Enhancement of Phytosterol and Triterpenoid Production in Plant Hairy Root Cultures—Simultaneous Stimulation or Competition?

Alterations in oleanolic acid and sterol content in marigold (Calendula officinalis) hairy root cultures in response to stimulation by selected phytohormones

(2021) Abdulwadood S. M. Alsoufi et al.   ACTA PHYSIOLOGIAE PLANTARUM

Two triterpene synthases from Imperata cylindrica catalyzing the formation of a pair of diastereoisomers through boat or chair cyclization

(2021) Shingo Naraki et al.   CHEMBIOCHEM

Unraveling the roles of plant specialized metabolites: using synthetic biology to design molecular biosensors

(2021) Constantine Garagounis et al.   NEW PHYTOLOGIST

Role and activity of jasmonates in plants under in vitro conditions

(2021) Monika Kamińska   PLANT CELL TISSUE AND ORGAN CULTURE

Full-Length Transcriptome Analyses of Genes Involved in Triterpenoid Saponin Biosynthesis of Psammosilene tunicoides Hairy Root Cultures With Exogenous Salicylic Acid

(2021) Lingye Su et al.   Frontiers in Genetics

Improving diosgenin production and its biosynthesis in Trigonella foenum-graecum L. hairy root cultures

(2020) Farnaz Zolfaghari et al.   INDUSTRIAL CROPS AND PRODUCTS

Hairy Root Cultures—A Versatile Tool With Multiple Applications

(2020) Noemi Gutierrez-Valdes et al.   Frontiers in Plant Science

Antioxidative enzymes activities and accumulation of steroids in hairy roots of Trigonella

(2020) Somayeh Kohsari et al.   PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS

The role of sterols in plant response to abiotic stress

(2020) Agata Rogowska et al.   PHYTOCHEMISTRY REVIEWS

To Grow or Defend? More on the Plant Cornelian Dilemma

(2020) Anne-Sophie Fiorucci   PLANT PHYSIOLOGY

Enhanced production of celastrol in Tripterygium wilfordii hairy root cultures by overexpression of TwSQS2

(2020) Bin Zhang et al.   BIOCHEMICAL ENGINEERING JOURNAL

Production of plant bioactive triterpenoid saponins: from metabolites to genes and back

(2020) Yve Verônica da Silva Magedans et al.   PHYTOCHEMISTRY REVIEWS

A hairy-root transformation protocol for Trigonella foenum-graecum L. as a tool for metabolic engineering and specialised metabolite pathway elucidation

(2020) Constantine Garagounis et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Yeast extract improved biosynthesis of astragalosides in hairy root cultures of Astragalus membranaceus

(2020) Yun Ji Park et al.   PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY

Characterization and overexpression of sterol Δ22-desaturase, a key enzyme modulates the biosyntheses of stigmasterol and withanolides in Withania somnifera (L.) Dunal

(2020) Arti Sharma et al.   PLANT SCIENCE

Enhancement of saponin accumulation in adventitious root culture of Javanese ginseng (Talinum paniculatum Gaertn.) through methyl jasmonate and salicylic acid elicitation

(2019) Faizal Ahmad et al.   AFRICAN JOURNAL OF BIOTECHNOLOGY

Effect of jasmonic acid and chitosan on triterpenoid production in Calendula officinalis hairy root cultures

(2019) Abdulwadood Shakir Mahmood Alsoufi et al.   Phytochemistry Letters

Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance

(2019) Tanya Biswas et al.   PROTOPLASMA

Influence of Selected Abiotic Factors on Triterpenoid Biosynthesis and Saponin Secretion in Marigold (Calendula officinalis L.) in Vitro Hairy Root Cultures

(2019) Abdulwadood Shakir Mahmood Alsoufi et al.   MOLECULES

Effect of biotic and abiotic elicitors on production of betulin and betulinic acid in the hairy root culture of Betula pendula Roth

(2019) Razieh Jafari Hajati et al.   PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY

Enhanced biosynthesis of triterpenoids in Centella asiatica hairy root culture by precursor feeding and elicitation

(2019) Seungeun Baek et al.   Plant Biotechnology Reports

The Chemical Structure and Bioactivity of Cycloartane-type Compounds

(2019) Wenyan Gao et al.   CURRENT ORGANIC CHEMISTRY

Source of nitrogen as a factor limiting saponin production by hairy root and suspension cultures of Calendula officinalis L.

(2018) Marek Długosz et al.   ACTA PHYSIOLOGIAE PLANTARUM

Progress on the Studies of the Key Enzymes of Ginsenoside Biosynthesis

(2018) Jin-Ling Yang et al.   MOLECULES

Response of Plant Secondary Metabolites to Environmental Factors

(2018) et al.   MOLECULES

Increased synthesis of a new oleanane-type saponin in hairy roots of marigold (Calendula officinalis) after treatment with jasmonic acid

(2018) Michał Markowski et al.   NATURAL PRODUCT RESEARCH

Elicitation Enhanced the Yield of Glycyrrhizin and Antioxidant Activities in Hairy Root Cultures of Glycyrrhiza glabra L.

(2018) Mrinalini Srivastava et al.   JOURNAL OF PLANT GROWTH REGULATION

The Increase of Triterpene Saponin Production Induced by Trans-Anethole in Hairy Root Cultures of Panax quinquefolium

(2018) Ewa Kochan et al.   MOLECULES

The never ending story of rol genes: a century after

(2017) Maria Luisa Mauro et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Secondary metabolism of pharmaceuticals in the plant in vitro cultures: strategies, approaches, and limitations to achieving higher yield

(2017) Tasiu Isah et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Modeling of Dolichol Mass Spectra Isotopic Envelopes as a Tool to Monitor Isoprenoid Biosynthesis

(2017) Adam Jozwiak et al.   PLANT PHYSIOLOGY

Bioactivity of Phytosterols and Their Production in Plant in Vitro Cultures

(2016) Begoña Miras-Moreno et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Elicitation, an Effective Strategy for the Biotechnological Production of Bioactive High-Added Value Compounds in Plant Cell Factories

(2016) Karla Ramirez-Estrada et al.   MOLECULES

Effects of oligosaccharide elicitors from endophyitc Fusarium oxysporum Dzf17 on diosgenin accumulation in Dioscorea zingiberensis seedling cultures

(2016) Li Peiqin et al.   Journal of Medicinal Plants Research

Triterpene and Flavonoid Biosynthesis and Metabolic Profiling of Hairy Roots, Adventitious Roots, and Seedling Roots of Astragalus membranaceus

(2015) Yun Ji Park et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hairy root biotechnology—indicative timeline to understand missing links and future outlook

(2015) Shakti Mehrotra et al.   PROTOPLASMA

A Decade of Molecular Understanding of Withanolide Biosynthesis and In vitro Studies in Withania somnifera (L.) Dunal: Prospects and Perspectives for Pathway Engineering

(2015) Niha Dhar et al.   Frontiers in Plant Science

Enhanced Biosynthesis of Withanolides by Elicitation and Precursor Feeding in Cell Suspension Culture of Withania somnifera (L.) Dunal in Shake-Flask Culture and Bioreactor

(2014) Ganeshan Sivanandhan et al.   PLoS One

Enhanced Triterpene Accumulation in Panax ginseng Hairy Roots Overexpressing Mevalonate-5-pyrophosphate Decarboxylase and Farnesyl Pyrophosphate Synthase

(2014) Yong-Kyoung Kim et al.   ACS Synthetic Biology

Enhanced Accumulation of Phytosterol and Triterpene in Hairy Root Cultures of Platycodon grandiflorum by Overexpression of Panax ginseng 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase

(2013) Yong-Kyoung Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biologyin vivoandin vitro

(2013) Tessa Moses et al.   NEW PHYTOLOGIST

Structural and biochemical perspectives in plant isoprenoid biosynthesis

(2013) Sangita Kumari et al.   PHYTOCHEMISTRY REVIEWS

Plant chemical defense: at what cost?

(2013) Elizabeth H. Neilson et al.   TRENDS IN PLANT SCIENCE

Sugar availability modulates polyisoprenoid and phytosterol profiles in Arabidopsis thaliana hairy root culture

(2012) Adam Jozwiak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hairy root cultures: A suitable biological system for studying secondary metabolic pathways in plants

(2012) Poojadevi Sharma et al.   ENGINEERING IN LIFE SCIENCES

Genetically transformed roots: from plant disease to biotechnological resource

(2012) Milen I. Georgiev et al.   TRENDS IN BIOTECHNOLOGY

Production and metabolic engineering of bioactive substances in plant hairy root culture

(2011) Mei-Liang Zhou et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Nitric oxide elicitation for secondary metabolite production in cultured plant cells

(2011) Ben Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Overexpression of the Arabidopsis thaliana squalene synthase gene in Withania coagulans hairy root cultures

(2011) M. H. Mirjalili et al.   BIOLOGIA PLANTARUM

Natural plant genetic engineer Agrobacterium rhizogenes: role of T-DNA in plant secondary metabolism

(2011) Sheela Chandra   BIOTECHNOLOGY LETTERS

Engineering secondary metabolite production in hairy roots

(2011) Sheela Chandra et al.   PHYTOCHEMISTRY REVIEWS

A raison d’être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?

(2011) Andréa Hemmerlin et al.   PROGRESS IN LIPID RESEARCH

Production of Plant Bioactive Triterpenoid Saponins: Elicitation Strategies and Target Genes to Improve Yields

(2010) Anna C. A. Yendo et al.   MOLECULAR BIOTECHNOLOGY

Upregulation of phytosterol and triterpene biosynthesis in Centella asiatica hairy roots overexpressed ginseng farnesyl diphosphate synthase

(2010) Ok Tae Kim et al.   PLANT CELL REPORTS

The multiplicity of hairy root cultures: Prolific possibilities

(2010) Nadia N. Ono et al.   PLANT SCIENCE

Gene regulation patterns in triterpene biosynthetic pathway driven by overexpression of squalene synthase and methyl jasmonate elicitation in Bupleurum falcatum

(2010) Young Soon Kim et al.   PLANTA

Biotransformation of triterpenes

(2010) Kai Muffler et al.   PROCESS BIOCHEMISTRY

Antisense Suppression of Cycloartenol Synthase Results in Elevated Ginsenoside Levels in Panax ginseng Hairy Roots

(2009) Yanlong Liang et al.   PLANT MOLECULAR BIOLOGY REPORTER

Progress in understanding of ginsenoside biosynthesis

(2008) Y. Liang et al.   PLANT BIOLOGY

The Arabidopsis thaliana Type I Isopentenyl Diphosphate Isomerases Are Targeted to Multiple Subcellular Compartments and Have Overlapping Functions in Isoprenoid Biosynthesis

(2008) M. A. Phillips et al.   PLANT CELL