KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage

Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET

(2014) Erinn B. Rankin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers

(2014) Haiyang Yu et al.   Nature Communications

KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells

(2013) W. L. Berry et al.   CANCER RESEARCH

JMJD2B Promotes Epithelial-Mesenchymal Transition by Cooperating with  -Catenin and Enhances Gastric Cancer Metastasis

(2013) L. Zhao et al.   CLINICAL CANCER RESEARCH

The Apoptosis Repressor with a CARD Domain (ARC) Gene Is a Direct Hypoxia-Inducible Factor 1 Target Gene and Promotes Survival and Proliferation of VHL-Deficient Renal Cancer Cells

(2013) O. V. Razorenova et al.   MOLECULAR AND CELLULAR BIOLOGY

KDM4B is a Master Regulator of the Estrogen Receptor Signalling Cascade

(2013) Luke Gaughan et al.   NUCLEIC ACIDS RESEARCH

The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover

(2013) Kelly Coffey et al.   NUCLEIC ACIDS RESEARCH

p53 promotes repair of heterochromatin DNA by regulating JMJD2b and SUV39H1 expression

(2013) H Zheng et al.   ONCOGENE

The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression

(2012) Leah C. Young et al.   Biochemistry and Cell Biology

HIF-1α-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism

(2012) Linna Fu et al.   CARCINOGENESIS

An epigenetic role for PRL-3 as a regulator of H3K9 methylation in colorectal cancer

(2012) Yongxia Liu et al.   GUT

Inflammasomes in carcinogenesis and anticancer immune responses

(2012) Laurence Zitvogel et al.   NATURE IMMUNOLOGY

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Complexities of occupancy and sequence

(2012) Mary Muers   NATURE REVIEWS GENETICS

p53-mediated heterochromatin reorganization regulates its cell fate decisions

(2012) Sathish Kumar Mungamuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Global histone modification pattern associated with recurrence and disease-free survival in non-small cell lung cancer patients

(2012) Joon Seon Song et al.   PATHOLOGY INTERNATIONAL

Regulation of Tumor Suppressor p53 and HCT116 Cell Physiology by Histone Demethylase JMJD2D/KDM4D

(2012) Tae-Dong Kim et al.   PLoS One

Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1

(2012) Y. Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer

(2011) Wenjuan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Histone Demethylase JMJD2B Plays an Essential Role in Human Carcinogenesis through Positive Regulation of Cyclin-Dependent Kinase 6

(2011) G. Toyokawa et al.   Cancer Prevention Research

Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family

(2011) Lars Hillringhaus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells

(2011) Tae-Dong Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Stabilization of Suv39H1 by SirT1 Is Part of Oxidative Stress Response and Ensures Genome Protection

(2011) Laia Bosch-Presegué et al.   MOLECULAR CELL

Cancer-associated alteration of pericentromeric heterochromatin may contribute to chromosome instability

(2011) R B Slee et al.   ONCOGENE

Histone Demethylase JMJD2B Functions as a Co-Factor of Estrogen Receptor in Breast Cancer Proliferation and Mammary Gland Development

(2011) Masahito Kawazu et al.   PLoS One

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis

(2011) L. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cooperative Epigenetic Modulation by Cancer Amplicon Genes

(2010) Lixin Rui et al.   CANCER CELL

The Histone Demethylase JMJD2B Is Regulated by Estrogen Receptor   and Hypoxia, and Is a Key Mediator of Estrogen Induced Growth

(2010) J. Yang et al.   CANCER RESEARCH

MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output

(2010) Lihong Chen et al.   EMBO JOURNAL

Prognostic relevance of global histone H3 lysine 4 (H3K4) methylation in renal cell carcinoma

(2010) Jörg Ellinger et al.   INTERNATIONAL JOURNAL OF CANCER

Drosophilap53 Is Required to Increase the Levels of the dKDM4B Demethylase after UV-induced DNA Damage to Demethylate Histone H3 Lysine 9

(2010) Zoraya Palomera-Sanchez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone demethylases in development and disease

(2010) Marianne Terndrup Pedersen et al.   TRENDS IN CELL BIOLOGY

Global Histone Modifications in Breast Cancer Correlate with Tumor Phenotypes, Prognostic Factors, and Patient Outcome

(2009) S. E. Elsheikh et al.   CANCER RESEARCH

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Regulation of the Histone Demethylase JMJD1A by Hypoxia-Inducible Factor 1  Enhances Hypoxic Gene Expression and Tumor Growth

(2009) A. J. Krieg et al.   MOLECULAR AND CELLULAR BIOLOGY

KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis

(2009) Chunyan Tian et al.   NATURE CELL BIOLOGY

Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer

(2009) G Liu et al.   ONCOGENE

Global levels of histone modifications predict prostate cancer recurrence

(2009) Jörg Ellinger et al.   PROSTATE

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α

(2008) Patrick J. Pollard et al.   BIOCHEMICAL JOURNAL

The emerging field of dynamic lysine methylation of non-histone proteins

(2008) Jing Huang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF

(2008) Sophie Beyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers

(2008) Yongkun Wei et al.   MOLECULAR CARCINOGENESIS

The genetics of the p53 pathway, apoptosis and cancer therapy

(2008) Alexei Vazquez et al.   NATURE REVIEWS DRUG DISCOVERY

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY