Smouldering fire or conflagration? An illustrated update on the concept of inflammation in pulmonary arterial hypertension

Central Role of Dendritic Cells in Pulmonary Arterial Hypertension in Human and Mice

(2021) Denise van Uden et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models

(2021) James D. West et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sotatercept for the Treatment of Pulmonary Arterial Hypertension

(2021) Marc Humbert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mendelian randomisation and experimental medicine approaches to IL-6 as a drug target in PAH

(2021) Mark Toshner et al.   EUROPEAN RESPIRATORY JOURNAL

Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease

(2020) Grégoire Manaud et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Altered Gut Microbiome Profile in Patients With Pulmonary Arterial Hypertension

(2020) Seungbum Kim et al.   HYPERTENSION

TNF Induces Obliterative Pulmonary Vascular Disease in a Novel Model of Connective Tissue Disease Associated Pulmonary Arterial Hypertension (CTD‐PAH)

(2020) Richard D. Bell et al.   Arthritis & Rheumatology

Implication of Potassium Channels in the Pathophysiology of Pulmonary Arterial Hypertension

(2020) Hélène Le Ribeuz et al.   Biomolecules

Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension

(2019) Aurélie Hautefort et al.   CIRCULATION

Glibenclamide treatment in a Cantú syndrome patient with a pathogenic ABCC9 gain‐of‐function variant: Initial experience

(2019) Alan Ma et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Characterization of Kcnk3 -Mutated Rat, a Novel Model of Pulmonary Hypertension

(2019) Mélanie Lambert et al.   CIRCULATION RESEARCH

Beyond the Lungs: Systemic Manifestations of Pulmonary Arterial Hypertension

(2019) Nils P Nickel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Phenotypically-Silent Bone Morphogenetic Protein Receptor 2 ( Bmpr2 ) Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing The Risk for Neointimal Transformation

(2019) Wen Tian et al.   CIRCULATION

Ion Channels of the Islets in Type 2 Diabetes

(2019) David Jacobson et al.   JOURNAL OF MOLECULAR BIOLOGY

Th2 CD4 + T Cells Are Necessary and Sufficient for Schistosoma‐ Pulmonary Hypertension

(2019) Rahul Kumar et al.   Journal of the American Heart Association

Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary HypertensionNovelty and Significance

(2018) Rasa Tamosiuniene et al.   CIRCULATION RESEARCH

The integrated stress response system in cardiovascular disease

(2018) Diana Santos-Ribeiro et al.   DRUG DISCOVERY TODAY

Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension

(2018) Yuichi Tamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial Mechanotransduction, Redox Signaling and the Regulation of Vascular Inflammatory Pathways

(2018) Shampa Chatterjee   Frontiers in Physiology

TGFβ and BMPRII signalling pathways in the pathogenesis of pulmonary arterial hypertension

(2018) Birger Tielemans et al.   DRUG DISCOVERY TODAY

Genetics and genomics of pulmonary arterial hypertension

(2018) Nicholas W. Morrell et al.   EUROPEAN RESPIRATORY JOURNAL

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

T-cell immunology of the lung: maintaining the balance between host defence and immune pathology

(2018) Daniel M. Altmann   IMMUNOLOGY

Pattern Recognition Receptors and the Host Cell Death Molecular Machinery

(2018) Gustavo P. Amarante-Mendes et al.   Frontiers in Immunology

TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications

(2017) Andrea Olschewski et al.   EUROPEAN RESPIRATORY JOURNAL

Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial HypertensionCLINICAL PERSPECTIVE

(2016) Fabrice Antigny et al.   CIRCULATION

The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

(2016) Rajesh Ravindran et al.   NATURE

Stress Kinase GCN2 Controls the Proliferative Fitness and Trafficking of Cytotoxic T Cells Independent of Environmental Amino Acid Sensing

(2016) Lee-Ann Van de Velde et al.   Cell Reports

Transcription Factors, Transcriptional Coregulators, and Epigenetic Modulation in the Control of Pulmonary Vascular Cell Phenotype: Therapeutic Implications for Pulmonary Hypertension (2015 Grover Conference Series)

(2016) Soni S. Pullamsetti et al.   Pulmonary Circulation

Chemotherapy-Induced Pulmonary Hypertension

(2015) Benoît Ranchoux et al.   AMERICAN JOURNAL OF PATHOLOGY

T-Helper 17 Cell Polarization in Pulmonary Arterial Hypertension

(2015) Aurélie Hautefort et al.   CHEST

Mitomycin-Induced Pulmonary Veno-Occlusive DiseaseCLINICAL PERSPECTIVE

(2015) Frédéric Perros et al.   CIRCULATION

Management of Pulmonary Arterial Hypertension

(2015) Vallerie V. McLaughlin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension

(2015) Takahiro Hashimoto-Kataoka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Th17 cells in autoimmune diseases

(2015) Lei Han et al.   Frontiers of Medicine

Immune Dysregulation and Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2014) Alice Huertas et al.   CIRCULATION

ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease

(2014) Christopher Lathen et al.   CIRCULATION

Inflammation in pulmonary hypertension: what we know and what we could logically and safely target first

(2014) Sylvia Cohen-Kaminsky et al.   DRUG DISCOVERY TODAY

Preventive and remedial application of etanercept attenuate monocrotaline-induced pulmonary arterial hypertension

(2014) Ling-ling Zhang et al.   International Journal of Rheumatic Diseases

The two faces of IL-6 in the tumor microenvironment

(2014) Daniel T. Fisher et al.   SEMINARS IN IMMUNOLOGY

Bronchus-associated Lymphoid Tissue in Pulmonary Hypertension Produces Pathologic Autoantibodies

(2013) Kelley L. Colvin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Erythrocytes Induce Proinflammatory Endothelial Activation in Hypoxia

(2013) Alice Huertas et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Protective Role of IL-6 in Vascular Remodeling inSchistosomaPulmonary Hypertension

(2013) Brian B. Graham et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Plasma interleukin-6 adds prognostic information in pulmonary arterial hypertension

(2013) G. A. Heresi et al.   EUROPEAN RESPIRATORY JOURNAL

Proinflammatory cytokine levels are linked to death in pulmonary arterial hypertension

(2013) J.-L. Cracowski et al.   EUROPEAN RESPIRATORY JOURNAL

A Novel Channelopathy in Pulmonary Arterial Hypertension

(2013) Lijiang Ma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vaccine Activation of the Nutrient Sensor GCN2 in Dendritic Cells Enhances Antigen Presentation

(2013) R. Ravindran et al.   SCIENCE

Modern Age Pathology of Pulmonary Arterial Hypertension

(2012) Elvira Stacher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cytotoxic Cells and Granulysin in Pulmonary Arterial Hypertension and Pulmonary Veno-occlusive Disease

(2012) Frédéric Perros et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Impaired Natural Killer Cell Phenotype and Function in Idiopathic and Heritable Pulmonary Arterial Hypertension

(2012) Mark L. Ormiston et al.   CIRCULATION

Leptin and regulatory T-lymphocytes in idiopathic pulmonary arterial hypertension

(2012) Alice Huertas et al.   EUROPEAN RESPIRATORY JOURNAL

Tertiary lymphoid organs in infection and autoimmunity

(2012) Katrijn Neyt et al.   TRENDS IN IMMUNOLOGY

Severe Pulmonary Hypertension in Idiopathic Nonspecific Interstitial Pneumonia

(2012) Robert W. Hallowell et al.   Pulmonary Circulation

High Pulsatility Flow Induces Acute Endothelial Inflammation Through Overpolarizing Cells to Activate NF-κB

(2012) Min Li et al.   Cardiovascular Engineering and Technology

Pulmonary Lymphoid Neogenesis in Idiopathic Pulmonary Arterial Hypertension

(2011) Frédéric Perros et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulatory T Cells Limit Vascular Endothelial Injury and Prevent Pulmonary Hypertension

(2011) Rasa Tamosiuniene et al.   CIRCULATION RESEARCH

The development of inducible bronchus-associated lymphoid tissue depends on IL-17

(2011) Javier Rangel-Moreno et al.   NATURE IMMUNOLOGY

Association of a KCNA5 gene polymorphism with systemic sclerosis-associated pulmonary arterial hypertension in the European Caucasian population

(2010) J. Wipff et al.   ARTHRITIS AND RHEUMATISM

The role of dendritic and epithelial cells as master regulators of allergic airway inflammation

(2010) Bart N Lambrecht et al.   LANCET

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

(2010) N. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system

(2009) Stefan Bittner et al.   BRAIN

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

Interleukin-6 Overexpression Induces Pulmonary Hypertension

(2008) M. Kathryn Steiner et al.   CIRCULATION RESEARCH

Understanding the Role of CD4+CD25high (So-Called Regulatory) T Cells in Idiopathic Pulmonary Arterial Hypertension

(2008) Frédéric Perros et al.   RESPIRATION