Ursolic Acid and Its Derivatives as Bioactive Agents

Natural Product Triterpenoids and Their Semi-Synthetic Derivatives with Potential Anticancer Activity

(2019) Yulin Ren et al.   PLANTA MEDICA

Recent advances in allelopathy for weed control: from knowledge to applications

(2019) Francisco A Macías et al.   PEST MANAGEMENT SCIENCE

Anti-inflammatory and antihistaminic activity of triterpenoids isolated from Bursera cuneata (Schldl.) Engl

(2019) Verónica Rodríguez-López et al.   JOURNAL OF ETHNOPHARMACOLOGY

Allelochemicals and esters from leaves and inflorescences of Sambucus nigra L

(2019) Josep Basas-Jaumandreu et al.   Phytochemistry Letters

Design, synthesis, evaluation, and molecular docking of ursolic acid derivatives containing a nitrogen heterocycle as anti-inflammatory agents

(2018) Zhi-Yu Wei et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent developments on the extraction and application of ursolic acid. A review

(2018) Lucía López-Hortas et al.   FOOD RESEARCH INTERNATIONAL

Ursolic acid in health and disease

(2018) Dae Yun Seo et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Weed Suppressing Potential and Isolation of Potent Plant Growth Inhibitors from Castanea crenata Sieb. et Zucc

(2018) Phung Tuyen et al.   MOLECULES

Antibacterial triterpenoids from the leaves of Ilex hainanensis Merr.

(2018) Wen-Wen Zhao et al.   NATURAL PRODUCT RESEARCH

Hopanoid lipids: from membranes to plant–bacteria interactions

(2018) Brittany J. Belin et al.   NATURE REVIEWS MICROBIOLOGY

Antihyperuricemic and xanthine oxidase inhibitory activities of Tribulus arabicus and its isolated compound, ursolic acid: In vitro and in vivo investigation and docking simulations

(2018) Eman Abu-Gharbieh et al.   PLoS One

New Targets for Growth Inhibition of Mycobacterium tuberculosis: Why Do Natural Terpenoids Exhibit Antitubercular Activity?

(2018) V. E. Kataev et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Phytotoxicity of pentacyclic triterpene acids from Citharexylum spinosum L. to radish, lettuce and canary grass

(2018) I. Saidi et al.   ALLELOPATHY JOURNAL

Phytochemistry and Allelophatic Potential of Torelliodora Eucalyptus Leaves on Germination and Initial Growth of Mutambo

(2018) S.R. PEREIRA et al.   Planta Daninha

Ursolic acid derivatives for pharmaceutical use: a patent review (2012-2016)

(2017) Hidayat Hussain et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Synthesis and antitumor activity evaluation of novel oleanolic acid derivatives

(2017) Yan-Qiu Meng et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Ursolic acid activates the TGR5 receptor to enhance GLP-1 secretion in type 1-like diabetic rats

(2017) Shih-Hsiang Lo et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Simultaneous Analysis of Ursolic Acid and Oleanolic Acid in Guava Leaves Using QuEChERS-Based Extraction Followed by High-Performance Liquid Chromatography

(2017) Chang Xu et al.   Journal of Analytical Methods in Chemistry

Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments

(2017) Panchanan Maiti et al.   Translational Neurodegeneration

Synthesis and biological evaluation of novel ursolic acid analogues as potential α-glucosidase inhibitors

(2017) Pan-Pan Wu et al.   Scientific Reports

Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells

(2016) Vanessa I.S. Mendes et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ursolic acid attenuates oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in MPTP-induced Parkinsonian mouse model

(2016) Sachchida Nand Rai et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Ursolic acid (UA): A metabolite with promising therapeutic potential

(2016) Dharambir Kashyap et al.   LIFE SCIENCES

Semisynthesis of Derivatives of Oleanolic Acid fromSyzygium aromaticumand Their Antinociceptive and Anti-Inflammatory Properties

(2016) Sibusiso Rali et al.   MEDIATORS OF INFLAMMATION

Anti-inflammatory potential of ursolic acid in Mycobacterium tuberculosis-sensitized and Concanavalin A-stimulated cells

(2016) TAMANNA ZERIN et al.   Molecular Medicine Reports

Plant Resources, 13C-NMR Spectral Characteristic and Pharmacological Activities of Dammarane-Type Triterpenoids

(2016) Jingya Ruan et al.   MOLECULES

Antibacterial and Synergistic Activity of Pentacyclic Triterpenoids Isolated from Alstonia scholaris

(2016) Chao-Min Wang et al.   MOLECULES

Anti-hepatocellular carcinoma activity and mechanism of chemopreventive compounds: ursolic acid derivatives

(2016) Qiuxia Huang et al.   PHARMACEUTICAL BIOLOGY

Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury

(2016) Yanzhe Wang et al.   Drug Design Development and Therapy

Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents

(2015) Haijun Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial Activity of Oleanolic and Ursolic Acids: An Update

(2015) Jéssica A. Jesus et al.   Evidence-based Complementary and Alternative Medicine

Parameters for Martini sterols and hopanoids based on a virtual-site description

(2015) M. N. Melo et al.   JOURNAL OF CHEMICAL PHYSICS

Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities

(2015) Łukasz Woźniak et al.   MOLECULES

Triterpenes as Potentially Cytotoxic Compounds

(2015) Malwina Chudzik et al.   MOLECULES

Triterpenoids

(2015) Robert A. Hill et al.   NATURAL PRODUCT REPORTS

Hopanoids as functional analogues of cholesterol in bacterial membranes

(2015) James P. Sáenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural and semisynthetic protein tyrosine phosphatase 1B (PTP1B) inhibitors as anti-diabetic agents

(2015) Li-Jun Wang et al.   RSC Advances

Synthesis and Evaluation of Novel Triterpene Analogues of Ursolic Acid as Potential Antidiabetic Agent

(2015) Panpan Wu et al.   PLoS One

Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK/NF-κB pathway

(2014) Jie-Qiong Ma et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

In vitro and in vivo evaluation of the antidiabetic activity of ursolic acid derivatives

(2014) Pan-Pan Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel ring-A fused hybrids of oleanolic acid with capabilities to arrest cell cycle and induce apoptosis in breast cancer cells

(2014) Uppuluri Venkata Mallavadhani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potent anti-inflammatory activity of betulinic acid treatment in a model of lethal endotoxemia

(2014) José Fernando Oliveira Costa et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Triterpenoid Saponin Biosynthetic Pathway Profiling and Candidate Gene Mining of the Ilex asprella Root Using RNA-Seq

(2014) Xiasheng Zheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In Vitro and in Vivo Antitumor Effects of Folate-Targeted Ursolic Acid Stealth Liposome

(2014) Guang Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antibacterial and Antioxidant Activities of Ursolic Acid and Derivatives

(2014) Patrícia do Nascimento et al.   MOLECULES

Ursolic acid reduces oxidative stress to alleviate early brain injury following experimental subarachnoid hemorrhage

(2014) Tingting Zhang et al.   NEUROSCIENCE LETTERS

Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies

(2013) Muthu K. Shanmugam et al.   BIOCHEMICAL PHARMACOLOGY

Ursolic and oleanolic acids as antimicrobial and immunomodulatory compounds for tuberculosis treatment

(2013) Adelina Jiménez-Arellanes et al.   BMC Complementary and Alternative Medicine

Synthesis and biological evaluation of ursolic acid-triazolyl derivatives as potential anti-cancer agents

(2013) Showkat Rashid et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cytotoxic Activity of Ursolic Acid Derivatives Obtained by Isolation and Oxidative Derivatization

(2013) Kishor Mazumder et al.   MOLECULES

Triterpenoids

(2013) Robert A. Hill et al.   NATURAL PRODUCT REPORTS

Extraction of ursolic acid from Ocimum sanctum and synthesis of its novel derivatives: effects on extracellular homocysteine, dihydrofolate reductase activity and proliferation of HepG2 human hepatoma cells

(2013) Apsara Batra et al.   PTERIDINES

Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells

(2012) Ana S. Leal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits

(2012) Zong Zhuang et al.   BMC NEUROSCIENCE

Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice

(2012) Litao Li et al.   BRAIN RESEARCH

Extraction of ursolic acid from Ocimum sanctum leaves: Kinetics and modeling

(2012) Mangesh D. Vetal et al.   FOOD AND BIOPRODUCTS PROCESSING

Synthesis and Antiplasmodial Activity of Betulinic Acid and Ursolic Acid Analogues

(2012) Adrine Innocente et al.   MOLECULES

In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives

(2011) Jing-Wei Shao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Alhagi maurorum: A convenient source of lupeol

(2011) Abdul Hafeez Laghari et al.   INDUSTRIAL CROPS AND PRODUCTS

Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product

(2011) Nighat Sultana   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Analgesic and anti-inflammatory activity of β-sitosterol isolated from Nyctanthes arbortristis leaves

(2011) Sunil A. Nirmal et al.   INFLAMMOPHARMACOLOGY

Betulin and ursolic acid synthetic derivatives as inhibitors of Papilloma virus

(2010) Oxana B. Kazakova et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Beneficial health effects of lupeol triterpene: A review of preclinical studies

(2010) Hifzur Rahman Siddique et al.   LIFE SCIENCES

Synthesis and in vitro Cytotoxicity of Novel Ursolic Acid Derivatives

(2010) Yanqiu Meng et al.   MOLECULES

Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene

(2009) Mohammad Saleem   CANCER LETTERS

Ursolic acid analogues: non-phenolic functional food components in Jamaican raspberry fruits

(2009) Camille S. Bowen-Forbes et al.   FOOD CHEMISTRY

Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts

(2009) Sebastian Jäger et al.   MOLECULES

Effects of cranberry extracts and ursolic acid derivatives on P-fimbriatedEscherichia coli, COX-2 activity, pro-inflammatory cytokine release and the NF-κβ transcriptional responsein vitro

(2009) Yue Huang et al.   PHARMACEUTICAL BIOLOGY

Isolation of Ursolic Acid from Apple Peels and Its Specific Efficacy as a Potent Antitumor Agent

(2008) Hideaki Yamaguchi et al.   JOURNAL OF HEALTH SCIENCE

Ursolic acid: An anti- and pro-inflammatory triterpenoid

(2008) Yasutaka Ikeda et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Variation of Ursolic Acid Content in Eight Ocimum Species from Northeastern Brazil

(2008) M. Goretti Silva et al.   MOLECULES