Immunosuppression in Glioblastoma: Current Understanding and Therapeutic Implications

Short non-coding RNA sequencing of glioblastoma extracellular vesicles

(2020) Tristan de Mooij et al.   JOURNAL OF NEURO-ONCOLOGY

The role of extracellular vesicles and PD-L1 in glioblastoma-mediated immunosuppressive monocyte induction

(2020) Benjamin T Himes et al.   NEURO-ONCOLOGY

Targeted deletion of PD-1 in myeloid cells induces antitumor immunity

(2020) Laura Strauss et al.   Science Immunology

Temporal and spatial modulation of the tumor and systemic immune response in the murine Gl261 glioma model

(2020) Kelly J. McKelvey et al.   PLoS One

Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner

(2020) Defne Bayik et al.   Cancer Discovery

Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma

(2020) David A. Reardon et al.   JAMA Oncology

Brain cancer induces systemic immunosuppression through release of non-steroid soluble mediators

(2020) Katayoun Ayasoufi et al.   BRAIN

Tim-3/galectin-9 pathway and mMDSC control primary and secondary resistances to PD-1 blockade in lung cancer patients

(2019) Emeric Limagne et al.   OncoImmunology

Pilot Trial of Adoptive Transfer of Chimeric Antigen Receptor–transduced T Cells Targeting EGFRvIII in Patients With Glioblastoma

(2019) Stephanie L. Goff et al.   JOURNAL OF IMMUNOTHERAPY

Glioblastoma-Derived IL-6 Induces Immunosuppressive Peripheral Myeloid Cell PD-L1 and Promotes Tumor Growth

(2019) Jonathan B Lamano et al.   CLINICAL CANCER RESEARCH

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma

(2019) Jason Miska et al.   Cell Reports

LOX-1+ PMN-MDSC enhances immune suppression which promotes glioblastoma multiforme progression

(2019) ErQing Chai et al.   Cancer Management and Research

The current state of immunotherapy for gliomas: an eye toward the future

(2019) Peter E. Fecci et al.   JOURNAL OF NEUROSURGERY

Current state of immunotherapy for glioblastoma

(2018) Michael Lim et al.   Nature Reviews Clinical Oncology

Temozolomide for immunomodulation in the treatment of glioblastoma

(2018) Aida Karachi et al.   NEURO-ONCOLOGY

Recurrent Glioblastoma Treated with Recombinant Poliovirus

(2018) Annick Desjardins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms

(2018) Dmitri Negorev et al.   Scientific Reports

Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression

(2018) Viktor Fleming et al.   Frontiers in Immunology

The blood mMDSC to DC ratio is a sensitive and easy to assess independent predictive factor for epithelial ovarian cancer survival

(2018) S. J. A. M. Santegoets et al.   OncoImmunology

The immune checkpoint protein PD-L1 induces and maintains regulatory T cells in glioblastoma

(2018) Joseph DiDomenico et al.   OncoImmunology

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

(2018) Franz L. Ricklefs et al.   Science Advances

Regulatory mechanisms of PD-L1 expression in cancer cells

(2018) Yongyu Shi   CANCER IMMUNOLOGY IMMUNOTHERAPY

Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors

(2018) Pakawat Chongsathidkiet et al.   NATURE MEDICINE

TLR2 Promotes Glioma Immune Evasion by Downregulating MHC Class II Molecules in Microglia

(2018) Jiawen Qian et al.   Cancer Immunology Research

Combining Immune Checkpoint Inhibitors With Conventional Cancer Therapy

(2018) Yiyi Yan et al.   Frontiers in Immunology

Cancer Neoantigens

(2018) Ton N. Schumacher et al.   Annual Review of Immunology

The CNS Immune-Privilege Goes Down the Drain(age)

(2018) Simone Brioschi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

VEGF as a modulator of the innate immune response in glioblastoma

(2017) Kati Turkowski et al.   GLIA

Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma

(2017) Roger Stupp et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

(2017) Michael Weller et al.   LANCET ONCOLOGY

Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma

(2017) Jeffrey Weber et al.   NEW ENGLAND JOURNAL OF MEDICINE

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

(2017) Sattva S. Neelapu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophils in Gliomas

(2017) Matteo Massara et al.   Frontiers in Immunology

Modulating glioma-mediated myeloid-derived suppressor cell development with sulforaphane

(2017) Ravi Kumar et al.   PLoS One

Cancer immunotherapy: the beginning of the end of cancer?

(2016) Sofia Farkona et al.   BMC Medicine

Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function

(2016) Paul R. Gielen et al.   NEURO-ONCOLOGY

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

On the origin of myeloid-derived suppressor cells

(2016) Camilla Rydberg Millrud et al.   Oncotarget

Inhibiting MDSC differentiation from bone marrow with phytochemical polyacetylenes drastically impairs tumor metastasis

(2016) Wen-Chi Wei et al.   Scientific Reports

Innate Immune Recognition of Cancer

(2015) Seng-Ryong Woo et al.   Annual Review of Immunology

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

Immune Checkpoint Blockade in Cancer Therapy

(2015) Michael A. Postow et al.   JOURNAL OF CLINICAL ONCOLOGY

The role of regulatory T cells and microglia in glioblastoma-associated immunosuppression

(2015) Alfred P. See et al.   JOURNAL OF NEURO-ONCOLOGY

Increase in Both CD14-Positive and CD15-Positive Myeloid-Derived Suppressor Cell Subpopulations in the Blood of Patients With Glioma But Predominance of CD15-Positive Myeloid-Derived Suppressor Cells in Glioma Tissue

(2015) Paul R. Gielen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Prospects of immune checkpoint modulators in the treatment of glioblastoma

(2015) Matthias Preusser et al.   Nature Reviews Neurology

CD4+T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients

(2015) Daniel Dubinski et al.   NEURO-ONCOLOGY

Immunosuppressive mechanisms in glioblastoma: Fig. 1.

(2015) Edjah K. Nduom et al.   NEURO-ONCOLOGY

PD-L1 expression and prognostic impact in glioblastoma

(2015) Edjah K. Nduom et al.   NEURO-ONCOLOGY

Nivolumab in Previously Untreated Melanoma without BRAF Mutation

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Somatic mutation in cancer and normal cells

(2015) I. Martincorena et al.   SCIENCE

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

(2015) B. M. Carreno et al.   SCIENCE

PD-1 Restrains Radiotherapy-Induced Abscopal Effect

(2015) S. S. Park et al.   Cancer Immunology Research

Hypoxia-inducible factors in regulation of immune responses in tumour microenvironment

(2014) Vinit Kumar et al.   IMMUNOLOGY

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

(2014) Liufu Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of IDO in brain tumor immunotherapy

(2014) Lijie Zhai et al.   JOURNAL OF NEURO-ONCOLOGY

Prophylactic plastic surgery closure of neurosurgical scalp incisions reduces the incidence of wound complications in previously-operated patients treated with bevacizumab (Avastin®) and radiation

(2014) Alyssa Reiffel Golas et al.   JOURNAL OF NEURO-ONCOLOGY

Influenza vaccine immunogenicity in patients with primary central nervous system malignancy

(2014) R. E. Strowd et al.   NEURO-ONCOLOGY

Increasing glioma-associated monocytes leads to increased intratumoral and systemic myeloid-derived suppressor cells in a murine model

(2014) Michael Chae et al.   NEURO-ONCOLOGY

Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma

(2014) Olivier L. Chinot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extracellular vesicles: emerging targets for cancer therapy

(2014) Pieter Vader et al.   TRENDS IN MOLECULAR MEDICINE

GM-CSF Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor- 

(2013) G. Kohanbash et al.   CANCER RESEARCH

Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences

(2013) Janesh Pillay et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Glioma Grade Is Associated with the Accumulation and Activity of Cells Bearing M2 Monocyte Markers

(2013) M. Prosniak et al.   CLINICAL CANCER RESEARCH

Myeloid-derived suppressor cells in glioma

(2013) Masoud Mirghorbani et al.   Expert Review of Neurotherapeutics

Glioblastoma and Other Malignant Gliomas

(2013) Antonio Omuro   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

(2013) Omid Hamid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting Tregs in Malignant Brain Cancer: Overcoming IDO

(2013) Derek A. Wainwright et al.   Frontiers in Immunology

TGF-β as a therapeutic target in high grade gliomas – Promises and challenges

(2012) Justin V. Joseph et al.   BIOCHEMICAL PHARMACOLOGY

Novel Delivery Strategies for Glioblastoma

(2012) Jiangbing Zhou et al.   CANCER JOURNAL

IDO Expression in Brain Tumors Increases the Recruitment of Regulatory T Cells and Negatively Impacts Survival

(2012) D. A. Wainwright et al.   CLINICAL CANCER RESEARCH

Leptomeningeal spinal metastases from glioblastoma multiforme: treatment and management of an uncommon manifestation of disease

(2012) Cort D. Lawton et al.   JOURNAL OF NEUROSURGERY-SPINE

Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial

(2012) Axel Hauschild et al.   LANCET

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

Soluble factors secreted by glioblastoma cell lines facilitate recruitment, survival, and expansion of regulatory T cells: implications for immunotherapy

(2012) C. A. Crane et al.   NEURO-ONCOLOGY

Radiation necrosis following treatment of high grade glioma—a review of the literature and current understanding

(2011) Alan Siu et al.   ACTA NEUROCHIRURGICA

Macrophage migration inhibitory factor (MIF) expression in human malignant gliomas contributes to immune escape and tumour progression

(2011) Michel Mittelbronn et al.   ACTA NEUROPATHOLOGICA

Neutrophil Degranulation and Immunosuppression in Patients with GBM: Restoration of Cellular Immune Function by Targeting Arginase I

(2011) T. R. Sippel et al.   CLINICAL CANCER RESEARCH

Improved survival time trends for glioblastoma using the SEER 17 population-based registries

(2011) Matthew Koshy et al.   JOURNAL OF NEURO-ONCOLOGY

Normal human monocytes exposed to glioma cells acquire myeloid-derived suppressor cell-like properties

(2011) Jennifer C. Rodrigues et al.   NEURO-ONCOLOGY

Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma

(2011) B. Raychaudhuri et al.   NEURO-ONCOLOGY

Hypoxia Potentiates Glioma-Mediated Immunosuppression

(2011) Jun Wei et al.   PLoS One

Characteristics of the Alternative Phenotype of Microglia/Macrophages and its Modulation in Experimental Gliomas

(2011) Konrad Gabrusiewicz et al.   PLoS One

Tumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism

(2011) Jeremy D. Waight et al.   PLoS One

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma

(2011) Olivier Keunen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct effects of human glioblastoma immunoregulatory molecules programmed cell death ligand-1 (PDL-1) and indoleamine 2,3-dioxygenase (IDO) on tumour-specific T cell functions

(2010) Tony Avril et al.   JOURNAL OF NEUROIMMUNOLOGY

Systemic immune suppression in glioblastoma: the interplay between CD14+HLA-DRlo/neg monocytes, tumor factors, and dexamethasone

(2010) Michael P. Gustafson et al.   NEURO-ONCOLOGY

Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma

(2010) J. H. Sampson et al.   NEURO-ONCOLOGY

Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors

(2009) Hiroaki Ikushima et al.   Cell Stem Cell

The EGFRvIII variant in glioblastoma multiforme

(2009) Hui K. Gan et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

(2009) Henry S. Friedman et al.   JOURNAL OF CLINICAL ONCOLOGY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Glioblastoma-Derived Mechanisms of Systemic Immunosuppression

(2009) Allen Waziri   NEUROSURGERY CLINICS OF NORTH AMERICA

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Factors affecting graft infection after cranioplasty

(2008) Yu-Kai Cheng et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Cancer Immunology

(2008) Olivera J. Finn   NEW ENGLAND JOURNAL OF MEDICINE