Microbial Biosynthesis of L-Malic Acid and Related Metabolic Engineering Strategies: Advances and Prospects

In silico evolution of Aspergillus niger organic acid production suggests strategies for switching acid output

(2020) Daniel J. Upton et al.   Biotechnology for Biofuels

Improved Production of Malic Acid in Aspergillus niger by Abolishing Citric Acid Accumulation and Enhancing Glycolytic Flux

(2020) Yongxue Xu et al.   ACS Synthetic Biology

Systems and synthetic biology tools for advanced bioproduction hosts

(2020) Yan Chen et al.   CURRENT OPINION IN BIOTECHNOLOGY

Identification and engineering a C4-dicarboxylate transporter for improvement of malic acid production in Aspergillus niger

(2020) Wei Cao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Direct production of commodity chemicals from lignocellulose using Myceliophthora thermophila

(2019) Jingen Li et al.   METABOLIC ENGINEERING

Process optimization and kinetic analysis of malic acid production from crude glycerol using Aspergillus niger

(2019) J. Iyyappan et al.   BIORESOURCE TECHNOLOGY

Recent advances in microbial production of malic acid from renewable byproducts

(2019) J. Iyyappan et al.   REVIEWS IN ENVIRONMENTAL SCIENCE AND BIO-TECHNOLOGY

Engineering energetically efficient transport of dicarboxylic acids in yeast Saccharomyces cerevisiae

(2019) Behrooz Darbani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a Cre-loxP-based genetic system in Aspergillus niger ATCC1015 and its application to construction of efficient organic acid-producing cell factories

(2019) Yongxue Xu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Identification of major malate export systems in an engineered malate-producing Escherichia coli aided by substrate similarity search

(2019) Gavin Kurgan et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Malic acid production from renewables: a review

(2019) Aline Kövilein et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Malic acid production through the whole-cell hydration of fumaric acid with immobilised Rhizopus oryzae

(2018) Andre Naude et al.   BIOCHEMICAL ENGINEERING JOURNAL

Current advance in biological production of malic acid using wild type and metabolic engineered strains

(2018) Zhongxue Dai et al.   BIORESOURCE TECHNOLOGY

Malic acid production by chemically induced Aspergillus niger MTCC 281 mutant from crude glycerol

(2018) J. Iyyappan et al.   BIORESOURCE TECHNOLOGY

Enhancement of malate production through engineering of the periplasmic rTCA pathway in Escherichia coli

(2018) Liang Guo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Engineering of Escherichia coli for Krebs cycle-dependent production of malic acid

(2018) Debora Trichez et al.   Microbial Cell Factories

Enhancing l-malate production of Aspergillus oryzae FMME218-37 by improving inorganic nitrogen utilization

(2018) Qiang Ding et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Malic acid production from biodiesel derived crude glycerol using morphologically controlled Aspergillus niger in batch fermentation

(2018) J. Iyyappan et al.   BIORESOURCE TECHNOLOGY

Synergistic Rewiring of Carbon Metabolism and Redox Metabolism in Cytoplasm and Mitochondria of Aspergillus oryzae for Increased l-Malate Production

(2018) Jingjing Liu et al.   ACS Synthetic Biology

Engineering of the citrate exporter protein enables high citric acid production in Aspergillus niger

(2018) Matthias G. Steiger et al.   METABOLIC ENGINEERING

Cloning and characterization of pyruvate carboxylase gene responsible for calcium malate overproduction in Penicillium viticola 152 and its expression analysis

(2017) Ibrar Khan et al.   GENE

Rewiring the reductive tricarboxylic acid pathway and L-malate transport pathway of Aspergillus oryzae for overproduction of L-malate

(2017) Jingjing Liu et al.   JOURNAL OF BIOTECHNOLOGY

Metabolic engineering of Aspergillus oryzae for efficient production of l -malate directly from corn starch

(2017) Jingjing Liu et al.   JOURNAL OF BIOTECHNOLOGY

High yield production of four-carbon dicarboxylic acids by metabolically engineered Escherichia coli

(2017) Irene Martinez et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Overexpression of a C4-dicarboxylate transporter is the key for rerouting citric acid to C4-dicarboxylic acid production in Aspergillus carbonarius

(2017) Lei Yang et al.   Microbial Cell Factories

Aspergillus as a versatile cell factory for organic acid production

(2017) Lei Yang et al.   Fungal Biology Reviews

Enhanced succinate production from glycerol by engineered Escherichia coli strains

(2016) Qing Li et al.   BIORESOURCE TECHNOLOGY

Metabolic engineering of Escherichia coli W3110 to produce L-malate

(2016) Xiaoxiang Dong et al.   BIOTECHNOLOGY AND BIOENGINEERING

Efficient malic acid production from glycerol with Ustilago trichophora TZ1

(2016) Thiemo Zambanini et al.   Biotechnology for Biofuels

Enhanced malic acid production from glycerol with high-cell density Ustilago trichophora TZ1 cultivations

(2016) Thiemo Zambanini et al.   Biotechnology for Biofuels

Metabolic engineering of a laboratory-evolvedThermobifida fuscamuC strain for malic acid production on cellulose and minimal treated lignocellulosic biomass

(2016) Yu Deng et al.   BIOTECHNOLOGY PROGRESS

One-step fermentative production of poly(lactate-co-glycolate) from carbohydrates in Escherichia coli

(2016) So Young Choi et al.   NATURE BIOTECHNOLOGY

Overexpression of transport proteins improves the production of 5-aminovalerate from l-lysine in Escherichia coli

(2016) Zhong Li et al.   Scientific Reports

Metabolic engineering in the biotechnological production of organic acids in the tricarboxylic acid cycle of microorganisms: Advances and prospects

(2015) Xian Yin et al.   BIOTECHNOLOGY ADVANCES

Fungal biotransformation of crude glycerol into malic acid

(2015) Thomas P. West   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Identification of a Classical Mutant in the Industrial Host Aspergillus niger by Systems Genetics: LaeA Is Required for Citric Acid Production and Regulates the Formation of Some Secondary Metabolites

(2015) Jing Niu et al.   G3-Genes Genomes Genetics

Adaptation and Transcriptome Analysis of Aureobasidium pullulans in Corncob Hydrolysate for Increased Inhibitor Tolerance to Malic Acid Production

(2015) Xiang Zou et al.   PLoS One

Process characterization and influence of alternative carbon sources and carbon-to-nitrogen ratio on organic acid production by Aspergillus oryzae DSM1863

(2014) Katrin Ochsenreither et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Physiological characterization of the high malic acid-producing Aspergillus oryzae strain 2103a-68

(2014) Christoph Knuf et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

High levels of malic acid production by the bioconversion of corn straw hydrolyte using an isolated Rhizopus delemar strain

(2014) Xingjiang Li et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Microbial biosynthesis and secretion ofl-malic acid and its applications

(2014) Zhe Chi et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Metabolic engineering of carbon and redox flow in the production of small organic acids

(2014) Chandresh Thakker et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Metabolic engineering of Corynebacterium glutamicum for L-arginine production

(2014) Seok Hyun Park et al.   Nature Communications

Investigation of Malic Acid Production in Aspergillus oryzae under Nitrogen Starvation Conditions

(2013) Christoph Knuf et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Calcium malate overproduction by Penicillium viticola 152 using the medium containing corn steep liquor

(2013) Ibrar Khan et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering of Aspergillus oryzae NRRL 3488 for increased production of l-malic acid

(2013) Stephen H. Brown et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

High-level production of calcium malate from glucose by Penicillium sclerotiorum K302

(2013) Zhi-Peng Wang et al.   BIORESOURCE TECHNOLOGY

Production of polymalic acid and malic acid byAureobasidium pullulansfermentation and acid hydrolysis

(2013) Xiang Zou et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic engineering of Torulopsis glabrata for malate production

(2013) Xiulai Chen et al.   METABOLIC ENGINEERING

A reverse glyoxylate shunt to build a non-native route from C4 to C2 in Escherichia coli

(2013) Samuel E. Mainguet et al.   METABOLIC ENGINEERING

Genetically switched d-lactate production in Escherichia coli

(2012) Li Zhou et al.   METABOLIC ENGINEERING

Engineered Bacillus subtilis 168 produces l-malate by heterologous biosynthesis pathway construction and lactate dehydrogenase deletion

(2012) Li Mu et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Malic acid production from thin stillage by Aspergillus species

(2011) Thomas P. West   BIOTECHNOLOGY LETTERS

Identification of C4-Dicarboxylate Transport Systems in Pseudomonas aeruginosaPAO1

(2011) M. Valentini et al.   JOURNAL OF BACTERIOLOGY

l-Malate Production by Metabolically EngineeredEscherichiacoli

(2010) X. Zhang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Key Process Conditions for Production of C4 Dicarboxylic Acids in Bioreactor Batch Cultures of an Engineered Saccharomyces cerevisiae Strain

(2009) R. M. Zelle et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Highly active, citrate inhibition resistant form of Aspergillus niger 6-phosphofructo-1-kinase encoded by a modified pfkA gene

(2009) Maja Capuder et al.   JOURNAL OF BIOTECHNOLOGY

Overexpression of isocitrate lyase—glyoxylate bypass influence on metabolism in Aspergillus niger

(2009) S. Meijer et al.   METABOLIC ENGINEERING

Malic Acid Production by Saccharomyces cerevisiae: Engineering of Pyruvate Carboxylation, Oxaloacetate Reduction, and Malate Export

(2008) R. M. Zelle et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Microbial production of organic acids: expanding the markets

(2008) Michael Sauer et al.   TRENDS IN BIOTECHNOLOGY

Combining metabolic engineering and metabolic evolution to develop nonrecombinant strains ofEscherichia coli C that produce succinate and malate

(2007) Kaemwich Jantama et al.   BIOTECHNOLOGY AND BIOENGINEERING