- Home
- Publications
- Publication Search
- Publication Details
Title
Passive Immunization in Alpha-Synuclein Preclinical Animal Models
Authors
Keywords
-
Journal
Biomolecules
Volume 12, Issue 2, Pages 168
Publisher
MDPI AG
Online
2022-01-21
DOI
10.3390/biom12020168
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson’s Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline
- (2021) Per Borghammer Journal of Parkinsons Disease
- Gastrointestinal Dysfunction in Parkinson’s Disease
- (2021) Casper Skjærbæk et al. Journal of Clinical Medicine
- Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain
- (2021) Nelson Ferreira et al. Acta Neuropathologica Communications
- Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats
- (2021) Nathalie Van Den Berge et al. BRAIN
- The Prion-Like Spreading of Alpha-Synuclein in Parkinson’s Disease: Update on Models and Hypotheses
- (2021) Asad Jan et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Dermal and cardiac autonomic fiber involvement in Parkinson's disease and multiple system atrophy
- (2021) Joachim Brumberg et al. NEUROBIOLOGY OF DISEASE
- Cerebrospinal fluid and plasma distribution of anti-α-synuclein IgMs and IgGs in multiple system atrophy and Parkinson's disease
- (2021) Jonas Folke et al. PARKINSONISM & RELATED DISORDERS
- Asymmetric Dopaminergic Dysfunction in Brain-First versus Body-First Parkinson’s Disease Subtypes
- (2021) Karoline Knudsen et al. Journal of Parkinsons Disease
- Administration of AAV-Alpha Synuclein NAC Antibody Improves Locomotor Behavior in Rats Overexpressing Alpha Synuclein
- (2021) Yun-Hsiang Chen et al. Genes
- Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric α-synuclein accumulation in the brain and gut
- (2021) Jacqui T. Nimmo et al. ACTA NEUROPATHOLOGICA
- ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease
- (2021) Eva Nordström et al. NEUROBIOLOGY OF DISEASE
- Animal models of brain-first and body-first Parkinson's disease
- (2021) Nathalie Van Den Berge et al. NEUROBIOLOGY OF DISEASE
- Neuropathological evidence of body-first vs. brain-first Lewy body disease
- (2021) Per Borghammer et al. NEUROBIOLOGY OF DISEASE
- Targeting alpha-synuclein via the immune system in Parkinson's disease: Current vaccine therapies
- (2021) Sheila M. Fleming et al. NEUROPHARMACOLOGY
- Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions
- (2020) Seiji Kaji et al. Translational Neurodegeneration
- Clinicopathologic and genetic features of multiple system atrophy with Lewy body disease
- (2020) Shunsuke Koga et al. BRAIN PATHOLOGY
- Autonomic dysfunction and phenoconversion in idiopathic REM sleep behavior disorder
- (2020) Stuart J. McCarter et al. CLINICAL AUTONOMIC RESEARCH
- Immunization therapies for Parkinson’s disease: state of the art and considerations for future clinical trials
- (2020) Angelo Antonini et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Dementia with Lewy bodies and Parkinson disease dementia
- (2020) Melissa J. Armstrong et al. NEUROLOGY
- α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease
- (2020) Cecilia S. Lindestam Arlehamn et al. Nature Communications
- Skin Biopsy May Help to Distinguish Multiple System Atrophy–Parkinsonism from Parkinson's Disease with Orthostatic Hypotension
- (2020) Vincenzo Donadio et al. MOVEMENT DISORDERS
- Altered sensorimotor cortex noradrenergic function in idiopathic REM sleep behaviour disorder – A PET study
- (2020) Katrine B. Andersen et al. PARKINSONISM & RELATED DISORDERS
- Brain-first versus body-first Parkinson’s disease: a multimodal imaging case-control study
- (2020) Jacob Horsager et al. BRAIN
- Inflammatory bowel disease and Parkinson’s disease: common pathophysiological links
- (2020) Ho-Su Lee et al. GUT
- A Phase 1 Randomized Trial of Specific Active α‐Synuclein Immunotherapies PD01A and PD03A in Multiple System Atrophy
- (2020) Wassilios G. Meissner et al. MOVEMENT DISORDERS
- Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology
- (2019) Xinyi Li et al. ACTA NEUROPATHOLOGICA
- Autonomic Dysfunction in α-Synucleinopathies
- (2019) José Javier Mendoza-Velásquez et al. Frontiers in Neurology
- Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats
- (2019) Nathalie Van Den Berge et al. ACTA NEUROPATHOLOGICA
- Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease
- (2019) Sangjune Kim et al. NEURON
- Lewy-related pathology exhibits two anatomically and genetically distinct progression patterns: a population-based study of Finns aged 85+
- (2019) Anna Raunio et al. ACTA NEUROPATHOLOGICA
- Orthostatic Hypotension in Parkinson Disease
- (2019) Jose-Alberto Palma et al. CLINICS IN GERIATRIC MEDICINE
- The Intestinal Barrier in Parkinson’s Disease: Current State of Knowledge
- (2019) Sven C. D. van IJzendoorn et al. Journal of Parkinsons Disease
- Brain-First versus Gut-First Parkinson’s Disease: A Hypothesis
- (2019) Per Borghammer et al. Journal of Parkinsons Disease
- Increasing Comparability and Utility of Gut Microbiome Studies in Parkinson’s Disease: A Systematic Review
- (2019) Jeffrey M. Boertien et al. Journal of Parkinsons Disease
- Encoding the Sequence of Specific Autoantibodies Against beta-Amyloid and alpha-Synuclein in Neurodegenerative Diseases
- (2019) Alexandra Albus et al. Frontiers in Immunology
- Distinct Autoimmune Anti-α-Synuclein Antibody Patterns in Multiple System Atrophy and Parkinson’s Disease
- (2019) Jonas Folke et al. Frontiers in Immunology
- Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities
- (2019) Naomi P. Visanji et al. Translational Neurodegeneration
- Inflammatory Bowel Diseases and Parkinson’s Disease
- (2019) Tomasz Brudek Journal of Parkinsons Disease
- Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo
- (2019) Darren J. Schofield et al. NEUROBIOLOGY OF DISEASE
- Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease
- (2019) Michael X. Henderson et al. NEUROBIOLOGY OF DISEASE
- Diagnosis of multiple system atrophy
- (2018) Jose-Alberto Palma et al. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
- Is Lewy pathology in the human nervous system chiefly an indicator of neuronal protection or of toxicity?
- (2018) Suzanne Chartier et al. CELL AND TISSUE RESEARCH
- Is Braak staging valid for all types of Parkinson’s disease?
- (2018) Kurt A. Jellinger JOURNAL OF NEURAL TRANSMISSION
- Structural characteristics and membrane interactions of tandem α-synuclein oligomers
- (2018) Chunhua Dong et al. Scientific Reports
- Region-Specific Effects of Immunotherapy With Antibodies Targeting α-synuclein in a Transgenic Model of Synucleinopathy
- (2018) Martin Kallab et al. Frontiers in Neuroscience
- Skin Nerve Phosphorylated α-Synuclein Deposits in Parkinson Disease With Orthostatic Hypotension
- (2018) Vincenzo Donadio et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- A Systematic Review and Meta-Analysis of Alpha Synuclein Auto-Antibodies in Parkinson's Disease
- (2018) Kirsten M. Scott et al. Frontiers in Neurology
- Naturally occurring autoantibodies against α-synuclein rescues memory and motor deficits and attenuates α-synuclein pathology in mouse model of Parkinson's disease
- (2018) Ya-ru Huang et al. NEUROBIOLOGY OF DISEASE
- Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models
- (2018) Andreas Weihofen et al. NEUROBIOLOGY OF DISEASE
- Autoimmune antibody decline in Parkinson’s disease and Multiple System Atrophy; a step towards immunotherapeutic strategies
- (2017) Tomasz Brudek et al. Molecular Neurodegeneration
- How does parkinson's disease begin? Perspectives on neuroanatomical pathways, prions, and histology
- (2017) Per Borghammer MOVEMENT DISORDERS
- T cells from patients with Parkinson’s disease recognize α-synuclein peptides
- (2017) David Sulzer et al. NATURE
- α-Synuclein promotes dilation of the exocytotic fusion pore
- (2017) Todd Logan et al. NATURE NEUROSCIENCE
- Idiopathic REM sleep behaviour disorder and neurodegeneration — an update
- (2017) Birgit Högl et al. Nature Reviews Neurology
- Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy
- (2017) Omar El-Agnaf et al. NEUROBIOLOGY OF DISEASE
- Vagotomy and Parkinson disease
- (2017) Bojing Liu et al. NEUROLOGY
- REM sleep behavior disorder is related to enteric neuropathology in Parkinson disease
- (2017) Laurène Leclair-Visonneau et al. NEUROLOGY
- Gastrointestinal Transit Time in Parkinson’s Disease Using a Magnetic Tracking System
- (2017) Karoline Knudsen et al. Journal of Parkinsons Disease
- RNA Interference of Human α-Synuclein in Mouse
- (2017) Young-Cho Kim et al. Frontiers in Neurology
- Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy
- (2017) Brian Spencer et al. Acta Neuropathologica Communications
- Pathological α-synuclein in gastrointestinal tissues from prodromal Parkinson disease patients
- (2016) Morten Gersel Stokholm et al. ANNALS OF NEUROLOGY
- Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration
- (2016) Michel Goedert et al. BRAIN
- Pure Autonomic Failure
- (2016) Pariwat Thaisetthawatkul Current Neurology and Neuroscience Reports
- The Impact of N-terminal Acetylation of α-Synuclein on Phospholipid Membrane Binding and Fibril Structure
- (2016) Aditya Iyer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies
- (2016) Maria Xilouri et al. MOVEMENT DISORDERS
- Progression of alpha-synuclein pathology in multiple system atrophy of the cerebellar type
- (2016) J. Brettschneider et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Conformational ensemble of human α-synuclein physiological form predicted by molecular simulations
- (2016) G. Rossetti et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders
- (2016) Martin Ingelsson Frontiers in Neuroscience
- Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies
- (2015) Toshiki Uchihara et al. ACTA NEUROPATHOLOGICA
- Vagotomy and subsequent risk of Parkinson's disease
- (2015) Elisabeth Svensson et al. ANNALS OF NEUROLOGY
- Expanding the spectrum of neuronal pathology in multiple system atrophy
- (2015) Matthew D. Cykowski et al. BRAIN
- Parkinson's disease
- (2015) Lorraine V Kalia et al. LANCET
- Development of Passive Immunotherapies for Synucleinopathies
- (2015) Ann-Louise Bergström et al. MOVEMENT DISORDERS
- Normalization of Overexpressed α-Synuclein Causing Parkinson's Disease By a Moderate Gene Silencing With RNA Interference
- (2015) Masaki Takahashi et al. Molecular Therapy-Nucleic Acids
- Anti-Human α-Synuclein N-Terminal Peptide Antibody Protects against Dopaminergic Cell Death and Ameliorates Behavioral Deficits in an AAV-α-Synuclein Rat Model of Parkinson’s Disease
- (2015) Md Shahaduzzaman et al. PLoS One
- Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis
- (2014) K. J. Vargas et al. JOURNAL OF NEUROSCIENCE
- Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models
- (2014) D. Games et al. JOURNAL OF NEUROSCIENCE
- Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice
- (2014) Veronica Lindström et al. NEUROBIOLOGY OF DISEASE
- α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
- (2014) Hien T. Tran et al. Cell Reports
- Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation
- (2014) Diana F. Lázaro et al. PLoS Genetics
- α-Synuclein mutations cluster around a putative protein loop
- (2013) Eleanna Kara et al. NEUROSCIENCE LETTERS
- -Synuclein in Parkinson's Disease
- (2013) L. Stefanis Cold Spring Harbor Perspectives in Medicine
- Antibody-Aided Clearance of Extracellular -Synuclein Prevents Cell-to-Cell Aggregate Transmission
- (2012) E.-J. Bae et al. JOURNAL OF NEUROSCIENCE
- N-terminal acetylation is critical for forming α-helical oligomer of α-synuclein
- (2012) Adam J. Trexler et al. PROTEIN SCIENCE
- α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
- (2011) Tim Bartels et al. NATURE
- Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
- (2011) Eliezer Masliah et al. PLoS One
- A soluble -synuclein construct forms a dynamic tetramer
- (2011) W. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Papp–Lantos inclusions and the pathogenesis of multiple system atrophy: an update
- (2010) Kurt A. Jellinger et al. ACTA NEUROPATHOLOGICA
- Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders
- (2010) Thomas G. Beach et al. ACTA NEUROPATHOLOGICA
- Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes
- (2010) Yien-Ming Kuo et al. HUMAN MOLECULAR GENETICS
- Are synucleinopathies prion-like disorders?
- (2010) Elodie Angot et al. LANCET NEUROLOGY
- In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration
- (2010) Oleg S Gorbatyuk et al. MOLECULAR THERAPY
- Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice
- (2010) Francisco Pan-Montojo et al. PLoS One
- Glial cytoplasmic inclusions in neurologically normal elderly: prodromal multiple system atrophy?
- (2008) Hiroshige Fujishiro et al. ACTA NEUROPATHOLOGICA
- Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance
- (2008) Laura Parkkinen et al. ACTA NEUROPATHOLOGICA
- Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease
- (2008) Dennis W. Dickson et al. ACTA NEUROPATHOLOGICA
- A critical evaluation of current staging of α-synuclein pathology in Lewy body disorders
- (2008) Kurt A. Jellinger BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
- (2008) Jia-Yi Li et al. NATURE MEDICINE
- Patterns and stages of -synucleinopathy: Relevance in a population-based cohort
- (2008) J. Zaccai et al. NEUROLOGY
- Second consensus statement on the diagnosis of multiple system atrophy
- (2008) S. Gilman et al. NEUROLOGY
- Lewy body pathology in long-term fetal nigral transplants: is parkinson's disease transmitted from one neural system to another?
- (2008) Jeffrey H Kordower et al. NEUROPSYCHOPHARMACOLOGY
- Axonal -synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease
- (2007) S. Orimo et al. BRAIN
- Nonmotor symptoms of Parkinson's disease: Prevalence and awareness of patients and families
- (2007) Sang-Myung Cheon et al. PARKINSONISM & RELATED DISORDERS
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started