The Diverse Roles of Histone Demethylase KDM4B in Normal and Cancer Development and Progression
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Diverse Roles of Histone Demethylase KDM4B in Normal and Cancer Development and Progression
Authors
Keywords
-
Journal
Frontiers in Cell and Developmental Biology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-02-03
DOI
10.3389/fcell.2021.790129
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Histone demethylase JMJD2B/KDM4B regulates transcriptional program via distinctive epigenetic targets and protein interactors for the maintenance of trophoblast stem cells
- (2021) Kylie Hin-Man Mak et al. Scientific Reports
- TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis
- (2021) Narumi Suzuki et al. Autophagy
- Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging
- (2021) Peng Deng et al. Cell Stem Cell
- Activation of TC10-Like Transcription by Lysine Demethylase KDM4B in Colorectal Cancer Cells
- (2021) Baoyu Chen et al. Frontiers in Cell and Developmental Biology
- Advances in histone demethylase KDM4 as cancer therapeutic targets
- (2020) Dong Hoon Lee et al. FASEB JOURNAL
- KDM4B facilitates colorectal cancer growth and glucose metabolism by stimulating TRAF6-mediated AKT activation
- (2020) Haijie Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Ascorbate and Iron Are Required for the Specification and Long-Term Self-Renewal of Human Skeletal Mesenchymal Stromal Cells
- (2020) Tong Ming Liu et al. Stem Cell Reports
- Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts
- (2020) Albert Gris-Oliver et al. CLINICAL CANCER RESEARCH
- A Novel, Circulating Tumor Cell Enrichment Method Reduces ARv7 False Positivity in Patients with Castration-Resistant Prostate Cancer
- (2020) Takehiko Nakasato et al. Diagnostics
- Targeting the KDM4B‐AR‐c‐Myc axis promotes sensitivity to androgen receptor targeted therapy in advanced prostate cancer
- (2020) Dong‐E Tang et al. JOURNAL OF PATHOLOGY
- Oncometabolites suppress DNA repair by disrupting local chromatin signalling
- (2020) Parker L. Sulkowski et al. NATURE
- Oncometabolites and the response to radiotherapy
- (2020) Kexu Xiang et al. Radiation Oncology
- JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells
- (2019) Lei Duan et al. ONCOGENE
- IL-6 and sIL-6R induces STAT3-dependent differentiation of human VSMCs into osteoblast-like cells through JMJD2B-mediated histone demethylation of RUNX2
- (2019) Akira Kurozumi et al. BONE
- The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance
- (2019) Karl Agger et al. BLOOD
- Upregulated KDM4B promotes prostate cancer cell proliferation by activating autophagy
- (2019) Jianjun Sha et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The Histone Demethylase Enzymes KDM3A and KDM4B Co-Operatively Regulate Chromatin Transactions of the Estrogen Receptor in Breast Cancer
- (2019) Jones et al. Cancers
- Chromatin regulators mediate anthracycline sensitivity in breast cancer
- (2019) Jose A. Seoane et al. NATURE MEDICINE
- Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation
- (2019) Lingling Duan et al. NUCLEIC ACIDS RESEARCH
- Identification of hub genes and key pathways associated with the progression of gynecological cancer
- (2019) Xi Zhang et al. Oncology Letters
- H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming
- (2018) Xin Liu et al. DEVELOPMENT
- Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases
- (2018) Tuomas Laukka et al. JOURNAL OF MOLECULAR BIOLOGY
- KDM4B promotes DNA damage response via STAT3 signaling and is a target of CREB in colorectal cancer cells
- (2018) Wei-Wu Deng et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- KDM4B protects against obesity and metabolic dysfunction
- (2018) Yingduan Cheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity
- (2018) May Levin et al. Oncotarget
- JMJD2B/KDM4B inactivation in adipose tissues accelerates obesity and systemic metabolic abnormalities
- (2018) Changkeun Kang et al. GENES TO CELLS
- KDM4B-regulated unfolded protein response as a therapeutic vulnerability in PTEN-deficient breast cancer
- (2018) Wenyu Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery
- (2018) Hui-Ju Hsieh et al. Nature Communications
- Distal-less homeobox 5 promotes the osteo-/dentinogenic differentiation potential of stem cells from apical papilla by activating histone demethylase KDM4B through a positive feedback mechanism
- (2018) Haoqing Yang et al. EXPERIMENTAL CELL RESEARCH
- KDM4B promotes gastric cancer metastasis by regulating miR-125b-mediated activation of Wnt signaling
- (2018) Jia-Chen Jing et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Unraveling KDM4 histone demethylase expression and its association with adverse cytogenetic findings in chronic lymphocytic leukemia
- (2018) Luma Dayane de Carvalho Filiú-Braga et al. MEDICAL ONCOLOGY
- KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage
- (2017) Laura Castellini et al. NUCLEIC ACIDS RESEARCH
- Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models
- (2017) Young K. Chen et al. ACS Medicinal Chemistry Letters
- Histone H3K9 Demethylase JMJD2B Activates Adipogenesis by Regulating H3K9 Methylation on PPARγ and C/EBPα during Adipogenesis
- (2017) Min-Kyung Jang et al. PLoS One
- Strong KDM4B and KDM4D Expression Associates with Radioresistance and Aggressive Phenotype in Classical Hodgkin Lymphoma
- (2016) HAMID BUR et al. ANTICANCER RESEARCH
- The Prognostic Impact of Jumonji Domain-containing 2B in Patients with Resected Lung Adenocarcinoma
- (2016) GOUJI TOYOKAWA et al. ANTICANCER RESEARCH
- Repositioning the Old Fungicide Ciclopirox for New Medical Uses
- (2016) Tao Shen et al. CURRENT PHARMACEUTICAL DESIGN
- Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self‐renewal and early development
- (2016) Marianne Terndrup Pedersen et al. EMBO JOURNAL
- GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER+ Breast Cancer Outcome
- (2016) D. C. West et al. MOLECULAR CANCER RESEARCH
- The histone demethylase KDM4B regulates peritoneal seeding of ovarian cancer
- (2016) C Wilson et al. ONCOGENE
- Reader domain specificity and lysine demethylase-4 family function
- (2016) Zhangli Su et al. Nature Communications
- JMJD2B is required for Helicobacter pylori-induced gastric carcinogenesis via regulating COX-2 expression
- (2016) Fengjuan Han et al. Oncotarget
- KDM4B plays an important role in mitochondrial apoptosis by upregulating HAX1 expression in colorectal cancer
- (2016) Haijie Li et al. Oncotarget
- KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism
- (2016) Erhu Zhao et al. Cell Reports
- Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse
- (2016) K Fujiwara et al. Translational Psychiatry
- Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases
- (2016) Salminen Antero et al. Aging and Disease
- KDM4B promotes epithelial-mesenchymal transition through up-regulation of ZEB1 in pancreatic cancer
- (2015) Shuo Li et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- JMJD2B as a potential diagnostic immunohistochemical marker for hepatocellular carcinoma: A tissue microarray-based study
- (2015) Jeng-Wei Lu et al. ACTA HISTOCHEMICA
- The histone demethylase KDM4B interacts with MyoD to regulate myogenic differentiation in C2C12 myoblast cells
- (2015) Jang Hyun Choi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes
- (2015) Lingling Duan et al. CHEMISTRY & BIOLOGY
- miR-491-5p functions as a tumor suppressor by targeting JMJD2B in ERα-positive breast cancer
- (2015) Zeng Hui et al. FEBS LETTERS
- Histone demethylase KDM4B regulates otic vesicle invagination via epigenetic control ofDlx3expression
- (2015) Rosa A. Uribe et al. JOURNAL OF CELL BIOLOGY
- The Role of Histone Demethylase KDM4B in Myc Signaling in Neuroblastoma
- (2015) Jun Yang et al. JNCI-Journal of the National Cancer Institute
- Histone demethylase JMJD2B and JMJD2C induce fibroblast growth factor 2: mediated tumorigenesis of osteosarcoma
- (2015) Xiaojiang Li et al. MEDICAL ONCOLOGY
- Emodin attenuates radioresistance induced by hypoxia in HepG2 cells via the enhancement of PARP1 cleavage and inhibition of JMJD2B
- (2015) SANG YOUN HWANG et al. ONCOLOGY REPORTS
- Transforming Growth Factor-β-Induced KDM4B Promotes Chondrogenic Differentiation of Human Mesenchymal Stem Cells
- (2015) Hye-Lim Lee et al. STEM CELLS
- KDM4B and KDM4A promote endometrial cancer progression by regulating androgen receptor, c-myc, and p27kip1
- (2015) Mei-Ting Qiu et al. Oncotarget
- The Role of Histone Demethylase KDM4B in Myc Signaling in Neuroblastoma
- (2015) Jun Yang et al. JNCI-Journal of the National Cancer Institute
- Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer
- (2014) L Chen et al. BRITISH JOURNAL OF CANCER
- Distal-less homeobox 2 promotes the osteogenic differentiation potential of stem cells from apical papilla
- (2014) Binbin Qu et al. CELL AND TISSUE RESEARCH
- Stimulation of β-catenin and colon cancer cell growth by the KDM4B histone demethylase
- (2014) WILLIAM L. BERRY et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Silencing of JMJD2B induces cell apoptosis via mitochondria-mediated and death receptor-mediated pathway activation in colorectal cancer
- (2014) Bei Bei Sun et al. Journal of Digestive Diseases
- KDM4B as a Target for Prostate Cancer: Structural Analysis and Selective Inhibition by a Novel Inhibitor
- (2014) Chia-Han Chu et al. JOURNAL OF MEDICINAL CHEMISTRY
- KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells
- (2013) W. L. Berry et al. CANCER RESEARCH
- JMJD2B Promotes Epithelial-Mesenchymal Transition by Cooperating with -Catenin and Enhances Gastric Cancer Metastasis
- (2013) L. Zhao et al. CLINICAL CANCER RESEARCH
- Deregulated expression of selected histone methylases and demethylases in prostate carcinoma
- (2013) Filipa Quintela Vieira et al. ENDOCRINE-RELATED CANCER
- Heat Shock Protein 90 (Hsp90) Selectively Regulates the Stability of KDM4B/JMJD2B Histone Demethylase
- (2013) Inbal Ipenberg et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Distinct and Combinatorial Functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in Mouse Embryonic Stem Cell Identity
- (2013) Partha Pratim Das et al. MOLECULAR CELL
- KDM4B is a Master Regulator of the Estrogen Receptor Signalling Cascade
- (2013) Luke Gaughan et al. NUCLEIC ACIDS RESEARCH
- The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover
- (2013) Kelly Coffey et al. NUCLEIC ACIDS RESEARCH
- The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression
- (2012) Leah C. Young et al. Biochemistry and Cell Biology
- Histone demethylase JMJD2B-mediated cell proliferation regulated by hypoxia and radiation in gastric cancer cell
- (2012) Joong-Gook Kim et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- HIF-1α-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism
- (2012) Linna Fu et al. CARCINOGENESIS
- Histone demethylase Kdm4b functions as a co-factor of C/EBPβ to promote mitotic clonal expansion during differentiation of 3T3-L1 preadipocytes
- (2012) L Guo et al. CELL DEATH AND DIFFERENTIATION
- Histone Demethylases KDM4B and KDM6B Promotes Osteogenic Differentiation of Human MSCs
- (2012) Ling Ye et al. Cell Stem Cell
- TSA-induced JMJD2B downregulation is associated with cyclin B1-dependent survivin degradation and apoptosis in LNCap cells
- (2012) Shan Zhu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Transient JMJD2B-Mediated Reduction of H3K9me3 Levels Improves Reprogramming of Embryonic Stem Cells into Cloned Embryos
- (2012) J. Antony et al. MOLECULAR AND CELLULAR BIOLOGY
- Functional Analysis of Histone Demethylase Jmjd2b on Lipopolysaccharide-Treated Murine Neural Stem Cells (NSCs)
- (2012) Nando Dulal Das et al. NEUROTOXICITY RESEARCH
- Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B
- (2011) Lu Wen et al. ACTA PHARMACOLOGICA SINICA
- Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer
- (2011) Wenjuan Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Testis-Enriched Histone Demethylase, KDM4D, Regulates Methylation of Histone H3 Lysine 9 During Spermatogenesis in the Mouse but Is Dispensable for Fertility1
- (2011) Naoki Iwamori et al. BIOLOGY OF REPRODUCTION
- JmjN interacts with JmjC to ensure selective proteolysis of Gis1 by the proteasome
- (2011) Z. Quan et al. MICROBIOLOGY-SGM
- Histone Demethylase JMJD2B Functions as a Co-Factor of Estrogen Receptor in Breast Cancer Proliferation and Mammary Gland Development
- (2011) Masahito Kawazu et al. PLoS One
- Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis
- (2011) L. Shi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Histone Demethylase JMJD2B Is Regulated by Estrogen Receptor and Hypoxia, and Is a Key Mediator of Estrogen Induced Growth
- (2010) J. Yang et al. CANCER RESEARCH
- Ciclopirox
- (2010) Alessandro Subissi et al. DRUGS
- Design, Synthesis, Enzyme-Inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors
- (2010) Shohei Hamada et al. JOURNAL OF MEDICINAL CHEMISTRY
- Dynamic Nuclear Organization of Constitutive Heterochromatin During Fetal Male Germ Cell Development in Mice1
- (2009) Hirotaka Yoshioka et al. BIOLOGY OF REPRODUCTION
- Alterations of histone modifications by cobalt compounds
- (2009) Qin Li et al. CARCINOGENESIS
- Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins
- (2009) Patrick Trojer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α
- (2008) Patrick J. Pollard et al. BIOCHEMICAL JOURNAL
- The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF
- (2008) Sophie Beyer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases⊥
- (2008) Nathan R. Rose et al. JOURNAL OF MEDICINAL CHEMISTRY
- Regulation of cancer cell metabolism by hypoxia-inducible factor 1
- (2008) Gregg L. Semenza SEMINARS IN CANCER BIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started