Stress Relief Techniques: p38 MAPK Determines the Balance of Cell Cycle and Apoptosis Pathways

Diversity and versatility of p38 kinase signalling in health and disease

(2021) Begoña Canovas et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MCL1 binding to the reverse BH3 motif of P18INK4C couples cell survival to cell proliferation

(2020) Robert H. Whitaker et al.   Cell Death & Disease

The p38 Pathway: From Biology to Cancer Therapy

(2020) Adrián Martínez-Limón et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Understanding MAPK Signaling Pathways in Apoptosis

(2020) Jicheng Yue et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review

(2020) Kai Liu et al.   Cancer Cell International

Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate

(2020) Colin Chih-Chien Wu et al.   CELL

CDK4/6 and MAPK—Crosstalk as Opportunity for Cancer Treatment

(2020) Lisa Scheiblecker et al.   Pharmaceuticals

A Code of Mono-phosphorylation Modulates the Function of RB

(2019) Ioannis Sanidas et al.   MOLECULAR CELL

p38γ is essential for cell cycle progression and liver tumorigenesis

(2019) Antonia Tomás-Loba et al.   NATURE

Regulating the BCL2 Family to Improve Sensitivity to Microtubule Targeting Agents

(2019) Robert H. Whitaker et al.   Cells

Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

(2018) Begoña Cánovas et al.   CANCER CELL

Atypical APC/C‐dependent degradation of Mcl‐1 provides an apoptotic timer during mitotic arrest

(2018) Lindsey A Allan et al.   EMBO JOURNAL

Venetoclax for the treatment of patients with chronic lymphocytic leukemia

(2017) Jennifer Crombie et al.   Future Oncology

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival

(2017) Charlotte Viant et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

(2017) Isabel Jaco et al.   MOLECULAR CELL

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection

(2017) Manoj B. Menon et al.   NATURE CELL BIOLOGY

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death

(2017) Yves Dondelinger et al.   NATURE CELL BIOLOGY

Down-regulation of UBC9 increases the sensitivity of hepatocellular carcinoma to doxorubicin

(2017) Sufen Fang et al.   Oncotarget

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells

(2016) Albert Gubern et al.   MOLECULAR CELL

Redefining the BH3 Death Domain as a ‘Short Linear Motif’

(2015) Abdel Aouacheria et al.   TRENDS IN BIOCHEMICAL SCIENCES

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

(2015) Maria Maryanovich et al.   Nature Communications

Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt’s lymphoma B cells

(2015) Gorbatchev Ambroise et al.   Oncotarget

Dual Function of p38α MAPK in Colon Cancer: Suppression of Colitis-Associated Tumor Initiation but Requirement for Cancer Cell Survival

(2014) Jalaj Gupta et al.   CANCER CELL

Phosphorylation of the Retinoblastoma protein (Rb) on serine-807 is required for association with Bax

(2014) Lisa A Antonucci et al.   CELL CYCLE

Phosphorylation of the Proapoptotic BH3-Only Protein Bid Primes Mitochondria for Apoptosis during Mitotic Arrest

(2014) Pengbo Wang et al.   Cell Reports

Cyclin D activates the Rb tumor suppressor by mono-phosphorylation

(2014) Anil M Narasimha et al.   eLife

MAPK p38 and JNK have opposing activities on TRAIL-induced apoptosis activation in NSCLC H460 cells that involves RIP1 and caspase-8 and is mediated by Mcl-1

(2013) Kaamar Azijli et al.   APOPTOSIS

Mcl1 regulates the terminal mitosis of neural precursor cells in the mammalian brain through p27Kip1

(2013) S. M. M. Hasan et al.   DEVELOPMENT

The retinoblastoma protein induces apoptosis directly at the mitochondria

(2013) K. I. Hilgendorf et al.   GENES & DEVELOPMENT

p38MAPK/p53-Mediated Bax induction contributes to neurons degeneration in rotenone-induced cellular and rat models of Parkinson’s disease

(2013) Feng Wu et al.   NEUROCHEMISTRY INTERNATIONAL

Persistent Inhibition of ABL Tyrosine Kinase Causes Enhanced Apoptotic Response to TRAIL and Disrupts the Pro-Apoptotic Effect of Chloroquine

(2013) Priya Sridevi et al.   PLoS One

Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity

(2013) F. Kopper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling Pathways that Control Cell Proliferation

(2013) R. J. Duronio et al.   Cold Spring Harbor Perspectives in Biology

Downregulation of Mcl-1 through inhibition of translation contributes to benzyl isothiocyanate-induced cell cycle arrest and apoptosis in human leukemia cells

(2013) T Zhou et al.   Cell Death & Disease

The many faces of p38 mitogen-activated protein kinase in progenitor/stem cell differentiation

(2012) Feride Oeztuerk-Winder et al.   BIOCHEMICAL JOURNAL

Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts

(2012) Dagmar Faust et al.   Cell Communication and Signaling

Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival

(2012) Tina M. Thornton et al.   International Journal of Biological Sciences

The ATM–BID pathway regulates quiescence and survival of haematopoietic stem cells

(2012) Maria Maryanovich et al.   NATURE CELL BIOLOGY

Identification of a Novel Mcl-1 Protein Binding Motif

(2011) William J. Placzek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCF TrCP mediates stress-activated MAPK-induced Cdc25B degradation

(2011) S. Uchida et al.   JOURNAL OF CELL SCIENCE

2-Methoxyestradiol induced bax phosphorylation and apoptosis in human retinoblastoma cells via p38 MAPK activation

(2011) Hongbo Min et al.   MOLECULAR CARCINOGENESIS

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

Resistance to docetaxel-induced apoptosis in prostate cancer cells by p38/p53/p21 signaling

(2011) Lu Gan et al.   PROSTATE

Conserved RB functions in development and tumor suppression

(2011) Gabriel M. Gordon et al.   Protein & Cell

Hypoxia-induced Bcl-2 expression in endothelial cells via p38 MAPK pathway

(2010) Cui-Li Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis

(2010) Jerry E. Chipuk et al.   CELL CYCLE

TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1

(2010) J K Son et al.   CELL DEATH AND DIFFERENTIATION

Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

(2010) Margaret E Harley et al.   EMBO JOURNAL

BH3 Domains other than Bim and Bid Can Directly Activate Bax/Bak

(2010) Han Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p38 Mitogen-Activated Protein Kinase Promotes Cell Survival in Response to DNA Damage but Is Not Required for the G2 DNA Damage Checkpoint in Human Cancer Cells

(2010) M. S. Phong et al.   MOLECULAR AND CELLULAR BIOLOGY

P38 Mitogen-activated Protein Kinase Activity Is Required during Mitosis for Timely Satisfaction of the Mitotic Checkpoint But Not for the Fidelity of Chromosome Segregation

(2010) Kyunghee Lee et al.   MOLECULAR BIOLOGY OF THE CELL

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization

(2010) H. Christian Reinhardt et al.   MOLECULAR CELL

ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia

(2010) S H Tonino et al.   ONCOGENE

Proapoptotic Function of the Retinoblastoma Tumor Suppressor Protein

(2009) Alessandra Ianari et al.   CANCER CELL

Targeting protein kinases for the development of anti-inflammatory drugs

(2009) Philip Cohen   CURRENT OPINION IN CELL BIOLOGY

BH3-only proteins in apoptosis and beyond: an overview

(2009) E Lomonosova et al.   ONCOGENE

p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription

(2008) Beibei Cai et al.   APOPTOSIS

Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells

(2008) Xianling Guo et al.   BMC CANCER

Bcl2, a transcriptional target of p38α, is critical for neuronal commitment of mouse embryonic stem cells

(2008) M Trouillas et al.   CELL DEATH AND DIFFERENTIATION

The complexity of mitogen-activated protein kinases (MAPKs) made simple

(2008) M. Krishna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CDK Inhibitors: Cell Cycle Regulators and Beyond

(2008) Arnaud Besson et al.   DEVELOPMENTAL CELL

The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways

(2008) M Hassan et al.   ONCOGENE