Cardiac Fibroblast Growth Factor 23 Excess Does Not Induce Left Ventricular Hypertrophy in Healthy Mice

A Land of Controversy: Fibroblast Growth Factor-23 and Uremic Cardiac Hypertrophy

(2020) Jing-Fu Bao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4

(2020) Yinghui Huang et al.   Nature Communications

Active vitamin D is cardioprotective in experimental uraemia but not in children with CKD Stages 3–5

(2020) Anne Schön et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation

(2019) Yuichi Takashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF23-Mediated Activation of Local RAAS Promotes Cardiac Hypertrophy and Fibrosis

(2019) Ineke Böckmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation and Effects of FGF23 in Chronic Kidney Disease

(2019) John Musgrove et al.   Annual Review of Physiology

Fibroblast Growth Factor-23 and Risks of Cardiovascular and Noncardiovascular Diseases: A Meta-Analysis

(2018) Amarnath Marthi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk

(2018) Eva-Maria Pastor-Arroyo et al.   KIDNEY INTERNATIONAL

Fibroblast growth factor 23 is induced by an activated renin–angiotensin–aldosterone system in cardiac myocytes and promotes the pro-fibrotic crosstalk between cardiac myocytes and fibroblasts

(2018) Maren Leifheit-Nestler et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

FGF23 Actions on Target Tissues—With and Without Klotho

(2018) Beatrice Richter et al.   Frontiers in Endocrinology

Impact of Altered Mineral Metabolism on Pathological Cardiac Remodeling in Elevated Fibroblast Growth Factor 23

(2018) Maren Leifheit-Nestler et al.   Frontiers in Endocrinology

Fibroblast Growth Factor-23 May Follow Cardiovascular Disease Rather than Causing It in Chronic Kidney Disease

(2018) Chenchen Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling

(2018) Gaozhi Chen et al.   NATURE

Cardioprotective Effects of Paricalcitol Alone and in Combination With FGF23 Receptor Inhibition in Chronic Renal Failure: Experimental and Clinical Studies

(2018) Brian Czaya et al.   AMERICAN JOURNAL OF HYPERTENSION

Vitamin D treatment attenuates cardiac FGF23/FGFR4 signaling and hypertrophy in uremic rats

(2017) Maren Leifheit-Nestler et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Protocol for Efficient Generation and Characterization of Adeno-Associated Viral Vectors

(2017) Andreas Jungmann et al.   Human Gene Therapy Methods

Klotho Improves Cardiac Function by Suppressing Reactive Oxygen Species (ROS) Mediated Apoptosis by Modulating Mapks/Nrf2 Signaling in Doxorubicin-Induced Cardiotoxicity

(2017) Huolan Zhu et al.   MEDICAL SCIENCE MONITOR

FGF23/FGFR4-mediated left ventricular hypertrophy is reversible

(2017) Alexander Grabner et al.   Scientific Reports

Genetic Ablation of Fgf23 or Klotho Does not Modulate Experimental Heart Hypertrophy Induced by Pressure Overload

(2017) Svetlana Slavic et al.   Scientific Reports

Association of Fibroblast Growth Factor 23 With Atrial Fibrillation in Chronic Kidney Disease, From the Chronic Renal Insufficiency Cohort Study

(2016) Rupal Mehta et al.   JAMA Cardiology

Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy

(2015) Alexander Grabner et al.   Cell Metabolism

Efficacy and safety of myocardial gene transfer of adenovirus, adeno-associated virus and lentivirus vectors in the mouse heart

(2015) M Merentie et al.   GENE THERAPY

Experimental Myocardial Infarction Upregulates Circulating Fibroblast Growth Factor-23

(2015) Olena Andrukhova et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The failing heart is a major source of circulating FGF23 via oncostatin M receptor activation

(2015) Manfred Richter et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy

(2015) K. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Induction of cardiac FGF23/FGFR4 expression is associated with left ventricular hypertrophy in patients with chronic kidney disease

(2015) Maren Leifheit-Nestler et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase

(2014) Stanislas Werfel et al.   CARDIOVASCULAR RESEARCH

Fibroblast Growth Factor-23 and Cardiovascular Disease in the General Population

(2014) Bryan Kestenbaum et al.   Circulation-Heart Failure

Coupling fibroblast growth factor 23 production and cleavage

(2014) Myles Wolf et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

FGF23 regulates renal sodium handling and blood pressure

(2014) Olena Andrukhova et al.   EMBO Molecular Medicine

Klotho and Phosphate Are Modulators of Pathologic Uremic Cardiac Remodeling

(2014) M. C. Hu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis

(2014) V. S. Tagliabracci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibroblast Growth Factor‐23 and Incident Coronary Heart Disease, Heart Failure, and Cardiovascular Mortality: The Atherosclerosis Risk In Communities Study

(2014) Pamela L. Lutsey et al.   Journal of the American Heart Association

Cardiac-Selective Expression of Extracellular Superoxide Dismutase After Systemic Injection of Adeno-Associated Virus 9 Protects the Heart Against Post–Myocardial Infarction Left Ventricular Remodeling

(2013) Prasad R. Konkalmatt et al.   Circulation-Cardiovascular Imaging

Fibroblast Growth Factor-23 and Cardiovascular Events in CKD

(2013) J. J. Scialla et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fibroblast Growth Factor-23 and Death, Heart Failure, and Cardiovascular Events in Community-Living Individuals

(2012) Joachim H. Ix et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart

(2012) Jian Xie et al.   Nature Communications

FGF23 induces left ventricular hypertrophy

(2011) Christian Faul et al.   JOURNAL OF CLINICAL INVESTIGATION

FGF-23 Associates with Death, Cardiovascular Events, and Initiation of Chronic Dialysis

(2011) J. Kendrick et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease

(2011) Tamara Isakova et al.   KIDNEY INTERNATIONAL

Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease

(2009) Orlando M. Gutiérrez et al.   CIRCULATION

Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis

(2008) Orlando M. Gutiérrez et al.   NEW ENGLAND JOURNAL OF MEDICINE