Cell Death Related Proteins Beyond Apoptosis in the CNS

Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits

(2021) Anastasia Noël et al.   Cell Death & Disease

Involvement of Bcl-xL in Neuronal Function and Development

(2021) Julie Bas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling

(2021) Luam E. Araya et al.   ACS Chemical Biology

Bcl-xL and IP3R interaction: Intimate relationship with an uncertain outcome

(2021) Nikolay Popgeorgiev et al.   CELL CALCIUM

Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis

(2021) Nicolas Rosa et al.   CELL DEATH AND DIFFERENTIATION

Therapeutic potential of Nlrp1 inflammasome, Caspase-1, or Caspase-6 against Alzheimer disease cognitive impairment

(2021) Joseph Flores et al.   CELL DEATH AND DIFFERENTIATION

Downregulation of phosphoglycerate mutase 5 improves microglial inflammasome activation after traumatic brain injury

(2021) Yuhua Chen et al.   Cell Death Discovery

SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L

(2020) Elena Coccia et al.   Cell Death & Disease

Estrogen Protects Optic Nerve Head Astrocytes Against Oxidative Stress by Preventing Caspase-3 Activation, Tau Dephosphorylation at Ser422 and the Formation of Tau Protein Aggregates

(2020) John C. Means et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer’s Disease

(2020) Goonho Park et al.   Cell Reports

Microglia: Agents of the CNS Pro-Inflammatory Response

(2020) José A. Rodríguez-Gómez et al.   Cells

Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis

(2020) Brienne A. McKenzie et al.   Journal of Neuroinflammation

Caspase inhibition rescues F1Fo ATP synthase dysfunction-mediated dendritic spine elimination

(2020) Hao Chen et al.   Scientific Reports

Amyloid β Oligomers Increase ER-Mitochondria Ca2+ Cross Talk in Young Hippocampal Neurons and Exacerbate Aging-Induced Intracellular Ca2+ Remodeling

(2019) Maria Calvo-Rodriguez et al.   Frontiers in Cellular Neuroscience

Loss of Non-Apoptotic Role of Caspase-3 in the PINK1 Mouse Model of Parkinson’s Disease

(2019) Paola Imbriani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration

(2019) Nicholas T. Hertz et al.   NEURON

Impact of sex differences and gender specificity on behavioral characteristics and pathophysiology of neurodegenerative disorders

(2019) Mohammad Fahad Ullah et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Brainiac Caspases: Beyond the Wall of Apoptosis

(2019) Ana María Espinosa-Oliva et al.   Frontiers in Cellular Neuroscience

Fiery Cell Death: Pyroptosis in the Central Nervous System

(2019) Brienne A. McKenzie et al.   TRENDS IN NEUROSCIENCES

Tau localises within mitochondrial sub-compartments and its caspase cleavage affects ER-mitochondria interactions and cellular Ca 2+ handling

(2018) Domenico Cieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Breast Cancer Targeting through Inhibition of the Endoplasmic Reticulum-Based Apoptosis Regulator Nrh/BCL2L10

(2018) Adrien Nougarede et al.   CANCER RESEARCH

C-terminal truncation exacerbates the aggregation and cytotoxicity of α-Synuclein: A vicious cycle in Parkinson's disease

(2018) Liang Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance

(2018) Dale D. O. Martin et al.   FASEB JOURNAL

TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation

(2018) Cun-Jin Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Sexual dimorphism in inflammasome-containing extracellular vesicles and the regulation of innate immunity in the brain of reproductive senescent females

(2018) Ami P. Raval et al.   NEUROCHEMISTRY INTERNATIONAL

Apoptosis versus axon pruning: Molecular intersection of two distinct pathways for axon degeneration

(2018) Matthew J. Geden et al.   NEUROSCIENCE RESEARCH

Caspases orchestrate microglia instrumental functions

(2018) Xianli Shen et al.   PROGRESS IN NEUROBIOLOGY

A Novel Non-Apoptotic Role of Procaspase-3 in the Regulation of Mitochondrial Biogenesis Activators

(2017) Ji-Soo Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Autism Protein Ube3A/E6AP Remodels Neuronal Dendritic Arborization via Caspase-Dependent Microtubule Destabilization

(2017) Natasha Khatri et al.   JOURNAL OF NEUROSCIENCE

Mir363-3p improves ischemic stroke outcomes in female but not male rats

(2017) Amutha Selvamani et al.   NEUROCHEMISTRY INTERNATIONAL

Skilled Movements Require Non-apoptotic Bax/Bak Pathway-Mediated Corticospinal Circuit Reorganization

(2017) Zirong Gu et al.   NEURON

Proteomic identification of synaptic caspase substrates

(2017) Ken G. Victor et al.   SYNAPSE

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

(2017) Yingying Zhang et al.   Nature Communications

C-Terminal Cleavage of the Amyloid-β Protein Precursor at Asp664: A Switch Associated with Alzheimer's Disease

(2017) Surita Banwait et al.   JOURNAL OF ALZHEIMERS DISEASE

Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles

(2016) Olivier Julien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sculpting Neural Circuits by Axon and Dendrite Pruning

(2015) Martin M. Riccomagno et al.   Annual Review of Cell and Developmental Biology

Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

(2015) V Kaushal et al.   CELL DEATH AND DIFFERENTIATION

Regulation of Bcl-xL-ATP Synthase Interaction by Mitochondrial Cyclin B1-Cyclin-Dependent Kinase-1 Determines Neuronal Survival

(2015) M. Veas-Perez de Tudela et al.   JOURNAL OF NEUROSCIENCE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Olfactory bulb proteome dynamics during the progression of sporadic Alzheimer’s disease: identification of common and distinct olfactory targets across Alzheimer-related co-pathologies

(2015) María Victoria Zelaya et al.   Oncotarget

Activation of Necroptosis in Multiple Sclerosis

(2015) Dimitry Ofengeim et al.   Cell Reports

Characterizing Protease Specificity: How Many Substrates Do We Need?

(2015) Michael Schauperl et al.   PLoS One

Die another way – non-apoptotic mechanisms of cell death

(2014) Stephen W. G. Tait et al.   JOURNAL OF CELL SCIENCE

Bcl-2 Family Proteins Participate in Mitochondrial Quality Control by Regulating Parkin/PINK1-Dependent Mitophagy

(2014) Emilie Hollville et al.   MOLECULAR CELL

RUFY, Rab and Rap Family Proteins Involved in a Regulation of Cell Polarity and Membrane Trafficking

(2013) Yasuko Kitagishi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Bcl-xL–Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis

(2013) Hongmei Li et al.   NATURE CELL BIOLOGY

Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning

(2013) Corey L. Cusack et al.   Nature Communications

Axon degeneration in Parkinson's disease

(2012) Robert E. Burke et al.   EXPERIMENTAL NEUROLOGY

α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions

(2012) Tito Calì et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Caspase Cascade Regulating Developmental Axon Degeneration

(2012) D. J. Simon et al.   JOURNAL OF NEUROSCIENCE

Caspase-3 in the central nervous system: beyond apoptosis

(2012) Marcello D’Amelio et al.   TRENDS IN NEUROSCIENCES

Bcl-xLregulates mitochondrial energetics by stabilizing the inner membrane potential

(2011) Ying-bei Chen et al.   JOURNAL OF CELL BIOLOGY

Nonapoptotic Function of BAD and BAX in Long-Term Depression of Synaptic Transmission

(2011) Song Jiao et al.   NEURON

Protein aggregate spreading in neurodegenerative diseases: Problems and perspectives

(2011) Seung-Jae Lee et al.   NEUROSCIENCE RESEARCH

miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia

(2011) C. Siegel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cascleave: towards more accurate prediction of caspase substrate cleavage sites

(2010) Jiangning Song et al.   BIOINFORMATICS

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

(2010) Zheng Li et al.   CELL

Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis

(2010) Feifan Zhou et al.   FEBS Journal

Inflammatory Stimuli Regulate Caspase Substrate Profiles

(2010) Nicholas J. Agard et al.   MOLECULAR & CELLULAR PROTEOMICS

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity

(2010) S. Ohsawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of recombinant caspase specificity by competitive substrates

(2009) Bistra Benkova et al.   ANALYTICAL BIOCHEMISTRY

Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system

(2009) James C. Vickers et al.   BRAIN RESEARCH BULLETIN

Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease

(2008) Natalia Louneva et al.   AMERICAN JOURNAL OF PATHOLOGY

Global Sequencing of Proteolytic Cleavage Sites in Apoptosis by Specific Labeling of Protein N Termini

(2008) Sami Mahrus et al.   CELL

Global Mapping of the Topography and Magnitude of Proteolytic Events in Apoptosis

(2008) Melissa M. Dix et al.   CELL

Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons

(2008) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA