Digital Twins for Continuous mRNA Production

Towards Autonomous Operation by Advanced Process Control—Process Analytical Technology for Continuous Biologics Antibody Manufacturing

(2021) Heribert Helgers et al.   Processes

mRNA vaccines manufacturing: Challenges and bottlenecks

(2021) Sara Sousa Rosa et al.   VACCINE

Digital Twin of mRNA-Based SARS-COVID-19 Vaccine Manufacturing towards Autonomous Operation for Improvements in Speed, Scale, Robustness, Flexibility and Real-Time Release Testing

(2021) Axel Schmidt et al.   Processes

BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans

(2021) Ugur Sahin et al.   NATURE

Covid-19: FDA approves Pfizer-BioNTech vaccine in record time

(2021) Janice Hopkins Tanne   BMJ-British Medical Journal

Analysis of the Effects of Process Parameters on Start-Up Operation in Continuous Wet Granulation

(2021) Kensaku Matsunami et al.   Processes

Digital Twins in Pharmaceutical and Biopharmaceutical Manufacturing: A Literature Review

(2020) Yingjie Chen et al.   Processes

Resources, Production Scales and Time Required for Producing RNA Vaccines for the Global Pandemic Demand

(2020) Zoltán Kis et al.   Vaccines

Accelerating Biologics Manufacturing by Modeling or: Is Approval under the QbD and PAT Approaches Demanded by Authorities Acceptable Without a Digital-Twin?

(2019) Steffen Zobel-Roos et al.   Processes

Design of in vitro Transcribed mRNA Vectors for Research and Therapy

(2019) Marina Tusup et al.   CHIMIA

Distinct and Quantitative Validation Method for Predictive Process Modeling with Examples of Liquid-Liquid Extraction Processes of Complex Feed Mixtures

(2019) Axel Schmidt et al.   Processes

Accelerating Biomanufacturing by Modeling of Continuous Bioprocessing—Piloting Case Study of Monoclonal Antibody Manufacturing

(2019) Kornecki et al.   Processes

A Comparison of Plasmid DNA and mRNA as Vaccine Technologies

(2019) Liu   Vaccines

Modeling of a liquid membrane in Taylor flow integrated with lactic acid fermentation

(2019) Alan D. Pérez et al.   CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION

Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response

(2019) Sergio Linares-Fernández et al.   TRENDS IN MOLECULAR MEDICINE

Emergence of synthetic mRNA: In vitro synthesis of mRNA and its applications in regenerative medicine

(2018) Hyokyoung Kwon et al.   BIOMATERIALS

Toward a Distinct and Quantitative Validation Method for Predictive Process Modelling—On the Example of Solid-Liquid Extraction Processes of Complex Plant Extracts

(2018) Maximilian Sixt et al.   Processes

The development of an alternative fermentation model system for vinegar production

(2018) Nurul Khadijah Mat Isham et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Conscious coupling: The challenges and opportunities of cascading enzymatic microreactors

(2017) Pia Gruber et al.   Biotechnology Journal

Determination of critical quality attributes for monoclonal antibodies using quality by design principles

(2016) Nadja Alt et al.   BIOLOGICALS

A general method for rapid and cost-efficient large-scale production of 5′ capped RNA

(2016) Anna-Lisa Fuchs et al.   RNA

Characterization Method for Separation Devices Based on Micro Technology

(2015) Tim Wellsandt et al.   CHEMIE INGENIEUR TECHNIK

Understanding Pharmaceutical Quality by Design

(2014) Lawrence X. Yu et al.   AAPS Journal

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

A modified dinucleotide for site-specific RNA-labelling by transcription priming and click chemistry

(2013) Ayan Samanta et al.   CHEMICAL COMMUNICATIONS

RNA: The new revolution in nucleic acid vaccines

(2013) Andrew J. Geall et al.   SEMINARS IN IMMUNOLOGY

Developing mRNA-vaccine technologies

(2012) Thomas Schlake et al.   RNA Biology

Hybrid simulation-optimization based approach for the optimal design of single-product biotechnological processes

(2011) Robert Brunet et al.   COMPUTERS & CHEMICAL ENGINEERING

Pharmaceutical Quality by Design: Product and Process Development, Understanding, and Control

(2008) Lawrence X. Yu   PHARMACEUTICAL RESEARCH