Selection and Modelling of a New Single-Domain Intrabody Against TDP-43

Scalable molecular dynamics on CPU and GPU architectures with NAMD

(2020) James C. Phillips et al.   JOURNAL OF CHEMICAL PHYSICS

The role of TDP-43 mislocalization in amyotrophic lateral sclerosis

(2020) Terry R. Suk et al.   Molecular Neurodegeneration

PAINT using proteins: A new brush for super‐resolution artists

(2020) Curran Oi et al.   PROTEIN SCIENCE

An improved yeast surface display platform for the screening of nanobody immune libraries

(2019) Tomasz Uchański et al.   Scientific Reports

Nanobody Detection of Standard Fluorescent Proteins Enables Multi-Target DNA-PAINT with High Resolution and Minimal Displacement Errors

(2019) Shama Sograte-Idrissi et al.   Cells

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

(2019) Archana Prasad et al.   Frontiers in Molecular Neuroscience

RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43

(2019) Elsa Zacco et al.   JOURNAL OF MOLECULAR BIOLOGY

Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology

(2019) Silvia Pozzi et al.   JOURNAL OF CLINICAL INVESTIGATION

AbRSA: A robust tool for antibody numbering

(2019) Lei Li et al.   PROTEIN SCIENCE

RRM adjacent TARDBP mutations disrupt RNA binding and enhance TDP-43 proteinopathy

(2019) Han-Jou Chen et al.   BRAIN

Structure and development of single domain antibodies as modules for therapeutics and diagnostics

(2019) Robert J Hoey et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Targeted protein degradation: expanding the toolbox

(2019) Matthieu Schapira et al.   NATURE REVIEWS DRUG DISCOVERY

Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody

(2019) Hiroki Akiba et al.   Scientific Reports

Optimizing intracellular antibodies (intrabodies/nanobodies) to treat neurodegenerative disorders

(2019) Anne Messer et al.   NEUROBIOLOGY OF DISEASE

Pathomechanisms of TDP-43 in neurodegeneration

(2018) Ju Gao et al.   JOURNAL OF NEUROCHEMISTRY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor

(2018) Sahil Gulati et al.   Nature Communications

Super-resolution microscopy demystified

(2018) Lothar Schermelleh et al.   NATURE CELL BIOLOGY

Targeting the Post-translational Proteome with Intrabodies

(2018) Antonino Cattaneo et al.   TRENDS IN BIOTECHNOLOGY

The ClusPro web server for protein–protein docking

(2017) Dima Kozakov et al.   Nature Protocols

Assessment of antibody library diversity through next generation sequencing and technical error compensation

(2017) Marco Fantini et al.   PLoS One

Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state

(2017) Iebe Rossey et al.   Nature Communications

The TDP-43 N-terminal domain structure at high resolution

(2016) Miguel Mompeán et al.   FEBS Journal

A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior

(2016) Tobias Kromann-Hansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies

(2016) Ian R. A. Mackenzie et al.   JOURNAL OF NEUROCHEMISTRY

The frontotemporal dementia-motor neuron disease continuum

(2016) James R Burrell et al.   LANCET

ABodyBuilder: Automated antibody structure prediction with data–driven accuracy estimation

(2016) Jinwoo Leem et al.   mAbs

Optimization of dilution refolding conditions for a camelid single domain antibody against human beta-2-microglobulin

(2016) Xiaobo Bao et al.   PROTEIN EXPRESSION AND PURIFICATION

Motor neuron disease-frontotemporal dementia: a clinical continuum

(2015) Emma Devenney et al.   Expert Review of Neurotherapeutics

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

(2015) Jumin Lee et al.   Journal of Chemical Theory and Computation

Motor neuron disease-frontotemporal dementia: a clinical continuum

(2015) Emma Devenney et al.   Expert Review of Neurotherapeutics

TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies

(2015) Joery Goossens et al.   Acta Neuropathologica Communications

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain

(2014) Mauricio Budini et al.   HUMAN MOLECULAR GENETICS

Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum

(2014) Giovanni Meli et al.   Nature Communications

OpenStructure: an integrated software framework for computational structural biology

(2013) M. Biasini et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Optimized atomic statistical potentials: assessment of protein interfaces and loops

(2013) Guang Qiang Dong et al.   BIOINFORMATICS

The Role of Aromatic–Aromatic Interactions in Strand–Strand Stabilization of β-Sheets

(2013) Ivan L. Budyak et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43

(2013) Peter J Lukavsky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intrabodies as Neuroprotective Therapeutics

(2013) Anne Messer et al.   Neurotherapeutics

Ab initiostructure prediction of the antibody hypervariable H3 loop

(2013) Kai Zhu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The Structural Basis of Antibody-Antigen Recognition

(2013) Inbal Sela-Culang et al.   Frontiers in Immunology

Analysis of the antibody structure based on high-resolution crystallographic studies

(2011) Jo Erika T. Narciso et al.   New Biotechnology

TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies

(2011) Todd J. Cohen et al.   TRENDS IN MOLECULAR MEDICINE

Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis

(2010) S. J. Barmada et al.   JOURNAL OF NEUROSCIENCE

Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis

(2009) G. S. Pesiridis et al.   HUMAN MOLECULAR GENETICS

Direct in Vivo Intracellular Selection of Conformation-sensitive Antibody Domains Targeting Alzheimer's Amyloid-β Oligomers

(2009) Giovanni Meli et al.   JOURNAL OF MOLECULAR BIOLOGY

FREAD revisited: Accurate loop structure prediction using a database search algorithm

(2009) Yoonjoo Choi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation

(2008) Matthew J. Winton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural determinants of the cellular localization and shuttling of TDP-43

(2008) Y. M. Ayala et al.   JOURNAL OF CELL SCIENCE

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease

(2007) Emanuele Buratti   Frontiers in Bioscience-Landmark