Novel Delivery Strategies for Glioblastoma

Effects of Base Polymer Hydrophobicity and End-Group Modification on Polymeric Gene Delivery

(2011) Joel C. Sunshine et al.   BIOMACROMOLECULES

A brain-targeted rabies virus glycoprotein-disulfide linked PEI nanocarrier for delivery of neurogenic microRNA

(2011) Do Won Hwang et al.   BIOMATERIALS

Octa-functional PLGA nanoparticles for targeted and efficient siRNA delivery to tumors

(2011) Jiangbing Zhou et al.   BIOMATERIALS

Therapeutic effect of neural stem cells expressing TRAIL and bortezomib in mice with glioma xenografts

(2011) Irina V. Balyasnikova et al.   CANCER LETTERS

A Developmental Taxonomy of Glioblastoma Defined and Maintained by MicroRNAs

(2011) T.-M. Kim et al.   CANCER RESEARCH

Human Glioma Growth Is Controlled by MicroRNA-10b

(2011) G. Gabriely et al.   CANCER RESEARCH

HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

(2011) J. Mathieu et al.   CANCER RESEARCH

Reduced VEGF Production, Angiogenesis, and Vascular Regrowth Contribute to the Antitumor Properties of Dual mTORC1/mTORC2 Inhibitors

(2011) B. L. Falcon et al.   CANCER RESEARCH

Bortezomib Primes Glioblastoma, Including Glioblastoma Stem Cells, for TRAIL by Increasing tBid Stability and Mitochondrial Apoptosis

(2011) T. Unterkircher et al.   CLINICAL CANCER RESEARCH

Modulation of CCAAT/Enhancer Binding Protein Homologous Protein (CHOP)-dependent DR5 Expression by Nelfinavir Sensitizes Glioblastoma Multiforme Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)

(2011) Xiaobing Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas

(2011) Deviney Chaponis et al.   JOURNAL OF NEURO-ONCOLOGY

A Molecular Screening Approach to Identify and Characterize Inhibitors of Glioblastoma Stem Cells

(2011) K. Visnyei et al.   MOLECULAR CANCER THERAPEUTICS

Pathway Analysis of Glioblastoma Tissue after Preoperative Treatment with the EGFR Tyrosine Kinase Inhibitor Gefitinib--A Phase II Trial

(2011) M. E. Hegi et al.   MOLECULAR CANCER THERAPEUTICS

Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery

(2011) Jiangbing Zhou et al.   NATURE MATERIALS

Pathway inhibition: emerging molecular targets for treating glioblastoma

(2011) W. Wick et al.   NEURO-ONCOLOGY

Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide

(2011) G. Prasad et al.   NEURO-ONCOLOGY

Colocalization of Gadolinium-Diethylene Triamine Pentaacetic Acid With High-Molecular-Weight Molecules After Intracerebral Convection-Enhanced Delivery in Humans

(2011) John H Sampson et al.   NEUROSURGERY

Surface modification of PLGA nanospheres with Gd-DTPA and Gd-DOTA for high-relaxivity MRI contrast agents

(2010) Gerda Ratzinger et al.   BIOMATERIALS

Targeted delivery of chlorotoxin-modified DNA-loaded nanoparticles to glioma via intravenous administration

(2010) Rongqin Huang et al.   BIOMATERIALS

Pharmacology of capsaicin-, anandamide-, and N -arachidonoyl-dopamine-evoked cell death in a homogeneous transient receptor potential vanilloid subtype 1 receptor population

(2010) J.W. Davies et al.   BRITISH JOURNAL OF ANAESTHESIA

Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts

(2010) K. Michaud et al.   CANCER RESEARCH

EGFRvIII Antibody-Conjugated Iron Oxide Nanoparticles for Magnetic Resonance Imaging-Guided Convection-Enhanced Delivery and Targeted Therapy of Glioblastoma

(2010) C. G. Hadjipanayis et al.   CANCER RESEARCH

An RNAi Screen Identifies TRRAP as a Regulator of Brain Tumor-Initiating Cell Differentiation

(2010) Heiko Wurdak et al.   Cell Stem Cell

Gene delivery by lipoplexes and polyplexes

(2010) Conchita Tros de Ilarduya et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells

(2010) T Kato et al.   GENE THERAPY

Enzyme-synthesized poly(amine-co-esters) as nonviral vectors for gene delivery

(2010) Jie Liu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Phase III Study of Enzastaurin Compared With Lomustine in the Treatment of Recurrent Intracranial Glioblastoma

(2010) Wolfgang Wick et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeted Nanoparticles Deliver siRNA to Melanoma

(2010) Yunching Chen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Retrospective study of dasatinib for recurrent glioblastoma after bevacizumab failure

(2010) C. Lu-Emerson et al.   JOURNAL OF NEURO-ONCOLOGY

Vorinostat enhances the cytotoxic effects of the topoisomerase I inhibitor SN38 in glioblastoma cell lines

(2010) Bhaswati Sarcar et al.   JOURNAL OF NEURO-ONCOLOGY

Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma

(2010) Surasak Phuphanich et al.   JOURNAL OF NEURO-ONCOLOGY

Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide

(2010) Elizabeth R. Gerstner et al.   JOURNAL OF NEURO-ONCOLOGY

A Chelator-Free Multifunctional [64Cu]CuS Nanoparticle Platform for Simultaneous Micro-PET/CT Imaging and Photothermal Ablation Therapy

(2010) Min Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Novel Hsp90 Inhibitor NXD30001 Induces Tumor Regression in a Genetically Engineered Mouse Model of Glioblastoma Multiforme

(2010) H. Zhu et al.   MOLECULAR CANCER THERAPEUTICS

Sorafenib Induces Growth Arrest and Apoptosis of Human Glioblastoma Cells through the Dephosphorylation of Signal Transducers and Activators of Transcription 3

(2010) Fan Yang et al.   MOLECULAR CANCER THERAPEUTICS

Emetine Promotes von Hippel-Lindau-Independent Degradation of Hypoxia-Inducible Factor-2  in Clear Cell Renal Carcinoma

(2010) H.-S. Kong et al.   MOLECULAR PHARMACOLOGY

Safety and efficacy of erlotinib in first-relapse glioblastoma: a phase II open-label study

(2010) W. K. A. Yung et al.   NEURO-ONCOLOGY

Enzastaurin plus temozolomide with radiation therapy in glioblastoma multiforme: A phase I study

(2010) N. Butowski et al.   NEURO-ONCOLOGY

Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02)

(2010) F. M. Iwamoto et al.   NEURO-ONCOLOGY

Canine spontaneous glioma: A translational model system for convection-enhanced delivery

(2010) P. J. Dickinson et al.   NEURO-ONCOLOGY

Sorafenib exerts anti-glioma activity in vitro and in vivo

(2010) Markus D. Siegelin et al.   NEUROSCIENCE LETTERS

The many roles of microRNAs in brain tumor biology

(2010) Jay D. Turner et al.   Neurosurgical Focus

Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM

(2010) W. R. Wiedemeyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Convection-enhanced delivery of camptothecin-loaded polymer nanoparticles for treatment of intracranial tumors

(2010) Andrew J. Sawyer et al.   Drug Delivery and Translational Research

Convection-enhanced delivery of nanocarriers for the treatment of brain tumors

(2009) Emilie Allard et al.   BIOMATERIALS

Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies

(2009) A Diaz Miqueli et al.   BRITISH JOURNAL OF CANCER

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

A phase I/II trial of GW572016 (lapatinib) in recurrent glioblastoma multiforme: clinical outcomes, pharmacokinetics and molecular correlation

(2009) Brian Thiessen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors

(2009) Hiroaki Ikushima et al.   Cell Stem Cell

PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells

(2009) Anne-Marie Bleau et al.   Cell Stem Cell

Phase II Study of Neoadjuvant Imatinib in Glioblastoma: Evaluation of Clinical and Molecular Effects of the Treatment

(2009) E. Razis et al.   CLINICAL CANCER RESEARCH

A Phase I Trial of Enzastaurin in Patients with Recurrent Gliomas

(2009) T. N. Kreisl et al.   CLINICAL CANCER RESEARCH

Glioblastoma multiforme: a review of where we have been and where we are going

(2009) Cory Adamson et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Tat-BMPs-PAMAM Conjugates Enhance Therapeutic Effect of Small Interference RNA on U251 Glioma Cells In Vitro and In Vivo

(2009) Lei Han et al.   HUMAN GENE THERAPY

Phase II Trial of Vorinostat in Recurrent Glioblastoma Multiforme: A North Central Cancer Treatment Group Study

(2009) Evanthia Galanis et al.   JOURNAL OF CLINICAL ONCOLOGY

A survey of glioblastoma genomic amplifications and deletions

(2009) Shailaja K. Rao et al.   JOURNAL OF NEURO-ONCOLOGY

Poor drug distribution as a possible explanation for the results of the PRECISE trial

(2009) John H. Sampson et al.   JOURNAL OF NEUROSURGERY

Radioisotopic Imaging of Neuroinflammation

(2009) A. Winkeler et al.   JOURNAL OF NUCLEAR MEDICINE

U-SPECT-II: An Ultra-High-Resolution Device for Molecular Small-Animal Imaging

(2009) F. van der Have et al.   JOURNAL OF NUCLEAR MEDICINE

Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma

(2009) V. Milano et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells

(2009) G. L. Gallia et al.   MOLECULAR CANCER THERAPEUTICS

Nanotechnology for delivery of drugs to the brain for epilepsy

(2009) Margaret F. Bennewitz et al.   Neurotherapeutics

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

PET versus SPECT: strengths, limitations and challenges

(2009) Arman Rahmim et al.   NUCLEAR MEDICINE COMMUNICATIONS

Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer

(2009) Fancy C. Thomas et al.   PHARMACEUTICAL RESEARCH

Pharmacokinetics and tumor dynamics of the nanoparticle IT-101 from PET imaging and tumor histological measurements

(2009) T. Schluep et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine

(2009) Sherry Shu-Jung Hu et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

(2009) D. Guo et al.   Science Signaling

In Vivo SPECT and Real-Time Gamma Camera Imaging of Biodistribution and Pharmacokinetics of siRNA Delivery Using an Optimized Radiolabeling and Purification Procedure

(2008) Olivia M. Merkel et al.   BIOCONJUGATE CHEMISTRY

Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2

(2008) A Régina et al.   BRITISH JOURNAL OF PHARMACOLOGY

Aggravated Endoplasmic Reticulum Stress as a Basis for Enhanced Glioblastoma Cell Killing by Bortezomib in Combination with Celecoxib or Its Non-Coxib Analogue, 2,5-Dimethyl-Celecoxib

(2008) A. Kardosh et al.   CANCER RESEARCH

microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

(2008) B. Kefas et al.   CANCER RESEARCH

Deforolimus (AP23573) a novel mTOR inhibitor in clinical development

(2008) Monica Mita et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Epidermal Growth Factor Plays a Crucial Role in Mitogenic Regulation of Human Brain Tumor Stem Cells

(2008) Akio Soeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

(2008) S.-M. Maira et al.   MOLECULAR CANCER THERAPEUTICS

Phase II preradiation R115777 (tipifarnib) in newly diagnosed GBM with residual enhancing disease

(2008) Robert Lustig et al.   NEURO-ONCOLOGY

A small-animal imaging system capable of multipinhole circular/helical SPECT and parallel-hole SPECT

(2008) Jianguo Qian et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

Preparation and initial characterization of biodegradable particles containing gadolinium-DTPA contrast agent for enhanced MRI

(2008) A. L. Doiron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma

(2008) Tim F Cloughesy et al.   PLOS MEDICINE