Ginsenoside Rg3 Attenuates TNF-α-Induced Damage in Chondrocytes through Regulating SIRT1-Mediated Anti-Apoptotic and Anti-Inflammatory Mechanisms

Ginsenoside Rg3 attenuates angiotensin II-induced myocardial hypertrophy through repressing NLRP3 inflammasome and oxidative stress via modulating SIRT1/NF-κB pathway

(2021) Bei Ren et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

SIRT1 directly activates autophagy in human chondrocytes

(2020) Pradeep K. Sacitharan et al.   Cell Death Discovery

Ginsenoside Rg3 alleviates inflammation in a rat model of myocardial infarction via the SIRT1/NF-κB pathway

(2020) Chenchen Tu et al.   Experimental and Therapeutic Medicine

PKR Promotes Oxidative Stress and Apoptosis of Human Articular Chondrocytes by Causing Mitochondrial Dysfunction through p38 MAPK Activation—PKR Activation Causes Apoptosis in Human Chondrocytes

(2019) Ching-Hou Ma et al.   Antioxidants

20( R )-ginsenoside Rg3, a rare saponin from red ginseng, ameliorates acetaminophen-induced hepatotoxicity by suppressing PI3K/AKT pathway-mediated inflammation and apoptosis

(2018) Yan-dan Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Activation of AMPK-SIRT3 Signaling is Chondroprotective by Preserving Mitochondrial DNA Integrity and Function

(2018) Liang-Yu Chen et al.   OSTEOARTHRITIS AND CARTILAGE

Ginsenoside Rg3 suppresses mast cell–mediated allergic inflammation via mitogen-activated protein kinase signaling pathway

(2018) Ji-Ye Kee et al.   Journal of Ginseng Research

Non-clinical pharmacokinetic behavior of ginsenosides

(2018) Hyo-Joong Won et al.   Journal of Ginseng Research

PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes

(2018) Ching-Hou Ma et al.   Redox Biology

Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats

(2018) Qi-Yu Yang et al.   TOXICOLOGY

Mechanisms and Dynamics of Protein Acetylation in Mitochondria

(2016) Josue Baeza et al.   TRENDS IN BIOCHEMICAL SCIENCES

The expression of SIRT1 in articular cartilage of patients with knee osteoarthritis and its correlation with disease severity

(2016) Yusheng Li et al.   Journal of Orthopaedic Surgery and Research

The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis

(2016) Mona Dvir-Ginzberg et al.   Current Rheumatology Reports

Anti-Inflammatory Effects of Ginsenoside Rg3 via NF-κB Pathway in A549 Cells and Human Asthmatic Lung Tissue

(2016) In-Seung Lee et al.   Journal of Immunology Research

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

(2016) Angela V. Hafner et al.   Aging-US

Mitochondrial Biogenesis Is Impaired in Osteoarthritis Chondrocytes but Reversible via Peroxisome Proliferator-Activated Receptor γ Coactivator 1α

(2015) Yun Wang et al.   Arthritis & Rheumatology

Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation

(2014) Je Hyeong Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective effects of ginsenoside Rg3 on human osteoarthritic chondrocytes

(2014) Min Wook So et al.   Modern Rheumatology

A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases

(2014) Chang Ho Lee et al.   Journal of Ginseng Research

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

(2013) M. J. Rardin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma

(2013) L Wei et al.   Cell Death & Disease

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

(2012) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes

(2012) Takehiko Matsushita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

(2012) Alexander S. Hebert et al.   MOLECULAR CELL

SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes

(2012) M.-H. Moon et al.   OSTEOARTHRITIS AND CARTILAGE

Protective Effect of Ginsenoside Rb1on Hydrogen Peroxide-induced Oxidative Stress in Rat Articular Chondrocytes

(2012) Sok-Ho Kim et al.   Journal of Ginseng Research

Anti-apoptotic Activity of Ginsenoside Rb1in Hydrogen Peroxide-treated Chondrocytes: Stabilization of Mitochondria and the Inhibition of Caspase-3

(2012) Ji-Young Na et al.   Journal of Ginseng Research

SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance

(2011) F. Niederer et al.   ANNALS OF THE RHEUMATIC DISEASES

Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes

(2011) Mona Dvir-Ginzberg et al.   ARTHRITIS AND RHEUMATISM

75-kd sirtuin 1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes

(2011) Hanna Oppenheimer et al.   ARTHRITIS AND RHEUMATISM

Peroxisome Proliferator-activated Receptor-γ Coactivator-1α Controls Transcription of theSirt3Gene, an Essential Component of the Thermogenic Brown Adipocyte Phenotype

(2011) Albert Giralt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway

(2010) Viktoria Gagarina et al.   ARTHRITIS AND RHEUMATISM

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions

(2010) Norifumi Fujita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders

(2010) Rita Dreier   ARTHRITIS RESEARCH & THERAPY

SIRT1 regulation of apoptosis of human chondrocytes

(2009) Koji Takayama et al.   ARTHRITIS AND RHEUMATISM

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

(2009) Nagalingam R. Sundaresan et al.   JOURNAL OF CLINICAL INVESTIGATION

p38/NF‐kB‐dependent expression of COX‐2 during differentiation and inflammatory response of chondrocytes

(2008) Valentina Ulivi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Differential effects of tumor necrosis factor-α and interleukin-1β on cell death in human articular chondrocytes

(2007) B. Caramés et al.   OSTEOARTHRITIS AND CARTILAGE