Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy

Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse

(2021) Alexander Leithner et al.   JOURNAL OF CELL BIOLOGY

Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer

(2021) Maria Tello-Lafoz et al.   IMMUNITY

Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions

(2020) Daan Vorselen et al.   Nature Communications

Mechanosensing through YAP controls T cell activation and metabolism

(2020) Kevin P. Meng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex

(2020) Daniel Blumenthal et al.   eLife

Targeted Delivery of Cell Softening Micelles to Schlemm's Canal Endothelial Cells for Treatment of Glaucoma

(2020) Trevor Stack et al.   Small

Mechanical Immunoengineering of T cells for Therapeutic Applications

(2020) Kewen Lei et al.   ACCOUNTS OF CHEMICAL RESEARCH

Probe Sensitivity to Cortical versus Intracellular Cytoskeletal Network Stiffness

(2019) A. Vahabikashi et al.   BIOPHYSICAL JOURNAL

Engineering an Artificial T‐Cell Stimulating Matrix for Immunotherapy

(2019) John W. Hickey et al.   ADVANCED MATERIALS

Mechanobiology of Macrophages: How Physical Factors Coregulate Macrophage Plasticity and Phagocytosis

(2019) Nikhil Jain et al.   Annual Review of Biomedical Engineering

Mechanosensing through immunoreceptors

(2019) Cheng Zhu et al.   NATURE IMMUNOLOGY

Mechanogenetics for the remote and noninvasive control of cancer immunotherapy

(2018) Yijia Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Biomaterial-assisted targeted modulation of immune cells in cancer treatment

(2018) Hua Wang et al.   NATURE MATERIALS

Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

(2018) Pascale André et al.   CELL

Cell volume change through water efflux impacts cell stiffness and stem cell fate

(2017) Ming Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Locally Triggered Release of the Chemokine CCL21 Promotes Dendritic Cell Transmigration across Lymphatic Endothelia

(2017) Kari Vaahtomeri et al.   Cell Reports

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

(2017) Michael Saitakis et al.   eLife

Cell stiffness determined by atomic force microscopy and its correlation with cell motility

(2016) Qing Luo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing

(2016) Roshni Basu et al.   CELL

Cortical actin and the plasma membrane: inextricably intertwined

(2016) Darius V Köster et al.   CURRENT OPINION IN CELL BIOLOGY

Cyclodextrins in pharmaceutical formulations I: structure and physicochemical properties, formation of complexes, and types of complex

(2016) Sunil S. Jambhekar et al.   DRUG DISCOVERY TODAY

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

Ionic immune suppression within the tumour microenvironment limits T cell effector function

(2016) Robert Eil et al.   NATURE

Real-time deformability cytometry: on-the-fly cell mechanical phenotyping

(2015) Oliver Otto et al.   NATURE METHODS

Cell membrane softening in human breast and cervical cancer cells

(2015) Chris Händel et al.   NEW JOURNAL OF PHYSICS

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

Actin Dynamics, Architecture, and Mechanics in Cell Motility

(2014) Laurent Blanchoin et al.   PHYSIOLOGICAL REVIEWS

CD28 and CD3 have complementary roles in T-cell traction forces

(2014) Keenan T. Bashour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Traction force microscopy in physics and biology

(2014) Robert W. Style et al.   Soft Matter

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Increased plasticity of the stiffness of melanoma cells correlates with their acquisition of metastatic properties

(2013) Gilles Weder et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mechanosensing in T Lymphocyte Activation

(2012) Edward Judokusumo et al.   BIOPHYSICAL JOURNAL

Spatial organization of the extracellular matrix regulates cell-cell junction positioning

(2012) Q. Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of cholesterol on nano-mechanical properties of the living cell plasma membrane

(2012) Nima Khatibzadeh et al.   Soft Matter

Mechanical Stiffness Grades Metastatic Potential in Patient Tumor Cells and in Cancer Cell Lines

(2011) V. Swaminathan et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Are biomechanical changes necessary for tumour progression?

(2010) Anatol Fritsch et al.   Nature Physics

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology