Anti-Planktonic and Anti-Biofilm Properties of Pentacyclic Triterpenes—Asiatic Acid and Ursolic Acid as Promising Antibacterial Future Pharmaceuticals

Ursolic acid inhibits multi-species biofilms developed by Streptococcus mutans, Streptococcus sanguinis, and Streptococcus gordonii

(2021) Xiaoying Lyu et al.   ARCHIVES OF ORAL BIOLOGY

Antifungal activity and potential mechanism of Asiatic acid alone and in combination with fluconazole against Candida albicans

(2021) Yuting Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Antimicrobial and biofilm inhibiting potential of an amide derivative [N-(2′, 4′-dinitrophenyl)-3β-hydroxyurs-12-en-28-carbonamide] of ursolic acid by modulating membrane potential and quorum sensing against colistin resistant Acinetobacter baumannii

(2021) Yamina Usmani et al.   MICROBIAL PATHOGENESIS

Anticancer effects of asiatic acid against doxorubicin-resistant breast cancer cells via an AMPK-dependent pathway in vitro

(2021) Zhu Zhu et al.   PHYTOMEDICINE

Ursolic Acid Targets Glucosyltransferase and Inhibits Its Activity to Prevent Streptococcus mutans Biofilm Formation

(2021) Yucui Liu et al.   Frontiers in Microbiology

Are Uropathogenic Bacteria Living in Multispecies Biofilm Susceptible to Active Plant Ingredient—Asiatic Acid?

(2021) Zuzanna Sycz et al.   Biomolecules

Chinese herb microneedle patch for wound healing

(2021) Junjie Chi et al.   Bioactive Materials

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

(2020) Boju Sun et al.   Frontiers in Pharmacology

Ursolic acid inhibits colistin efflux and curtails colistin resistant Enterobacteriaceae

(2019) Niranjana Sri Sundaramoorthy et al.   AMB Express

Comparative gene expression analysis of planktonic Porphyromonas gingivalis ATCC 33277 in the presence of a growing biofilm versus planktonic cells

(2019) María C. Sánchez et al.   BMC MICROBIOLOGY

Ursolic Acid and Its Derivatives as Bioactive Agents

(2019) Sithenkosi Mlala et al.   MOLECULES

Biofilm formation by multidrug resistant Enterobacteriaceae strains isolated from solid organ transplant recipients

(2019) José Ramos-Vivas et al.   Scientific Reports

Bacterial Persisters and Infection: Past, Present, and Progressing

(2019) Bridget Gollan et al.   Annual Review of Microbiology

Recent developments on the extraction and application of ursolic acid. A review

(2018) Lucía López-Hortas et al.   FOOD RESEARCH INTERNATIONAL

Evaluation of nano hydrogel composite based on gelatin/HA/CS suffused with Asiatic acid/ZnO and CuO nanoparticles for second degree burns

(2018) Thanusha A.V. et al.   Materials Science & Engineering C-Materials for Biological Applications

Asiatic acid attenuates lipopolysaccharide-induced injury by suppressing activation of the Notch signaling pathway

(2018) Xiong Yuyun et al.   Oncotarget

Ursolic Acid Hydrazide Based Organometallic Complexes: Synthesis, Characterization, Antibacterial, Antioxidant, and Docking Studies

(2018) Muafia Jabeen et al.   Frontiers in Chemistry

Pharmacological Review on Asiatic Acid and Its Derivatives: A Potential Compound

(2018) Junwei Lv et al.   SLAS Technology

Inhibition and Eradication of Pseudomonas aeruginosa Biofilms by Host Defence Peptides

(2018) Hongwei Chen et al.   Scientific Reports

Antimicrobial Effect of Asiatic Acid Against Clostridium difficile Is Associated With Disruption of Membrane Permeability

(2018) Phurt Harnvoravongchai et al.   Frontiers in Microbiology

Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise

(2018) Mohamed Fizur Nagoor Meeran et al.   Frontiers in Pharmacology

Antimicrobial activity and synergism of ursolic acid 3-O-α-L-arabinopyranoside with oxacillin against methicillin-resistant Staphylococcus aureus

(2017) Tian Zhou et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Antibiotic susceptibility of planktonic- and biofilm-grown staphylococci isolated from implant-associated infections: should MBEC and nature of biofilm formation replace MIC?

(2017) Aaron J Brady et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Influence of oxidative stress on the antibacterial activity of betulin, betulinic acid and ursolic acid

(2017) H.O.B. Oloyede et al.   MICROBIAL PATHOGENESIS

Synergy between Ursolic and Oleanolic Acids from Vitellaria paradoxa Leaf Extract and β-Lactams against Methicillin-Resistant Staphylococcus aureus: In Vitro and In Vivo Activity and Underlying Mechanisms

(2017) Lucy Catteau et al.   MOLECULES

Anti-enterococcal activities of pentacyclic triterpenes

(2017) Dorota Wojnicz et al.   Advances in Clinical and Experimental Medicine

Killing of Serratia marcescens biofilms with chloramphenicol

(2017) Christopher Ray et al.   Annals of Clinical Microbiology and Antimicrobials

Ursolic acid (UA): A metabolite with promising therapeutic potential

(2016) Dharambir Kashyap et al.   LIFE SCIENCES

Antibacterial and Synergistic Activity of Pentacyclic Triterpenoids Isolated from Alstonia scholaris

(2016) Chao-Min Wang et al.   MOLECULES

The Pleiotropic Antibacterial Mechanisms of Ursolic Acid against Methicillin-Resistant Staphylococcus aureus (MRSA)

(2016) Chao-Min Wang et al.   MOLECULES

Anti-proliferative and antibacterialin vitroevaluation of the polyurethane nanostructures incorporating pentacyclic triterpenes

(2016) Camelia Oprean et al.   PHARMACEUTICAL BIOLOGY

A Myrtus communis extract enriched in myrtucummulones and ursolic acid reduces resistance of Propionibacterium acnes biofilms to antibiotics used in acne vulgaris

(2016) Catherine Feuillolay et al.   PHYTOMEDICINE

Studies of the interactions of ursane-type bioactive terpenes with the model of Escherichia coli inner membrane—Langmuir monolayer approach

(2015) Marcin Broniatowski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Synthesis, in vitro antimicrobial and cytotoxic activities of new carbazole derivatives of ursolic acid

(2015) Wen Gu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Drug Resistance Reversal Potential of Ursolic Acid Derivatives against Nalidixic Acid- and Multidrug-resistantEscherichia coli

(2015) Gaurav Raj Dwivedi et al.   Chemical Biology & Drug Design

Biofilm-specific antibiotic tolerance and resistance

(2015) I. Olsen   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Pentacyclic triterpene derivatives possessing polyhydroxyl ring A inhibit Gram-positive bacteria growth by regulating metabolism and virulence genes expression

(2015) Lirong Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial Activity of Oleanolic and Ursolic Acids: An Update

(2015) Jéssica A. Jesus et al.   Evidence-based Complementary and Alternative Medicine

Pentacyclic triterpenes combined with ciprofloxacin help to eradicate the biofilm formed in vitro by Escherichia coli

(2015) Dorota Wojnicz et al.   INDIAN JOURNAL OF MEDICAL RESEARCH

Metabolomics-Based Screening of Biofilm-Inhibitory Compounds against Pseudomonas aeruginosa from Burdock Leaf

(2015) Zaixiang Lou et al.   MOLECULES

Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities

(2015) Łukasz Woźniak et al.   MOLECULES

Chemical Composition Analysis, Antimicrobial Activity and Cytotoxicity Screening of Moss Extracts (Moss Phytochemistry)

(2015) Laura Klavina et al.   MOLECULES

Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteria

(2015) M. Gilabert et al.   PHYTOMEDICINE

Transcriptome analysis of the biofilm formed by methicillin-susceptible Staphylococcus aureus

(2015) Xiaojuan Tan et al.   Scientific Reports

Elastase LasB of Pseudomonas aeruginosa promotes biofilm formation partly through rhamnolipid-mediated regulation

(2014) Hua Yu et al.   CANADIAN JOURNAL OF MICROBIOLOGY

Antibacterial and Antioxidant Activities of Ursolic Acid and Derivatives

(2014) Patrícia do Nascimento et al.   MOLECULES

Centella asiaticain Dermatology: An Overview

(2014) Wiesława Bylka et al.   PHYTOTHERAPY RESEARCH

RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus biofilm inhibition by ursolic acid and resveratrol

(2014) Nan Qin et al.   Scientific Reports

Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes

(2013) Shengjie Yang et al.   Chemistry Central Journal

Search for a potent microbicidal spermicide from the isolates of Shorea robusta resin

(2013) Yogesh P. Bharitkar et al.   CONTRACEPTION

Effect of asiatic and ursolic acids on growth and virulence factors of uropathogenic Escherichia coli strains

(2013) Dorota WOJNICZ et al.   TURKISH JOURNAL OF BIOLOGY

Effect of asiatic and ursolic acids on morphology, hydrophobicity, and adhesion of UPECs to uroepithelial cells

(2012) Wojnicz Dorota et al.   FOLIA MICROBIOLOGICA

Thein vitrostudy of ursolic acid and oleanolic acid inhibiting cariogenic microorganisms as well as biofilm

(2012) L Zhou et al.   ORAL DISEASES

Modulation of antibiotic resistance in bacterial pathogens by oleanolic acid and ursolic acid

(2012) Anna Kurek et al.   PHYTOMEDICINE

Antimicrobial activity of pentacyclic triterpenes isolated from Acacia mellifera

(2011) C Mutai et al.   African Journal of Traditional Complementary and Alternative Medicines

Triterpenoid Saponins fromSymplocos lancifolia

(2011) Ivone Lucia Acebey-Castellon et al.   JOURNAL OF NATURAL PRODUCTS

Norfloxacin and ursolic acid: in vitro association and postantibiotic effect against Staphylococcus aureus

(2011) A. Filocamo et al.   LETTERS IN APPLIED MICROBIOLOGY

Chemical constituents and antibacterial activity ofMelastoma malabathricumL.

(2011) Keng-Chong Wong et al.   NATURAL PRODUCT RESEARCH

Extracellular enzymes affect biofilm formation of mucoid Pseudomonas aeruginosa

(2010) P. Tielen et al.   MICROBIOLOGY-SGM

Triterpene-based plant defenses

(2010) Azucena González-Coloma et al.   PHYTOCHEMISTRY REVIEWS

Antibacterial activity of oleanolic and ursolic acids and their derivatives

(2010) Krystyna Wolska et al.   Open Life Sciences

Oleanolic acid and ursolic acid affect peptidoglycan metabolism in Listeria monocytogenes

(2009) Anna Kurek et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts

(2009) Sebastian Jäger et al.   MOLECULES

Pentacyclic Triterpenoids from the Medicinal Herb, Centella asiatica (L.) Urban

(2009) Jacinda James et al.   MOLECULES

Effects of cranberry extracts and ursolic acid derivatives on P-fimbriatedEscherichia coli, COX-2 activity, pro-inflammatory cytokine release and the NF-κβ transcriptional responsein vitro

(2009) Yue Huang et al.   PHARMACEUTICAL BIOLOGY

Evaluation of the antibacterial activity of the methylene chloride extract ofMiconia ligustroides, isolated triterpene acids, and ursolic acid derivatives

(2009) Wilson R. Cunha et al.   PHARMACEUTICAL BIOLOGY

Two New Triterpenes from the Rhizome of Dryopteris crassirhizoma, and Inhibitory Activities of Its Constituents on Human Immunodeficiency Virus-1 Protease

(2008) Ji Suk Lee et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

New antibacterial pentacyclic triterpenes from Myricaria elegans Royle. (tamariscineae)

(2008) Manzoor Ahmad et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Ursolic, oleanolic and betulinic acids: Antibacterial spectra and selectivity indexes

(2008) Stéphane Fontanay et al.   JOURNAL OF ETHNOPHARMACOLOGY