Article
Biochemistry & Molecular Biology
Giannis Maimaris, Andri Christodoulou, Niovi Santama, Carsten Werner Lederer
Summary: TMEM147 plays a crucial role in regulating various cellular activities by controlling the endoplasmic reticulum, impacting both nuclear and cytoplasmic processes. Its functions include regulating the production and transport of multipass membrane proteins, neuronal signaling, nuclear morphology, and cholesterol synthesis among others. This protein also interacts with a wide range of cellular proteins and pathways, highlighting its diverse and essential roles in cellular function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Logesvaran Krshnan, Wingyan Skyla Siu, Michael Van de Weijer, Daniel Hayward, Elena Navarro Guerrero, Ulrike Gruneberg, Pedro Carvalho
Summary: This article describes a mechanism of regulated degradation of SUN2, an inner nuclear membrane protein. The study found that the binding of SUN2 to the ubiquitin ligase SCF beta TrCP is regulated by Casein Kinase 2 and CTDNEP1. The degradation of SUN2 via this mechanism is important for maintaining normal nuclear architecture.
Article
Cell Biology
Yiming Xu, Weilin Sang, Yiming Zhong, Song Xue, Mengkai Yang, Cong Wang, Haiming Lu, Renchun Huan, Xinjie Mao, Libo Zhu, Chuanglong He, Jinzhong Ma
Summary: The study showed that CoCrMo nanoparticles induced ferroptosis in osteoblasts and led to particle-induced osteolysis (PIO) in animal models. Blocking ferroptosis with inhibitor Ferrostatin-1 reduced particle-induced ferroptosis significantly. CoNPs downregulated the expression of Nrf2 in osteoblasts, while overexpression of Nrf2 or using Nrf2 activator suppressed ferroptosis. In PIO animal models, combined use of Ferrostatin-1 and Oltipraz ameliorated ferroptosis and osteolysis severity.
CELL PROLIFERATION
(2021)
Article
Cell Biology
Fernando Hernandez-Sanchez, Leonardo Peraza-Reyes
Summary: Eukaryotic cell development involves precise regulation of organelles to adapt to changing requirements. Meiotic development involves the formation and dynamics of distinct intracellular membrane compartments, and plays important roles in organelle segregation, quality control, and cell rejuvenation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Bisa Andov, Aurelia Boulaflous-Stevens, Charlotte Pain, Sarah Mermet, Maxime Voisin, Camille Charrondiere, Emmanuel Vanrobays, Sylvie Tutois, David E. Evans, Verena Kriechbaumer, Christophe Tatout, Katja Graumann
Summary: Mid-SUN proteins are a type III membrane protein family of ancient origin that have been overlooked, but are widely present in plants, animals, and fungi. Previous studies have shown their involvement in the nuclear envelope and endoplasmic reticulum (ER) functions in plants. This study used high-resolution confocal light microscopy to investigate the localization of SUN3 and SUN4 in the perinuclear region, explore their topology, and study their impact on ER morphology. The interaction between SUN3 and the ER membrane-bound transcription factor maMYB further supports the role of SUN3 in the ER. These findings highlight the importance of mid-SUNs as functional components of the ER and outer nuclear membrane.
Article
Cell Biology
Nuria Ferrandiz, Laura Downie, Georgina P. Starling, Stephen J. Royle
Summary: Misalignment of chromosomes during mitosis can result in chromosome missegregation and the formation of micronuclei, which are associated with cancer. A study showed that chromosomes located beyond the exclusion zone become ensheathed in multiple layers of endomembranes, leading to delayed mitosis and increased frequency of chromosome missegregation and micronucleus formation. Clearance of endomembranes can rescue those chromosomes that were destined for missegregation, indicating that endomembranes promote the missegregation of misaligned chromosomes outside the exclusion zone and pose a risk factor for aneuploidy.
JOURNAL OF CELL BIOLOGY
(2022)
Review
Plant Sciences
Verena Iven, Isabeau Vanbuel, Sophie Hendrix, Ann Cuypers
Summary: Cadmium uptake inhibits plant growth and disturbs physiological processes by affecting the cellular redox environment. Glutathione, an antioxidant, plays a role in redox homeostasis but can be depleted due to its involvement in Cd chelation. This triggers a signaling cascade involving the phytohormone ethylene, organellar stress signaling, and autophagy, leading to acclimation and plant tolerance to Cd stress.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Microbiology
Anika Groth, Kerstin Schmitt, Oliver Valerius, Britta Herzog, Stefanie Poeggeler
Summary: The STRIPAK complex is essential for vegetative growth, fruiting-body development, and hyphal fusion in the filamentous fungus Sordaria macrospora. The recently identified protein SCI1 and transmembrane nucleoporin SmPOM33 play important roles in potential nuclear anchoring and cellular localization of the SmSTRIPAK complex. Results from pulldown experiments and LC/MS analysis revealed enrichment of ER membrane proteins associated with various cellular processes. The deletion mutant of SmPOM33 did not significantly affect the growth of S. macrospora, suggesting its potential role in SmSTRIPAK anchoring.
Article
Biochemistry & Molecular Biology
Richa Maheshwari, Mohammad M. Rahman, Seth Drey, Megan Onyundo, Gunar Fabig, Michael A. Q. Martinez, David Q. Matus, Thomas Mueller-Reichert, Orna Cohen-Fix
Summary: In this study, using volume electron microscopy, researchers discovered that centrosomes in the Caenorhabditis elegans early embryo are surrounded by a three-dimensional membrane reticulum called the centriculum. The formation of the centriculum depends on the presence of centrosomes and microtubules. Moreover, the centriculum affects the function of centrosomes.
Review
Cell Biology
Kouminin Kanwore, Piniel Alphayo Kambey, Xiao-Xiao Guo, Ayanlaja Abdulrahman Abiola, Ying Xia, Dianshuai Gao
Summary: The external and internal factors of the cell play a critical role in glioma initiation, with multiple factors and molecules implicated in brain cancer progression. Glioma stem cells have been identified as the origin, and oncogene overexpression is involved in tumorigenesis, maintenance, and progression. Additionally, defects in cell organelles contribute to cancer cell resistance to drugs, apoptosis, and immune cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Kasim Khan, Olivier Van Aken
Summary: The article uses phylogenetics to track the evolutionary origins of factors involved in plant mitochondrial retrograde regulation (MRR). It shows that the transition to land was a major driving force for developing plant MRR pathways.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Multidisciplinary Sciences
Ulises Diaz, Wallace Marshall, Blake Riggs
Summary: Modern quantitative live cell imaging techniques are important for exploring cell biology, but current cell culture model systems have limitations. There is a need for a scalable high-throughput imaging system. This study describes a method for simultaneously acquiring multiple videos of Drosophila melanogaster embryos using a high-content image analyzer.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Review
Plant Sciences
Chieko Goto, Ikuko Hara-Nishimura, Kentaro Tamura
Summary: The shape of plant nuclei varies among different species, tissues, and cell types, regulated by several nuclear envelope proteins. These proteins not only influence nuclear shape but also participate in nuclear and cellular functions such as maintenance of chromatin structure, gene expression, and plant growth.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Multidisciplinary Sciences
Sana A. Bentebbal, Bakhita R. Meqbel, Anna Salter, Victoria Allan, Brian Burke, Henning F. Horn
Summary: KASH5 is a recently discovered protein involved in meiosis. A variant in human KASH5 (L535Q) has been linked to male infertility and azoospermia, possibly due to its effect on protein subcellular localization.
SCIENTIFIC REPORTS
(2021)
Review
Plant Sciences
Gilles Dupouy, Yihan Dong, Etienne Herzog, Marie-Edith Chaboute, Alexandre Berr
Summary: The nucleus is a central organelle in eukaryotic cells that undergoes dynamic structural changes during cellular processes. This review focuses on recent data obtained in plants, particularly in response to mechanical stress, and highlights the similarities and differences between animal and plant cells in terms of nuclear envelope dynamics and functional impacts.
Article
Biochemistry & Molecular Biology
Ulrike Bechtold, Christopher A. Penfold, Dafyd J. Jenkins, Roxane Legaie, Jonathan D. Moore, Tracy Lawson, Jack S. A. Matthews, Silvere R. M. Vialet-Chabrand, Laura Baxter, Sunitha Subramaniam, Richard Hickman, Hannah Florance, Christine Sambles, Deborah L. Salmon, Regina Feil, Laura Bowden, Claire Hill, Neil R. Baker, John E. Lunn, Baerbel Finkenstaedt, Andrew Mead, Vicky Buchanan-Wollaston, Jim Beynon, David A. Rand, David L. Wild, Katherine J. Denby, Sascha Ott, Nicholas Smirnoff, Philip M. Mullineaux
Article
Multidisciplinary Sciences
Marino Exposito-Rodriguez, Pierre Philippe Laissue, Gabriel Yvon-Durocher, Nicholas Smirnoff, Philip M. Mullineaux
NATURE COMMUNICATIONS
(2017)
Meeting Abstract
Biochemistry & Molecular Biology
Calero Nieves, Manuel Fernandez Alejandro, Maria Rodriguez-Serrano, Ana M. Laureano-Marin, Marino Exposito, Philip Mullineaux, Cecilia Gotor, Maria C. Romero-Puertas, Adela Olmedilla, Luisa M. Sandalio
FREE RADICAL BIOLOGY AND MEDICINE
(2018)
Review
Biochemistry & Molecular Biology
Philip M. Mullineaux, Marino Exposito-Rodriguez, Pierre Philippe Laissue, Nicholas Smirnoff
FREE RADICAL BIOLOGY AND MEDICINE
(2018)
Review
Plant Sciences
Ulrike Bechtold, John N. Ferguson, Philip M. Mullineaux
JOURNAL OF EXPERIMENTAL BOTANY
(2018)
Article
Plant Sciences
Waleed S. Albihlal, Irabonosi Obomighie, Thomas Blein, Ramona Persad, Igor Chernukhin, Martin Crespi, Ulrike Bechtold, Philip M. Mullineaux
JOURNAL OF EXPERIMENTAL BOTANY
(2018)
Article
Endocrinology & Metabolism
Elizabeth Dickinson, Martin J. Rusilowicz, Michael Dickinson, Adrian J. Charlton, Ulrike Bechtold, Philip M. Mullineaux, Julie Wilson
Article
Plant Sciences
Tracy Lawson, Phillip A. Davey, Steven A. Yates, Ulrike Bechtold, Mohammed Baeshen, Nabih Baeshen, Mohammed Z. Mutwakil, Jamal Sabir, Neil R. Baker, Philip M. Mullineaux
Article
Plant Sciences
Annette C. Ryan, C. Nicholas Hewitt, Malcolm Possell, Claudia E. Vickers, Anna Purnell, Philip M. Mullineaux, William J. Davies, Ian C. Dodd
Article
Plant Sciences
Nieves Calero-Munoz, Marino Exposito-Rodriguez, Aurelio M. Collado-Arenal, Maria Rodriguez-Serrano, Ana M. Laureano-Marin, M. Estrella Santamaria, Cecilia Gotor, Isabel Diaz, Philip M. Mullineaux, Maria C. Romero-Puertas, Adela Olmedilla, Luisa M. Sandalio
PLANT CELL AND ENVIRONMENT
(2019)
Review
Biology
Philip M. Mullineaux, Marino Exposito-Rodriguez, Pierre Philippe Laissue, Nicholas Smirnoff, Eunsook Park
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Soyanni Holness, Ulrike Bechtold, Phillip Mullineaux, Giovanna Serino, Paola Vittorioso
Summary: In plants, priming allows for a more rapid and robust response to recurring stresses. However, less is known about how priming due to one stress can help plants cope with subsequent different stresses. This study investigated the priming effects in Arabidopsis plants subjected to high light (HL) stress followed by drought (D) stress, and found that HL can mediate transcriptional priming and enhance plant responses to stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Marino Exposito-Rodriguez, Philippe P. Laissue, Patricia E. Lopez-Calcagno, Philip M. Mullineaux, Christine A. Raines, Andrew J. Simkin