MLKL and CaMKII Are Involved in RIPK3-Mediated Smooth Muscle Cell Necroptosis

Single-Cell RNA Sequencing Reveals Heterogeneity of Vascular Cells in Early Stage Murine Abdominal Aortic Aneurysm

(2021) Huan Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bisphenol A induces coronary endothelial cell necroptosis by activating RIP3/CamKII dependent pathway

(2020) P. Reventun et al.   Scientific Reports

Loss of MLKL (Mixed Lineage Kinase Domain-Like Protein) Decreases Necrotic Core but Increases Macrophage Lipid Accumulation in Atherosclerosis

(2020) Adil Rasheed et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

(2020) Andre L. Samson et al.   Nature Communications

RIP1/RIP3/MLKL-mediated necroptosis contributes to vinblastine-induced myocardial damage

(2020) Huiling Zhou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models

(2019) Ting Zhou et al.   Cell Death & Disease

Cellular Mechanisms of Aortic Aneurysm Formation

(2019) Raymundo Alain Quintana et al.   CIRCULATION RESEARCH

ZYZ-803 Mitigates Endoplasmic Reticulum Stress-Related Necroptosis after Acute Myocardial Infarction through Downregulating the RIP3-CaMKII Signaling Pathway

(2019) Lingling Chang et al.   Oxidative Medicine and Cellular Longevity

Necroptosis in development and diseases

(2018) Bing Shan et al.   GENES & DEVELOPMENT

Melatonin attenuates chronic pain related myocardial ischemic susceptibility through inhibiting RIP3-MLKL/CaMKII dependent necroptosis

(2018) Zheng Yang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

RIPK3 interactions with MLKL and CaMKII mediate oligodendrocytes death in the developing brain

(2017) Yi Qu et al.   Cell Death & Disease

Inhibition of Receptor-Interacting Protein Kinase 1 with Necrostatin–1s ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model

(2017) Qiwei Wang et al.   Scientific Reports

Ca2+/calmodulin-dependent protein kinase II-γ (CaMKIIγ) negatively regulates vascular smooth muscle cell proliferation and vascular remodeling

(2016) Fatima Z. Saddouk et al.   FASEB JOURNAL

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis

(2016) D. Karunakaran et al.   Science Advances

5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Inhibits RIPK1/RIPK3-Dependent Necroptosis in THP-1-Derived Foam Cells

(2016) Fang Tian et al.   Scientific Reports

Receptor-Interacting Protein Kinase 3 Contributes to Abdominal Aortic Aneurysms via Smooth Muscle Cell Necrosis and Inflammation

(2015) Q. Wang et al.   CIRCULATION RESEARCH

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development

(2013) Juan Lin et al.   Cell Reports

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Analysis of risk factors for abdominal aortic aneurysm in a cohort of more than 3 million individuals

(2010) K. Craig Kent et al.   JOURNAL OF VASCULAR SURGERY

CaM kinase IIδ2-dependent regulation of vascular smooth muscle cell polarization and migration

(2008) Melissa Z. Mercure et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

CaMKII-δ Isoform Regulation of Neointima Formation After Vascular Injury

(2007) Suzanne J. House et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY