Selenium-Catalyzed Reduction of Hydroperoxides in Chemistry and Biology

Effect of Methylmercury Binding on the Peroxide-Reducing Potential of Cysteine and Selenocysteine

(2021) Andrea Madabeni et al.   INORGANIC CHEMISTRY

Modeling the Catalytic Cycle of Glutathione Peroxidase by Nuclear Magnetic Resonance Spectroscopic Analysis of Selenocysteine Selenenic Acids

(2021) Ryosuke Masuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Methylmercury Can Facilitate the Formation of Dehydroalanine in Selenoenzymes: Insight from DFT Molecular Modeling

(2021) Pablo Andrei Nogara et al.   CHEMICAL RESEARCH IN TOXICOLOGY

In silico Studies on the Interaction between Mpro and PLpro From SARS‐CoV‐2 and Ebselen, its Metabolites and Derivatives

(2021) Pablo Andrei Nogara et al.   Molecular Informatics

Mechanistic Insight into SARS-CoV-2 Mpro Inhibition by Organoselenides: The Ebselen Case Study

(2021) Andrea Madabeni et al.   Applied Sciences-Basel

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections

(2020) Helmut Sies et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phenylselanyl Group Incorporation for “Glutathione Peroxidase-Like” Activity Modulation

(2020) Magdalena Obieziurska-Fabisiak et al.   MOLECULES

A dual attack on the peroxide bond. The common principle of peroxidatic cysteine or selenocysteine residues

(2020) M. Dalla Tiezza et al.   Redox Biology

Crystallization and structure of ebselen bound to Cys141 of human inositol monophosphatase

(2020) Gareth D. Fenn et al.   Acta Crystallographica Section F-Structural Biology Communications

Proton Transfer and S N 2 Reactions as Steps of Fast Selenol and Thiol Oxidation in Proteins: A Model Molecular Study Based on GPx

(2020) Marco Dalla Tiezza et al.   ChemPlusChem

Looking Back at the Early Stages of Redox Biology

(2020) Leopold Flohé   Antioxidants

Ebselen has lithium-like effects on central 5-HT2A receptor function

(2018) I Antoniadou et al.   BRITISH JOURNAL OF PHARMACOLOGY

Key steps and intermediates in the catalytic mechanism for the reduction of peroxides by the antioxidant ebselen

(2018) Kai N. Sands et al.   TETRAHEDRON

Organodiselenides: organic catalysis and drug design learning from glutathione peroxidase

(2018) Marco Dalla Tiezza et al.   CURRENT ORGANIC CHEMISTRY

Structural snapshots of OxyR reveal the peroxidatic mechanism of H2O2 sensing

(2018) Brandán Pedre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organoselenium-Catalyzed Oxidative C═C Bond Cleavage: A Relatively Green Oxidation of Alkenes into Carbonyl Compounds with Hydrogen Peroxide

(2017) Tingting Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Selenium-Catalyzed Oxacyclization of Alkenoic Acids and Alkenols

(2017) Luca Sancineto et al.   Asian Journal of Organic Chemistry

Selective continuous flow synthesis of hydroxy lactones from alkenoic acids

(2017) Bruno Cerra et al.   Reaction Chemistry & Engineering

Why Nature Chose Selenium

(2016) Hans J. Reich et al.   ACS Chemical Biology

Addition–Elimination or Nucleophilic Substitution? Understanding the Energy Profiles for the Reaction of Chalcogenolates with Dichalcogenides

(2016) Marco Bortoli et al.   Journal of Chemical Theory and Computation

Insights on selenium and tellurium diaryldichalcogenides: A benchmark DFT study

(2016) Francesco Zaccaria et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Cytosolic thiol switches regulating basic cellular functions: GAPDH as an information hub?

(2015) Thomas Hildebrandt et al.   BIOLOGICAL CHEMISTRY

Peroxidase Activity of Organic Selenides: Mechanistic Insights from Quantum Chemistry

(2015) Lando P. Wolters et al.   CURRENT ORGANIC CHEMISTRY

Understanding mammalian glutathione peroxidase 7 in the light of its homologs

(2015) Matilde Maiorino et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selenocysteine oxidation in glutathione peroxidase catalysis: an MS-supported quantum mechanics study

(2015) Laura Orian et al.   FREE RADICAL BIOLOGY AND MEDICINE

Developments in Synthetic Application of Selenium(IV) Oxide and Organoselenium Compounds as Oxygen Donors and Oxygen-Transfer Agents

(2015) Jacek Młochowski et al.   MOLECULES

“The green side of the moon: ecofriendly aspects of organoselenium chemistry”

(2014) Stefano Santoro et al.   RSC Advances

Modeling the Glutathione Peroxidase-Like Activity of a Cyclic Seleninate by DFT and Solvent-Assisted Proton Exchange

(2013) Craig A. Bayse et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Organochalcogen peroxidase mimetics as potential drugs: a long story of a promise still unfulfilled

(2013) Laura Orian et al.   FREE RADICAL BIOLOGY AND MEDICINE

A highly efficient, green and recoverable catalytic system for the epoxidation of fatty esters and biodiesel with H2O2

(2012) Miriam De Torres et al.   APPLIED CATALYSIS A-GENERAL

Loss of the Oxidative Stress Sensor NPGPx Compromises GRP78 Chaperone Activity and Induces Systemic Disease

(2012) Pei-Chi Wei et al.   MOLECULAR CELL

Polarizable continuum model

(2012) Benedetta Mennucci   Wiley Interdisciplinary Reviews-Computational Molecular Science

Modeling the Mechanism of the Glutathione Peroxidase Mimic Ebselen

(2011) Sonia Antony et al.   INORGANIC CHEMISTRY

Systematic Study of the Performance of Density Functional Theory Methods for Prediction of Energies and Geometries of Organoselenium Compounds

(2011) Gavin S. Heverly-Coulson et al.   JOURNAL OF PHYSICAL CHEMISTRY A

GPx-Like Activity of Selenides and Selenoxides: Experimental Evidence for the Involvement of Hydroxy Perhydroxy Selenane as the Active Species

(2011) Vanessa Nascimento et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transition states for cysteine redox processes modeled by DFT and solvent-assisted proton exchange

(2011) Craig A. Bayse   ORGANIC & BIOMOLECULAR CHEMISTRY

Functional Mimics of Glutathione Peroxidase: Bioinspired Synthetic Antioxidants

(2010) Krishna P. Bhabak et al.   ACCOUNTS OF CHEMICAL RESEARCH

Irreversible Inactivation of Glutathione Peroxidase 1 and Reversible Inactivation of Peroxiredoxin II by H2O2 in Red Blood Cells

(2010) Chun-Seok Cho et al.   ANTIOXIDANTS & REDOX SIGNALING

Selenium and Sulfur in Exchange Reactions: A Comparative Study

(2010) Daniel Steinmann et al.   JOURNAL OF ORGANIC CHEMISTRY

Green Chemistry with Selenium Reagents: Development of Efficient Catalytic Reactions

(2009) Diana M. Freudendahl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic mechanisms and specificities of glutathione peroxidases: Variations of a basic scheme

(2009) Stefano Toppo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

(2008) Yvonne M.W. Janssen-Heininger et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of inhibition of zinc-finger transcription factors by selenium compounds ebselen and selenite

(2008) Jason L. Larabee et al.   JOURNAL OF INORGANIC BIOCHEMISTRY