Mesenchymal stromal cell-derived small extracellular vesicles promote neurological recovery and brain remodeling after distal middle cerebral artery occlusion in aged rats

Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles

(2021) Mario Gimona et al.   CYTOTHERAPY

Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice

(2021) Jonas Gregorius et al.   BASIC RESEARCH IN CARDIOLOGY

CD133+Exosome Treatment Improves Cardiac Function after Stroke in Type 2 Diabetic Mice

(2020) Poornima Venkat et al.   Translational Stroke Research

Mesenchymal Stromal Cell–Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils

(2020) Chen Wang et al.   STROKE

MiR-17-92 enriched exosomes derived from multipotent mesenchymal stromal cells enhance axon-myelin remodeling and motor electrophysiological recovery after stroke

(2020) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Human placental mesenchymal stem cells improve stroke outcomes via extracellular vesicles-mediated preservation of cerebral blood flow

(2020) Mansoureh Barzegar et al.   EBioMedicine

Animal models of ischemic stroke and their impact on drug discovery

(2019) Dirk M. Hermann et al.   Expert Opinion on Drug Discovery

Mesenchymal derived exosomes enhance recovery of motor function in a monkey model of cortical injury

(2019) T.L. Moore et al.   RESTORATIVE NEUROLOGY AND NEUROSCIENCE

Identification of the right cell sources for the production of therapeutically active extracellular vesicles in ischemic stroke

(2019) Bernd Giebel et al.   Annals of Translational Medicine

Extracellular vesicles from mesenchymal stem cells reduce microglial-mediated neuroinflammation after cortical injury in aged Rhesus monkeys

(2019) Veronica Go et al.   GeroScience

Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization

(2018) Mei Jiang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MicroRNA-17–92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats

(2017) Hongqi Xin et al.   STROKE

White Matter Repair After Extracellular Vesicles Administration in an Experimental Animal Model of Subcortical Stroke

(2017) Laura Otero-Ortega et al.   Scientific Reports

Concise Review: Extracellular Vesicles Overcoming Limitations of Cell Therapies in Ischemic Stroke

(2017) Thorsten R. Doeppner et al.   Stem Cells Translational Medicine

Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model

(2017) Robin L. Webb et al.   Translational Stroke Research

Human mesenchymal and murine stromal cells support human lympho-myeloid progenitor expansion but not maintenance of multipotent haematopoietic stem and progenitor cells

(2016) Stefan Radtke et al.   CELL CYCLE

Exosomes Derived from Mesenchymal Stromal Cells Promote Axonal Growth of Cortical Neurons

(2016) Yi Zhang et al.   MOLECULAR NEUROBIOLOGY

Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke

(2016) Kuan-Hung Chen et al.   Oncotarget

Microvesicles from brain-extract—treated mesenchymal stem cells improve neurological functions in a rat model of ischemic stroke

(2016) Ji Yong Lee et al.   Scientific Reports

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

(2015) Thorsten R. Doeppner et al.   Stem Cells Translational Medicine

MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease

(2014) L Kordelas et al.   LEUKEMIA

Multimodal Approaches for Regenerative Stroke Therapies: Combination of Granulocyte Colony-Stimulating Factor with Bone Marrow Mesenchymal Stem Cells is Not Superior to G-CSF Alone

(2014) Adrian Tudor Balseanu et al.   Frontiers in Aging Neuroscience

Transcriptomics of Post-Stroke Angiogenesis in the Aged Brain

(2014) Ana Maria Buga et al.   Frontiers in Aging Neuroscience

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation

(2012) Dirk M Hermann et al.   LANCET NEUROLOGY

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

(2012) Hongqi Xin et al.   STEM CELLS

Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy

(2011) Viktoriya Sokolova et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Sleep deprivation attenuates experimental stroke severity in rats

(2010) Mihai Moldovan et al.   EXPERIMENTAL NEUROLOGY

Effects of Granulocyte-Colony Stimulating Factor After Stroke in Aged Rats

(2010) Aurel Popa-Wagner et al.   STROKE

Long-term hypothermia reduces infarct volume in aged rats after focal ischemia

(2008) Baltromejus Florian et al.   NEUROSCIENCE LETTERS