Mesenchymal Stem Cells Influence Activation of Hepatic Stellate Cells, and Constitute a Promising Therapy for Liver Fibrosis

Human placental mesenchymal stem cells ameliorate liver fibrosis in mice by upregulation of Caveolin1 in hepatic stellate cells

(2021) Yunqi Yao et al.   Stem Cell Research & Therapy

Applications of Mesenchymal Stem Cells in Liver Fibrosis: Novel Strategies, Mechanisms, and Clinical Practice

(2021) Mengmei Zhu et al.   Stem Cells International

Stem cell-derived cell sheet transplantation for heart tissue repair in myocardial infarction

(2020) Rui Guo et al.   Stem Cell Research & Therapy

Immunomodulatory role of mesenchymal stem cells in Alzheimer's disease

(2020) Lu Zhang et al.   LIFE SCIENCES

Mesenchymal Stem Cell Immunomodulation: Mechanisms and Therapeutic Potential

(2020) Na Song et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Overexpressing TGF-β1 in mesenchymal stem cells attenuates organ dysfunction during CLP-induced septic mice by reducing macrophage-driven inflammation

(2020) Feng Liu et al.   Stem Cell Research & Therapy

Mesenchymal stem cell-based cell-free strategies: safe and effective treatments for liver injury

(2020) Chenxia Hu et al.   Stem Cell Research & Therapy

Enhanced viability and function of mesenchymal stromal cell spheroids is mediated via autophagy induction

(2020) Shobha Regmi et al.   Autophagy

Extracellular vesicles‐derived miR‐150‐5p secreted by adipose‐derived mesenchymal stem cells inhibits CXCL1 expression to attenuate hepatic fibrosis

(2020) Zhiyong Du et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

sEVs from tonsil-derived mesenchymal stromal cells alleviate activation of hepatic stellate cells and liver fibrosis through miR-486-5p

(2020) Jieun Kim et al.   MOLECULAR THERAPY

The development of mesenchymal stem cell therapy in the present, and the perspective of cell-free therapy in the future

(2020) Yusuke Watanabe et al.   Clinical and Molecular Hepatology

Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt/β-catenin pathway

(2019) Xiaoli Rong et al.   Stem Cell Research & Therapy

Protein composition reflects extracellular vesicle heterogeneity

(2019) Tatyana Vagner et al.   PROTEOMICS

Transforming growth factor-β1-overexpressing mesenchymal stromal cells induced local tolerance in rat renal ischemia/reperfusion injury

(2019) Jieru Cai et al.   CYTOTHERAPY

The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine

(2019) Praveen Kumar L. et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases

(2019) Nathan P. Staff et al.   MAYO CLINIC PROCEEDINGS

Mesenchymal Stem Cells Improve Glycometabolism and Liver Regeneration in the Treatment of Post-hepatectomy Liver Failure

(2019) Hao-ran Ding et al.   Frontiers in Physiology

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

Human umbilical cord perivascular cells-derived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice

(2019) Esteban Fiore et al.   GENE THERAPY

Exosomal miR‐1246 derived from human umbilical cord blood mesenchymal stem cells attenuates hepatic ischemia reperfusion injury by modulating T helper 17/regulatory T balance

(2019) Kun Xie et al.   IUBMB LIFE

Autophagy inhibition via Becn1 downregulation improves the mesenchymal stem cells antifibrotic potential in experimental liver fibrosis

(2019) Hang Yu Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hydrogel-Mediated Sustained Systemic Delivery of Mesenchymal Stem Cell-Derived Extracellular Vesicles Improves Hepatic Regeneration in Chronic Liver Failure

(2019) Soura Mardpour et al.   ACS Applied Materials & Interfaces

Tumor necrosis factor-inducible gene 6 reprograms hepatic stellate cells into stem-like cells, which ameliorates liver damage in mouse

(2019) Sihyung Wang et al.   BIOMATERIALS

Mesenchymal Stem Cells for the Treatment of Liver Disease: Present and Perspectives

(2019) Seong Hee Kang et al.   Gut and Liver

Intraportally delivered stem cell spheroids localize in the liver and protect hepatocytes against GalN/LPS-induced fulminant hepatic toxicity

(2019) Shobha Regmi et al.   Stem Cell Research & Therapy

Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Nonalcoholic Fatty Liver Disease in Obese Type 2 Diabetic Mice

(2019) Bing Li et al.   Stem Cells International

A highlight on Sonic hedgehog pathway

(2018) Gabriela Basile Carballo et al.   Cell Communication and Signaling

Hedgehog signalling in liver pathophysiology

(2018) Mariana Verdelho Machado et al.   JOURNAL OF HEPATOLOGY

Liver diseases: A major, neglected global public health problem requiring urgent actions and large-scale screening

(2018) Patrick Marcellin et al.   LIVER INTERNATIONAL

TSG-6: A multifunctional protein with anti-inflammatory and tissue-protective properties

(2018) Anthony J. Day et al.   MATRIX BIOLOGY

MicroRNA-378 is involved in hedgehog-driven epithelial-to-mesenchymal transition in hepatocytes of regenerating liver

(2018) Jieun Kim et al.   Cell Death & Disease

Human Umbilical Cord MSC-Derived Exosomes Suppress the Development of CCl4-Induced Liver Injury through Antioxidant Effect

(2018) Wenqian Jiang et al.   Stem Cells International

Mesenchymal Stem Cells Enhance Liver Regeneration via Improving Lipid Accumulation and Hippo Signaling

(2018) Yang Liu et al.   Stem Cells International

NADPH Oxidase Signaling Pathway Mediates Mesenchymal Stem Cell-Induced Inhibition of Hepatic Stellate Cell Activation

(2018) Haowen Qiao et al.   Stem Cells International

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

(2018) Eduard Willms et al.   Frontiers in Immunology

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

Liver Transplantation Today: Where we are now and where we are going

(2018) Adam S. Bodzin et al.   LIVER TRANSPLANTATION

Exosomes produced from three-dimensional cultures of mesenchymal stem cells by tangential flow filtration show higher yield and improved activity

(2018) Reka Agnes Haraszti et al.   MOLECULAR THERAPY

Non-alcoholic fatty liver disease – A global public health perspective

(2018) Zobair M. Younossi   JOURNAL OF HEPATOLOGY

Conditioned Medium from Human Amnion-Derived Mesenchymal Stem Cells Regulates Activation of Primary Hepatic Stellate Cells

(2018) Qingjie Fu et al.   Stem Cells International

Tangential Flow Filtration for Highly Efficient Concentration of Extracellular Vesicles from Large Volumes of Fluid

(2018) Sara Busatto et al.   Cells

Milk Fat Globule-EGF Factor 8, Secreted by Mesenchymal Stem Cells, Protects Against Liver Fibrosis in Mice

(2017) Su Yeon An et al.   GASTROENTEROLOGY

TGF-β engineered mesenchymal stem cells (TGF-β/MSCs) for treatment of Type 1 diabetes (T1D) mice model

(2017) Saeed Daneshmandi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mesenchymal Stem Cell-Dependent Modulation of Liver Diseases

(2017) Marina Gazdic et al.   International Journal of Biological Sciences

Manufacturing of Human Extracellular Vesicle-Based Therapeutics for Clinical Use

(2017) Mario Gimona et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine

(2017) Francisco Vizoso et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MiR-122 modification enhances the therapeutic efficacy of adipose tissue-derived mesenchymal stem cells against liver fibrosis

(2017) Guohua Lou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exosomes derived from miR-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation

(2017) Ying Qu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Mesenchymal stem cells attenuate acute liver injury by altering ratio between interleukin 17 producing and regulatory natural killer T cells

(2017) Neda Milosavljevic et al.   LIVER TRANSPLANTATION

hucMSC Exosome-Derived GPX1 Is Required for the Recovery of Hepatic Oxidant Injury

(2017) Yongmin Yan et al.   MOLECULAR THERAPY

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Eminent Sources of Adult Mesenchymal Stem Cells and Their Therapeutic Imminence

(2017) Dannie Macrin et al.   Stem Cell Reviews and Reports

Mesenchymal stem cells attenuate liver fibrosis by suppressing Th17 cells - an experimental study

(2017) Neda Milosavljevic et al.   TRANSPLANT INTERNATIONAL

Mesenchymal stem cell therapy in type 2 diabetes mellitus

(2017) Li Zang et al.   Diabetology & Metabolic Syndrome

Adipose-derived mesenchymal stem cells modulate CD14++CD16+ expression on monocytes from sepsis patients in vitro via prostaglandin E2

(2017) Guanguan Qiu et al.   Stem Cell Research & Therapy

Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles

(2017) Agnes T. Reiner et al.   Stem Cells Translational Medicine

Concise Review: Musculoskeletal Stem Cells to Treat Age-Related Osteoporosis

(2017) Jeffrey Kiernan et al.   Stem Cells Translational Medicine

Hepatocyte-like Versus Mesenchymal Stem Cells in CCl4-induced Liver Fibrosis

(2017) Suzy Fayez Ewida et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Eminent Sources of Adult Mesenchymal Stem Cells and Their Therapeutic Imminence

(2017) Dannie Macrin et al.   Stem Cell Reviews and Reports

Phase I clinical study of liver regenerative therapy for cirrhosis by intrahepatic arterial infusion of freshly isolated autologous adipose tissue-derived stromal/stem (regenerative) cell

(2017) Yoshio Sakai et al.   Regenerative Therapy

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

The PDGF system and its antagonists in liver fibrosis

(2016) Erawan Borkham-Kamphorst et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Transplantation with autologous bone marrow-derived mesenchymal stem cells for alcoholic cirrhosis: Phase 2 trial

(2016) Ki Tae Suk et al.   HEPATOLOGY

Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model

(2016) Sook In Chung et al.   JOURNAL OF HEPATOLOGY

TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis

(2016) Fengyun Xu et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Clinical-scale expansion of mesenchymal stromal cells: a large banking experience

(2016) Chantal Lechanteur et al.   Journal of Translational Medicine

Global epidemiology and burden of HCV infection and HCV-related disease

(2016) Aaron P. Thrift et al.   Nature Reviews Gastroenterology & Hepatology

Umbilical cord-derived mesenchymal stem cells alleviate liver fibrosis in rats

(2016) Ning-Li Chai et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Liver transplantation: Current status and challenges

(2016) Caroline C Jadlowiec   WORLD JOURNAL OF GASTROENTEROLOGY

Autophagy Improves the Immunosuppression of CD4+ T Cells by Mesenchymal Stem Cells Through Transforming Growth Factor-β1

(2016) Liangbin Gao et al.   Stem Cells Translational Medicine

Hepatocellular carcinoma

(2016) Josep M. Llovet et al.   Nature Reviews Disease Primers

Hepatocytes: a key cell type for innate immunity

(2015) Zhou Zhou et al.   Cellular & Molecular Immunology

Inhibition of hedgehog signaling ameliorates hepatic inflammation in mice with nonalcoholic fatty liver disease

(2015) Hyunjoo Kwon et al.   HEPATOLOGY

Stem cell therapy for inflammatory bowel disease

(2015) Kanna Nagaishi et al.   JOURNAL OF GASTROENTEROLOGY

Hepatocytes in liver injury: Victim, bystander, or accomplice in progressive fibrosis?

(2015) Thomas Tu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Adipose-derived mesenchymal stem cells inhibit activation of hepatic stellate cells in vitro and ameliorate rat liver fibrosis in vivo

(2015) Fuxiang Yu et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Efficacy of autologous mesenchymal stem cell transplantation in patients with liver cirrhosis

(2015) Murat Kantarcioglu et al.   Turkish Journal of Gastroenterology

MicroRNA125b-mediated Hedgehog signaling influences liver regeneration by chorionic plate-derived mesenchymal stem cells

(2015) Jeongeun Hyun et al.   Scientific Reports

Tonsil-derived Mesenchymal Stem Cells Ameliorate CCl4–induced Liver Fibrosis in Mice via Autophagy Activation

(2015) Minhwa Park et al.   Scientific Reports

Tumor necrosis factor-inducible gene 6 promotes liver regeneration in mice with acute liver injury

(2015) Sihyung Wang et al.   Stem Cell Research & Therapy

Human Adipose-Derived Mesenchymal Stem Cells in Cell Therapy: Safety and Feasibility in Different "Hospital Exemption" Clinical Applications

(2015) Sophie Vériter et al.   PLoS One

Overexpression of TGF-β1 enhances chondrogenic differentiation and proliferation of human synovium-derived stem cells

(2014) Yong Il Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis

(2014) Ali A Mokdad et al.   BMC Medicine

Randomized trial of autologous bone marrow mesenchymal stem cells transplantation for hepatitis B virus cirrhosis: Regulation of Treg/Th17 cells

(2014) Lanman Xu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation

(2014) Woosook Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human adipose–derived mesenchymal stem cells attenuate liver ischemia–reperfusion injury and promote liver regeneration

(2014) Reza F. Saidi et al.   SURGERY

Secretion of immunoregulatory cytokines by mesenchymal stem cells

(2014) Dobroslav Kyurkchiev   World Journal of Stem Cells

Embryonic and Induced Pluripotent Stem Cells: Understanding, Creating, and Exploiting the Nano-Niche for Regenerative Medicine

(2013) Emmajayne Kingham et al.   ACS Nano

Randomized placebo-controlled trial of mesenchymal stem cell transplantation in decompensated cirrhosis

(2013) Mehdi Mohamadnejad et al.   LIVER INTERNATIONAL

Histological improvement following administration of autologous bone marrow-derived mesenchymal stem cells for alcoholic cirrhosis: a pilot study

(2013) Yoon Ok Jang et al.   LIVER INTERNATIONAL

Role of Oxidative Stress and Molecular Changes in Liver Fibrosis: A Review

(2012) V. Sanchez-Valle et al.   CURRENT MEDICINAL CHEMISTRY

Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients

(2012) Zheng Zhang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

HGF and Direct Mesenchymal Stem Cells Contact Synergize to Inhibit Hepatic Stellate Cells Activation through TLR4/NF-kB Pathway

(2012) Pei-pei Wang et al.   PLoS One

Analysis of Tissues Following Mesenchymal Stromal Cell Therapy in Humans Indicates Limited Long-Term Engraftment and No Ectopic Tissue Formation

(2012) L. von Bahr et al.   STEM CELLS

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Liver Fibrosis

(2012) Tingfen Li et al.   STEM CELLS AND DEVELOPMENT

Human Mesenchymal Stem Cell Transfusion Is Safe and Improves Liver Function in Acute-on-Chronic Liver Failure Patients

(2012) Ming Shi et al.   Stem Cells Translational Medicine

The antiapoptotic effect of mesenchymal stem cell transplantation on ischemic myocardium is enhanced by anoxic preconditioning

(2011) Aina He et al.   CANADIAN JOURNAL OF CARDIOLOGY

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

(2011) Michael Quante et al.   CANCER CELL

Clinical and laboratory evaluation of patients with end-stage liver cell failure injected with bone marrow-derived hepatocyte-like cells

(2011) Mohie-Eldeen M. Amer et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Reactive Oxygen Species Released from Hypoxic Hepatocytes Regulates MMP-2 Expression in Hepatic Stellate Cells

(2011) Jing Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of Notch1 signaling by marrow-derived mesenchymal stem cells through cell–cell contact inhibits proliferation of hepatic stellate cells

(2011) Si Chen et al.   LIFE SCIENCES

Phase II Trial: Undifferentiated Versus Differentiated Autologous Mesenchymal Stem Cells Transplantation in Egyptian Patients with HCV Induced Liver Cirrhosis

(2011) Mervat El-Ansary et al.   Stem Cell Reviews and Reports

Myogenic differentiation of mesenchymal stem cells co-cultured with primary myoblasts

(2010) Justus P. Beier et al.   CELL BIOLOGY INTERNATIONAL

Signals from dying hepatocytes trigger growth of liver progenitors

(2010) Y. Jung et al.   GUT

Hedgehog signaling in the liver

(2010) Alessia Omenetti et al.   JOURNAL OF HEPATOLOGY

Hepatocyte Death: A Clear and Present Danger

(2010) Harmeet Malhi et al.   PHYSIOLOGICAL REVIEWS

Mesenchymal stem cell therapy: Two steps forward, one step back

(2010) James Ankrum et al.   TRENDS IN MOLECULAR MEDICINE

Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetes

(2009) L. Vija et al.   DIABETES & METABOLISM

Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I–II clinical trial

(2009) Pedram Kharaziha et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Role for hedgehog pathway in regulating growth and function of invariant NKT cells

(2009) Wing-Kin Syn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inhibition of hepatic stellate cells proliferation by mesenchymal stem cells and the possible mechanisms

(2009) Jing Wang et al.   HEPATOLOGY RESEARCH

Hepatic stellate cell: A star cell in the liver

(2009) Luigi Atzori et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nerve growth factor-mediated paracrine regulation of hepatic stellate cells by multipotent mesenchymal stromal cells

(2009) Nan Lin et al.   LIFE SCIENCES

Is the intravascular administration of mesenchymal stem cells safe?

(2009) Dario Furlani et al.   MICROVASCULAR RESEARCH

Liver architecture, cell function, and disease

(2009) Hiromi Ishibashi et al.   Seminars in Immunopathology

In vitro hepatic differentiation of human bone marrow mesenchymal stem cells under differential exposure to liver-specific factors

(2009) Mihaela Chivu et al.   Translational Research

Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage

(2008) William S. Blaner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

PDGF, TGF- , and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages

(2008) F. Ng et al.   BLOOD

Immunomodulation by Mesenchymal Stem Cells: A Potential Therapeutic Strategy for Type 1 Diabetes

(2008) R. Abdi et al.   DIABETES

Accumulation of Hedgehog-Responsive Progenitors Parallels Alcoholic Liver Disease Severity in Mice and Humans

(2008) Youngmi Jung et al.   GASTROENTEROLOGY

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET

Mesenchymal Stem Cells Derived from Human Adipose Tissues Favor Tumor Cell Growth in vivo

(2008) Ji Min Yu et al.   STEM CELLS AND DEVELOPMENT