Antidepressants and Circadian Rhythm: Exploring Their Bidirectional Interaction for the Treatment of Depression

A circadian clock regulates efflux by the blood-brain barrier in mice and human cells

(2021) Shirley L. Zhang et al.   Nature Communications

Circadian misalignment by environmental light/dark shifting causes circadian disruption in colon

(2021) Laura Tran et al.   PLoS One

Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic

(2021) Damian F Santomauro et al.   LANCET

Timing in drug absorption and disposition: the past, present and future of chronopharmacokinetics

(2020) Joana Bicker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pineal Gland Volume in Major Depressive and Bipolar Disorders

(2020) Tsutomu Takahashi et al.   Frontiers in Psychiatry

Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes

(2020) Robert S. Pulido et al.   NEURON

The importance of determining circadian parameters in pharmacological studies

(2019) Laetitia Gaspar et al.   BRITISH JOURNAL OF PHARMACOLOGY

In‐vitro and in situ assessment of the efflux of five antidepressants by breast cancer resistance protein

(2019) Suqin Feng et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Antidepressants with different mechanisms of action show different chronopharmacological profiles in the tail suspension test in mice

(2019) Hiroshi Kawai et al.   CHRONOBIOLOGY INTERNATIONAL

The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group

(2019) Mirko Koziolek et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling

(2019) Alper Okyar et al.   Scientific Reports

Pharmacokinetic considerations for current state-of-the-art antidepressants

(2019) Elżbieta Wyska   Expert Opinion on Drug Metabolism & Toxicology

Dosing time matters

(2019) Marc D. Ruben et al.   SCIENCE

Desipramine restores the alterations in circadian entrainment induced by prenatal exposure to glucocorticoids

(2019) Stefan Spulber et al.   Translational Psychiatry

The Effect Of Fluvoxamine On Sleep Architecture Of Depressed Patients With Insomnia: An 8-Week, Open-Label, Baseline-Controlled Study

(2019) Yanli Hao et al.   Nature and Science of Sleep

Chronopharmacological Analysis of Antidepressant Activity of a Dual-Action Serotonin Noradrenaline Reuptake Inhibitor (SNRI), Milnacipran, in Rats

(2018) Hiroshi Kawai et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Effects of vortioxetine and fluoxetine on the level of Brain Derived Neurotrophic Factors (BDNF) in the hippocampus of chronic unpredictable mild stress-induced depressive rats

(2018) Yanxia Lu et al.   BRAIN RESEARCH BULLETIN

A Circadian Clock in the Blood-Brain Barrier Regulates Xenobiotic Efflux

(2018) Shirley L. Zhang et al.   CELL

Evening types demonstrate reduced SSRI treatment efficacy

(2018) E. M. McGlashan et al.   CHRONOBIOLOGY INTERNATIONAL

Clinical Pharmacodynamics: Principles of Drug Response and Alterations in Kidney Disease

(2018) Frieder Keller et al.   Clinical Journal of the American Society of Nephrology

Circadian clock-mediated regulation of blood pressure

(2018) Lauren G. Douma et al.   FREE RADICAL BIOLOGY AND MEDICINE

The mammalian circadian system: a hierarchical multi-oscillator structure for generating circadian rhythm

(2018) Sato Honma   Journal of Physiological Sciences

Sucrose preference test for measurement of stress-induced anhedonia in mice

(2018) Meng-Ying Liu et al.   Nature Protocols

The role of the circadian clock system in physiology

(2018) Violetta Pilorz et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Effects of light and dark phase testing on the investigation of behavioural paradigms in mice: Relevance for behavioural neuroscience

(2018) Juliet Richetto et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The choroid plexus is an important circadian clock component

(2018) Jihwan Myung et al.   Nature Communications

Agomelatine-induced modulation of brain-derived neurotrophic factor (BDNF) in the rat hippocampus

(2018) Yanxia Lu et al.   LIFE SCIENCES

The SSRI citalopram increases the sensitivity of the human circadian system to light in an acute dose

(2018) E. M. McGlashan et al.   PSYCHOPHARMACOLOGY

Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies

(2018) Sho Moriguchi et al.   MOLECULAR PSYCHIATRY

The emerging link between cancer, metabolism, and circadian rhythms

(2018) Selma Masri et al.   NATURE MEDICINE

abcb1ab p-glycoprotein is involved in the uptake of the novel antidepressant vortioxetine into the brain of mice

(2018) Derek Spieler et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Clock Genes and Altered Sleep–Wake Rhythms: Their Role in the Development of Psychiatric Disorders

(2017) Annaëlle Charrier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacological treatment of unipolar depressive disorders: summary of WFSBP guidelines

(2017) Michael Bauer et al.   INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE

The relationship between chronotype and depressive symptoms: A meta-analysis

(2017) Jacky Au et al.   JOURNAL OF AFFECTIVE DISORDERS

Circadian Rhythms in Plasma Brain-derived Neurotrophic Factor Differ in Men and Women

(2017) Sean W. Cain et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Disruption of Bmal1 Impairs Blood–Brain Barrier Integrity via Pericyte Dysfunction

(2017) Ryota Nakazato et al.   JOURNAL OF NEUROSCIENCE

Circadian Clock Is Involved in Regulation of Hepatobiliary Transport Mediated by Multidrug Resistance-Associated Protein 2

(2017) Ju-Hee Oh et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Naming for Psychotropic Drugs: Dilemma and Challenge

(2017) Hiroyuki Uchida et al.   PHARMACOPSYCHIATRY

Relationships between circadian measures, depression, and response to antidepressant treatment: A preliminary investigation

(2017) Leslie M. Swanson et al.   PSYCHIATRY RESEARCH

TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response

(2017) Zhenzhong Ma et al.   Nature Communications

Rodent Models for the Analysis of Tissue Clock Function in Metabolic Rhythms Research

(2017) Anthony H. Tsang et al.   Frontiers in Endocrinology

The Role of Norepinephrine and Its α-Adrenergic Receptors in the Pathophysiology and Treatment of Major Depressive Disorder and Schizophrenia: A Systematic Review

(2017) Vladimir Maletic et al.   Frontiers in Psychiatry

Robust circadian clock oscillation and osmotic rhythms in inner medulla reflecting cortico-medullary osmotic gradient rhythm in rodent kidney

(2017) Masayuki Hara et al.   Scientific Reports

Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function

(2017) Zeng-liang Jin et al.   Scientific Reports

P-glycoprotein Function in the Rodent Brain Displays a Daily Rhythm, a Quantitative In Vivo PET Study

(2016) Heli Savolainen et al.   AAPS Journal

Genetic Disruption of Circadian Rhythms in the Suprachiasmatic Nucleus Causes Helplessness, Behavioral Despair, and Anxiety-like Behavior in Mice

(2016) Dominic Landgraf et al.   BIOLOGICAL PSYCHIATRY

P-glycoprotein differentially affects escitalopram, levomilnacipran, vilazodone and vortioxetine transport at the mouse blood–brain barrier in vivo

(2016) Christoffer Bundgaard et al.   NEUROPHARMACOLOGY

Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity

(2016) Ewa A. Ogłodek et al.   Pharmacological Reports

Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults

(2016) Isak Sundberg et al.   PLoS One

Maintained superiority of chronotherapeutics vs. exercise in a 20-week randomized follow-up trial in major depression

(2015) K. Martiny et al.   ACTA PSYCHIATRICA SCANDINAVICA

Fluoxetine normalizes disrupted light-induced entrainment, fragmented ultradian rhythms and altered hippocampal clock gene expression in an animal model of high trait anxiety- and depression-related behavior

(2015) Jörg Schaufler et al.   ANNALS OF MEDICINE

Faster, better, stronger: Towards new antidepressant therapeutic strategies

(2015) Olivia F. O’Leary et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 1, a pharmacokinetic/pharmacodynamic comparison with paroxetine in healthy men

(2015) Sue Wilson et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Diurnal and seasonal variation of the brain serotonin system in healthy male subjects

(2015) Granville J. Matheson et al.   NEUROIMAGE

Exploring the role of drug-metabolising enzymes in antidepressant side effects

(2015) Karen Hodgson et al.   PSYCHOPHARMACOLOGY

Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model

(2015) Kana Tanabe et al.   Scientific Reports

Recent advances in circadian rhythms in cardiovascular system

(2015) Lihong Chen et al.   Frontiers in Pharmacology

PATHOPHYSIOLOGY OF DEPRESSION: DO WE HAVE ANY SOLID EVIDENCE OF INTEREST TO CLINICIANS?

(2015) GREGOR HASLER   World Psychiatry

Diurnal Variation in P-glycoprotein-Mediated Transport and Cerebrospinal Fluid Turnover in the Brain

(2014) Laura Kervezee et al.   AAPS Journal

Circahoralian (Ultradian) metabolic rhythms

(2014) V. Y. Brodsky   BIOCHEMISTRY-MOSCOW

Fluoxetine: a case history of its discovery and preclinical development

(2014) Laura Perez-Caballero et al.   Expert Opinion on Drug Discovery

Molecular mechanisms of the circadian clockwork in mammals

(2014) I. Robinson et al.   FEBS LETTERS

Fast BDNF serum level increase and diurnal BDNF oscillations are associated with therapeutic response after partial sleep deprivation

(2014) Maria Giese et al.   JOURNAL OF PSYCHIATRIC RESEARCH

MAPK signaling correlates with the antidepressant effects of ketamine

(2014) Gislaine Z. Réus et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Expressions of Tight Junction Proteins Occludin and Claudin-1 Are under the Circadian Control in the Mouse Large Intestine: Implications in Intestinal Permeability and Susceptibility to Colitis

(2014) Kyoko Oh-oka et al.   PLoS One

Chronopharmacology: New Insights and Therapeutic Implications

(2013) Robert Dallmann et al.   Annual Review of Pharmacology and Toxicology

Like melatonin, agomelatine (S20098) increases the amplitude of oscillations of two clock outputs: melatonin and temperature rhythms

(2013) Amélie Castanho et al.   CHRONOBIOLOGY INTERNATIONAL

Agomelatine in the tree shrew model of depression: Effects on stress-induced nocturnal hyperthermia and hormonal status

(2013) Barthel Schmelting et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood–brain barrier permeability

(2013) Fionn E. O'Brien et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Severe sleepiness and excess sleep duration induced by paroxetine treatment is a beneficial pharmacological effect, not an adverse reaction

(2013) Yusuke Murata et al.   JOURNAL OF AFFECTIVE DISORDERS

P-glycoprotein Inhibition Increases the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents

(2013) Fionn E O'Brien et al.   NEUROPSYCHOPHARMACOLOGY

Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver

(2013) D. Mauvoisin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diurnal alterations in circadian genes and peptides in major depressive disorder before and after escitalopram treatment

(2013) Su-Xia Li et al.   PSYCHONEUROENDOCRINOLOGY

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Inhibition of P-glycoprotein enhances transport of imipramine across the blood-brain barrier: microdialysis studies in conscious freely moving rats

(2012) FE O'Brien et al.   BRITISH JOURNAL OF PHARMACOLOGY

Circadian Typology: A Comprehensive Review

(2012) Ana Adan et al.   CHRONOBIOLOGY INTERNATIONAL

Chronic agomelatine treatment corrects the abnormalities in the circadian rhythm of motor activity and sleep/wake cycle induced by prenatal restraint stress in adult rats

(2012) Jerome Mairesse et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Intestinal Expression of MouseAbcg2/Breast Cancer Resistance Protein (BCRP) Gene Is under Control of Circadian Clock-activating Transcription Factor-4 Pathway

(2012) Ahmed M. Hamdan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Assessment of Sleep-Wake Behavior in Mice

(2012) Simon P. Fisher et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Using the rat forced swim test to assess antidepressant-like activity in rodents

(2012) David A Slattery et al.   Nature Protocols

The daily rhythm of mice

(2011) Jürgen A. Ripperger et al.   FEBS LETTERS

6-Sulfatoxymelatonin as a predictor of clinical outcome in depressive patients

(2011) Maria Paz Loayza Hidalgo et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Beneficial behavioural and neurogenic effects of agomelatine in a model of depression/anxiety

(2011) Quentin Rainer et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

cAMP-response Element (CRE)-mediated Transcription by Activating Transcription Factor-4 (ATF4) Is Essential for Circadian Expression of thePeriod2Gene

(2011) Satoru Koyanagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

(2011) Benny Bang-Andersen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ketamine Influences CLOCK:BMAL1 Function Leading to Altered Circadian Gene Expression

(2011) Marina M. Bellet et al.   PLoS One

Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters

(2011) Britta Haenisch et al.   PSYCHOPHARMACOLOGY

Efficacy of the Novel Antidepressant Agomelatine on the Circadian Rest-Activity Cycle and Depressive and Anxiety Symptoms in Patients With Major Depressive Disorder

(2010) Siegfried Kasper et al.   JOURNAL OF CLINICAL PSYCHIATRY

Review: Restoring circadian rhythms: a new way to successfully manage depression

(2010) Philip Gorwood   JOURNAL OF PSYCHOPHARMACOLOGY

α 1A - and α 1B -adrenergic receptors differentially modulate antidepressant-like behavior in the mouse

(2009) Van A. Doze et al.   BRAIN RESEARCH

Adverse reactions to antidepressants

(2009) Rudolf Uher et al.   BRITISH JOURNAL OF PSYCHIATRY

New light on the serotonergic paradox in the rat circadian system

(2009) Marc Cuesta et al.   JOURNAL OF NEUROCHEMISTRY

Circadian misalignment in major depressive disorder

(2009) Jonathan Emens et al.   PSYCHIATRY RESEARCH

Influence of the novel antidepressant and melatonin agonist/serotonin2C receptor antagonist, agomelatine, on the rat sleep–wake cycle architecture

(2009) Amandine Descamps et al.   PSYCHOPHARMACOLOGY

Healthy clocks, healthy body, healthy mind

(2009) Akhilesh B. Reddy et al.   TRENDS IN CELL BIOLOGY

Beyond the monoaminergic hypothesis: Agomelatine, a new antidepressant with an innovative mechanism of action

(2009) Siegfried Kasper et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Seasonal Variation in Human Brain Serotonin Transporter Binding

(2008) Nicole Praschak-Rieder et al.   ARCHIVES OF GENERAL PSYCHIATRY

Regulation of Monoamine Oxidase A by Circadian-Clock Components Implies Clock Influence on Mood

(2008) Gabriele Hampp et al.   CURRENT BIOLOGY

Circadian Expression Profiles of Drug-Processing Genes and Transcription Factors in Mouse Liver

(2008) Y.-K. J. Zhang et al.   DRUG METABOLISM AND DISPOSITION

Circadian Clock-Controlled Intestinal Expression of the Multidrug-Resistance Gene mdr1a in Mice

(2008) Yuichi Murakami et al.   GASTROENTEROLOGY

Plasma brain-derived neurotrophic factor daily variations in men: correlation with cortisol circadian rhythm

(2008) Silvia Begliuomini et al.   JOURNAL OF ENDOCRINOLOGY

A Causal Role for Brain-Derived Neurotrophic Factor in the Homeostatic Regulation of Sleep

(2008) U. Faraguna et al.   JOURNAL OF NEUROSCIENCE

Diurnal Rhythmicity in the Transcription of Jejunal Drug Transporters

(2008) Adam T. Stearns et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Effect of antidepressants on melatonin metabolite in depressed patients

(2008) LA Carvalho et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Selective serotonin reuptake inhibitors and raft inhibitors shorten the period of Period1-driven circadian bioluminescence rhythms in rat-1 fibroblasts

(2008) Kazumi Nomura et al.   LIFE SCIENCES