Stefan Bienert et al.   NUCLEIC ACIDS RESEARCH

The cryo-EM structure of a ribosome–Ski2-Ski3-Ski8 helicase complex

(2016) Christian Schmidt et al.   SCIENCE

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation

(2016) Ryuta Ishimura et al.   eLife

Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2

(2015) Su Jung Lee et al.   BIOCHEMICAL JOURNAL

Asc1, homolog of human RACK1, prevents frameshifting in yeast by ribosomes stalled at CGA codon repeats

(2015) Andrew S. Wolf et al.   RNA

Keeping the eIF2 alpha kinase Gcn2 in check

(2014) Beatriz A. Castilho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

eIF5A Promotes Translation of Polyproline Motifs

(2013) Erik Gutierrez et al.   MOLECULAR CELL

Overexpression of Eukaryotic Translation Elongation Factor 3 Impairs Gcn2 Protein Activation

(2012) Jyothsna Visweswaraiah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rbg1–Tma46 dimer structure reveals new functional domains and their role in polysome recruitment

(2012) Sandrea M. Francis et al.   NUCLEIC ACIDS RESEARCH

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The highly conserved eukaryotic DRG factors are required for efficient translation in a manner redundant with the putative RNA helicase Slh1

(2010) Marie-Claire Daugeron et al.   NUCLEIC ACIDS RESEARCH

Independent stabilizations of polysomal Drg1/Dfrp1 complex and non-polysomal Drg2/Dfrp2 complex in mammalian cells

(2009) Kosuke Ishikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Saccharomyces cerevisiaeRbg1 Protein and Its Binding Partner Gir2 Interact on Polyribosomes with Gcn1

(2009) P. K. Wout et al.   EUKARYOTIC CELL

Solution structure of the C-terminal domain of multiprotein bridging factor 1 (MBF1) ofTrichoderma reesei

(2008) Roberto K. Salinas et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS