Review
Rheumatology
Tamas Nemeth, Gyorgy Nagy, Thomas Pap
Summary: Fibroblast-like synoviocytes (FLS) are crucial cellular components in the synovial membrane of joints, contributing to normal joint function. However, under inflammatory conditions like rheumatoid arthritis (RA), FLS can become overactive and promote inflammation. Therefore, understanding the role of FLS in RA is essential for disease treatment.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Anil K. Singh, Mahamudul Haque, Bhanupriya Madarampalli, Yuanyuan Shi, Benjamin J. Wildman, Abdul Basit, Sadik A. Khuder, Bhagwat Prasad, Quamarul Hassan, Salahuddin Ahmed, Madhu M. Ouseph
Summary: IL-6 trans-signaling induces molecular reprogramming of RASFs to osteoclast-like cells through the activation of transcription factor Ets2, leading to increased expression of osteoclast-specific proteins and markers of invasive phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Jie Gao, Hongliang Zhang, Yanyan Yang, Jinhui Tao
Summary: The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a cytoplasmic multiprotein complex involved in innate immune response. Its aberrant activation is associated with various inflammatory diseases including rheumatoid arthritis (RA). This review discusses the current understanding of NLRP3 activation in RA pathogenesis and its impact on innate and adaptive immunity, as well as the potential application of specific NLRP3 inhibitors as therapeutic strategies for RA.
Review
Immunology
Liyun Cheng, Yanyan Wang, Ruihe Wu, Tingting Ding, Hongwei Xue, Chong Gao, Xiaofeng Li, Caihong Wang
Summary: Single-cell RNA sequencing (scRNA-seq) technology has the potential to make significant breakthroughs in the study of synovial cell differentiation and development, subset identification, functional analysis, and new therapeutic targets in rheumatoid arthritis (RA).
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Hui Yin, Na Liu, Keshav Raj Sigdel, Lihua Duan
Summary: Rheumatoid arthritis is a chronic inflammatory disease characterized by immune system abnormalities. Recent studies suggest that NLRP3 inflammasome might play an important role in the development of rheumatoid arthritis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiangxiang Liu, Xiaomei Chen, Cheng Zhang, Meixia Huang, Hongmin Yu, Yingzheng Wang, Yinghao Wang
Summary: This study investigated the mechanism by which Notopterygium regulates the NLRP3 inflammasome in the treatment of rheumatoid arthritis, aiming to reveal the scientific implications of Notopterygium in RA treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Rheumatology
Maximilian Kugler, Mirjam Dellinger, Felix Kartnig, Lena Mueller, Teresa Preglej, Leonhard X. Heinz, Elisabeth Simader, Lisa Goeschl, Stephan E. Puchner, Sebastian Weiss, Lisa E. Shaw, Matthias Farlik, Wolfgang Weninger, Giulio Superti-Furga, Josef S. Smolen, Guenter Steiner, Daniel Aletaha, Hans P. Kiener, Myles J. Lewis, Costantino Pitzalis, Anela Tosevska, Thomas Karonitsch, Michael Bonelli
Summary: Activated FLS play a critical role in synovial tissue remodeling and interaction with immune cells in rheumatoid arthritis (RA). Co-culture experiments demonstrated that cytokine-activated FLS enhance T cell activation, proliferation, and differentiation. Transcriptomic analysis revealed a correlation between FLS cytokine signatures and infiltrating CD4(+) T cells in RA synovial tissue. ICAM1 was identified as an important mediator in TNF-mediated FLS-T cell interaction.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Do-Wan Shim, Hyo-Joung Cho, Inhwa Hwang, Taek-Yeol Jung, Hyun-Seok Kim, Ju Hee Ryu, Je-Wook Yu
Summary: The depletion of NAD(+) affects the innate immune potential of macrophages and has an impact on NLRP3 activation. FK866 facilitates NLRP3 activation by promoting perinuclear clustering of mitochondria, while supplementation with NAD(+) can counteract the FK866-induced caspase-1 cleavage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Xinyu Yang, Ning Zhan, Yang Jin, Hanzhi Ling, Chipeng Xiao, Zhen Xie, Hao Zhong, Xinxin Yu, Runhua Tang, Jinglan Ma, Jubo Guan, Guoyu Yin, Gan Wu, Liangjing Lu, Jianguang Wang
Summary: Tofacitinib (TOF) restores the balance of gamma delta regulatory T-cells/gamma delta T17 cells in rheumatoid arthritis (RA) patients by reducing levels of gamma delta T17 cell-related cytokine and inhibiting excessive NLRP3 inflammasome activation.
Review
Immunology
Samuel Kemble, Adam P. Croft
Summary: This review focuses on discussing the disease persistence pathways of rheumatoid arthritis and treating the disease through regulating specific cellular behaviors. The article reveals the heterogeneity of tissue resident synovial cells and how they function in joint inflammation. Finally, specific targeted therapeutic strategies against pathogenic subsets of fibroblasts in RA are proposed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Chia George Hsu, Wenjia Li, Mark Sowden, Camila Lage Chavez, Bradford C. Berk
Summary: Pnpt1 plays critical roles in mitochondrial homeostasis and is involved in inflammation by regulating IL-1β and IL-18 secretion. The study demonstrates that Pnpt1 controls NLRP3 inflammasome activation through glycolysis and mt-ROS in macrophages.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Rheumatology
Li Zheng, Fanlei Hu, Wenjie Bian, Yingni Li, Linqi Zhang, Lianjie Shi, Xiaoxu Ma, Yanying Liu, Xuewu Zhang, Zhanguo Li
Summary: Dkk-1 exacerbates inflammation, cartilage erosion, and angiogenesis mediated by synovial fibroblasts in RA. Modulation of DKK-1 expression may facilitate the development of novel strategies to control RA.
CLINICAL RHEUMATOLOGY
(2021)
Article
Immunology
JingYu Wang, Yan Sun, LiangHong Chen, YiChong Wang, DongXin Shi, Yan Wu, XingHua Gao
Summary: The study found that supramolecular salicylic acid (SSA) can alleviate LL-37-induced rosacea-like inflammation and restore the skin barrier function. In addition, SSA reduces inflammatory cell infiltration and inhibits the production of inflammatory biomarkers associated with rosacea. Furthermore, SSA suppresses the activation of NLRP3-mediated inflammasome induced by LL-37.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Chun-Han Hou, Po-Chun Chen, Ju-Fang Liu
Summary: This study provides novel insights into the role of CXCL1 in the pathogenesis of rheumatoid arthritis by promoting COX-II expression to regulate disease progression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Asta Luciunaite, Indre Dalgediene, Rapolas Zilionis, Kristina Masalaite, Milda Norkiene, Andrius Sinkunas, Alma Gedvilaite, Indre Kucinskaite-Kodze, Aurelija Zvirbliene
Summary: This study investigates the effect of viral oligomeric proteins on the inflammatory response in macrophages. It finds that filamentous proteins do not induce inflammation, while spherical proteins mediate an inflammatory response and activate the NLRP3 inflammasome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Takeshi Harada, Hiroto Ohguchi, Asuka Oda, Michiyasu Nakao, Jumpei Teramachi, Masahiro Hiasa, Ryohei Sumitani, Masahiro Oura, Kimiko Sogabe, Tomoko Maruhashi, Mamiko Takahashi, Shiro Fujii, Shingen Nakamura, Hirokazu Miki, Kumiko Kagawa, Shuji Ozaki, Shigeki Sano, Teru Hideshima, Masahiro Abe
Summary: Histone deacetylase 1 (HDAC1) regulates the expression of transcription factor IRF4 and survival mediator PIM2 kinase in multiple myeloma (MM) cells. Inhibition of HDAC1 reduces the expression of IRF4 and PIM2, and decreases IRF4 transcription through histone hyperacetylation. External stimuli such as BM stromal cells and interleukin-6 (IL-6) upregulate PIM2, attenuating the cytotoxic effects of HDAC1 inhibitors.
Article
Dentistry, Oral Surgery & Medicine
Ryoko Shioyasono, Kaoru Yoshinaga, Atsushi Shioyasono, Ayami Ito, Keiichiro Watanabe, Masahiro Hiasa, Shinya Horiuchi, Eiji Tanaka
Summary: Sotos syndrome, a genetic disorder, is characterized by overgrowth in childhood, specific facial manifestations, advanced bone age, and mental retardation. This article describes the nonsurgical orthodontic treatment of a 10-year-old boy with Sotos syndrome, including maxillary lateral expansion and conventional orthodontic treatment. The results demonstrate the importance of early orthopedic treatment with the facemask and/or chincap in individuals with Sotos syndrome during the peripubertal period.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2023)
Review
Endocrinology & Metabolism
Toshiyuki Yoneda, Masahiro Hiasa, Tatsuo Okui, Kenji Hata
Summary: Cancer-induced bone pain (CIBP) is a common and debilitating complication associated with bone metastasis. This review discusses the role of the interactions between cancer cells and sensory nerves in bone in the pathophysiology of CIBP and cancer progression in bone.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Genetics & Heredity
Kaoru Yoshinaga, Akihiro Yasue, Silvia Naomi Mitsui, Yoshiyuki Minegishi, Seiichi Oyadomari, Issei Imoto, Eiji Tanaka
Summary: WNT molecules regulate various biological functions, including body axis formation, organ development, and cell proliferation and differentiation. WNT10A and WNT10B, considered as genes of the same origin, have been identified as causative genes for tooth deficiency in humans. However, the disrupted mutant of each gene does not show a decrease in teeth number.
Article
Medicine, General & Internal
Masaki Sawada, Saya Suetake, Hiroshi Yamada, Masaaki Higashino, Susumu Abe, Eiji Tanaka
Summary: This study investigated the impact of orthodontic treatment on the frontal sinus development of adult females. Results showed that orthodontic treatment did not affect frontal sinus development after growth.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yoshiki Higa, Masahiro Hiasa, Hirofumi Tenshin, Emiko Nakaue, Mariko Tanaka, Sooha Kim, Motosumi Nakagawa, So Shimizu, Kotaro Tanimoto, Jumpei Teramachi, Takeshi Harada, Asuka Oda, Masahiro Oura, Kimiko Sogabe, Tomoyo Hara, Ryohei Sumitani, Tomoko Maruhashi, Hiroki Yamagami, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka, Masahiro Abe
Summary: Xanthine oxidoreductase (XOR) is a rate-limiting enzyme in purine catabolism and a novel regulator of adipogenesis. The XOR inhibitor febuxostat alleviates adipose tissue mass increase in obese mouse models and disrupts adipocytic differentiation in vitro. Febuxostat suppresses ROS production, induces Nrf2 activation, and inhibits adipogenesis under oxidative conditions. These findings suggest that febuxostat may be a potential treatment for obesity associated with menopause or overeating.
Article
Hematology
Emiko Nakaue, Jumpei Teramachi, Hirofumi Tenshin, Masahiro Hiasa, Takeshi Harada, Asuka Oda, Yusuke Inoue, So Shimizu, Yoshiki Higa, Kimiko Sogabe, Masahiro Oura, Tomoyo Hara, Ryohei Sumitani, Tomoko Maruhashi, Hiroki Yamagami, Itsuro Endo, Eiji Tanaka, Masahiro Abe
Summary: Proteasome inhibitors (PIs) can restore bone in bone-defective lesions of multiple myeloma (MM) patients who respond well to the drugs. This study examined the effects of pulsatile treatment with PIs on bone metabolism to mimic in vivo PI pharmacokinetics. The results showed that pulsatile PI treatment suppressed osteoclastogenesis and bone resorption while enhancing osteoblastogenesis in good responders to PIs. The coupling between osteoclasts and osteoblasts appeared to be a predominant mechanism for bone regeneration in these patients.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2023)
Article
Oncology
Tatsuo Okui, Masahiro Hiasa, Kazuaki Hasegawa, Tomoya Nakamura, Kisho Ono, Soichiro Ibaragi, Takahiro Kanno, Akira Sasaki, Toshiyuki Yoneda
Summary: Breast cancer bone metastasis causes bone pain and the mechanism behind it is poorly understood. This study used a mouse model and found that lactate released from breast cancer cells through MCT4 activates GPR81 in sensory neurons, contributing to the induction of breast cancer bone pain. Silencing MCT4 and GPR81 reduced bone pain and the expression of molecular indicators of neuron excitation in sensory neurons.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Review
Endocrinology & Metabolism
Jumpei Teramachi, Hirokazu Miki, Shingen Nakamura, Masahiro Hiasa, Takeshi Harada, Masahiro Abe
Summary: This review summarizes the mechanisms of bone disease in multiple myeloma (MM) and the available evidence on its treatment. MM cells produce cytokines that stimulate osteoclastogenesis and suppress osteoblastic differentiation, leading to extensive bone destruction. The effects of new anti-MM agents on bone metabolism need to be further analyzed in MM patients.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Dentistry, Oral Surgery & Medicine
Toyoaki Takagi, Eiji Tanaka
Summary: This report describes the successful treatment of an adult case of unilateral posterior crossbite caused by maxillary transverse deficiency with miniscrew-assisted rapid palatal expansion (MARPE). The treatment involved improving the posterior crossbite and using fixed appliances to achieve a good occlusion. The results demonstrate that MARPE is effective for the treatment of maxillary transverse deficiency in adult patients.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2023)
Article
Nutrition & Dietetics
Takahiro Kato, Satoshi Kamiya, Soshi Narasaki, Ayako Sumii, Yasuo M. Tsutsumi, Kyoka Machida, Kanako Hara, Yuna Izumi-Mishima, Rie Tsutsumi, Hiroshi Sakaue
Summary: The consumption of partially hydrolyzed guar gum (PHGG) can improve the gut environment, alleviate the negative effects of H1N1 influenza virus infection, by promoting the production of short-chain fatty acids (SCFAs), inhibiting the increase of inflammatory cytokines, and enhancing natural killer cell activity and regulatory T-cell differentiation.
Editorial Material
Medicine, General & Internal
Eiji Tanaka
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Engineering, Biomedical
Shankargouda Patil, Shilpa Bhandi, Khalid J. Alzahrani, Mrim M. Alnfiai, Luca Testarelli, Burke W. Soffe, Frank W. Licari, Kamran H. Awan, Eiji Tanaka
Summary: This review identified six studies investigating the use of laser therapy and antimicrobial photodynamic therapy in achieving re-osseointegration in peri-implantitis sites in animal models. Four out of six studies reported a higher degree of re-osseointegration following laser therapy. However, conflicting outcomes and limitations in the evidence quality warrant caution in drawing definitive conclusions.
LASERS IN MEDICAL SCIENCE
(2023)