Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor

A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis

(2017) Eshan Ghosh et al.   Nature Nanotechnology

Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism

(2017) Sahil Gulati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex

(2017) Van Son Nguyen et al.   Nature Microbiology

An effective thiol-reactive probe for differential scanning fluorimetry with a standard real-time polymerase chain reaction device

(2016) Lukas Hofmann et al.   ANALYTICAL BIOCHEMISTRY

i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4

(2016) Katherine Griffiths et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

Spontaneous Synaptic Activation of Muscarinic Receptors by Striatal Cholinergic Neuron Firing

(2016) Aphroditi A. Mamaligas et al.   NEURON

Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family

(2015) Eric R Geertsma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family

(2015) Eric R Geertsma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

Targeted delivery of protein and gene medicines through the blood-brain barrier

(2015) WM Pardridge   CLINICAL PHARMACOLOGY & THERAPEUTICS

A general protocol for the generation of Nanobodies for structural biology

(2014) Els Pardon et al.   Nature Protocols

Biased ligands at G-protein-coupled receptors: promise and progress

(2014) Jonathan D. Violin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Dissociated GαGTPand Gβγ Protein Subunits Are the Major Activated Form of Heterotrimeric Gi/o Proteins

(2013) Alexey Bondar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Overlapped and Noisy Hydrogen/Deuterium Exchange Mass Spectra

(2013) Miklos Guttman et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Cell Penetrable Humanized-VH/VHH That Inhibit RNA Dependent RNA Polymerase (NS5B) of HCV

(2012) Kanyarat Thueng-in et al.   PLoS One

Understanding Molecular Recognition by G protein    Subunits on the Path to Pharmacological Targeting

(2011) Y. Lin et al.   MOLECULAR PHARMACOLOGY

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Therapeutic antibodies directed at G protein-coupled receptors

(2010) Catherine J. Hutchings et al.   mAbs

CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

(2010) S. Jahnichen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers

(2009) Bettye Hollins et al.   CELLULAR SIGNALLING

Engineering of recombinant crystallization chaperones

(2009) Shohei Koide   CURRENT OPINION IN STRUCTURAL BIOLOGY

A Self-Scaffolding Model for G Protein Signaling

(2009) Jingting Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

NMR analysis of G-protein    subunit complexes reveals a dynamic G -G   subunit interface and multiple protein recognition modes

(2009) A. V. Smrcka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY