Synovial fibroblasts as potential drug targets in rheumatoid arthritis, where do we stand and where shall we go?

Role of synovial fibroblast subsets across synovial pathotypes in rheumatoid arthritis: a deconvolution analysis

(2022) Raphael Micheroli et al.   RMD Open

A Phase 2 Study of E6011, an Anti-Fractalkine Monoclonal Antibody, in Patients with Rheumatoid Arthritis Inadequately Responding to Biological Disease-modifying Antirheumatic Drugs

(2021) Yoshiya Tanaka et al.   Modern Rheumatology

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

(2021) Jasna Friščić et al.   IMMUNITY

Cross-tissue organization of the fibroblast lineage

(2021) Matthew B. Buechler et al.   NATURE

JAK1: Number one in the family; number one in inflammation?

(2021) Francesca Romana Spinelli et al.   RHEUMATOLOGY

Notch‐1 and Notch‐3 Mediates Hypoxia‐Induced Synovial Fibroblasts Activation in Rheumatoid Arthritis

(2021) Jianhai Chen et al.   Arthritis & Rheumatology

EULAR points to consider for the management of difficult-to-treat rheumatoid arthritis

(2021) György Nagy et al.   ANNALS OF THE RHEUMATIC DISEASES

Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis

(2021) Denise Beckmann et al.   Nature Communications

The IRAK4 kinase inhibitor PF‐06650833 blocks inflammation in preclinical models of rheumatologic disease and in humans enrolled in a randomized clinical trial

(2021) Aaron Winkler et al.   Arthritis & Rheumatology

Methotrexate and theaflavin-3, 3′-digallate synergistically restore the balance between apoptosis and autophagy in synovial fibroblast of RA: an ex vivo approach with cultured human RA FLS

(2021) Sanchaita Misra et al.   INFLAMMOPHARMACOLOGY

Targeting the IL-6–Yap–Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis

(2021) Rebecca A Symons et al.   ANNALS OF THE RHEUMATIC DISEASES

TNF induces glycolytic shift in fibroblast like synoviocytes via GLUT1 and HIF1A

(2021) Kathrin Koedderitzsch et al.   Scientific Reports

Antibody-mediated inhibition of syndecan-4 dimerisation reduces interleukin (IL)-1 receptor trafficking and signalling

(2020) Lars Godmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Synovial fibroblasts and articular tissue remodelling: Role and mechanisms

(2020) Thomas Pap et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Notch signalling drives synovial fibroblast identity and arthritis pathology

(2020) Kevin Wei et al.   NATURE

Adipokines and Inflammation Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts and Endothelial Cells

(2020) Rebecca Hasseli et al.   Frontiers in Immunology

RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares

(2020) Dana E. Orange et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeted photodynamic therapy selectively kills activated fibroblasts in experimental arthritis

(2020) Daphne N Dorst et al.   RHEUMATOLOGY

Role of JAK-STAT signaling in the pathogenic behavior of fibroblast-like synoviocytes in rheumatoid arthritis: Effect of the novel JAK inhibitor peficitinib

(2020) Takashi Emori et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The emerging role of epigenetics in human autoimmune disorders

(2019) Roberta Mazzone et al.   Clinical Epigenetics

Distinct fibroblast subsets drive inflammation and damage in arthritis

(2019) Adam P. Croft et al.   NATURE

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness

(2019) David Kuo et al.   Science Translational Medicine

Syndecan‐4 involves in the pathogenesis of rheumatoid arthritis by regulating the inflammatory response and apoptosis of fibroblast‐like synoviocytes

(2019) Peian Cai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Rheumatoid Arthritis Risk Gene AIRE Is Induced by Cytokines in Fibroblast-Like Synoviocytes and Augments the Pro-inflammatory Response

(2019) Beatrice Bergström et al.   Frontiers in Immunology

Regulation of Immune Responses and Chronic Inflammation by Fibroblast-Like Synoviocytes

(2019) Hiroyuki Yoshitomi   Frontiers in Immunology

Bromodomain and Extraterminal Proteins as Novel Epigenetic Targets for Renal Diseases

(2019) Jose Luis Morgado-Pascual et al.   Frontiers in Pharmacology

Epigenetics in rheumatoid arthritis; fibroblast‐like synoviocytes as an emerging paradigm in the pathogenesis of the disease

(2019) Jafar Karami et al.   IMMUNOLOGY AND CELL BIOLOGY

Advances in Hypoxia-Inducible Factor Biology

(2018) Hani Choudhry et al.   Cell Metabolism

Integrin, alpha9 subunit blockade suppresses collagen-induced arthritis with minimal systemic immunomodulation

(2018) Shingo Sugahara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

(2018) Fumitaka Mizoguchi et al.   Nature Communications

JAK-STAT blockade alters synovial bioenergetics, mitochondrial function and pro-inflammatory mediators in Rheumatoid arthritis

(2018) Trudy McGarry et al.   Arthritis & Rheumatology

Ontology and Function of Fibroblast-Like and Macrophage-Like Synoviocytes: How Do They Talk to Each Other and Can They Be Targeted for Rheumatoid Arthritis Therapy?

(2018) Jiajie Tu et al.   Frontiers in Immunology

Rheumatoid arthritis

(2018) Josef S. Smolen et al.   Nature Reviews Disease Primers

Interactions between rheumatoid arthritis synovial fibroblast migration and endothelial cells

(2018) Birgit Zimmermann-Geller et al.   IMMUNOLOGY AND CELL BIOLOGY

Interferon‐gamma production in Lyme arthritis synovial tissue promotes differentiation of fibroblast‐like synoviocytes into immune effector cells

(2018) Robert B. Lochhead et al.   CELLULAR MICROBIOLOGY

Targeted inhibition of Janus kinases abates interfon gamma-induced invasive behaviour of fibroblast-like synoviocytes

(2017) Thomas Karonitsch et al.   RHEUMATOLOGY

Joint morphogenetic cells in the adult mammalian synovium

(2017) Anke J. Roelofs et al.   Nature Communications

GC/TOF-MS-based metabolomic profiling in cultured fibroblast-like synoviocytes from rheumatoid arthritis

(2016) Joong Kyong Ahn et al.   JOINT BONE SPINE

Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes

(2016) Ricard Garcia-Carbonell et al.   Arthritis & Rheumatology

Mesenchymal stem cells alleviate experimental rheumatoid arthritis through microRNA-regulated IκB expression

(2016) Xin Yan et al.   Scientific Reports

RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation

(2015) Lynett Danks et al.   ANNALS OF THE RHEUMATIC DISEASES

Hypoxia-inducible factor-1α perpetuates synovial fibroblast interactions with T cells and B cells in rheumatoid arthritis

(2015) Fanlei Hu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

Umbilical Cord-Derived Mesenchymal Stem Cells Inhibit Cadherin-11 Expression by Fibroblast-Like Synoviocytes in Rheumatoid Arthritis

(2015) Cheng Zhao et al.   Journal of Immunology Research

The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts

(2014) Kerstin Klein et al.   ANNALS OF THE RHEUMATIC DISEASES

Cadherin-11 mRNA transcripts are frequently found in rheumatoid arthritis peripheral blood and correlate with established polyarthritis

(2014) P.P. Sfikakis et al.   CLINICAL IMMUNOLOGY

Phosphoinositide 3-Kinase   Regulates Migration and Invasion of Synoviocytes in Rheumatoid Arthritis

(2014) B. Bartok et al.   JOURNAL OF IMMUNOLOGY

The roles of IFN-γ versus IL-17 in pathogenic effects of human Th17 cells on synovial fibroblasts

(2014) Hiroshi Kato et al.   Modern Rheumatology

Clinicopathological Correlations of Podoplanin (gp38) Expression in Rheumatoid Synovium and Its Potential Contribution to Fibroblast Platelet Crosstalk

(2014) Manuel J. Del Rey et al.   PLoS One

Inhibition of Spermidine/Spermine N1-Acetyltransferase Activity: A New Therapeutic Concept in Rheumatoid Arthritis

(2014) Michel Neidhart et al.   Arthritis & Rheumatology

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

 9 1 integrin acts as a critical intrinsic regulator of human rheumatoid arthritis

(2013) T. Asano et al.   RHEUMATOLOGY

Early structural changes in cartilage and bone are required for the attachment and invasion of inflamed synovial tissue during destructive inflammatory arthritis

(2012) Adelheid Korb-Pap et al.   ANNALS OF THE RHEUMATIC DISEASES

DNA methylome signature in rheumatoid arthritis

(2012) Kazuhisa Nakano et al.   ANNALS OF THE RHEUMATIC DISEASES

A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells

(2011) M. Bombardieri et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased recycling of polyamines is associated with global DNA hypomethylation in rheumatoid arthritis synovial fibroblasts

(2011) Emmanuel Karouzakis et al.   ARTHRITIS AND RHEUMATISM

 9 1 Integrin-Mediated Signaling Serves as an Intrinsic Regulator of Pathogenic Th17 Cell Generation

(2011) M. Kanayama et al.   JOURNAL OF IMMUNOLOGY

Integrins and their ligands in rheumatoid arthritis

(2011) Torsten Lowin et al.   ARTHRITIS RESEARCH & THERAPY

Synovial tissue hypoxia and inflammation in vivo

(2010) C. T. Ng et al.   ANNALS OF THE RHEUMATIC DISEASES

DNA hypomethylation in rheumatoid arthritis synovial fibroblasts

(2009) Emmanuel Karouzakis et al.   ARTHRITIS AND RHEUMATISM

Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

(2009) Beatrix Bartok et al.   IMMUNOLOGICAL REVIEWS

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

(2009) Stephanie Lefèvre et al.   NATURE MEDICINE

Spermidine/spermine-N1-acetyltransferase: a key metabolic regulator

(2008) Anthony E. Pegg   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis

(2008) Caroline Ospelt et al.   ARTHRITIS AND RHEUMATISM