PI3K/AKT/mTOR Signaling Pathway Is Required for JCPyV Infection in Primary Astrocytes

GRK2 mediates β-arrestin interactions with 5-HT2 receptors for JC polyomavirus endocytosis

(2021) Colleen L. Mayberry et al.   JOURNAL OF VIROLOGY

The MAPK/ERK Pathway and the Role of DUSP1 in JCPyV Infection of Primary Astrocytes

(2021) Michael P. Wilczek et al.   Viruses-Basel

Association of Antineoplastic Therapy With Decreased SARS-CoV-2 Infection Rates in Patients With Cancer

(2021) Michael B. Foote et al.   JAMA Oncology

Skp2 modulates proliferation, senescence and tumorigenesis of glioma

(2020) Juan Wu et al.   Cancer Cell International

Sirolimus and other mTOR inhibitors directly activate latent pathogenic human polyomavirus replication

(2020) Jennifer Alvarez Orellana et al.   JOURNAL OF INFECTIOUS DISEASES

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor

(2020) Bethany A. O’Hara et al.   PLoS Pathogens

Phosphoinositide 3′-Kinase γ Facilitates Polyomavirus Infection

(2020) Paul Clark et al.   Viruses-Basel

ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells

(2020) Pedro Fuentes et al.   Nature Communications

mTOR inhibition in COVID‐19: A commentary and review of efficacy in RNA viruses

(2020) Basil S. Karam et al.   JOURNAL OF MEDICAL VIROLOGY

Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease

(2020) Irene Cortese et al.   Nature Reviews Neurology

Rapamycin and Alzheimer’s disease: Time for a clinical trial?

(2019) Matt Kaeberlein et al.   Science Translational Medicine

Targeting PI3K in cancer: mechanisms and advances in clinical trials

(2019) Jing Yang et al.   Molecular Cancer

JC Polyomavirus Entry by Clathrin-Mediated Endocytosis is Driven by β-arrestin

(2019) Colleen L. Mayberry et al.   JOURNAL OF VIROLOGY

Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy

(2019) Irene Cortese et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-Throughput Characterization of Viral and Cellular Protein Expression Patterns During JC Polyomavirus Infection

(2019) Jeanne K. DuShane et al.   Frontiers in Microbiology

JCPyV-Induced MAPK Signaling Activates Transcription Factors during Infection

(2019) Jeanne K. DuShane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Toward understanding the origin and evolution of cellular organisms

(2019) Minoru Kanehisa   PROTEIN SCIENCE

Progressive multifocal leukoencephalopathy

(2019) Pria Anand et al.   Neurology-Neuroimmunology & Neuroinflammation

Rapamycin for longevity: opinion article

(2019) Mikhail V. Blagosklonny   Aging-US

JC Polyomavirus Infection Reveals Delayed Progression of the Infectious Cycle in Normal Human Astrocytes

(2019) Michael P. Wilczek et al.   JOURNAL OF VIROLOGY

ERK Is a Critical Regulator of JC Polyomavirus Infection

(2018) Jeanne K. DuShane et al.   JOURNAL OF VIROLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Allogeneic BK Virus–Specific T Cells for Progressive Multifocal Leukoencephalopathy

(2018) Muharrem Muftuoglu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Replication of JC Virus DNA in the G144 Oligodendrocyte Cell Line Is Dependent Upon Akt

(2017) Jesse N. Peterson et al.   JOURNAL OF VIROLOGY

Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence

(2017) Hyun Jin Kwun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insufficient Radiofrequency Ablation Treated Hepatocellular Carcinoma Cells Promote Metastasis by Up-Regulation ITGB3

(2017) Ning Zhang et al.   Journal of Cancer

Pharmacological inhibition of PI3K class III enhances the production of pro- and anti-inflammatory cytokines in dendritic cells stimulated by TLR agonists

(2016) Álvaro Pittini et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Natalizumab-Related Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis: Findings from an Italian Independent Registry

(2016) Luca Prosperini et al.   PLoS One

Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells

(2016) Ji heon Rhim et al.   Scientific Reports

BK Polyomavirus Replication in Renal Tubular Epithelial Cells Is Inhibited by Sirolimus, but Activated by Tacrolimus Through a Pathway Involving FKBP-12

(2015) H. H. Hirsch et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Phase II study of an AKT inhibitor MK2206 in patients with relapsed or refractory lymphoma

(2015) Yasuhiro Oki et al.   BRITISH JOURNAL OF HAEMATOLOGY

Progressive multifocal leukoencephalopathy: current treatment options and future perspectives

(2015) Dejan Pavlovic et al.   Therapeutic Advances in Neurological Disorders

PI3K/AKT signaling pathway and cancer: an updated review

(2014) Miriam Martini et al.   ANNALS OF MEDICINE

Antiviral Potential of ERK/MAPK and PI3K/AKT/mTOR Signaling Modulation for Middle East Respiratory Syndrome Coronavirus Infection as Identified by Temporal Kinome Analysis

(2014) Jason Kindrachuk et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Human glial chimeric mice reveal astrocytic dependence of JC virus infection

(2014) Yoichi Kondo et al.   JOURNAL OF CLINICAL INVESTIGATION

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

BK Polyomavirus in Solid Organ Transplantation

(2013) H. H. Hirsch et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The human JC polyomavirus (JCPyV): virological background and clinical implications

(2013) Hans H. Hirsch et al.   APMIS

5-HT2 Receptors Facilitate JC Polyomavirus Entry

(2013) B. Assetta et al.   JOURNAL OF VIROLOGY

MEK Inhibition Leads to PI3K/AKT Activation by Relieving a Negative Feedback on ERBB Receptors

(2012) A. B. Turke et al.   CANCER RESEARCH

Molecular Biology, Epidemiology, and Pathogenesis of Progressive Multifocal Leukoencephalopathy, the JC Virus-Induced Demyelinating Disease of the Human Brain

(2012) M. W. Ferenczy et al.   CLINICAL MICROBIOLOGY REVIEWS

Risk of Natalizumab-Associated Progressive Multifocal Leukoencephalopathy

(2012) Gary Bloomgren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathogenesis of Progressive Multifocal Leukoencephalopathy—Revisited

(2011) Martyn K. White et al.   JOURNAL OF INFECTIOUS DISEASES

Progressive Multifocal Leukoencephalopathy (PML) Development Is Associated With Mutations in JC Virus Capsid Protein VP1 That Change Its Receptor Specificity

(2011) Leonid Gorelik et al.   JOURNAL OF INFECTIOUS DISEASES

Proteomics Identification of ITGB3 as a Key Regulator in Reactive Oxygen Species-induced Migration and Invasion of Colorectal Cancer Cells

(2011) Yunlong Lei et al.   MOLECULAR & CELLULAR PROTEOMICS

Progressive multifocal leukoencephalopathy in a patient without immunodeficiency

(2011) I. L. Tan et al.   NEUROLOGY

Clinical outcomes of natalizumab-associated progressive multifocal leukoencephalopathy

(2011) P. Vermersch et al.   NEUROLOGY

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Polyomavirus JC-targeted T-cell therapy for progressive multiple leukoencephalopathy in a hematopoietic cell transplantation recipient

(2010) A Balduzzi et al.   BONE MARROW TRANSPLANTATION

Human Polyomavirus JC (JCV) Infection of Human B Lymphocytes: A Possible Mechanism for JCV Transmigration across the Blood‐Brain Barrier

(2010) Moti L. Chapagain et al.   JOURNAL OF INFECTIOUS DISEASES

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

JC Virus Small t Antigen Binds Phosphatase PP2A and Rb Family Proteins and Is Required for Efficient Viral DNA Replication Activity

(2010) Brigitte Bollag et al.   PLoS One

Anti-BK Virus Mechanisms of Sirolimus and Leflunomide Alone and in Combination: Toward a New Therapy for BK Virus Infection

(2010) Abdelhamid Liacini et al.   TRANSPLANTATION

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project

(2009) K. R. Carson et al.   BLOOD

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

(2009) Steven M. Pollard et al.   Cell Stem Cell

Incidence and Outcome of Progressive Multifocal Leukoencephalopathy over 20 Years of the Swiss HIV Cohort Study

(2009) Nina Khanna et al.   CLINICAL INFECTIOUS DISEASES

Prevalence of Polyomavirus BK and JC Infection and Replication in 400 Healthy Blood Donors

(2009) Adrian Egli et al.   JOURNAL OF INFECTIOUS DISEASES

JC Virus Mediates Invasion and Migration in Colorectal Metastasis

(2009) Alexander Link et al.   PLoS One

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

Seroepidemiology of Human Polyomaviruses

(2009) Jaime M. Kean et al.   PLoS Pathogens

Down-regulation of the PI3-kinase/Akt pathway by ERK MAP kinase in growth factor signaling

(2008) Hideko Hayashi et al.   GENES TO CELLS

Interaction between Simian Virus 40 Large T Antigen and Insulin Receptor Substrate 1 Is Disrupted by the K1 Mutation, Resulting in the Loss of Large T Antigen-Mediated Phosphorylation of Akt

(2008) Y. Yu et al.   JOURNAL OF VIROLOGY

Dephosphorylation of JC virus agnoprotein by protein phosphatase 2A: Inhibition by small t antigen

(2008) Ilker K. Sariyer et al.   VIROLOGY

Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma

(2008) Tim F Cloughesy et al.   PLOS MEDICINE